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The large-scale storage and stable supply of oil products are essential for national energy security and economic development. As the economy expands and energy demands rise, centralized storage and supply systems become increasingly vital for ensuring the efficiency and reliability of oil product distribution. However, large oil storage depots present substantial safety risks. In the event of fires, explosions, or other accidents, emergency response efforts face stringent demands and challenges. To enhance the emergency response capabilities of oil storage and transportation bases (OSTBs), this paper proposes an innovative approach that integrates the improved analytic hierarchy process (IAHP) with the Entropy Weight Method (EMW) to determine the combined weights of various indices. This approach reduces the subjective bias associated with the traditional analytic hierarchy process (AHP). The emergency response capabilities of OSTBs are subsequently evaluated through fuzzy comprehensive analysis. An empirical study conducted on an OSTB in the Zhoushan archipelago quantitatively assesses its emergency preparedness. The results show that the base excels in pre-incident prevention, demonstrates robust preparedness and response capabilities, and exhibits moderate recovery abilities after incidents. These findings provide a theoretical foundation for reducing the likelihood of accidents, enhancing emergency response efficiency, and mitigating the severity of consequences. Practical recommendations are also offered based on the results. [ABSTRACT FROM AUTHOR]

Self-powered photodetectors have the advantages of high sensitivity, sustainability, and small size and have become a research hotspot in advanced optoelectronic systems. However, the low output photocurrent density seriously hinders the practical application of ferroelectric self-powered photodetectors. Herein, the high-efficiency photoelectric detection performance of the Bi1-xHoxFeO3 ferroelectric self-powered photodetector is realized by doping Ho. The responsivity (R) and detectivity ( D * ) can reach 0.0159 A/W and 1.94 × 1011 Jones under monochromatic light with a wavelength of 900 nm. Meanwhile, the R and D * can reach 0.022 A/W and 2.65 × 1011 Jones under sunlight. These excellent photodetection performances are attributed to the high short-circuit current density (Jsc). When the Ho content is 6%, the output photocurrent reaches up to 0.81 mA/cm2. The systematic structure and photo-electric characteristic analysis suggest that the decrease in the band gap leads to the generation of a larger photocurrent while the ferroelectric polarization is reduced slightly. This work provides a new way to obtain high-performance self-powered photodetectors. [ABSTRACT FROM AUTHOR]

To realize real-time monitoring and short-term forecasting and forewarning of coalmine ventilation systems (CVS), in this paper, we first established a joint surface and underground CVS safety management system consisting of main ventilation fan, safety-partition linked passageways, and air-required locations. We then applied chaos theory to identify the air quantity and gas concentration of underground partition boundaries, and adopted a fixed data quantity, multi-step progressive, weighted first-order local-domain method to setup a chaos prediction model and a CVS safety forecasting and forewarning system formed by the normal change level, orange forewarning level, and red alarm level. We next conduct the on-field application of the system in a coalmine in Jining, Shandong, China. The results showed that (1) in the statistical scale of 5 min, the changes in both air quantity and gas concentration along CVS partition airflow boundaries were characteristic of chaos and could be used for short-term chaos prediction, and the latter was more chaotic than the former; (2) the setup chaos prediction model had a higher prediction precision and the established safety prediction system could not only predict the variation in CVS stability but also reflect the rationality of underground mining intensity. Thus, this CVS safety forecasting and forewarning system is of better application value. Keywords: Mine ventilation system, Safety partition, Reconstructed phase space, Maximum Lyapunov exponent, Chaos forecasting and forewarning

CD19+CD24hiCD27+ memory Breg cells exhibit decreased abundance in patients with chronic graft-versus-host disease (cGVHD) after liver transplantation and produce less IL-10 than those from patients without cGVHD and healthy donors. Due to the lack of Breg cells and the difficulty in expanding them in vitro , in mouse models and early human clinical trials, the adoptive transfer of Breg cells to autoimmune diseases is greatly restricted. Glycogen synthase kinase 3β (GSK-3β) is a multifunctional serine/threonine (ser/thr) protein kinase that can participate in B cell growth, metabolic activity, and proliferation. Phosphoprotein array analysis showed that p-GSK-3β-s9 was highly expressed in mBreg cells. Furthermore, here, we demonstrated that GSK-3β expression in mBreg cells is lower than that observed in B cells by flow cytometry. We found that the treatment of B cells with the specific GSK-3β inhibitor SB216763 can significantly increase the proportion and immunosuppressive function of mBreg cells in vitro. Nuclear factor of activated T cells (NFAT) is one of a pivotal regulator of gene expression in adaptive immune system. Here, we observed that inhibition of GSK-3β by SB216763 results in enhanced expression of NFATc1 in B cells, which is essential in regulating the ability of B cells to secrete IL-10. By constructing a xGVHD mouse model, we observed that SB216763-treated mBreg cells effectively prevent xenogeneic GVHD. Here we propose a novel strategy using SB216763 to inhibit GSK-3β and then enhance the proportion and immunosuppressive function of mBreg cells by increasing the expression of NFATc1. This approach may be used as a therapy to ameliorate GVHD and inflammatory diseases. [ABSTRACT FROM AUTHOR]