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Spontaneous intracranial hemorrhage (ICH) patients are still at risk of postoperative ischemic complications (PICs) after surgery. In addition, the proportion of patients receiving antiplatelet therapy (APT) in ICH patients increased significantly with age. This study aims to evaluate the impact of preoperative antiplatelet therapy on PICs in ICH patients. This is a cohort study that retrospectively analyzed the data of ICH patients who underwent surgical treatment. PICs rate was compared between patients with preoperative ATP and those without preoperative ATP. Univariate and multivariate analyses were conducted to evaluate the impact of preoperative APT on PICs. In addition, Kaplan-Meier method was used for survival analysis and the impact of PICs on patients' postoperative outcomes was evaluated. A total of 216 patients were included in this study. There were 47 patients (21.76%) with preoperative APT; 169 patients (78.24%) without preoperative APT. The incidence of PICs in the APT group was significantly higher when compared with that in the nAPT group (36.17% vs. 20.71%, p = 0.028＜0.05). Furthermore, significant differences were both observed in multivariate analysis (p = 0.035＜0.05) and survival analysis (log rank χ2 = 5.415, p = 0.020＜0.05). However, there was no significant difference between the outcomes of patients suffering from PICs and that of patients not suffering from PICs (p = 0.377 > 0.05). In conclusion, preoperative APT may be a risk factor for PICs in ICH patients undergoing surgical treatment significantly. [ABSTRACT FROM AUTHOR]

This article provides a clinicopathological and genomic analysis of intestinal adenosquamous carcinoma, a rare form of cancer characterized by the presence of both adenocarcinoma and squamous components. The study conducted a retrospective analysis of patients with intestinal tumors and performed whole-exome sequencing on three cases of duodenal adenosquamous carcinoma. The findings revealed the relative proportions of adenocarcinoma and squamous cell carcinoma components, identified mutations in specific genes, and discussed the limitations of the study. The research contributes valuable insights into the characteristics and mutational landscape of this type of cancer, potentially informing future therapeutic development. [Extracted from the article]

Background: Potential neurovascular uncoupling (NVU) related to perinidal angiogenesis (PA) of brain arteriovenous malformations (AVMs) may cause inappropriate presurgical mapping using functional magnetic resonance imaging (fMRI), resulting in overconfident resection and postoperative morbidity. Purpose: To evaluate the potential impact of PA upon fMRI blood oxygen level‐dependent signal in the periphery of AVMs. Study Type: Prospective. Population: Twenty‐one patients with AVMs located in the primary sensorimotor cortex (SM1) undergoing task‐based fMRI (hand motor), and 19 patients with supratentorial AVMs undergoing resting‐state fMRI. Field Strength/Sequence: 3.0T, echo‐planar, time‐of‐flight, and magnetization‐prepared rapid gradient‐echo. Assessment: The presence of PA was determined by three observers (Y.C., J.W., and X.C.) according to digital subtraction angiography and MR angiography. Interhemispheric asymmetry of fMRI activations contralateral to hand movements was evaluated with the interhemispheric ratio of the average t‐value within ipsilesional SM1 to contralesional SM1. Regional homogeneity (ReHo) and fractional amplitude of low‐frequency fluctuations (fALFF) were extracted from ring‐shaped perinidal regions and contralateral homologous regions, and the corresponding interhemispheric ratios were calculated. The effect of PA on the interhemispheric asymmetry of motor activations, ReHo, and fALFF was estimated. Statistical Tests: Pearson analysis, paired and independent t‐test, multiple linear regression, Friedman test, and factorial analysis of variance were used. Results: Motor activations were significantly reduced in ipsilesional SM1 compared to contralesional SM1 (P < 0.05). The presence of PA was the independent predictor of activation loss in ipsilateral SM1(P < 0.05). Furthermore, perinidal regions exhibited reduced ReHo compared to the homologous regions (P < 0.05). PA was significantly associated with the decline of ReHo and fALFF in perinidal regions (P < 0.05, for both). Data Conclusion: The presence of PA can predict perinidal NVU that may confound the interpretation of both task‐based and resting‐state fMRI, highlighting the importance of alternative approaches of brain functional localization in improving treatment of AVMs. Level of Evidence: 2 Technical Efficacy Stage: 2 [ABSTRACT FROM AUTHOR]

Objective: To investigate the value of high-sensitivity C-reactive protein (hs-CRP) in evaluating the myocardial damage and prognosis in children with mycoplasmal pneumonia., Materials: A total of 150 children with mycoplasmal pneumonia were selected. According to their serum creatine kinase isoenzyme (CK-MB) level, they were divided into 72 cases of the myocardial damage group and 78 cases of the non-myocardial damage group. Eighty healthy children undergoing physical examination were selected as the control group. The electrocardiography results and serum CK-MB and hs-CRP levels were compared among the subjects. The correlations among the above indexes were analyzed., Results: The levels of hs-CRP and CK-MB in the myocardial damage group were significantly higher than those in the nonmyocardial damage group and control group, respectively ( P <0.05). The rates of abnormal hs-CRP and abnormal electrocardiogram in the myocardial damage group were significantly higher than those in the non-myocardial damage group, respectively ( P <0.05). In the 150 children with mycoplasmal pneumonia, the serum hs-CRP and CK-MB levels were positively correlated ( P <0.001), and the abnormal hs-CRP rate was positively correlated with the abnormal electrocardiogram rate ( P <0.001). In the myocardial damage group, the serum levels of hs-CRP and CK-MB after treatment were significantly lower than those before treatment, respectively ( P <0.05). After treatment, each index in the myocardial damage group had no significant difference with those in the control group ( P >0.05)., Conclusion: hs-CRP may be an important index for evaluating the myocardial damage and prognosis in children with mycoplasmal pneumonia. The combination of hs-CRP and CK-MB detection has obvious guiding significance for the monitoring and treatment of mycoplasmal pneumonia complicated by myocardial damage., (© 2021 by the Association of Clinical Scientists, Inc.)