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34. Additional file 1 of Abnormally increased DNA methylation in chorionic tissue might play an important role in development of ectopic pregnancy

Author

Cai, Wen, Yang, Liu, Zhang, Ruiqing, Yang, Yixia, Li, Shuangdi, and Zhang, Jiarong

Abstract

Additional file 1: Figure S1. T-test of all differential methylated genes. Figure S2. The biological process GO analysis of hypermethylated genes. The most enriched GO targets were involved in T-helper 1 type immune response, homophilic cell adhesion via plasma membrane adhesion molecules, positive regulation of filopodium assembly et al. Figure S3. The biological process GO analysis of hypomethylated genes. The most enriched GO targets were involved in homophilic cell adhesion via plasma membrane adhesion molecules, transcription from RNA polymerase II promoter, nervous system development et al. Figure S4. The cellular component GO analysis of hypermethylated genes. The most enriched GO targets were involved in transport vesicle membrane, clathrin-coated endocytic vesicle membrane, trans-Golgi network membrane et al. Figure S5. The cellular component GO analysis of hypomethylated genes. The most enriched GO targets were involved in plasma membrane, integral component of plasma membrane, MHC class II protein complex et al. Figure S6. The molecular function GO analysis of hypermethylated genes. The most enriched GO targets were involved in phosphatidylinositol-3-phosphate binding, GTPase activator activity, calcium ion binding et al. Figure S7. The molecular function GO analysis of hypomethylated genes. The most enriched GO targets were involved in calcium binding, sequence-specific DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding et al. Figure S8. The KEGG analysis of hypermethylated genes. The most enriched KEGG targets were involved in leishmaniasis, phagosome, Type I diabetes mellitus et al. Figure S9. The KEGG analysis of hypomethylated genes. The most enriched KEGG targets were involved in Type I diabetes mellitus, allograft rejection, graft-versus-host disease et al. Figure S10. SDR42E1 CpG derived methylation data. Figure S11. CAMTA1 CpG derived methylation data. Figure S12. TSTD1 CpG derived methylation data. Figure S13. PIP5K1C CpG derived methylation data. Figure S14. DNER CpG derived methylation data. Figure S15. KIAA1614 CpG derived methylation data.

Published
2021
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37. A dual-signal sensing strategy based on ratiometric fluorescence and colorimetry for determination of Cu2+ and glyphosate.

Author

Yang, Yixia, Li, Li, Lin, Liyun, Wang, Xianfeng, Li, Jiawei, Liu, Huan, Liu, Xiaofang, Huo, Danqun, and Hou, Changjun

Subjects
COLORIMETRY, FLUORESCENCE resonance energy transfer, GLYPHOSATE, FLUORESCENCE
Abstract

Herein, a dual-signal sensing strategy based on ratiometric fluorescence and colorimetry for Cu2+ and glyphosate determination was constructed. Fluorescence silicon nanoparticles (SiNPs) were prepared by hydrothermal reaction, which has maximum fluorescence intensity under the excitation of 355 nm. o-Phenylenediamine (OPD) was oxidized through Cu2+ to generate 2,3-diaminophenazine (oxOPD). The obtained oxOPD showed a strong absorption peak at 417 nm and quenched the fluorescence of SiNPs at 446 nm due to fluorescence resonance energy transfer (FRET). Meanwhile, oxOPD produced a new fluorescence emission at 556 nm forming a ratiometric state. With increasing Cu2+, the original solution changed from colorless to yellow. When glyphosate was present, the interaction between Cu2+ and the functional groups of glyphosate could reduce the oxidation of oxOPD, resulting in the enhancement of fluorescence at 446 nm and the decrease of fluorescence at 556 nm. Furthermore, the addition of glyphosate changed yellow solution to colorless. Under the optimal conditions of OPD (1 mM), 20 mM Tris–HCl buffer (pH 7.5), and incubation time (4 h), the ratiometric fluorescence sensor had good selectivity and showed a wide linear range of 0.025–20 μM with the LOD of 0.008 μM for Cu2+ and 0.15–1.5 μg/mL with the LOD of 0.003 μg/mL for glyphosate, respectively. Besides, it is worth mentioning that this developed sensing system showed good performance in real samples, providing a simple and reliable dual-signal detection strategy. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Aberrant expression of oxidative stress related proteins affects the pregnancy outcome of gestational diabetes mellitus patients

Author

Zhang, Chenchen, Yang, Yixia, Chen, Ruiying, Wei, Youheng, Feng, Youji, Zheng, Wenxin, Liao, Hong, and Zhang, Zhenbo

Subjects
endocrine system diseases, nutritional and metabolic diseases, Original Article, female genital diseases and pregnancy complications
Abstract

Gestational diabetemellitus (GDM) is a condition whereby a mother's glucose tolerance is impaired with onset or first recognition during pregnancy which is not either type 1 or type 2 diabetes mellitus. Oxidative stress plays an essential role in diabetes, however, whether it also includes in GDM has not been fully clarified. Therefore, we investigated the changes of oxidative stress biomarkers and their relationship with pregnancy outcomes in patients with GDM. The serum and placenta were collected for absorbance-based assay and immunohistochemistry assay (IHC). The patients' clinical information was collected and the pregnancy outcome was tracked. It was found that elder age is a risk factor to result in GDM. Moreover, GDM patients showed poor clinical factors or outcomes including higher prepregnancy weight and BMI value, premature delivery, higher rates of cesarean delivery, macrosomia, premature rupture of fetal membranes (PROM). Increasing serum MDA level and decline GSH and SOD levels were observed in GDM patients. Meanwhile, HO-1, Nrf2 and NQO1 overexpressed in GDM placental tissues. In the GDM group, MDA level was negatively associated with prepregnancy weight, while, SOD level was positively correlated with neonatal birth weight. We found an intensive relationship between SOD content and preterm birth in the GDM group. There is no significant difference between the level of MDA/GSH and neonatal birth weight as well as preterm birth. MDA, GSH and SOD levels were not associated with an increased risk of cesarean delivery or PROM. This study indicates aberrant expression of oxidative stress related proteins affects the pregnancy outcome of GDM patients.

Published
2019

47. The construction of a CND/Cu2+fluorescence sensing system for the ultrasensitive detection of glyphosateElectronic supplementary information (ESI) available. See DOI: 10.1039/c9ay02303h

Author

Wang, Xianfeng, Sakinati, Mina, Yang, Yixia, Ma, Yi, Yang, Mei, Luo, Huibo, Hou, Changjun, and Huo, Danqun

Abstract

In this work, a coumarin derivative (CND) was synthesized by a one-step condensation reaction and exhibited selective fluorescence quenching by Cu2+. Glyphosate with amine and carboxylate groups provided strong chelation for Cu2+from the CND/Cu2+system, leading to fluorescence recovery. In this strategy, a CND/Cu2+fluorescence sensing system was constructed to achieve the quantitative analysis of glyphosate. Under the optimized experimental conditions, a good linear relationship between CND and Cu2+of glyphosate concentration in the range from 0.02 μg mL−1to 1.50 μg mL−1was obtained and the correlation coefficient was 0.99. The detection limit was calculated to be 18.30 ng mL−1(S/N = 3) and presented relative advantages compared with other methods. The interference study exhibited excellent selectivity towards glyphosate. In addition, satisfactory recoveries ranging from 91.31% to 105.28% were achieved for the real samples. These results indicate that the CND/Cu2+fluorescence sensing system has practical application prospects.

Published
2020
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48. Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer

Author

Ke, Jieqi, primary, Yang, Yixia, additional, Che, Qi, additional, Jiang, Feizhou, additional, Wang, Huihui, additional, Chen, Zheng, additional, Zhu, Minjiao, additional, Tong, Huan, additional, Zhang, Huilin, additional, Yan, Xiaofang, additional, Wang, Xiaojun, additional, Wang, Fangyuan, additional, Liu, Yuan, additional, Dai, Chenyun, additional, and Wan, Xiaoping, additional

Published
2016
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