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1,057 results on '"Yang, Weizhong"'

18. Seasonal association between viral causes of hospitalised acute lower respiratory infections and meteorological factors in China: a retrospective study

Author

Xu, Bing, Wang, Jinfeng, Li, Zhongjie, Xu, Chengdong, Liao, Yilan, Hu, Maogui, Yang, Jing, Lai, Shengjie, Wang, Liping, and Yang, Weizhong

Subjects
Statistics - Applications
Abstract

Acute lower respiratory infections caused by respiratory viruses are common and persistent infectious diseases worldwide and in China, which have pronounced seasonal patterns. Meteorological factors have important roles in the seasonality of some major viruses. Our aim was to identify the dominant meteorological factors and to model their effects on common respiratory viruses in different regions of China. We analysed monthly virus data on patients from 81 sentinel hospitals in 22 provinces in mainland China from 2009 to 2013. The geographical detector method was used to quantify the explanatory power of each meteorological factor, individually and interacting in pairs. 28369 hospitalised patients with ALRI were tested, 10387 were positive for at least one virus, including RSV, influenza virus, PIV, ADV, hBoV, hCoV and hMPV. RSV and influenza virus had annual peaks in the north and biannual peaks in the south. PIV and hBoV had higher positive rates in the spring summer months. hMPV had an annual peak in winter spring, especially in the north. ADV and hCoV exhibited no clear annual seasonality. Temperature, atmospheric pressure, vapour pressure, and rainfall had most explanatory power on most respiratory viruses in each region. Relative humidity was only dominant in the north, but had no significant explanatory power for most viruses in the south. Hours of sunlight had significant explanatory power for RSV and influenza virus in the north, and for most viruses in the south. Wind speed was the only factor with significant explanatory power for human coronavirus in the south. For all viruses, interactions between any two of the paired factors resulted in enhanced explanatory power, either bivariately or non-linearly., Comment: 6 figures and tables

Published
2020
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35. Diabetic Microenvironment‐Unlocked BioHJzyme with H2S Evolution for Robust Anti‐Pathogens and Hyperinflammatory Wound Regeneration Through TGF‐β/Smad Pathway.

Author

Gao, Xiangyu, He, Miaomiao, Chen, Wanxi, Wang, Zuyao, Li, Yunfei, Bai, Ding, Yin, Guangfu, Shu, Rui, Deng, Yi, and Yang, Weizhong

Subjects
SKIN regeneration, GLUCOSE oxidase, INFRARED lasers, TURNOVER frequency (Catalysis), HYDROXYL group, RECEPTOR for advanced glycation end products (RAGE)
Abstract

Deferred diabetic skin healing is an ever‐growing complication owing to the hyperglycemic microenvironment, which accelerates the generation of advanced glycated end products (AGEs) and provides a hotbed for pathogenic infection. Here, the H2S‐evolving bio‐heterojunction enzyme (BioHJzyme), which is consisted by MXene/FeS2 and glucose oxidase (GOx) is devised. It presents glutathione peroxidase (GPx)‐ and peroxidase (POD)‐mimetic antibacterial activity for anti‐pathogens and wound regeneration by AGEs depression. The GOx catalyzes glucose, resulting in reducing the bacterial nutrient and supplying H2O2. The POD‐mimetic activity of the BioHJzyme catalyzes the H2O2 to hydroxyl radical (•OH) with a turnover number of 4.45 × 10−1 s−1, while the GPx‐mimetic activity of it consumes glutathione for further •OH accumulation. The anti‐pathogens can be enhanced by near infrared laser (NIR) irradiation owing to the efficient separation of electron‐hole pairs originated from the heterostructure, which presents NIR‐activatable •OH and 1O2 production. Moreover, the BioHJzyme evolves H2S in acidic environment, acting as an H2S donor, which protects cells around the wound from oxidative damage and AGEs, rescues mitochondrial respiration, improves the extracellular matrix deposition and ameliorates dysfunction of fibroblasts for diabetic skin regeneration through TGF‐β/Smad pathway. The work provides a proof‐of‐concept for bacteria‐invaded diabetic wound regeneration via H2S‐evolving BioHJzyme. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Construction of Emergency Prevention and Control System for Public Health Emergencies in China

Author

Wang Zhuoran, Li Mingsui, Jiang Huili, Yang Juntao, Yang Weizhong, and Liu Depei

Subjects
public health emergencies，prevention and control system，integration of prevention and treatment，detection and early warning，industrial support, Engineering (General). Civil engineering (General), TA1-2040
Abstract

Public health emergencies severely affect people’s lives and health, national security, social stability, and economic development. Against the background of coronavirus disease 2019 pandemic, this study analyzes the current status of China’s public health emergency prevention and control system from the aspects of its six major systems: monitoring, early warning, and evaluation; diagnosis and treatment; basic scientific research; personnel training; material, equipment, and industry support; and social mobilization and coordinated action. We conclude that strengthening system construction is a realistic demand of China in the new development stage. China’s public health system still faces challenges regarding institutional positioning, capacity building, hardware investment, and management system. Therefore, we propose that China should establish a national overall coordination and emergency command mechanism, strengthen clinical, science, education, and industrial support capacity, and further promote international cooperation.

Published
2021
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