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27 results on '"Yang, Yinxian"'

5. Grooved Microneedle Patch Augments Adoptive T Cell Therapy Against Solid Tumors via Diverting Regulatory T Cells

Author

Zhou, Ruyi, primary, Yu, Hao, additional, Sheng, Tao, additional, Wu, Yingke, additional, Chen, Yingxin, additional, You, Jiahuan, additional, Yang, Yinxian, additional, Luo, Bowen, additional, Zhao, Sheng, additional, Zheng, Yi, additional, Li, Hongjun, additional, Zhang, Yuqi, additional, Guo, Yugang, additional, Gu, Zhen, additional, and Yu, Jicheng, additional

Published
2024
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8. Platelet‐Drug Conjugates Engineered via One‐step Fusion Approach for Metastatic and Postoperative Cancer Treatment.

Author

Zhao, Zhengjie, Yang, Yinxian, Sheng, Tao, Bao, Yuhang, Yu, Ruixi, Yu, Xinmin, Jia, Shuangxu, Wu, Qing, Zhu, Chaojie, Shen, Xinyuan, Zhang, Wentao, Lu, Ziyi, Ji, Kangfan, Chen, Xiaofeng, Jiang, Xinyun, Zhang, Yuqi, Gu, Zhen, and Yu, Jicheng

Subjects
*DRUG delivery systems, *METASTASIS, *ANTINEOPLASTIC agents, *CANCER relapse, *CANCER treatment, *LIPOSOMES
Abstract

The exploration of cell‐based drug delivery systems for cancer therapy has gained growing attention. Approaches to engineering therapeutic cells with multidrug loading in an effective, safe, and precise manner while preserving their inherent biological properties remain of great interest. Here, we report a strategy to simultaneously load multiple drugs in platelets in a one‐step fusion process. We demonstrate doxorubicin (DOX)‐encapsulated liposomes conjugated with interleukin‐15 (IL‐15) could fuse with platelets to achieve both cytoplasmic drug loading and surface cytokine modification with a loading efficiency of over 70 % within minutes. Due to their inherent targeting ability to metastatic cancers and postoperative bleeding sites, the engineered platelets demonstrated a synergistic therapeutic effect to suppress lung metastasis and postoperative recurrence in mouse B16F10 melanoma tumor models. [ABSTRACT FROM AUTHOR]

Published
2024
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12. KERS‐Inspired Nanostructured Mineral Coatings Boost IFN‐γ mRNA Therapeutic Index for Antitumor Immunotherapy (Adv. Mater. 51/2023)

Author

Shao, Zhenxuan, primary, Chen, Liang, additional, Zhang, Zengjie, additional, Wu, Yan, additional, Mou, Haochen, additional, Jin, Xiaoqiang, additional, Teng, Wangsiyuan, additional, Wang, Fangqian, additional, Yang, Yinxian, additional, Zhou, Hao, additional, Xue, Yucheng, additional, Eloy, Yinwang, additional, Yao, Minjun, additional, Zhao, Shenzhi, additional, Cui, Wenguo, additional, Yu, Xiaohua, additional, and Ye, Zhaoming, additional

Published
2023
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17. Recent Advances in Oral and Transdermal Protein Delivery Systems.

Author

Yang, Yinxian, Zhou, Ruyi, Wang, Yanfang, Zhang, Yuqi, Yu, Jicheng, and Gu, Zhen

Subjects
*ORAL drug administration, *TRANSDERMAL medication, *PEPTIDE drugs, *PATIENT compliance, *PROTEIN drugs
Abstract

Protein and peptide drugs are predominantly administered by injection to achieve high bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug delivery with minimal invasiveness and high adherence represent attractive alternatives to injection administration. However, oral and transdermal administration of bioactive proteins must overcome biological barriers, namely the gastrointestinal and skin barriers, respectively. The rapid development of new materials and technologies promises to address these physiological obstacles. This review provides an overview of the latest advances in oral and transdermal protein delivery, including chemical strategies, synthetic nanoparticles, medical microdevices, and biomimetic systems for oral administration, as well as chemical enhancers, physical approaches, and microneedles in transdermal delivery. We also discuss challenges and future perspectives of the field with a focus on innovation and translation. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Frontispiz: Platelet‐Drug Conjugates Engineered via One‐step Fusion Approach for Metastatic and Postoperative Cancer Treatment.

Author

Zhao, Zhengjie, Yang, Yinxian, Sheng, Tao, Bao, Yuhang, Yu, Ruixi, Yu, Xinmin, Jia, Shuangxu, Wu, Qing, Zhu, Chaojie, Shen, Xinyuan, Zhang, Wentao, Lu, Ziyi, Ji, Kangfan, Chen, Xiaofeng, Jiang, Xinyun, Zhang, Yuqi, Gu, Zhen, and Yu, Jicheng

Subjects
*ENGINEERING
Abstract

The article titled "Frontispiz: Platelet-Drug Conjugates Engineered via One-step Fusion Approach for Metastatic and Postoperative Cancer Treatment" in the journal Angewandte Chemie discusses a new method for creating platelet-drug conjugates using fusion of multidrug-loaded liposomes. The authors, Zhen Gu, Jicheng Yu, and their colleagues, demonstrate that this strategy allows for the efficient and safe co-loading of multiple drugs into cells. The article provides valuable insights into potential advancements in cancer treatment. [Extracted from the article]

Published
2024
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21. Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

Author

Yang, Yinxian, primary, Sun, Bingjun, additional, Zuo, Shiyi, additional, Li, Ximu, additional, Zhou, Shuang, additional, Li, Lingxiao, additional, Luo, Cong, additional, Liu, Hongzhuo, additional, Cheng, Maosheng, additional, Wang, Yongjun, additional, Wang, Shujun, additional, He, Zhonggui, additional, and Sun, Jin, additional

Published
2020
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27. Optimization, characterization and in vitro/vivoevaluation of azilsartan nanocrystals

Author

Ma, Jingjing, Yang, Yinxian, Sun, Yinghua, and Sun, Jin

Abstract

Through formulation screening, the irregular-shaped azilsartan nanocrystals were prepared and optimized by bead milling method and solidified by freeze-drying. The best formulation which had the size of 300 nm was expressed in its state by the studies of morphology and crystal from. And azilsartan nanocrystals showed its improvement about in-vitrodissolution and in-vivobioavailability with physical mixture as reference.

Published
2017
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