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159 results on '"Yang, Seung Dae"'

28. Medical radioisotope 89Zr production with RFT-30 cyclotron.

Author

Lee, Jun Young, Hur, Min Goo, Kong, Young Bae, Lee, Eun Je, Yang, Seung Dae, Choi, Pyeong Seok, and Park, Jeong Hoon

Subjects
CYCLOTRONS, RADIOISOTOPES, POSITRON emission tomography, NUCLEAR energy, NUCLEAR research, NUCLEAR medicine
Abstract

89Zr is an emerging radionuclide with promising application in nuclear medicine for the non-invasive diagnosis of various cancers with PET imaging. This paper would discuss optimization efforts in the production of 89Zr carried out at Accelerator Radioisotope Development Team, Korea Atomic Energy Research Institute. Optimized conditions reveal high production yields of 89Zr ~ 37 ± 1.4 MBq/µA using 89Y(p,n)89Zr, ~ 12.7 MeV of proton, and 35 µA using yttrium coin target with indigenously constructed 30 MeV Cyclotron (RFT-30). Besides, the production optimization, quality control, and biological behavior of [89Zr]Zr-oxalate, chloride and, DFO demonstrated promising results. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Deep Learning Based Predictive Control for RFT-30 Cyclotron

Author

Kong, Young Bae, Hur, Min Goo, Lee, Eunje, Park, Jeong Hoon, Song, HoSeung, and Yang, Seung Dae

Subjects
06 Beam Instrumentation, Controls, Feedback, and Operational Aspects, T22 Reliability and Operability, Accelerator Physics
Abstract

Successful construction of the control system is an important problem in the accelerator. The RFT-30 cyclotron is 30 MeV cyclotron for radioisotope production and fundamental researches. To operate the RFT-30 cyclotron for beam irradiation, the human operators should carefully manipulate the control parameters. If the control does not function properly, it becomes difficult to handle the cyclotron and cannot perform the accurate operations for the control. In this work, we propose a deep learning based model predictive control approach for the RFT-30 cyclotron. The proposed approach is composed of two steps: system identification and a control design. In the system identification procedure, the proposed approach constructs the predictive model of the accelerator using the deep learning approach. In the control design stage, the controller finds the optimal control inputs by solving the optimization problem. To analyze the performance of the proposed approach, we applied the approach into the RFT-30 cyclotron., Proceedings of the 9th Int. Particle Accelerator Conf., IPAC2018, Vancouver, BC, Canada

Published
2018
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30. Neural Network Based Generalized Predictive Control for RFT-30 Cyclotron System

Author

Kong, Young Bae, Hur, Min Goo, Lee, Eun, Park, Jeong Hoon, Park, Yong Dae, and Yang, Seung Dae

Subjects
Accelerator Physics, Cyclotron Technology
Abstract

Beamline tuning is time consuming and difficult work in accelerator system. In this work, we propose a neural generalized predictive control (NGPC) approach for the RFT-30 cyclotron beamline. The proposed approach performs system identification with the NN model and finds the control parameters for the beamline. Performance results show that the proposed approach helps to predict optimal parameters without real experiments with the accelerator., Proceedings of the 21st Int. Conf. on Cyclotrons and their Applications, Cyclotrons2016, Zurich, Switzerland

Published
2017
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32. Development of EPICS Control System for ODA Magnet Power Supplies and GigE CCD Camera

Author

Cha, Sungsu, Buaphad, Pikad, Ha, Jang Ho, Kim, Jae-Ho, Kim, Yujong, and Yang, Seung Dae

Subjects
07 Accelerator Technology, Physics::Accelerator Physics, Accelerator Physics
Abstract

The Radiation Equipment Research Division of the Korea Atomic Energy Research Institute has been op-erating a 10 MeV RF electron linear accelerator, which is used for electron beam irradiation. The beam power and energy of the RF electron linear accelerator are 10 kW and 10 MeV. The accelerator is composed of an electron gun, an S-band (= 2856 MHz) accelerating structure, a klystron, electromagnetic solenoids, a scanning electromagnet, an RF driver, a modulator, and a chiller. The linac components have deteriorated due to a long operation time of 9 years. In this paper, we described Experimental Physics and Industrial Control System (EPICS) to control ODA magnet power sup-plies for solenoids and steering magnets of the 10 MeV electron beam irradiation accelerator., Proceedings of the 7th Int. Particle Accelerator Conf., IPAC2016, Busan, Korea

Published
2016
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37. Synthesis and evaluation of triphenylphosphonium conjugated 18F-labeled silica nanoparticles for PET imaging.

Author

Kim, Gun Gyun, Lee, Jun Young, Choi, Pyeong Seok, Vyas, Chirag K., Yang, Seung Dae, Hur, Min Gu, and Park, Jeong Hoon

Subjects
CANCER cells, CELL membranes, SILICA nanoparticles, POSITRON emission tomography, EXTRACELLULAR space
Abstract

Accumulation of triphenylphosphonium (TPP) is normally observed in the mitochondria from the extracellular spaces due to the high difference in plasma membrane potential of the mitochondria. In the cancer cells, the mitochondrial membrane potential gap is higher as compared to that of normal cells resulting in elevated uptake of TPP. Silica nanoparticles (SNPs) being widely developed and used for biomedical applications, in this study, we tried to modify the surface of SNPs with varying amounts of TPP to verify their possible application as a positron emission tomography (PET) agent. The studies confirmed that the high level of TPP loading on the surface of SNPs possess higher positive charge (+ 31.5 mV). Owing to this behavior of plasma membrane potential of cancerous cells the uptake of positively charged SNPs was much higher in tumor cells than that of normal cells which was confirmed by PET imaging. [ABSTRACT FROM AUTHOR]

Published
2018
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42. The Solid Target Control System for the RFT-30 30 MeV Cyclotron in KAERI

Author

Kim, In Jong, Choi, Sang Mu, Hur, Min Goo, Kim, Sang Wook, Park, Jeong Hoon, and Yang, Seung Dae

Subjects
U05 Applications, Other, 08 Applications of Accelerators, Technology Transfer and Industrial Relations, Accelerator Physics
Abstract

The solid target of the RFT-30 30 MeV cyclotron in KAERI was designed to produce the metalic radioisotopes, such as Zn-62, Cu-67, Ge-68, Pd-{103}, and In-111. The target control system should provide high reliability to prevent any kind of failure. Moreover, the operating procedures and maintenance cycle should be optimized and well organized to cover the unexpected situations. In this study, a simulation of the control system for the solid target in KAERI was carried out to confirm the operability of the solid target transport system. The receiving and irradiation stations are connected each other through square tube, and the control software was also checked. The developed solid target control system controls vacuum, cooling, and the whole procedures before, during, and after the irradiation., Proceedings of the 1st International Particle Accelerator Conference, IPAC2010, Kyoto, Japan

Published
2010
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