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2. Search for $\eta_c(2S)\to p\bar{p}$ and branching fraction measurements of $\chi_{cJ} \to p\bar{p}$ via $\psi(2S)$ radiative decays

Author

BESIII Collaboration, Ablikim, M., Achasov, M. N., Adlarson, P., Afedulidis, O., Ai, X. C., Aliberti, R., Amoroso, A., Bai, Y., Bakina, O., Balossino, I., Ban, Y., Bao, H. -R., Batozskaya, V., Begzsuren, K., Berger, N., Berlowski, M., Bertani, M., Bettoni, D., Bianchi, F., Bianco, E., Bortone, A., Boyko, I., Briere, R. A., Brueggemann, A., Cai, H., Cai, X., Calcaterra, A., Cao, G. F., Cao, N., Cetin, S. A., Chai, X. Y., Chang, J. F., Che, G. R., Che, Y. Z., Chelkov, G., Chen, C., Chen, C. H., Chen, Chao, Chen, G., Chen, H. S., Chen, H. Y., Chen, M. L., Chen, S. J., Chen, S. L., Chen, S. M., Chen, T., Chen, X. R., Chen, X. T., Chen, Y. B., Chen, Y. Q., Chen, Z. J., Choi, S. K., Cibinetto, G., Cossio, F., Cui, J. J., Dai, H. L., Dai, J. P., Dbeyssi, A., de Boer, R. E., Dedovich, D., Deng, C. Q., Deng, Z. Y., Denig, A., Denysenko, I., Destefanis, M., De~Mori, F., Ding, B., Ding, X. X., Ding, Y., Dong, J., Dong, L. Y., Dong, M. Y., Dong, X., Du, M. C., Du, S. X., Duan, Y. Y., Duan, Z. H., Egorov, P., Fan, G. F., Fan, J. J., Fan, Y. H., Fang, J., Fang, S. S., Fang, W. X., Fang, Y. Q., Farinelli, R., Fava, L., Feldbauer, F., Felici, G., Feng, C. Q., Feng, J. H., Feng, Y. T., Fritsch, M., Fu, C. D., Fu, J. L., Fu, Y. W., Gao, H., Gao, X. B., Gao, Y. N., Gao, Yang, Garbolino, S., Garzia, I., Ge, P. T., Ge, Z. W., Geng, C., Gersabeck, E. M., Gilman, A., Goetzen, K., Gong, L., Gong, W. X., Gradl, W., Gramigna, S., Greco, M., Gu, M. H., Gu, Y. T., Guan, C. Y., Guo, A. Q., Guo, L. B., Guo, M. J., Guo, R. P., Guo, Y. P., Guskov, A., Gutierrez, J., Han, K. L., Han, T. T., Hanisch, F., Hao, X. Q., Harris, F. A., He, K. K., He, K. L., Heinsius, F. H., Heinz, C. H., Heng, Y. K., Herold, C., Holtmann, T., Hong, P. C., Hou, G. Y., Hou, X. T., Hou, Y. R., Hou, Z. L., Hu, B. Y., Hu, H. M., Hu, J. F., Hu, Q. P., Hu, S. L., Hu, T., Hu, Y., Huang, G. S., Huang, K. X., Huang, L. Q., Huang, P., Huang, X. T., Huang, Y. P., Huang, Y. S., Hussain, T., Hölzken, F., Hüsken, N., der Wiesche, N. in, Jackson, J., Janchiv, S., Ji, Q., Ji, Q. P., Ji, W., Ji, X. B., Ji, X. L., Ji, Y. Y., Jia, X. Q., Jia, Z. K., Jiang, D., Jiang, H. B., Jiang, P. C., Jiang, S. S., Jiang, T. J., Jiang, X. S., Jiang, Y., Jiao, J. B., Jiao, J. K., Jiao, Z., Jin, S., Jin, Y., Jing, M. Q., Jing, X. M., Johansson, T., Kabana, S., Kalantar-Nayestanaki, N., Kang, X. L., Kang, X. S., Kavatsyuk, M., Ke, B. C., Khachatryan, V., Khoukaz, A., Kiuchi, R., Kolcu, O. B., Kopf, B., Kuessner, M., Kui, X., Kumar, N., Kupsc, A., Kühn, W., Lan, W. N., Lei, T. T., Lei, Z. H., Lellmann, M., Lenz, T., Li, C., Li, C. H., Li, Cheng, Li, D. M., Li, F., Li, G., Li, H. B., Li, H. J., Li, H. N., Li, Hui, Li, J. R., Li, J. S., Li, K., Li, K. L., Li, L. J., Li, Lei, Li, M. H., Li, P. L., Li, P. R., Li, Q. M., Li, Q. X., Li, R., Li, T., Li, T. Y., Li, W. D., Li, W. G., Li, X., Li, X. H., Li, X. L., Li, X. Y., Li, X. Z., Li, Y., Li, Y. G., Li, Z. J., Li, Z. Y., Liang, C., Liang, H., Liang, Y. F., Liang, Y. T., Liao, G. R., Liao, Y. P., Libby, J., Limphirat, A., Lin, C. C., Lin, C. X., Lin, D. X., Lin, T., Liu, B. J., Liu, B. X., Liu, C., Liu, C. X., Liu, F., Liu, F. H., Liu, Feng, Liu, G. M., Liu, H., Liu, H. B., Liu, H. H., Liu, H. M., Liu, Huihui, Liu, J. B., Liu, K., Liu, K. Y., Liu, Ke, Liu, L., Liu, L. C., Liu, Lu, Liu, M. H., Liu, P. L., Liu, Q., Liu, S. B., Liu, T., Liu, W. K., Liu, W. M., Liu, X., Liu, Y., Liu, Y. B., Liu, Z. A., Liu, Z. D., Liu, Z. Q., Lou, X. C., Lu, F. X., Lu, H. J., Lu, J. G., Lu, Y., Lu, Y. P., Lu, Z. H., Luo, C. L., Luo, J. R., Luo, M. X., Luo, T., Luo, X. L., Lyu, X. R., Lyu, Y. F., Ma, F. C., Ma, H., Ma, H. L., Ma, J. L., Ma, L. L., Ma, L. R., Ma, Q. M., Ma, R. Q., Ma, R. Y., Ma, T., Ma, X. T., Ma, X. Y., Ma, Y. M., Maas, F. E., MacKay, I., Maggiora, M., Malde, S., Mao, Y. J., Mao, Z. P., Marcello, S., Meng, Y. H., Meng, Z. X., Messchendorp, J. G., Mezzadri, G., Miao, H., Min, T. J., Mitchell, R. E., Mo, X. H., Moses, B., Muchnoi, N. Yu., Muskalla, J., Nefedov, Y., Nerling, F., Nie, L. S., Nikolaev, I. B., Ning, Z., Nisar, S., Niu, Q. L., Niu, W. D., Niu, Y., Olsen, S. L., Ouyang, Q., Pacetti, S., Pan, X., Pan, Y., Pathak, A., Pei, Y. P., Pelizaeus, M., Peng, H. P., Peng, Y. Y., Peters, K., Ping, J. L., Ping, R. G., Plura, S., Prasad, V., Qi, F. Z., Qi, H. R., Qi, M., Qian, S., Qian, W. B., Qiao, C. F., Qiao, J. H., Qin, J. J., Qin, L. Q., Qin, L. Y., Qin, X. P., Qin, X. S., Qin, Z. H., Qiu, J. F., Qu, Z. H., Redmer, C. F., Ren, K. J., Rivetti, A., Rolo, M., Rong, G., Rosner, Ch., Ruan, M. Q., Ruan, S. N., Salone, N., Sarantsev, A., Schelhaas, Y., Schoenning, K., Scodeggio, M., Shan, K. Y., Shan, W., Shan, X. Y., Shang, Z. J., Shangguan, J. F., Shao, L. G., Shao, M., Shen, C. P., Shen, H. F., Shen, W. H., Shen, X. Y., Shi, B. A., Shi, H., Shi, J. L., Shi, J. Y., Shi, S. Y., Shi, X., Song, J. J., Song, T. Z., Song, W. M., Song, Y. J., Song, Y. X., Sosio, S., Spataro, S., Stieler, F., Su, S. S, Su, Y. J., Sun, G. B., Sun, G. X., Sun, H., Sun, H. K., Sun, J. F., Sun, K., Sun, L., Sun, S. S., Sun, T., Sun, Y. J., Sun, Y. Z., Sun, Z. Q., Sun, Z. T., Tang, C. J., Tang, G. Y., Tang, J., Tang, M., Tang, Y. A., Tao, L. Y., Tat, M., Teng, J. X., Thoren, V., Tian, W. H., Tian, Y., Tian, Z. F., Uman, I., Wan, Y., Wang, S. J., Wang, B., Wang, Bo, Wang, C., Wang, D. Y., Wang, H. J., Wang, J. J., Wang, J. P., Wang, K., Wang, L. L., Wang, L. W., Wang, M., Wang, N. Y., Wang, S., Wang, T., Wang, T. J., Wang, W., Wang, W. P., Wang, X., Wang, X. F., Wang, X. J., Wang, X. L., Wang, X. N., Wang, Y., Wang, Y. D., Wang, Y. F., Wang, Y. H., Wang, Y. L., Wang, Y. N., Wang, Y. Q., Wang, Yaqian, Wang, Yi, Wang, Z., Wang, Z. L., Wang, Z. Y., Wei, D. H., Weidner, F., Wen, S. P., Wen, Y. R., Wiedner, U., Wilkinson, G., Wolke, M., Wollenberg, L., Wu, C., Wu, J. F., Wu, L. H., Wu, L. J., Wu, Lianjie, Wu, X., Wu, X. H., Wu, Y. H., Wu, Y. J., Wu, Z., Xia, L., Xian, X. M., Xiang, B. H., Xiang, T., Xiao, D., Xiao, G. Y., Xiao, H., Xiao, Y. L., Xiao, Z. J., Xie, C., Xie, X. H., Xie, Y., Xie, Y. G., Xie, Y. H., Xie, Z. P., Xing, T. Y., Xu, C. F., Xu, C. J., Xu, G. F., Xu, M., Xu, Q. J., Xu, Q. N., Xu, W. L., Xu, X. P., Xu, Y., Xu, Y. C., Xu, Z. S., Yan, F., Yan, L., Yan, W. B., Yan, W. C., Yan, W. P., Yan, X. Q., Yang, H. J., Yang, H. L., Yang, H. X., Yang, J. H., Yang, R. J., Yang, T., Yang, Y., Yang, Y. F., Yang, Y. X., Yang, Y. Z., Yang, Z. W., Yao, Z. P., Ye, M., Ye, M. H., Yin, Junhao, You, Z. Y., Yu, B. X., Yu, C. X., Yu, G., Yu, J. S., Yu, M. C., Yu, T., Yu, X. D., Yuan, C. Z., Yuan, J., Yuan, L., Yuan, S. C., Yuan, Y., Yuan, Z. Y., Yue, C. X., Yue, Ying, Zafar, A. A., Zeng, F. R., Zeng, S. H., Zeng, X., Zeng, Y., Zeng, Y. J., Zhai, X. Y., Zhai, Y. C., Zhan, Y. H., Zhang, A. Q., Zhang, B. L., Zhang, B. X., Zhang, D. H., Zhang, G. Y., Zhang, H., Zhang, H. C., Zhang, H. H., Zhang, H. Q., Zhang, H. R., Zhang, H. Y., Zhang, J., Zhang, J. J., Zhang, J. L., Zhang, J. Q., Zhang, J. S., Zhang, J. W., Zhang, J. X., Zhang, J. Y., Zhang, J. Z., Zhang, Jianyu, Zhang, L. M., Zhang, Lei, Zhang, P., Zhang, Q., Zhang, Q. Y., Zhang, R. Y., Zhang, S. H., Zhang, Shulei, Zhang, X. M., Zhang, X. Y, Zhang, X. Y., Zhang, Y., Zhang, Y. T., Zhang, Y. H., Zhang, Y. M., Zhang, Yan, Zhang, Z. D., Zhang, Z. H., Zhang, Z. L., Zhang, Z. X., Zhang, Z. Y., Zhang, Z. Z., Zhang, Zh. Zh., Zhao, G., Zhao, J. Y., Zhao, J. Z., Zhao, L., Zhao, Lei, Zhao, M. G., Zhao, N., Zhao, R. P., Zhao, S. J., Zhao, Y. B., Zhao, Y. X., Zhao, Z. G., Zhemchugov, A., Zheng, B., Zheng, B. M., Zheng, J. P., Zheng, W. J., Zheng, X. R., Zheng, Y. H., Zhong, B., Zhong, X., Zhou, H., Zhou, J. Y., Zhou, S., Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, X. Y., Zhou, Y. Z., Zhou, Z. C., Zhu, A. N., Zhu, J., Zhu, K., Zhu, K. J., Zhu, K. S., Zhu, L., Zhu, L. X., Zhu, S. H., Zhu, T. J., Zhu, W. D., Zhu, W. Z., Zhu, Y. C., Zhu, Z. A., Zou, J. H., and Zu, J.

Subjects
High Energy Physics - Experiment
Abstract

Using $(27.12\pm0.14) \times 10^{8}$ $\psi(2S)$ events collected by the BESIII detector operating at BEPCII, we search for the decay $\eta_c(2S)\to p\bar{p}$ via the process $\psi(2S)\to \gamma\eta_c(2S)$, and only find a signal with a significance of $1.7\,\sigma$. The upper limit of the product branching fraction at the 90% confidence level is determined to be $\mathcal{B}(\psi(2S)\to \gamma\eta_c(2S))\times \mathcal{B}(\eta_c(2S)\to p\bar{p})<2.4\times 10^{-7}$. The branching fractions of $\chi_{cJ}\to p\bar{p}~(J=0,1,2)$ are also measured to be $\mathcal{B}(\chi_{c0}\to p\bar{p})=(2.51\pm0.02\pm0.08)\times 10^{-4}$, $\mathcal{B}(\chi_{c1}\to p\bar{p})=(8.16\pm0.09\pm0.25)\times 10^{-4}$, and $\mathcal{B}(\chi_{c2}\to p\bar{p})=(8.33\pm0.09\pm0.22)\times 10^{-4}$, where the first uncertainty is statistical and the second systematic.

Published
2024

3. LHAASO detection of very-high-energy gamma-ray emission surrounding PSR J0248+6021

Author

Cao, Zhen, Aharonian, F., An, Q., Axikegu, Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Q., Cao, W. Y., Cao, Zhe, Chang, J., Chang, J. F., Chen, A. M., Chen, E. S., Chen, Liang, Chen, Lin, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, M. Y., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, Dong, X. Q., Duan, K. K., Fan, J. H., Fan, Y. Z., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gabici, S., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Giacinti, G., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. Y., He, X. B., He, Y., Hor, Y. K., Hou, B. W., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S. C., Huang, D. H., Huang, T. Q., Huang, W. J., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, X. W., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Kurinov, K., Li, B. B., Li, Cheng, Li, Cong, Li, D., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Min, Z., Mitthumsiri, W., Mu, H. J., Nan, Y. C., Neronov, A., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Sáiz, A., Semikoz, D., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shu, F. W., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Q. W., Tang, Z. B., Tian, W. W., Wang, C., Wang, C. B., Wang, G. W., Wang, H. G., Wang, H. H., Wang, J. C., Wang, K., Wang, L. P., Wang, L. Y., Wang, P. H., Wang, R., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. F., Xu, R. X., Xu, W. L., Xue, L., Yan, D. H., Yan, J. Z., Yan, T., Yang, C. W., Yang, F., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zha, M., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, J. H., Zhou, B., Zhou, H., Zhou, J. N., Zhou, M., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., Zou, Y. C., and Zuo, X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report the detection of an extended very-high-energy (VHE) gamma-ray source coincident with the locations of middle-aged (62.4~\rm kyr) pulsar PSR J0248+6021, by using the LHAASO-WCDA data of live 796 days and LHAASO-KM2A data of live 1216 days. A significant excess of \gray induced showers is observed both by WCDA in energy bands of 1-25~\rm TeV and KM2A in energy bands of $>$ 25~\rm TeV with 7.3 $\sigma$ and 13.5 $\sigma$, respectively. The best-fit position derived through WCDA data is R.A. = 42.06$^\circ \pm$ 0.12$^\circ$ and Dec. = 60.24$^\circ \pm $ 0.13$^\circ$ with an extension of 0.69$^\circ\pm$0.15$^\circ$ and that of the KM2A data is R.A.= 42.29$^\circ \pm $ 0.13$^\circ$ and Dec. = 60.38$^\circ \pm$ 0.07$^\circ$ with an extension of 0.37$^\circ\pm$0.07$^\circ$. No clear extended multiwavelength counterpart of this LHAASO source has been found from the radio band to the GeV band. The most plausible explanation of the VHE \gray emission is the inverse Compton process of highly relativistic electrons and positrons injected by the pulsar. These electrons/positrons are hypothesized to be either confined within the pulsar wind nebula or to have already escaped into the interstellar medium, forming a pulsar halo., Comment: 12 pages, 10 figures, Accepted by Sci. China-Phys. Mech. Astron

Published
2024

4. Search for $h_c \to \pi^+\pi^-J/\psi$ via $\psi(3686)\to \pi^0h_c$

Author

BESIII Collaboration, Ablikim, M., Achasov, M. N., Adlarson, P., Afedulidis, O., Ai, X. C., Aliberti, R., Amoroso, A., Bai, Y., Bakina, O., Balossino, I., Ban, Y., Bao, H. -R., Batozskaya, V., Begzsuren, K., Berger, N., Berlowski, M., Bertani, M., Bettoni, D., Bianchi, F., Bianco, E., Bortone, A., Boyko, I., Briere, R. A., Brueggemann, A., Cai, H., Cai, X., Calcaterra, A., Cao, G. F., Cao, N., Cetin, S. A., Chai, X. Y., Chang, J. F., Che, G. R., Che, Y. Z., Chelkov, G., Chen, C., Chen, C. H., Chen, Chao, Chen, G., Chen, H. S., Chen, H. Y., Chen, M. L., Chen, S. J., Chen, S. L., Chen, S. M., Chen, T., Chen, X. R., Chen, X. T., Chen, Y. B., Chen, Y. Q., Chen, Z. J., Choi, S. K., Cibinetto, G., Cossio, F., Cui, J. J., Dai, H. L., Dai, J. P., Dbeyssi, A., de Boer, R. E., Dedovich, D., Deng, C. Q., Deng, Z. Y., Denig, A., Denysenko, I., Destefanis, M., De Mori, F., Ding, B., Ding, X. X., Ding, Y., Dong, J., Dong, L. Y., Dong, M. Y., Dong, X., Du, M. C., Du, S. X., Duan, Y. Y., Duan, Z. H., Egorov, P., Fan, J. J., Fan, Y. H., Fang, J., Fang, S. S., Fang, W. X., Fang, Y., Fang, Y. Q., Farinelli, R., Fava, L., Feldbauer, F., Felici, G., Feng, C. Q., Feng, J. H., Feng, Y. T., Fritsch, M., Fu, C. D., Fu, J. L., Fu, Y. W., Gao, H., Gao, X. B., Gao, Y. N., Gao, Yang, Garbolino, S., Garzia, I., Ge, P. T., Ge, Z. W., Geng, C., Gersabeck, E. M., Gilman, A., Goetzen, K., Gong, L., Gong, W. X., Gradl, W., Gramigna, S., Greco, M., Gu, M. H., Gu, Y. T., Guan, C. Y., Guo, A. Q., Guo, L. B., Guo, M. J., Guo, R. P., Guo, Y. P., Guskov, A., Gutierrez, J., Han, K. L., Han, T. T., Hanisch, F., Hao, X. Q., Harris, F. A., He, K. K., He, K. L., Heinsius, F. H., Heinz, C. H., Heng, Y. K., Herold, C., Holtmann, T., Hong, P. C., Hou, G. Y., Hou, X. T., Hou, Y. R., Hou, Z. L., Hu, B. Y., Hu, H. M., Hu, J. F., Hu, Q. P., Hu, S. L., Hu, T., Hu, Y., Huang, G. S., Huang, K. X., Huang, L. Q., Huang, P., Huang, X. T., Huang, Y. P., Huang, Y. S., Hussain, T., Hölzken, F., Hüsken, N., der Wiesche, N. in, Jackson, J., Janchiv, S., Jeong, J. H., Ji, Q., Ji, Q. P., Ji, W., Ji, X. B., Ji, X. L., Ji, Y. Y., Jia, X. Q., Jia, Z. K., Jiang, D., Jiang, H. B., Jiang, P. C., Jiang, S. S., Jiang, T. J., Jiang, X. S., Jiang, Y., Jiao, J. B., Jiao, J. K., Jiao, Z., Jin, S., Jin, Y., Jing, M. Q., Jing, X. M., Johansson, T., Kabana, S., Kalantar-Nayestanaki, N., Kang, X. L., Kang, X. S., Kavatsyuk, M., Ke, B. C., Khachatryan, V., Khoukaz, A., Kiuchi, R., Kolcu, O. B., Kopf, B., Kuessner, M., Kui, X., Kumar, N., Kupsc, A., Kühn, W., Lan, W. N., Lei, T. T., Lei, Z. H., Lellmann, M., Lenz, T., Li, C., Li, C. H., Li, Cheng, Li, D. M., Li, F., Li, G., Li, H. B., Li, H. J., Li, H. N., Li, Hui, Li, J. R., Li, J. S., Li, K., Li, K. L., Li, L. J., Li, L. K., Li, Lei, Li, M. H., Li, P. R., Li, Q. M., Li, Q. X., Li, R., Li, T., Li, T. Y., Li, W. D., Li, W. G., Li, X., Li, X. H., Li, X. L., Li, X. Y., Li, X. Z., Li, Y., Li, Y. G., Li, Z. J., Li, Z. Y., Liang, C., Liang, H., Liang, Y. F., Liang, Y. T., Liao, G. R., Liao, Y. P., Libby, J., Limphirat, A., Lin, C. C., Lin, C. X., Lin, D. X., Lin, T., Liu, B. J., Liu, B. X., Liu, C., Liu, C. X., Liu, F., Liu, F. H., Liu, Feng, Liu, G. M., Liu, H., Liu, H. B., Liu, H. H., Liu, H. M., Liu, Huihui, Liu, J. B., Liu, J. Y., Liu, K., Liu, K. Y., Liu, Ke, Liu, L., Liu, L. C., Liu, Lu, Liu, M. H., Liu, P. L., Liu, Q., Liu, S. B., Liu, T., Liu, W. K., Liu, W. M., Liu, X., Liu, Y., Liu, Y. B., Liu, Z. A., Liu, Z. D., Liu, Z. Q., Lou, X. C., Lu, F. X., Lu, H. J., Lu, J. G., Lu, Y., Lu, Y. P., Lu, Z. H., Luo, C. L., Luo, J. R., Luo, M. X., Luo, T., Luo, X. L., Lyu, X. R., Lyu, Y. F., Ma, F. C., Ma, H., Ma, H. L., Ma, J. L., Ma, L. L., Ma, L. R., Ma, M. M., Ma, Q. M., Ma, R. Q., Ma, R. Y., Ma, T., Ma, X. T., Ma, X. Y., Ma, Y. M., Maas, F. E., MacKay, I., Maggiora, M., Malde, S., Mao, Y. J., Mao, Z. P., Marcello, S., Meng, Y. H., Meng, Z. X., Messchendorp, J. G., Mezzadri, G., Miao, H., Min, T. J., Mitchell, R. E., Mo, X. H., Moses, B., Muchnoi, N. Yu., Muskalla, J., Nefedov, Y., Nerling, F., Nie, L. S., Nikolaev, I. B., Ning, Z., Nisar, S., Niu, Q. L., Niu, W. D., Niu, Y., Olsen, S. L., Ouyang, Q., Pacetti, S., Pan, X., Pan, Y., Pathak, A., Pei, Y. P., Pelizaeus, M., Peng, H. P., Peng, Y. Y., Peters, K., Ping, J. L., Ping, R. G., Plura, S., Prasad, V., Qi, F. Z., Qi, H., Qi, H. R., Qi, M., Qian, S., Qian, W. B., Qiao, C. F., Qiao, J. H., Qin, J. J., Qin, L. Q., Qin, L. Y., Qin, X. P., Qin, X. S., Qin, Z. H., Qiu, J. F., Qu, Z. H., Redmer, C. F., Ren, K. J., Rivetti, A., Rolo, M., Rong, G., Rosner, Ch., Ruan, M. Q., Ruan, S. N., Salone, N., Sarantsev, A., Schelhaas, Y., Schoenning, K., Scodeggio, M., Shan, K. Y., Shan, W., Shan, X. Y., Shang, Z. J., Shangguan, J. F., Shao, L. G., Shao, M., Shen, C. P., Shen, H. F., Shen, W. H., Shen, X. Y., Shi, B. A., Shi, H., Shi, J. L., Shi, J. Y., Shi, S. Y., Shi, X., Song, J. J., Song, T. Z., Song, W. M., Song, Y. J., Song, Y. X., Sosio, S., Spataro, S., Stieler, F., Su, S. S, Su, Y. J., Sun, G. B., Sun, G. X., Sun, H., Sun, H. K., Sun, J. F., Sun, K., Sun, L., Sun, S. S., Sun, T., Sun, Y., Sun, Y. J., Sun, Y. Z., Sun, Z. Q., Sun, Z. T., Tang, C. J., Tang, G. Y., Tang, J., Tang, M., Tang, Y. A., Tao, L. Y., Tao, Q. T., Tat, M., Teng, J. X., Thoren, V., Tian, W. H., Tian, Y., Tian, Z. F., Uman, I., Wan, Y., Wang, S. J., Wang, B., Wang, Bo, Wang, C., Wang, D. Y., Wang, H. J., Wang, J. J., Wang, J. P., Wang, K., Wang, L. L., Wang, M., Wang, N. Y., Wang, S., Wang, T., Wang, T. J., Wang, W., Wang, W. P., Wang, X., Wang, X. F., Wang, X. J., Wang, X. L., Wang, X. N., Wang, Y., Wang, Y. D., Wang, Y. F., Wang, Y. H., Wang, Y. L., Wang, Y. N., Wang, Y. Q., Wang, Yaqian, Wang, Yi, Wang, Z., Wang, Z. L., Wang, Z. Y., Wei, D. H., Weidner, F., Wen, S. P., Wen, Y. R., Wiedner, U., Wilkinson, G., Wolke, M., Wollenberg, L., Wu, C., Wu, J. F., Wu, L. H., Wu, L. J., Wu, Lianjie, Wu, X., Wu, X. H., Wu, Y. H., Wu, Y. J., Wu, Z., Xia, L., Xian, X. M., Xiang, B. H., Xiang, T., Xiao, D., Xiao, G. Y., Xiao, H., Xiao, S. Y., Xiao, Y. L., Xiao, Z. J., Xie, C., Xie, X. H., Xie, Y., Xie, Y. G., Xie, Y. H., Xie, Z. P., Xing, T. Y., Xu, C. F., Xu, C. J., Xu, G. F., Xu, M., Xu, Q. J., Xu, Q. N., Xu, W., Xu, W. L., Xu, X. P., Xu, Y., Xu, Y. C., Xu, Z. S., Yan, F., Yan, L., Yan, W. B., Yan, W. C., Yan, W. P., Yan, X. Q., Yang, H. J., Yang, H. L., Yang, H. X., Yang, J. H., Yang, R. J., Yang, T., Yang, Y., Yang, Y. F., Yang, Y. X., Yang, Y. Z., Yang, Z. W., Yao, Z. P., Ye, M., Ye, M. H., Yin, J. H., Yin, Junhao, You, Z. Y., Yu, B. X., Yu, C. X., Yu, G., Yu, J. S., Yu, M. C., Yu, T., Yu, X. D., Yuan, C. Z., Yuan, J., Yuan, L., Yuan, S. C., Yuan, Y., Yuan, Z. Y., Yue, C. X., Yue, Ying, Zafar, A. A., Zeng, F. R., Zeng, S. H., Zeng, X., Zeng, Y., Zeng, Y. J., Zhai, X. Y., Zhai, Y. C., Zhan, Y. H., Zhang, A. Q., Zhang, B. L., Zhang, B. X., Zhang, D. H., Zhang, G. Y., Zhang, H., Zhang, H. C., Zhang, H. H., Zhang, H. Q., Zhang, H. R., Zhang, H. Y., Zhang, J., Zhang, J. J., Zhang, J. L., Zhang, J. Q., Zhang, J. S., Zhang, J. W., Zhang, J. X., Zhang, J. Y., Zhang, J. Z., Zhang, Jianyu, Zhang, L. M., Zhang, Lei, Zhang, P., Zhang, Q., Zhang, Q. Y., Zhang, R. Y., Zhang, S. H., Zhang, Shulei, Zhang, X. M., Zhang, X. Y, Zhang, X. Y., Zhang, Y., Zhang, Y. T., Zhang, Y. H., Zhang, Y. M., Zhang, Yan, Zhang, Z. D., Zhang, Z. H., Zhang, Z. L., Zhang, Z. X., Zhang, Z. Y., Zhang, Z. Z., Zhang, Zh. Zh., Zhao, G., Zhao, J. Y., Zhao, J. Z., Zhao, L., Zhao, Lei, Zhao, M. G., Zhao, N., Zhao, R. P., Zhao, S. J., Zhao, Y. B., Zhao, Y. X., Zhao, Z. G., Zhemchugov, A., Zheng, B., Zheng, B. M., Zheng, J. P., Zheng, W. J., Zheng, X. R., Zheng, Y. H., Zhong, B., Zhong, X., Zhou, H., Zhou, J. Y., Zhou, L. P., Zhou, S., Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, X. Y., Zhou, Y. Z., Zhou, Z. C., Zhu, A. N., Zhu, J., Zhu, K., Zhu, K. J., Zhu, K. S., Zhu, L., Zhu, L. X., Zhu, S. H., Zhu, T. J., Zhu, W. D., Zhu, W. Z., Zhu, Y. C., Zhu, Z. A., Zou, J. H., and Zu, J.

Subjects
High Energy Physics - Experiment
Abstract

Using $(2712.4 \pm 14.3) \times 10^6~\psi$(3686) events collected with the BESIII detector operating at the BEPCII collider, we search for the hadronic transition $h_c \to \pi^+\pi^-J/\psi$ via $\psi(3686)\to \pi^0 h_c$. No significant signal is observed. We set the most stringent upper limits to date on the branching fractions $\mathcal{B}(\psi(3686)\to \pi^0 h_c)\times\mathcal{B}(h_c\to\pi^+\pi^-J/\psi)$ and $\mathcal{B}(h_c \to \pi^+\pi^-J/\psi)$ at the 90$\%$ confidence level, which are determined to be $6.7\times 10^{-7}$ and $9.4 \times10^{-4}$, respectively.

Published
2024

5. Search for the rare decay $J/\psi \to \gamma D^0+c.c.$ at BESIII

Author

BESIII Collaboration, Ablikim, M., Achasov, M. N., Adlarson, P., Afedulidis, O., Ai, X. C., Aliberti, R., Amoroso, A., An, Q., Bai, Y., Bakina, O., Balossino, I., Ban, Y., Bao, H. -R., Batozskaya, V., Begzsuren, K., Berger, N., Berlowski, M., Bertani, M., Bettoni, D., Bianchi, F., Bianco, E., Bortone, A., Boyko, I., Briere, R. A., Brueggemann, A., Cai, H., Cai, X., Calcaterra, A., Cao, G. F., Cao, N., Cetin, S. A., Chai, X. Y., Chang, J. F., Che, G. R., Che, Y. Z., Chelkov, G., Chen, C., Chen, C. H., Chen, Chao, Chen, G., Chen, H. S., Chen, H. Y., Chen, M. L., Chen, S. J., Chen, S. L., Chen, S. M., Chen, T., Chen, X. R., Chen, X. T., Chen, Y. B., Chen, Y. Q., Chen, Z. J., Choi, S. K., Cibinetto, G., Cossio, F., Cui, J. J., Dai, H. L., Dai, J. P., Dbeyssi, A., de Boer, R. E., Dedovich, D., Deng, C. Q., Deng, Z. Y., Denig, A., Denysenko, I., Destefanis, M., De Mori, F., Ding, B., Ding, X. X., Ding, Y., Dong, J., Dong, L. Y., Dong, M. Y., Dong, X., Du, M. C., Du, S. X., Duan, Y. Y., Duan, Z. H., Egorov, P., Fan, G. F., Fan, J. J., Fan, Y. H., Fang, J., Fang, S. S., Fang, W. X., Fang, Y. Q., Farinelli, R., Fava, L., Feldbauer, F., Felici, G., Feng, C. Q., Feng, J. H., Feng, Y. T., Fritsch, M., Fu, C. D., Fu, J. L., Fu, Y. W., Gao, H., Gao, X. B., Gao, Y. N., Gao, Yang, Garbolino, S., Garzia, I., Ge, P. T., Ge, Z. W., Geng, C., Gersabeck, E. M., Gilman, A., Goetzen, K., Gong, L., Gong, W. X., Gradl, W., Gramigna, S., Greco, M., Gu, M. H., Gu, Y. T., Guan, C. Y., Guo, A. Q., Guo, L. B., Guo, M. J., Guo, R. P., Guo, Y. P., Guskov, A., Gutierrez, J., Han, K. L., Han, T. T., Hanisch, F., Hao, X. Q., Harris, F. A., He, K. K., He, K. L., Heinsius, F. H., Heinz, C. H., Heng, Y. K., Herold, C., Holtmann, T., Hong, P. C., Hou, G. Y., Hou, X. T., Hou, Y. R., Hou, Z. L., Hu, B. Y., Hu, H. M., Hu, J. F., Hu, Q. P., Hu, S. L., Hu, T., Hu, Y., Huang, G. S., Huang, K. X., Huang, L. Q., Huang, P., Huang, X. T., Huang, Y. P., Huang, Y. S., Hussain, T., Hölzken, F., Hüsken, N., der Wiesche, N. in, Jackson, J., Janchiv, S., Ji, Q., Ji, Q. P., Ji, W., Ji, X. B., Ji, X. L., Ji, Y. Y., Jia, X. Q., Jia, Z. K., Jiang, D., Jiang, H. B., Jiang, P. C., Jiang, S. S., Jiang, T. J., Jiang, X. S., Jiang, Y., Jiao, J. B., Jiao, J. K., Jiao, Z., Jin, S., Jin, Y., Jing, M. Q., Jing, X. M., Johansson, T., Kabana, S., Kalantar-Nayestanaki, N., Kang, X. L., Kang, X. S., Kavatsyuk, M., Ke, B. C., Khachatryan, V., Khoukaz, A., Kiuchi, R., Kolcu, O. B., Kopf, B., Kuessner, M., Kui, X., Kumar, N., Kupsc, A., Kühn, W., Lan, W. N., Lei, T. T., Lei, Z. H., Lellmann, M., Lenz, T., Li, C., Li, C. H., Li, Cheng, Li, D. M., Li, F., Li, G., Li, H. B., Li, H. J., Li, H. N., Li, Hui, Li, J. R., Li, J. S., Li, K., Li, K. L., Li, L. J., Li, Lei, Li, M. H., Li, P. L., Li, P. R., Li, Q. M., Li, Q. X., Li, R., Li, T., Li, T. Y., Li, W. D., Li, W. G., Li, X., Li, X. H., Li, X. L., Li, X. Y., Li, X. Z., Li, Y., Li, Y. G., Li, Z. J., Li, Z. Y., Liang, C., Liang, H., Liang, Y. F., Liang, Y. T., Liao, G. R., Liao, Y. P., Libby, J., Limphirat, A., Lin, C. C., Lin, C. X., Lin, D. X., Lin, T., Liu, B. J., Liu, B. X., Liu, C., Liu, C. X., Liu, F., Liu, F. H., Liu, Feng, Liu, G. M., Liu, H., Liu, H. B., Liu, H. H., Liu, H. M., Liu, Huihui, Liu, J. B., Liu, K., Liu, K. Y., Liu, Ke, Liu, L., Liu, L. C., Liu, Lu, Liu, M. H., Liu, P. L., Liu, Q., Liu, S. B., Liu, T., Liu, W. K., Liu, W. M., Liu, X., Liu, Y., Liu, Y. B., Liu, Z. A., Liu, Z. D., Liu, Z. Q., Lou, X. C., Lu, F. X., Lu, H. J., Lu, J. G., Lu, Y., Lu, Y. P., Lu, Z. H., Luo, C. L., Luo, J. R., Luo, M. X., Luo, T., Luo, X. L., Lyu, X. R., Lyu, Y. F., Ma, F. C., Ma, H., Ma, H. L., Ma, J. L., Ma, L. L., Ma, L. R., Ma, Q. M., Ma, R. Q., Ma, R. Y., Ma, T., Ma, X. T., Ma, X. Y., Ma, Y. M., Maas, F. E., MacKay, I., Maggiora, M., Malde, S., Mao, Y. J., Mao, Z. P., Marcello, S., Meng, Y. H., Meng, Z. X., Messchendorp, J. G., Mezzadri, G., Miao, H., Min, T. J., Mitchell, R. E., Mo, X. H., Moses, B., Muchnoi, N. Yu., Muskalla, J., Nefedov, Y., Nerling, F., Nie, L. S., Nikolaev, I. B., Ning, Z., Nisar, S., Niu, Q. L., Niu, W. D., Niu, Y., Olsen, S. L., Ouyang, Q., Pacetti, S., Pan, X., Pan, Y., Pathak, A., Pei, Y. P., Pelizaeus, M., Peng, H. P., Peng, Y. Y., Peters, K., Ping, J. L., Ping, R. G., Plura, S., Prasad, V., Qi, F. Z., Qi, H. R., Qi, M., Qian, S., Qian, W. B., Qiao, C. F., Qiao, J. H., Qin, J. J., Qin, L. Q., Qin, L. Y., Qin, X. P., Qin, X. S., Qin, Z. H., Qiu, J. F., Qu, Z. H., Redmer, C. F., Ren, K. J., Rivetti, A., Rolo, M., Rong, G., Rosner, Ch., Ruan, M. Q., Ruan, S. N., Salone, N., Sarantsev, A., Schelhaas, Y., Schoenning, K., Scodeggio, M., Shan, K. Y., Shan, W., Shan, X. Y., Shang, Z. J., Shangguan, J. F., Shao, L. G., Shao, M., Shen, C. P., Shen, H. F., Shen, W. H., Shen, X. Y., Shi, B. A., Shi, H., Shi, J. L., Shi, J. Y., Shi, S. Y., Shi, X., Song, J. J., Song, T. Z., Song, W. M., Song, Y. J., Song, Y. X., Sosio, S., Spataro, S., Stieler, F., Su, S. S, Su, Y. J., Sun, G. B., Sun, G. X., Sun, H., Sun, H. K., Sun, J. F., Sun, K., Sun, L., Sun, S. S., Sun, T., Sun, Y. J., Sun, Y. Z., Sun, Z. Q., Sun, Z. T., Tang, C. J., Tang, G. Y., Tang, J., Tang, M., Tang, Y. A., Tao, L. Y., Tat, M., Teng, J. X., Thoren, V., Tian, W. H., Tian, Y., Tian, Z. F., Uman, I., Wan, Y., Wang, S. J., Wang, B., Wang, Bo, Wang, C., Wang, D. Y., Wang, H. J., Wang, J. J., Wang, J. P., Wang, K., Wang, L. L., Wang, L. W., Wang, M., Wang, N. Y., Wang, S., Wang, T., Wang, T. J., Wang, W., Wang, W. P., Wang, X., Wang, X. F., Wang, X. J., Wang, X. L., Wang, X. N., Wang, Y., Wang, Y. D., Wang, Y. F., Wang, Y. H., Wang, Y. L., Wang, Y. N., Wang, Y. Q., Wang, Yaqian, Wang, Yi, Wang, Z., Wang, Z. L., Wang, Z. Y., Wei, D. H., Weidner, F., Wen, S. P., Wen, Y. R., Wiedner, U., Wilkinson, G., Wolke, M., Wollenberg, L., Wu, C., Wu, J. F., Wu, L. H., Wu, L. J., Wu, Lianjie, Wu, X., Wu, X. H., Wu, Y. H., Wu, Y. J., Wu, Z., Xia, L., Xian, X. M., Xiang, B. H., Xiang, T., Xiao, D., Xiao, G. Y., Xiao, H., Xiao, Y. L., Xiao, Z. J., Xie, C., Xie, X. H., Xie, Y., Xie, Y. G., Xie, Y. H., Xie, Z. P., Xing, T. Y., Xu, C. F., Xu, C. J., Xu, G. F., Xu, M., Xu, Q. J., Xu, Q. N., Xu, W. L., Xu, X. P., Xu, Y., Xu, Y. C., Xu, Z. S., Yan, F., Yan, L., Yan, W. B., Yan, W. C., Yan, W. P., Yan, X. Q., Yang, H. J., Yang, H. L., Yang, H. X., Yang, J. H., Yang, R. J., Yang, T., Yang, Y., Yang, Y. F., Yang, Y. X., Yang, Y. Z., Yang, Z. W., Yao, Z. P., Ye, M., Ye, M. H., Yin, Junhao, You, Z. Y., Yu, B. X., Yu, C. X., Yu, G., Yu, J. S., Yu, M. C., Yu, T., Yu, X. D., Yuan, C. Z., Yuan, J., Yuan, L., Yuan, S. C., Yuan, Y., Yuan, Z. Y., Yue, C. X., Yue, Ying, Zafar, A. A., Zeng, F. R., Zeng, S. H., Zeng, X., Zeng, Y., Zeng, Y. J., Zhai, X. Y., Zhai, Y. C., Zhan, Y. H., Zhang, A. Q., Zhang, B. L., Zhang, B. X., Zhang, D. H., Zhang, G. Y., Zhang, H., Zhang, H. C., Zhang, H. H., Zhang, H. Q., Zhang, H. R., Zhang, H. Y., Zhang, J., Zhang, J. J., Zhang, J. L., Zhang, J. Q., Zhang, J. S., Zhang, J. W., Zhang, J. X., Zhang, J. Y., Zhang, J. Z., Zhang, Jianyu, Zhang, L. M., Zhang, Lei, Zhang, P., Zhang, Q., Zhang, Q. Y., Zhang, R. Y., Zhang, S. H., Zhang, Shulei, Zhang, X. M., Zhang, X. Y, Zhang, X. Y., Zhang, Y., Zhang, Y. T., Zhang, Y. H., Zhang, Y. M., Zhang, Yan, Zhang, Z. D., Zhang, Z. H., Zhang, Z. L., Zhang, Z. X., Zhang, Z. Y., Zhang, Z. Z., Zhang, Zh. Zh., Zhao, G., Zhao, J. Y., Zhao, J. Z., Zhao, L., Zhao, Lei, Zhao, M. G., Zhao, N., Zhao, R. P., Zhao, S. J., Zhao, Y. B., Zhao, Y. X., Zhao, Z. G., Zhemchugov, A., Zheng, B., Zheng, B. M., Zheng, J. P., Zheng, W. J., Zheng, X. R., Zheng, Y. H., Zhong, B., Zhong, X., Zhou, H., Zhou, J. Y., Zhou, S., Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, X. Y., Zhou, Y. Z., Zhou, Z. C., Zhu, A. N., Zhu, J., Zhu, K., Zhu, K. J., Zhu, K. S., Zhu, L., Zhu, L. X., Zhu, S. H., Zhu, T. J., Zhu, W. D., Zhu, W. J., Zhu, W. Z., Zhu, Y. C., Zhu, Z. A., Zou, J. H., and Zu, J.

Subjects
High Energy Physics - Experiment
Abstract

Using $(10087\pm44)\times10^6J/\psi$ events collected with the BESIII detector, we search for the rare decay $J/\psi \to \gamma D^0+c.c.$ for the first time. No obvious signal is observed and the upper limit on the branching fraction is determined to be ${\cal B}(J/\psi \to \gamma D^{0}+c.c.)< 9.1 \times 10^{-8}$ at 90\% confidence level.

Published
2024

7. Centrality dependence of L\'evy-stable two-pion Bose-Einstein correlations in $\sqrt{s_{_{NN}}}=200$ GeV Au$+$Au collisions

Author

PHENIX Collaboration, Abdulameer, N. J., Acharya, U., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Ta'ani, H., Alexander, J., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bannier, B., Barish, K. N., Bassalleck, B., Bathe, S., Baublis, V., Baumgart, S., Bazilevsky, A., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Castera, P., Chen, C. -H., Chen, D., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Corliss, R., Csanád, M., Csörgő, T., D'Orazio, L., Dairaku, S., Datta, A., Daugherity, M. S., David, G., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Doomra, V., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Edwards, S., Efremenko, Y. V., Engelmore, T., Enokizono, A., Esha, R., Eyser, K. O., Fadem, B., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Guo, T., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hanks, J., Hashimoto, K., Haslum, E., Hayano, R., Hemmick, T. K., Hester, T., He, X., Hill, J. C., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Ichihara, T., Iinuma, H., Ikeda, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Issah, M., Ivanishchev, D., Jacak, B. V., Javani, M., Jiang, X., Ji, Z., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kasza, G., Kawall, D., Kazantsev, A. V., Kempel, T., Khanzadeev, A., Kijima, K. M., Kim, B. I., Kim, C., Kim, D. J., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, Y. -J., Kim, Y. K., Kinney, E., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Komatsu, Y., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Kovacs, L., Krizek, F., Král, A., Kunde, G. J., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Lewis, B., Lim, S. H., Levy, L. A. Linden, Liu, M. X., Lökös, S., Loomis, D. A., Love, B., Maguire, C. F., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., Masumoto, S., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Mohapatra, S., Moon, H. J., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Nihashi, M., Nouicer, R., Novák, T., Novitzky, N., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Okada, K., Orosz, M., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J. S., Park, S., Park, S. K., Patel, L., Pate, S. F., Pei, H., Peng, J. -C., Pereira, H., Peressounko, D. Yu., Petti, R., Pinkenburg, C., Pisani, R. P., Potekhin, M., Proissl, M., Purschke, M. L., Qu, H., Rak, J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Sahlmueller, B., Saito, N., Sakaguchi, T., Samsonov, V., Sano, M., Sarsour, M., Sawada, S., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sun, Z., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tennant, E., Themann, H., Todoroki, T., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Ujvari, B., Vale, C., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Vértesi, R., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., White, S. N., Winter, D., Wolin, S., Woody, C. L., Wysocki, M., Xia, B., Yamaguchi, Y. L., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Younus, I., You, Z., Yushmanov, I. E., Zajc, W. A., and Zelenski, A.

Subjects
Nuclear Experiment
Abstract

The PHENIX experiment measured the centrality dependence of two-pion Bose-Einstein correlation functions in $\sqrt{s_{_{NN}}}=200$~GeV Au$+$Au collisions at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory. The data are well represented by L\'evy-stable source distributions. The extracted source parameters are the correlation-strength parameter $\lambda$, the L\'evy index of stability $\alpha$, and the L\'evy-scale parameter $R$ as a function of transverse mass $m_T$ and centrality. The $\lambda(m_T)$ parameter is constant at larger values of $m_T$, but decreases as $m_T$ decreases. The L\'evy scale parameter $R(m_T)$ decreases with $m_T$ and exhibits proportionality to the length scale of the nuclear overlap region. The L\'evy exponent $\alpha(m_T)$ is independent of $m_T$ within uncertainties in each investigated centrality bin, but shows a clear centrality dependence. At all centralities, the L\'evy exponent $\alpha$ is significantly different from that of Gaussian ($\alpha=2$) or Cauchy ($\alpha=1$) source distributions. Comparisons to the predictions of Monte-Carlo simulations of resonance-decay chains show that in all but the most peripheral centrality class (50%-60%), the obtained results are inconsistent with the measurements, unless a significant reduction of the in-medium mass of the $\eta'$ meson is included. In each centrality class, the best value of the in-medium $\eta'$ mass is compared to the mass of the $\eta$ meson, as well as to several theoretical predictions that consider restoration of $U_A(1)$ symmetry in hot hadronic matter., Comment: 401 authors from 75 institutions, 20 pages, 15 figures, 2 tables. v1 is version submitted to Physical Review C. HEPdata tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2024

8. Constraints on Ultra Heavy Dark Matter Properties from Dwarf Spheroidal Galaxies with LHAASO Observations

Author

Cao, Zhen, Aharonian, F., An, Q., Axikegu, Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Q., Cao, W. Y., Cao, Zhe, Chang, J., Chang, J. F., Chen, A. M., Chen, E. S., Chen, Liang, Chen, Lin, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, M. Y., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Dong, X. Q., Duan, K. K., Fan, J. H., Fan, Y. Z., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gabici, S., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Giacinti, G., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. Y., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, B. W., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S. C., Huang, D. H., Huang, T. Q., Huang, W. J., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, X. W., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Kurinov, K., Li, B. B., Li, Cheng, Li, Cong, Li, D., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Min, Z., Mitthumsiri, W., Mu, H. J., Nan, Y. C., Neronov, A., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Saiz, A., Semikoz, D., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shu, F. W., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Q. W., Tang, Z. B., Tian, W. W., Wang, C., Wang, C. B., Wang, G. W., Wang, H. G., Wang, H. H., Wang, J. C., Wang, K., Wang, L. P., Wang, L. Y., Wang, P. H., Wang, R., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. F., Xu, R. X., Xu, W. L., Xue, L., Yan, D. H., Yan, J. Z., Yan, T., Yang, C. W., Yang, F., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zha, M., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zhou, B., Zhou, H., Zhou, J. N., Zhou, M., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

In this work we try to search for signals generated by ultra-heavy dark matter at the Large High Altitude Air Shower Observatory (LHAASO) data. We look for possible gamma-ray by dark matter annihilation or decay from 16 dwarf spheroidal galaxies in the field of view of LHAASO. Dwarf spheroidal galaxies are among the most promising targets for indirect detection of dark matter which have low fluxes of astrophysical $\gamma$-ray background while large amount of dark matter. By analyzing more than 700 days observational data at LHAASO, no significant dark matter signal from 1 TeV to 1 EeV is detected. Accordingly we derive the most stringent constraints on the ultra-heavy dark matter annihilation cross-section up to EeV. The constraints on the lifetime of dark matter in decay mode are also derived., Comment: 17 pages, 12 figures, accepted by PRL

Published
2024

9. Jet modification via $\pi^0$-hadron correlations in Au$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV

Author

PHENIX Collaboration, Abdulameer, N. J., Acharya, U., Adare, A., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Al-Bataineh, H., Alexander, J., Alfred, M., Aoki, K., Apadula, N., Aphecetche, L., Asai, J., Asano, H., Atomssa, E. T., Averbeck, R., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Baksay, G., Baksay, L., Baldisseri, A., Bandara, N. S., Bannier, B., Barish, K. N., Barnes, P. D., Bassalleck, B., Basye, A. T., Bathe, S., Batsouli, S., Baublis, V., Baumann, C., Bazilevsky, A., Beaumier, M., Beckman, S., Belikov, S., Belmont, R., Bennett, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Bickley, A. A., Blankenship, B., Blau, D. S., Boissevain, J. G., Bok, J. S., Borel, H., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Bunce, G., Butsyk, S., Camacho, C. M., Campbell, S., Chang, B. S., Chang, W. C., Charvet, J. L., Chen, C. -H., Chen, D., Chernichenko, S., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Choudhury, R. K., Chujo, T., Chung, P., Churyn, A., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Constantin, P., Corliss, R., Csanád, M., Csörgő, T., d'Enterria, D., Dahms, T., Dairaku, S., Danley, T. W., Das, K., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dietzsch, O., Dion, A., Diss, P. B., Donadelli, M., Doomra, V., Do, J. H., Drapier, O., Drees, A., Drees, K. A., Dubey, A. K., Durham, J. M., Durum, A., Dutta, D., Dzhordzhadze, V., Efremenko, Y. V., Ellinghaus, F., En'yo, H., Engelmore, T., Enokizono, A., Esha, R., Eyser, K. O., Fadem, B., Feege, N., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Fraenkel, Z., Frantz, J. E., Franz, A., Frawley, A. D., Fujiwara, K., Fukao, Y., Fusayasu, T., Gallus, P., Gal, C., Garg, P., Garishvili, I., Ge, H., Giordano, F., Glenn, A., Gong, H., Gonin, M., Gosset, J., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, T., Gustafsson, H. -Å., Hachiya, T., Henni, A. Hadj, Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Hanks, J., Han, R., Han, S. Y., Hartouni, E. P., Haruna, K., Hasegawa, S., Haseler, T. O. S., Hashimoto, K., Haslum, E., Hayano, R., Heffner, M., Hemmick, T. K., Hester, T., He, X., Hill, J. C., Hodges, A., Hohlmann, M., Hollis, R. S., Holzmann, W., Homma, K., Hong, B., Horaguchi, T., Hornback, D., Hoshino, T., Hotvedt, N., Huang, J., Ichihara, T., Ichimiya, R., Iinuma, H., Ikeda, Y., Imai, K., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Ishihara, M., Isobe, T., Issah, M., Isupov, A., Ivanishchev, D., Jacak, B. V., Jezghani, M., Jiang, X., Jin, J., Ji, Z., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kajihara, F., Kametani, S., Kamihara, N., Kamin, J., Kanda, S., Kang, J. H., Kapustinsky, J., Kawall, D., Kazantsev, A. V., Kempel, T., Key, J. A., Khachatryan, V., Khanzadeev, A., Kijima, K. M., Kikuchi, J., Kimelman, B., Kim, B. I., Kim, C., Kim, D. H., Kim, D. J., Kim, E., Kim, E. -J., Kim, G. W., Kim, M., Kim, S. H., Kinney, E., Kiriluk, K., Kiss, Á., Kistenev, E., Kitamura, R., Klatsky, J., Klay, J., Klein-Boesing, C., Kleinjan, D., Kline, P., Koblesky, T., Kochenda, L., Komkov, B., Konno, M., Koster, J., Kotov, D., Kovacs, L., Kozlov, A., Kravitz, A., Král, A., Kunde, G. J., Kurgyis, B., Kurita, K., Kurosawa, M., Kweon, M. J., Kwon, Y., Kyle, G. S., Lai, Y. S., Lajoie, J. G., Layton, D., Lebedev, A., Lee, D. M., Lee, K. B., Lee, S., Lee, S. H., Lee, T., Leitch, M. J., Leite, M. A. L., Lenzi, B., Liebing, P., Lim, S. H., Litvinenko, A., Liu, H., Liu, M. X., Liška, T., Li, X., Lokos, S., Loomis, D. A., Love, B., Lynch, D., Maguire, C. F., Makdisi, Y. I., Makek, M., Malakhov, A., Malik, M. D., Manion, A., Manko, V. I., Mannel, E., Mao, Y., Masui, H., Matathias, F., Mašek, L., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Means, N., Meles, A., Mendoza, M., Meredith, B., Miake, Y., Mignerey, A. C., Mikeš, P., Miki, K., Milov, A., Mishra, D. K., Mishra, M., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Miyasaka, S., Mizuno, S., Mohanty, A. K., Montuenga, P., Moon, T., Morino, Y., Morreale, A., Morrison, D. P., Moukhanova, T. V., Mukhopadhyay, D., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagamiya, S., Nagashima, K., Nagle, J. L., Naglis, M., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakamiya, Y., Nakamura, T., Nakano, K., Nattrass, C., Netrakanti, P. K., Newby, J., Nguyen, M., Niida, T., Nishimura, S., Nouicer, R., Novitzky, N., Novák, T., Nukazuka, G., Nyanin, A. S., O'Brien, E., Oda, S. X., Ogilvie, C. A., Okada, K., Oka, M., Onuki, Y., Koop, J. D. Orjuela, Orosz, M., Osborn, J. D., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Palounek, A. P. T., Pantuev, V., Papavassiliou, V., Park, J., Park, J. S., Park, S., Park, W. J., Patel, M., Pate, S. F., Pei, H., Peng, J. -C., Pereira, H., Perepelitsa, D. V., Perera, G. D. N., Peresedov, V., Peressounko, D. Yu., Perry, J., Petti, R., Pinkenburg, C., Pinson, R., Pisani, R. P., Potekhin, M., Purschke, M. L., Purwar, A. K., Qu, H., Rakotozafindrabe, A., Rak, J., Ramson, B. J., Ravinovich, I., Read, K. F., Rembeczki, S., Reygers, K., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Rosendahl, S. S. E., Rosnet, P., Rowan, Z., Rubin, J. G., Rukoyatkin, P., Ružička, P., Rykov, V. L., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakai, S., Sakashita, K., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Sato, T., Sawada, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seele, J., Seidl, R., Semenov, A. Yu., Semenov, V., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Silvestre, C., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Snowball, M., Soldatov, A., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Staley, F., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Suire, C., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Sziklai, J., Takagui, E. M., Taketani, A., Tanabe, R., Tanaka, Y., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarján, P., Themann, H., Thomas, T. L., Tieulent, R., Timilsina, A., Todoroki, T., Togawa, M., Toia, A., Tomita, Y., Tomášek, L., Tomášek, M., Torii, H., Towell, C. L., Towell, R., Towell, R. S., Tram, V-N., Tserruya, I., Tsuchimoto, Y., Ujvari, B., Vale, C., Valle, H., van Hecke, H. W., Veicht, A., Velkovska, J., Vinogradov, A. A., Virius, M., Vrba, V., Vznuzdaev, E., Vértesi, R., Wang, X. R., Watanabe, Y., Watanabe, Y. S., Wei, F., Wessels, J., White, A. S., White, S. N., Winter, D., Wong, C. P., Woody, C. L., Wysocki, M., Xia, B., Xie, W., Xue, L., Yalcin, S., Yamaguchi, Y. L., Yamaura, K., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Yoon, I., Yoo, J. H., Young, G. R., Younus, I., Yushmanov, I. E., Yu, H., Zajc, W. A., Zaudtke, O., Zelenski, A., Zhang, C., Zhou, S., Zolin, L., and Zou, L.

Subjects
Nuclear Experiment
Abstract

High-momentum two-particle correlations are a useful tool for studying jet-quenching effects in the quark-gluon plasma. Angular correlations between neutral-pion triggers and charged hadrons with transverse momenta in the range 4--12~GeV/$c$ and 0.5--7~GeV/$c$, respectively, have been measured by the PHENIX experiment in 2014 for Au$+$Au collisions at $\sqrt{s_{_{NN}}}=200$~GeV. Suppression is observed in the yield of high-momentum jet fragments opposite the trigger particle, which indicates jet suppression stemming from in-medium partonic energy loss, while enhancement is observed for low-momentum particles. The ratio and differences between the yield in Au$+$Au collisions and $p$$+$$p$ collisions, $I_{AA}$ and $\Delta_{AA}$, as a function of the trigger-hadron azimuthal separation, $\Delta\phi$, are measured for the first time at the Relativistic Heavy Ion Collider. These results better quantify how the yield of low-$p_T$ associated hadrons is enhanced at wide angle, which is crucial for studying energy loss as well as medium-response effects., Comment: 535 authors from 84 institutions, 12 pages, 8 figures. v2 is version accepted for publication in Physical Review C. HEPdata tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2024
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10. Data quality control system and long-term performance monitor of the LHAASO-KM2A

Author

Cao, Zhen, Aharonian, F., Axikegu, Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Bian, W., Bukevich, A. V., Cao, Q., Cao, W. Y., Cao, Zhe, Chang, J., Chang, J. F., Chen, A. M., Chen, E. S., Chen, H. X., Chen, Liang, Chen, Lin, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, M. Y., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, Dong, X. Q., Duan, K. K., Fan, J. H., Fan, Y. Z., Fang, J., Fang, J. H., Fang, K., Feng, C. F., Feng, H., Feng, L., Feng, S. H., Feng, X. T., Feng, Y., Feng, Y. L., Gabici, S., Gao, B., Gao, C. D., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Giacinti, G., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., Hasan, M., He, H. H., He, H. N., He, J. Y., He, Y., Hor, Y. K., Hou, B. W., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S. C., Huang, D. H., Huang, T. Q., Huang, W. J., Huang, X. T., Huang, X. Y., Huang, Y., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, X. W., Jiang, Z. J., Jin, M., Kang, M. M., Karpikov, I., Kuleshov, D., Kurinov, K., Li, B. B., Li, C. M., Li, Cheng, Li, Cong, Li, D., Li, F., Li, H. B., Li, H. C., Li, Jian, Li, Jie, Li, K., Li, S. D., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, D. B., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Luo, Q., Luo, Y., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Min, Z., Mitthumsiri, W., Mu, H. J., Nan, Y. C., Neronov, A., Ou, L. J., Pattarakijwanich, P., Pei, Z. Y., Qi, J. C., Qi, M. Y., Qiao, B. Q., Qin, J. J., Raza, A., Ruffolo, D., Sáiz, A., Saeed, M., Semikoz, D., Shao, L., Shchegolev, O., Sheng, X. D., Shu, F. W., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, D. X., Sun, Q. N., Sun, X. N., Sun, Z. B., Takata, J., Tam, P. H. T., Tang, Q. W., Tang, R., Tang, Z. B., Tian, W. W., Wang, C., Wang, C. B., Wang, G. W., Wang, H. G., Wang, H. H., Wang, J. C., Wang, Kai, Wang, L. P., Wang, L. Y., Wang, P. H., Wang, R., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, Q. W., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, Y. L., Xing, Y., Xiong, D. R., Xiong, Z., Xu, D. L., Xu, R. F., Xu, R. X., Xu, W. L., Xue, L., Yan, D. H., Yan, J. Z., Yan, T., Yang, C. W., Yang, C. Y., Yang, F., Yang, F. F., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, W. X., Yao, Y. H., Yao, Z. G., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zha, M., Zhang, B. B., Zhang, F., Zhang, H., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, Li, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zhao, X. H., Zheng, F., Zhong, W. J., Zhou, B., Zhou, H., Zhou, J. N., Zhou, M., Zhou, P., Zhou, R., Zhou, X. X., Zhu, B. Y., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., Zou, Y. C., and Zuo, X.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The KM2A is the largest sub-array of the Large High Altitude Air Shower Observatory (LHAASO). It consists of 5216 electromagnetic particle detectors (EDs) and 1188 muon detectors (MDs). The data recorded by the EDs and MDs are used to reconstruct primary information of cosmic ray and gamma-ray showers. This information is used for physical analysis in gamma-ray astronomy and cosmic ray physics. To ensure the reliability of the LHAASO-KM2A data, a three-level quality control system has been established. It is used to monitor the status of detector units, stability of reconstructed parameters and the performance of the array based on observations of the Crab Nebula and Moon shadow. This paper will introduce the control system and its application on the LHAASO-KM2A data collected from August 2021 to July 2023. During this period, the pointing and angular resolution of the array were stable. From the observations of the Moon shadow and Crab Nebula, the results achieved using the two methods are consistent with each other. According to the observation of the Crab Nebula at energies from 25 TeV to 100 TeV, the time averaged pointing errors are estimated to be $-0.003^{\circ} \pm 0.005^{\circ}$ and $0.001^{\circ} \pm 0.006^{\circ}$ in the R.A. and Dec directions, respectively., Comment: 15 pages, 9 figures

Published
2024

11. Discovery of Very-high-energy Gamma-ray Emissions from the Low Luminosity AGN NGC 4278 by LHAASO

Author

Cao, Zhen, Aharonian, F., An, Q., Axikegu, Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Q., Cao, W. Y., Cao, Zhe, Chang, J., Chang, J. F., Chen, A. M., Chen, E. S., Chen, Liang, Chen, Lin, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, M. Y., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, Dong, X. Q., Duan, K. K., Fan, J. H., Fan, Y. Z., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gabici, S., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Giacinti, G., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. Y., He, X. B., He, Y., Hor, Y. K., Hou, B. W., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S. C., Huang, D. H., Huang, T. Q., Huang, W. J., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, X. W., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Kurinov, K., Li, B. B., Li, Cheng, Li, Cong, Li, D., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Min, Z., Mitthumsiri, W., Mu, H. J., Nan, Y. C., Neronov, A., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Sáiz, A., Semikoz, D., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shu, F. W., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Q. W., Tang, Z. B., Tian, W. W., Wang, C., Wang, C. B., Wang, G. W., Wang, H. G., Wang, H. H., Wang, J. C., Wang, K., Wang, L. P., Wang, L. Y., Wang, P. H., Wang, R., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. F., Xu, R. X., Xu, W. L., Xue, L., Yan, D. H., Yan, J. Z., Yan, T., Yang, C. W., Yang, F., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zha, M., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, J. H., Zhou, B., Zhou, H., Zhou, J. N., Zhou, M., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., Zou, Y. C., and Zuo, X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The first source catalog of Large High Altitude Air Shower Observatory reported the detection of a very-high-energy gamma ray source, 1LHAASO J1219+2915. In this paper a further detailed study of the spectral and temporal behavior of this point-like source have been carried. The best-fit position of the TeV source ($\rm{RA}=185.05^{\circ}\pm0.04^{\circ}$, $\rm{Dec}=29.25^{\circ}\pm0.03^{\circ}$) is compatible with NGC 4278 within $\sim0.03$ degree. Variation analysis shows an indication of the variability at a few months level in the TeV band, which is consistent with low frequency observations. Based on these observations, we report the detection of TeV $\gamma$-ray emissions from this low-luminosity AGN NGC 4278. The observations by LHAASO-WCDA during active period has a significance level of 8.8\,$\sigma$ with best-fit photon spectral index $\varGamma=2.56\pm0.14$ and a flux $f_{1-10\,\rm{TeV}}=(7.0\pm1.1_{\rm{sta}}\pm0.35_{\rm{syst}})\times10^{-13}\,\rm{photons\,cm^{-2}\,s^{-1}}$, or approximately $5\%$ of the Crab Nebula. The discovery of VHE from NGC 4278 indicates that the compact, weak radio jet can efficiently accelerate particles and emit TeV photons., Comment: 11 pages, 5 figures

Published
2024

12. LHAASO-KM2A detector simulation using Geant4

Author

Cao, Zhen, Aharonian, F., An, Q., Axikegu, Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Q., Cao, W. Y., Cao, Zhe, Chang, J., Chang, J. F., Chen, A. M., Chen, E. S., Chen, Liang, Chen, Lin, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, M. Y., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, Dong, X. Q., Duan, K. K., Fan, J. H., Fan, Y. Z., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gabici, S., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Giacinti, G., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. Y., He, X. B., He, Y., Hor, Y. K., Hou, B. W., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S. C., Huang, D. H., Huang, T. Q., Huang, W. J., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, X. W., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Kurinov, K., Li, B. B., Li, Cheng, Li, Cong, Li, D., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Min, Z., Mitthumsiri, W., Mu, H. J., Nan, Y. C., Neronov, A., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Sáiz, A., Semikoz, D., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shu, F. W., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Q. W., Tang, Z. B., Tian, W. W., Wang, C., Wang, C. B., Wang, G. W., Wang, H. G., Wang, H. H., Wang, J. C., Wang, K., Wang, L. P., Wang, L. Y., Wang, P. H., Wang, R., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. F., Xu, R. X., Xu, W. L., Xue, L., Yan, D. H., Yan, J. Z., Yan, T., Yang, C. W., Yang, F., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zha, M., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, J. H., Zhou, B., Zhou, H., Zhou, J. N., Zhou, M., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

KM2A is one of the main sub-arrays of LHAASO, working on gamma ray astronomy and cosmic ray physics at energies above 10 TeV. Detector simulation is the important foundation for estimating detector performance and data analysis. It is a big challenge to simulate the KM2A detector in the framework of Geant4 due to the need to track numerous photons from a large number of detector units (>6000) with large altitude difference (30 m) and huge coverage (1.3 km^2). In this paper, the design of the KM2A simulation code G4KM2A based on Geant4 is introduced. The process of G4KM2A is optimized mainly in memory consumption to avoid memory overffow. Some simpliffcations are used to signiffcantly speed up the execution of G4KM2A. The running time is reduced by at least 30 times compared to full detector simulation. The particle distributions and the core/angle resolution comparison between simulation and experimental data of the full KM2A array are also presented, which show good agreement.

Published
2024
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13. Measurements of All-Particle Energy Spectrum and Mean Logarithmic Mass of Cosmic Rays from 0.3 to 30 PeV with LHAASO-KM2A

Author

The LHAASO Collaboration, Cao, Zhen, Aharonian, F., An, Q., Axikegu, A., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Q., Cao, W. Y., Cao, Zhe, Chang, J., Chang, J. F., Chen, A. M., Chen, E. S., Chen, Liang, Chen, Lin, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, M. Y., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Dong, X. Q., Duan, K. K., Fan, J. H., Fan, Y. Z., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gabici, S., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Giacinti, G., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. Y., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, B. W., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S. C., Huang, D. H., Huang, T. Q., Huang, W. J., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, X. W., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Kurinov, K., Li, B. B., Li, Cheng, Li, Cong, Li, D., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Min, Z., Mitthumsiri, W., Mu, H. J., Nan, Y. C., Neronov, A., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Sáiz, A., Semikoz, D., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shu, F. W., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Q. W., Tang, Z. B., Tian, W. W., Wang, C., Wang, C. B., Wang, G. W., Wang, H. G., Wang, H. H., Wang, J. C., Wang, K., Wang, L. P., Wang, L. Y., Wang, P. H., Wang, R., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. F., Xu, R. X., Xu, W. L., Xue, L., Yan, D. H., Yan, J. Z., Yan, T., Yang, C. W., Yang, F., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zha, M., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zhou, B., Zhou, H., Zhou, J. N., Zhou, M., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present the measurements of all-particle energy spectrum and mean logarithmic mass of cosmic rays in the energy range of 0.3-30 PeV using data collected from LHAASO-KM2A between September 2021 and December 2022, which is based on a nearly composition-independent energy reconstruction method, achieving unprecedented accuracy. Our analysis reveals the position of the knee at $3.67 \pm 0.05 \pm 0.15$ PeV. Below the knee, the spectral index is found to be -$2.7413 \pm 0.0004 \pm 0.0050$, while above the knee, it is -$3.128 \pm 0.005 \pm 0.027$, with the sharpness of the transition measured with a statistical error of 2%. The mean logarithmic mass of cosmic rays is almost heavier than helium in the whole measured energy range. It decreases from 1.7 at 0.3 PeV to 1.3 at 3 PeV, representing a 24% decline following a power law with an index of -$0.1200 \pm 0.0003 \pm 0.0341$. This is equivalent to an increase in abundance of light components. Above the knee, the mean logarithmic mass exhibits a power law trend towards heavier components, which is reversal to the behavior observed in the all-particle energy spectrum. Additionally, the knee position and the change in power-law index are approximately the same. These findings suggest that the knee observed in the all-particle spectrum corresponds to the knee of the light component, rather than the medium-heavy components., Comment: 8 pages, 3 figures

Published
2024
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15. ForMAX -- a beamline for multiscale and multimodal structural characterization of hierarchical materials

Author

Nygård, K., McDonald, S. A., González, J. B., Haghighat, V., Appel, C., Larsson, E., Ghanbari, R., Viljanen, M., Silva, J., Malki, S., Li, Y., Silva, V., Weninger, C., Engelmann, F., Jeppsson, T., Felcsuti, G., Rosén, T., Gordeyeva, K., Söderberg, L. D., Dierks, H., Zhang, Y., Yao, Z., Yang, R., Asimakopoulou, E. M., Rogalinski, J. K., Wallentin, J., Villanueva-Perez, P., Krüger, R., Dreier, T., Bech, M., Liebi, M., Bek, M., Kádár, R., Terry, A. E., Tarawneh, H., Ilinski, P., Malmqvist, J., and Cerenius, Y.

Subjects
Physics - Instrumentation and Detectors
Abstract

The ForMAX beamline at the MAX IV Laboratory provides multiscale and multimodal structural characterization of hierarchical materials in the nm to mm range by combining small- and wide-angle x-ray scattering with full-field microtomography. The modular design of the beamline is optimized for easy switching between different experimental modalities. The beamline has a special focus on the development of novel, fibrous materials from forest resources, but it is also well suited for studies within, e.g., food science and biomedical research., Comment: Accepted for publication in J. Synchrotron Rad

Published
2023

16. Charge-density wave transition in magnetic topological semimetal EuAl$_4$

Author

Yang, R., Le, C. C., Zhu, P., Wang, Z. W., Shang, T., Dai, Y. M., Hu, J. P., and Dressel, M.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science
Abstract

The interplay among topology, charge-density wave (CDW), and magnetism can give rise to a plethora of exotic quantum phenomena. Recently, a group of magnetic topological semimetals with tetragonal lattices and CDW order were found to exhibit anomalous magnetic instability, helical spin ordering, and the presence of skyrmions. However, the underlying mechanism responsible for these observations remains unclear. Here, we conducted a comprehensive investigation into the impact of CDW on the topological and magnetic properties of EuAl$_4$ using optical spectroscopy and the first-principles calculations. Through optical spectroscopy, we observed a partial gap (60~meV) on the Fermi surface and an enhanced mid-infrared absorption around 0.4~eV after the CDW transition. Magneto-optical spectroscopy and the first-principles calculations proved that, by affecting the band structure, the CDW order frustrates the antiferromagnetic interactions but strengthened the ferromagnetic ones, which can destabilize the magnetism. With lower symmetry in the CDW ordered state, carriers from the Weyl bands will mediate the anisotropic magnetic interactions promoting the formation of chiral spin textures. Conversely, without the CDW order, the counterpart EuGa$_4$ shows robust collinear antiferromagnetic order. Our findings uncover the pivotal role played by CDW order in arousing intricate magnetism in topological materials and provide valuable insights into controlling topological and magnetic properties through the manipulation of CDW orders., Comment: 8 pages, 4 figures

Published
2023
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19. Does or did the supernova remnant Cassiopeia A operate as a PeVatron?

Author

Cao, Zhen, Aharonian, F., An, Q., Axikegu, Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Q., Cao, W. Y., Cao, Zhe, Chang, J., Chang, J. F., Chen, A. M., Chen, E. S., Chen, Liang, Chen, Lin, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, M. Y., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Dong, X. Q., Duan, K. K., Fan, J. H., Fan, Y. Z., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gabici, S., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Giacinti, G., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. Y., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, B. W., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S. C., Huang, D. H., Huang, T. Q., Huang, W. J., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, X. W., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Kurinov, K., Li, B. B., Li, Cheng, Li, Cong, Li, D., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Min, Z., Mitthumsiri, W., Mu, H. J., Nan, Y. C., Neronov, A., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Sáiz, A., Semikoz, D., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shu, F. W., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Q. W., Tang, Z. B., Tian, W. W., Wang, C., Wang, C. B., Wang, G. W., Wang, H. G., Wang, H. H., Wang, J. C., Wang, K., Wang, L. P., Wang, L. Y., Wang, P. H., Wang, R., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. F., Xu, R. X., Xu, W. L., Xue, L., Yan, D. H., Yan, J. Z., Yan, T., Yang, C. W., Yang, F., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zha, M., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zhou, B., Zhou, H., Zhou, J. N., Zhou, M., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo., X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

For decades, supernova remnants (SNRs) have been considered the prime sources of Galactic Cosmic rays (CRs). But whether SNRs can accelerate CR protons to PeV energies and thus dominate CR flux up to the knee is currently under intensive theoretical and phenomenological debate. The direct test of the ability of SNRs to operate as CR PeVatrons can be provided by ultrahigh-energy (UHE; $E_\gamma \geq 100$~TeV) $\gamma$-rays. In this context, the historical SNR Cassiopeia A (Cas A) is considered one of the most promising target for UHE observations. This paper presents the observation of Cas A and its vicinity by the LHAASO KM2A detector. The exceptional sensitivity of LHAASO KM2A in the UHE band, combined with the young age of Cas A, enabled us to derive stringent model-independent limits on the energy budget of UHE protons and nuclei accelerated by Cas A at any epoch after the explosion. The results challenge the prevailing paradigm that Cas A-type SNRs are major suppliers of PeV CRs in the Milky Way., Comment: 11 pages, 3 figures, Accepted by the APJL

Published
2023

20. Very high energy gamma-ray emission beyond 10 TeV from GRB 221009A

Author

Cao, Zhen, Aharonian, F., An, Q., Axikegu, A., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Q., Cao, W. Y., Cao, Zhe, Chang, J., Chang, J. F., Chen, A. M., Chen, E. S., Chen, Liang, Chen, Lin, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, M. Y., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Dong, X. Q., Duan, K. K., Fan, J. H., Fan, Y. Z., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gabici, S., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Giacinti, G., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. Y., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, B. W., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S. C., Huang, D. H., Huang, T. Q., Huang, W. J., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, X. W., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Kurinov, K., Li, B. B., Li, Cheng, Li, Cong, Li, D., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Min, Z., Mitthumsiri, W., Mu, H. J., Nan, Y. C., Neronov, A., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Sáiz, A., Semikoz, D., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shu, F. W., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Q. W., Tang, Z. B., Tian, W. W., Wang, C., Wang, C. B., Wang, G. W., Wang, H. G., Wang, H. H., Wang, J. C., Wang, K., Wang, L. P., Wang, L. Y., Wang, P. H., Wang, R., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. F., Xu, R. X., Xu, W. L., Xue, L., Yan, D. H., Yan, J. Z., Yan, T., Yang, C. W., Yang, F., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zha, M., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zhou, B., Zhou, H., Zhou, J. N., Zhou, M., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The highest energy gamma-rays from gamma-ray bursts (GRBs) have important implications for their radiation mechanism. Here we report for the first time the detection of gamma-rays up to 13 TeV from the brightest GRB 221009A by the Large High Altitude Air-shower Observatory (LHAASO). The LHAASO-KM2A detector registered more than 140 gamma-rays with energies above 3 TeV during 230$-$900s after the trigger. The intrinsic energy spectrum of gamma-rays can be described by a power-law after correcting for extragalactic background light (EBL) absorption. Such a hard spectrum challenges the synchrotron self-Compton (SSC) scenario of relativistic electrons for the afterglow emission above several TeV. Observations of gamma-rays up to 13 TeV from a source with a measured redshift of z=0.151 hints more transparency in intergalactic space than previously expected. Alternatively, one may invoke new physics such as Lorentz Invariance Violation (LIV) or an axion origin of very high energy (VHE) signals., Comment: 49pages, 11figures

Published
2023
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21. Impact of disorder in the charge-density-wave state of Pd-intercalated ErTe$_3$ revealed by the electrodynamic response

Author

Corasaniti, M., Yang, R., Straquadine, J. A. W., Kapitulnik, A., Fisher, I. R., and Degiorgi, L.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

It is a general notion that disorder, introduced by either chemical substitution or intercalation as well as by electron-irradiation, is detrimental to the realisation of long-range charge-density-wave (CDW) order. We study the disorder-induced suppression of the in-plane CDW orders in the two-dimensional Pd-intercalated ErTe$_3$ compositions, by exploring the real part of the optical conductivity with light polarised along the in-plane $a$ and $c$ axes. Our findings reveal an anisotropic charge dynamics with respect to both incommensurate unidirectional CDW phases of ErTe$_3$, occurring within the $ac$-plane. The anisotropic optical response gets substantially washed out with Pd-intercalation, hand-in-hand with the suppression of both CDW orders. The spectral weight analysis though advances the scenario, for which the CDW phases evolve from a (partially) depleted Fermi surface already above their critical onset temperatures. We therefore argue that the long-range CDW orders of ErTe$_3$ tend to be progressively dwarfed by Pd-intercalation, which favours the presence of short-range CDW segments for both crystallographic directions persisting in a broad temperature ($T$) interval up to the normal state, and being suggestive of precursor effects of the CDW orders as well as possibly coexisting with superconductivity at low $T$., Comment: 16 pages, 17 figures

Published
2023
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22. An Eleven-Year Retrospective Survey of Anaerobic Bloodstream Infection in Adults in a General Hospital

Author

Yang R, Wang W, Yin G, Ma T, and Tao J

Subjects
anaerobes, bloodstream infections, blood cultures, clinical features, Infectious and parasitic diseases, RC109-216
Abstract

Ru Yang,1,&ast; Wen Wang,1,2,&ast; Guomin Yin,1,2 Tingting Ma,1,2 Jia Tao1,2 1Center of Medical Laboratory, General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 2Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jia Tao, Email taojia880625@163.comObjective: During conditions accompanied by the disruption of normal mucosal barriers, anaerobic bacteria, which a part of normal human mucosal microflora, may cause various infections. In this study, clinical features of anaerobic bloodstream infections (BSI) in a general hospital in China were investigated.Methods: Patients with anaerobic BSI were retrospectively enrolled between 2012 and 2022. Demographic data, clinical manifestations, antibiotic treatments, and disease outcomes were analyzed.Results: In total, 391 anaerobic bacterial strains were isolated from 381 patients aged older than 11 years of age. Given that medical records of 47 patients were missing, 334 patients were included in the clinical investigation. Patients with anaerobic BSI included in the study were predominantly older than 50 years of age. Intra-abdominal infections were the most common source of anaerobic BSI (59%), followed by those of the female genital tract (10.2%) and lower respiratory tract (7.2%). Among the isolates, Bacteroides and Clostridium spp. were the most frequently isolated anaerobes. Most of the patients received antibiotic therapy. The crude mortality was 4.5%.Conclusion: The detection rate of anaerobic BSI in Ningxia, China, remained relatively stable from 2012 to 2022. These results provide a reference for the diagnosis and empirical treatment of anaerobic BSI in this region of China. Continuous mul-ticenter studies should be conducted to monitor the incidence of anaerobic BSI and drug resistance of anaerobic isolates to improve the treatment outcomes of patients.Keywords: anaerobes, bloodstream infections, blood cultures, clinical features

Published
2024

23. Comprehensive Serum Proteomic and Metabolomic Profiles of Pediatric Patients with Moyamoya Disease Reveal Core Pathways

Author

Guo Q, Xie M, Wang QN, Li J, Liu S, Wang X, Yu D, Zou Z, Gao G, Zhang Q, Hao F, Feng J, Yang R, Wang M, Fu H, Bao X, and Duan L

Subjects
proteomics, metabolomics, pediatric patients, moyamoya disease, integration analysis, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Qingbao Guo,1,2,&ast; Manli Xie,3,&ast; Qian-Nan Wang,4,&ast; Jingjie Li,1,2 Simeng Liu,1,2 Xiaopeng Wang,1,2 Dan Yu,5 Zhengxing Zou,5 Gan Gao,1,2 Qian Zhang,5 Fangbin Hao,1,2 Jie Feng,5 Rimiao Yang,5 Minjie Wang,1,2 Heguan Fu,5 Xiangyang Bao,5 Lian Duan2 1Medical School of Chinese PLA, Beijing, People’s Republic of China; 2Department of Neurosurgery, First Medical Centre, Chinese PLA General Hospital, Beijing, People’s Republic of China; 3Department of Occupational Diseases, Xi’an Central Hospital, Xi’an, Shanxi, People’s Republic of China; 4Department of Neurosurgery, Eighth Medical Centre, Chinese PLA General Hospital, Beijing, People’s Republic of China; 5Department of Neurosurgery, Fifth Medical Centre, Chinese PLA General Hospital, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiangyang Bao; Lian Duan, Email bzy123@163.com; duanlian307@sina.comBackground: Moyamoya disease (MMD) signifies a cerebrovascular disorder with obscure origin and a more rapid and severe progression in children than adults. This investigation aims to uncover age-associated distinctions through proteomic and metabolomic profiling to gain insights into the underlying mechanisms of MMD.Methods: Twelve MMD patients—six children and six adults—along with six healthy controls (HC), participated, each providing a 10 mL blood sample. Serum proteomic and metabolomic analyses were conducted using ultra-performance liquid chromatography and high-resolution mass spectrometry, complemented by bioinformatics to identify differential biomolecules and their interactions. Pathway implications were ascertained using GO and KEGG enrichment analysis.Results: Notable proteomic and metabolomic discrepancies were observed between pediatric and adult MMD subjects. A total of 235 and 216 proteins varied in adult and pediatric cases compared to HCs, with 73 proteins shared. In addition, 129 and 74 anionic, plus 96 and 104 cationic metabolites, were differentially expressed in the pediatric and adult groups, respectively, with 34 anionic and 28 cationic metabolites in common. Age-specific biomolecules further characterized these distinctions. Enrichment analysis pinpointed immunity and inflammation pathways, with vitamin digestion and absorption highlighted as pivotal in pediatric MMD.Conclusion: This study unveils distinct metabolic and proteomic patterns within pediatric and adult MMD patients. The critical role of the vitamin digestion and absorption pathway in the pathogenesis of pediatric MMD offers novel insight into disease mechanisms. Keywords: proteomics, metabolomics, pediatric patients, moyamoya disease, integration analysis

Published
2024

24. Association of Pain Intensity and Sensitivity with Suicidal Ideation in Adolescents with Depressive Disorder

Author

Shen Q, Zhang Q, Liu Y, Cui Y, Shang J, Yuan X, Geng F, Sun L, Liu Z, Yang R, Zhang K, and Liu H

Subjects
adolescents, depressive disorder, pain intensity, pain sensitivity, suicidal ideation, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract

Qingqing Shen,1– 3,&ast; Qing Zhang,2,3,&ast; Yunxiao Liu,1– 3,&ast; Yingao Cui,1– 3 Jingwen Shang,1– 3 Xiaoping Yuan,2,3 Feng Geng,4 Liang Sun,5 Zhiwei Liu,5 Rongchun Yang,5 Kai Zhang,2,3 Huanzhong Liu2,3,6 1Department of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China; 3Anhui Psychiatric Center, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 4Department of Psychology and Sleep Medicine, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China; 5Department of Psychiatry, Fuyang Third People’s Hospital, Fuyang, Anhui, People’s Republic of China; 6Brain Bank Construction and Resource Utilization, Anhui Provincial Key Laboratory, Anhui, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Kai Zhang; Huanzhong Liu, Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China, Email zhangkai@ahmu.edu.cn; huanzhongliu@ahmu.edu.cnPurpose: The purpose of this study was to further explore the association of pain intensity and sensitivity with suicidal ideation in adolescents with depressive disorder by comparing the differences in pain intensity and sensitivity between adolescent patients with depressive disorders and healthy controls.Patients and Methods: A consecutive enrollment method was used to select 158 adolescent patients with depressive disorders from three hospitals in Anhui Province as the MDD group, and 47 healthy adolescents were recruited as the Control group. The subjects’ suicidal ideation was assessed using the Positive and Negative Suicide Ideation scale (PANSI), and the intensity of somatic pain was assessed using the Numerical Rating Scale-11 (NRS-11). Subjects were assessed for forearm and tibial pain sensitivity using a hand-held pressure pain instrument, and experimental pain sensitivity measures included pressure pain threshold (PPT) and pressure pain tolerance (PTO). Differences in pain intensity and sensitivity between the MDD group and the Control group were compared, and the association of pain intensity and sensitivity with suicidal ideation was analyzed.Results: The incidence of physical pain in adolescent depressive disorder was higher at 88.6%, which was significantly higher than the Control group (P< 0.001), and the pain intensity in the MDD group (3.77± 2.48) was significantly higher than the Control group (0.617± 0.99) (P < 0.001).The Pain tolerance was significantly higher in the MDD group (forearm 105.37 ± 41.46; tibia 121.29 ± 41.60) than in the Control group (forearm 91.92 ± 37.62; tibia 105.47 ± 35.52) (P < 0.05).Linear regression analysis showed that the greater the pain intensity and pain tolerance, the higher the total PANSI score.Binary logistic regression showed that pain intensity was an influencing factor for suicidal ideation.Conclusion: Adolescents with depressive disorders have higher pain intensity and lower pain sensitivity than healthy adolescents. Increased pain intensity and pain tolerance were positively correlated with suicidal ideation.Keywords: adolescents, depressive disorder, pain intensity, pain sensitivity, suicidal ideation

Published
2024

25. The First LHAASO Catalog of Gamma-Ray Sources

Author

Cao, Zhen, Aharonian, F., An, Q., Axikegu, Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Q., Cao, W. Y., Cao, Zhe, Chang, J., Chang, J. F., Chen, A. M., Chen, E. S., Chen, Liang, Chen, Lin, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, M. Y., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Dong, X. Q., Duan, K. K., Fan, J. H., Fan, Y. Z., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gabici, S., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Giacinti, G., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. Y., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, B. W., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S. C., Huang, D. H., Huang, T. Q., Huang, W. J., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, X. W., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Kurinov, K., Li, B. B., Li, Cheng, Li, Cong, Li, D., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Min, Z., Mitthumsiri, W., Mu, H. J., Nan, Y. C., Neronov, A., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Sáiz, A., Semikoz, D., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shu, F. W., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Q. W., Tang, Z. B., Tian, W. W., Wang, C., Wang, C. B., Wang, G. W., Wang, H. G., Wang, H. H., Wang, J. C., Wang, K., Wang, L. P., Wang, L. Y., Wang, P. H., Wang, R., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. F., Xu, R. X., Xu, W. L., Xue, L., Yan, D. H., Yan, J. Z., Yan, T., Yang, C. W., Yang, F., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zha, M., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zhou, B., Zhou, H., Zhou, J. N., Zhou, M., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo., X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

We present the first catalog of very-high energy and ultra-high energy gamma-ray sources detected by the Large High Altitude Air Shower Observatory (LHAASO). The catalog was compiled using 508 days of data collected by the Water Cherenkov Detector Array (WCDA) from March 2021 to September 2022 and 933 days of data recorded by the Kilometer Squared Array (KM2A) from January 2020 to September 2022. This catalog represents the main result from the most sensitive large coverage gamma-ray survey of the sky above 1 TeV, covering declination from $-$20$^{\circ}$ to 80$^{\circ}$. In total, the catalog contains 90 sources with an extended size smaller than $2^\circ$ and a significance of detection at $> 5\sigma$. Based on our source association criteria, 32 new TeV sources are proposed in this study. Among the 90 sources, 43 sources are detected with ultra-high energy ($E > 100$ TeV) emission at $> 4\sigma$ significance level. We provide the position, extension, and spectral characteristics of all the sources in this catalog., Comment: 40 pages, 13 figures, 4 tables

Published
2023
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26. Measurement of ultra-high-energy diffuse gamma-ray emission of the Galactic plane from 10 TeV to 1 PeV with LHAASO-KM2A

Author

Cao, Zhen, Aharonian, F., An, Q., Axikegu, Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Q., Cao, W. Y., Cao, Zhe, Chang, J., Chang, J. F., Chen, A. M., Chen, E. S., Chen, Liang, Chen, Lin, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, M. Y., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Dong, X. Q., Duan, K. K., Fan, J. H., Fan, Y. Z., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gabici, S., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Giacinti, G., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. Y., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, B. W., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S. C., Huang, D. H., Huang, T. Q., Huang, W. J., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, X. W., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Kurinov, K., Li, B. B., Li, Cheng, Li, Cong, Li, D., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Min, Z., Mitthumsiri, W., Mu, H. J., Nan, Y. C., Neronov, A., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Saiz, A., Semikoz, D., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shu, F. W., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Q. W., Tang, Z. B., Tian, W. W., Wang, C., Wang, C. B., Wang, G. W., Wang, H. G., Wang, H. H., Wang, J. C., Wang, K., Wang, L. P., Wang, L. Y., Wang, P. H., Wang, R., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. F., Xu, R. X., Xu, W. L., Xue, L., Yan, D. H., Yan, J. Z., Yan, T., Yang, C. W., Yang, F., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zha, M., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zhou, B., Zhou, H., Zhou, J. N., Zhou, M., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The diffuse Galactic $\gamma$-ray emission, mainly produced via interactions between cosmic rays and the interstellar medium and/or radiation field, is a very important probe of the distribution, propagation, and interaction of cosmic rays in the Milky Way. In this work we report the measurements of diffuse $\gamma$-rays from the Galactic plane between 10 TeV and 1 PeV energies, with the square kilometer array of the Large High Altitude Air Shower Observatory (LHAASO). Diffuse emissions from the inner ($15^{\circ}10$~TeV). The energy spectrum in the inner Galaxy regions can be described by a power-law function with an index of $-2.99\pm0.04$, which is different from the curved spectrum as expected from hadronic interactions between locally measured cosmic rays and the line-of-sight integrated gas content. Furthermore, the measured flux is higher by a factor of $\sim3$ than the prediction. A similar spectrum with an index of $-2.99\pm0.07$ is found in the outer Galaxy region, and the absolute flux for $10\lesssim E\lesssim60$ TeV is again higher than the prediction for hadronic cosmic ray interactions. The latitude distributions of the diffuse emission are consistent with the gas distribution, while the longitude distributions show clear deviation from the gas distribution. The LHAASO measurements imply that either additional emission sources exist or cosmic ray intensities have spatial variations., Comment: 12 pages, 8 figures, 5 tables; accepted for publication in Physical Review Letters; source mask file provided as ancillary file

Published
2023
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27. Lipoprotein Combine Index as a Better Marker for NAFLD Identification Than Traditional Lipid Parameters

Author

Qiu J, Huang X, Kuang M, Yang R, Li J, Sheng G, and Zou Y

Subjects
non-alcoholic fatty liver disease, lipoprotein combine index, nafld, traditional lipid parameters, lci., Specialties of internal medicine, RC581-951
Abstract

Jiajun Qiu,1– 3,&ast; Xin Huang,1– 3,&ast; Maobin Kuang,1– 3,&ast; Ruijuan Yang,1,4 Jiachong Li,1 Guotai Sheng,5,6 Yang Zou2,3 1Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China; 2Jiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi Province, People’s Republic of China; 3Jiangxi Cardiovascular Research Institute, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi Province, People’s Republic of China; 4Department of Endocrinology, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi Province, People’s Republic of China; 5Jiangxi Provincial Geriatric Hospital, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi Province, People’s Republic of China; 6Jiangxi Provincial Geriatric Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Guotai Sheng, Jiangxi Provincial Geriatric Hospital, Jiangxi Provincial People’s Hospital, No. 92 Aiguo Road, Nanchang, Jiangxi, 330006, People’s Republic of China, Email tgs200509@163.com Yang Zou, Jiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, No. 92 Aiguo Road, Nanchang, Jiangxi, 330006, People’s Republic of China, Email jxyxyzy@163.comPurpose: The association between traditional lipid parameters and non-alcoholic fatty liver disease (NAFLD) has been extensively discussed. This study aims to evaluate and compare the lipoprotein combine index (LCI) and traditional lipid parameters [total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)] to identify NAFLD.Patients and Methods: The analysis included 14,251 participants from the NAfld in the Gifu Area, Longitudinal Analysis (NAGALA). Logistic regression models were employed to calculate standardized odds ratios (ORs) and 95% confidence intervals (CIs) for assessing and comparing the association of LCI and traditional lipid parameters with NAFLD. Additionally, receiver operating characteristic (ROC) curves were used to calculate the area under the curve (AUC) for LCI and traditional lipid parameters in identifying NAFLD.Results: After adjusting for various confounders, we found that LCI was positively associated with NAFLD (OR=2.25, 95% CI 1.92– 2.63), and this association was stronger than that of traditional lipid parameters [OR: TC1.23, TG1.73 LDL-C1.10]. Further subgroup analyses revealed that the association of LCI with NAFLD was stronger than other traditional lipid parameters in all subgroups, including men and women, overweight/obese [body mass index (BMI)≥ 25 kg/m2] and non-obese (BMI< 25 kg/m2), and older (age≥ 45 years) and younger (age< 45 years) participants. Additionally, ROC analysis indicated that LCI (AUC=0.8118) had significantly higher accuracy (All DeLong P< 0.05) in identifying NAFLD compared to traditional lipid parameters (AUC: TC0.6309; TG0.7969; LDL-C0.6941); HDL-C0.7587). Sensitivity analysis further confirmed the robustness of the study findings.Conclusion: This study revealed for the first time a positive correlation between LCI and NAFLD. Compared to traditional lipid parameters, LCI has a higher correlation with NAFLD. Additionally, further ROC analysis demonstrated that LCI had higher accuracy in identifying NAFLD compared to traditional lipid parameters, suggesting that LCI may be a better marker for NAFLD identification than traditional lipid parameters.Keywords: non-alcoholic fatty liver disease, lipoprotein combine index, NAFLD, traditional lipid parameters, LCI

Published
2024

28. Assisted Reproductive Technology Outcomes in Women with Normal Ovarian Response Receiving Recombinant Luteinizing Hormone/Human Menopausal Gonadotropin: An Observational Study

Author

Liang Y, Hou X, Chen H, Yang R, Wang R, Mao R, Zhao J, and Cheng J

Subjects
in vitro fertilization, intracytoplasmic sperm injection, live birth rate, cumulative live birth rate, Gynecology and obstetrics, RG1-991
Abstract

Yingxiu Liang,1 Xiaohong Hou,1 Haoying Chen,1 Ruqing Yang,1 Ruina Wang,1 Ruotong Mao,1 Junzhao Zhao,1 Hui Chen,2 Jing Cheng1 1Reproductive Center, Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325088, People’s Republic of China; 2School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, 2007, AustraliaCorrespondence: Jing Cheng, Reproductive Center, Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, No. 306 Hualongqiao Road, Lucheng District, Wenzhou, Zhejiang Province, 325088, People’s Republic of China, Tel +86 13780193700, Fax +86 57788002304, Email jingchengdoc_gyn@hotmail.com Hui Chen, Faculty of Science, University of Technology Sydney, No. 15 of Broadway, Ultimo, New South Wales, 2007, Australia, Tel/Fax +61 295141328, Email chenhuimind@sina.comObjective: Additive human menopausal gonadotropin (HMG)/recombinant luteinizing hormone (r-LH) to follicle-stimulating hormone (FSH) can improve pregnancy outcomes in patients with poor ovarian response during assisted reproductive procedures. However, their effects on patients with normal ovarian response during such procedures are unclear, which formed the aim of this study.Methods: This retrospective study enrolled 456 infertile women who underwent in vitro fertilization or intracytoplasmic sperm injection treatment. Group 1 received FSH; Group 2 received FSH+HMG/r-LH; Group 3 received FSH+HMG+r-LH.Results: The age and Body Mass Index were significantly greater in Group III. The endometrial thickness was greater in Groups II and III, suggesting better endometrial receptivity. Better pregnancy and birth outcomes were seen in Group 3. In sub-cohorts of women older than 32 years old or with overweight/obesity, pregnancy and birth outcomes were also much better in Group 3, albeit without statistical significance.Conclusion: The addition of both HMG and r-LH to FSH may improve the chance of infertile women with normal ovarian responses to have more success in having live birth babies, specifically in those over 32 years of age or with overweight/obese patients who typically face challenges in conceiving and sustaining a pregnancy.Keywords: in vitro fertilization, intracytoplasmic sperm injection, live birth rate, cumulative live birth rate

Published
2024

29. Spermbots and Their Applications in Assisted Reproduction: Current Progress and Future Perspectives

Author

Zhang Y, Wang M, Zhang T, Wang H, Chen Y, Zhou T, and Yang R

Subjects
assisted reproduction, biohybrid nanorobot, clinical translation, male infertility, spermbot, Medicine (General), R5-920
Abstract

Yixuan Zhang,1,&ast; Min Wang,2,&ast; Ting Zhang,3 Honghua Wang,2 Ying Chen,1 Tao Zhou,1 Rui Yang1 1Research Institute for Reproductive Medicine and Genetic Diseases, Wuxi Maternity and Child Health Care Hospital, Wuxi, 214002, People’s Republic of China; 2Center for Reproductive Medicine, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, People’s Republic of China; 3Department of Laboratory Medicine, Wuxi Maternity and Child Health Care Hospital, Jiangnan University, Wuxi, 214002, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Tao Zhou; Rui Yang, Email zhoutao@njmu.edu.cn; ruiyang826@163.comAbstract: Sperm quality is declining dramatically during the past decades. Male infertility has been a serious health and social problem. The sperm cell driven biohybrid nanorobot opens a new era for automated and precise assisted reproduction. Therefore, it is urgent and necessary to conduct an updated review and perspective from the viewpoints of the researchers and clinicians in the field of reproductive medicine. In the present review, we first update the current classification, design, control and applications of various spermbots. Then, by a comprehensive summary of the functional features of sperm cells, the journey of sperms to the oocyte, and sperm-related dysfunctions, we provide a systematic guidance to further improve the design of spermbots. Focusing on the translation of spermbots into clinical practice, we point out that the main challenges are biocompatibility, effectiveness, and ethical issues. Considering the special requirements of assisted reproduction, we also propose the three laws for the clinical usage of spermbots: good genetics, gentle operation and no contamination. Finally, a three-step roadmap is proposed to achieve the goal of clinical translation. We believe that spermbot-based treatments can be validated and approved for in vitro clinical usage in the near future. However, multi-center and multi-disciplinary collaborations are needed to further promote the translation of spermbots into in vivo clinical applications. Keywords: assisted reproduction, biohybrid nanorobot, clinical translation, male infertility, spermbot

Published
2024

31. Optical fingerprints of the electronic band reconstruction in van der Waals magnetic materials

Author

Corasaniti, M., Yang, R., Liu, Y., Petrovic, C., and Degiorgi, L.

Subjects
Condensed Matter - Materials Science
Abstract

We report a broadband study of the charge dynamics in the van der Waals (vdW) magnetic materials 2H-$M_x$TaS$_2$ ($M$ = Mn and Co), which span the onset of both long-range antiferromagnetic (AFM) and ferromagnetic (FM) order, depending on the intercalation $M$ and its concentration $x$. We discover a spectral weight ($SW$) shift from high to low energy scales for FM compositions, while reversely $SW$ is removed from low towards high spectral energies for AFM compounds. This maps the related reconstruction of the electronic band structure along the crossover from the FM to AFM order, which restores an occupation balance in the density of states between spin majority and minority bands of the intercalated 3$d$ elements., Comment: 5 pages, 2 Figures, Supplementary Material provided by the Journal

Published
2023
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32. Optimizing for periodicity: a model-independent approach to flux crosstalk calibration for superconducting circuits

Author

Dai, X., Trappen, R., Yang, R., Disseler, S. M., Basham, J. I., Gibson, J., Melville, A. J., Niedzielski, B. M., Das, R., Kim, D. K., Yoder, J. L., Weber, S. J., Hirjibehedin, C. F., Lidar, D. A., and Lupascu, A.

Subjects
Quantum Physics
Abstract

Flux tunability is an important engineering resource for superconducting circuits. Large-scale quantum computers based on flux-tunable superconducting circuits face the problem of flux crosstalk, which needs to be accurately calibrated to realize high-fidelity quantum operations. Typical calibration methods either assume that circuit elements can be effectively decoupled and simple models can be applied, or require a large amount of data. Such methods become ineffective as the system size increases and circuit interactions become stronger. Here we propose a new method for calibrating flux crosstalk, which is independent of the underlying circuit model. Using the fundamental property that superconducting circuits respond periodically to external fluxes, crosstalk calibration of N flux channels can be treated as N independent optimization problems, with the objective functions being the periodicity of a measured signal depending on the compensation parameters. We demonstrate this method on a small-scale quantum annealing circuit based on superconducting flux qubits, achieving comparable accuracy with previous methods. We also show that the objective function usually has a nearly convex landscape, allowing efficient optimization.

Published
2022
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36. HucMSC-Exo Induced N2 Polarization of Neutrophils: Implications for Angiogenesis and Tissue Restoration in Wound Healing

Author

Yang J, Xie Y, Xia Z, Ji S, Yang X, Yue D, Liu Y, Yang R, and Fan Y

Subjects
hucmsc-exo, neutrophils, phenotype switching, cutaneous wound healing, tissue restoration, Medicine (General), R5-920
Abstract

Jiaman Yang,1,2,&ast; Yulin Xie,1,2,&ast; Zhikuan Xia,1,&ast; Shuaifei Ji,3,&ast; Xin Yang,1 Danxia Yue,1 Yuanyuan Liu,1,3 Rongya Yang,1– 3 Yunlong Fan1,3 1Department of Dermatology, the Seventh Medical Center of Chinese PLA General Hospital, Beijing, 100700, People’s Republic of China; 2The Second School of Clinical Medicine, SouThern Medical University, Guangzhou, 510599, People’s Republic of China; 3Chinese PLA Medical School, Beijing, 100853, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Rongya Yang, Department of Dermatology, the Seventh Medical Center of Chinese PLA General Hospital, No. 5, Nanmencang Alley, Dongsi Shitiao, Dongcheng District, Beijing, 100700, People’s Republic of China, Email YangRY301hospital@163.com Yunlong Fan, Department of Dermatology, the Seventh Medical Center of Chinese PLA General Hospital, No. 5, Nanmencang alley, Dongsi Shitiao, Dongcheng District, Beijing, 100700, People’s Republic of China, Email FanYL301hospital@163.comBackground: Neutrophils rapidly accumulate in large numbers at sites of tissue damage, exhibiting not only their well-known bactericidal capabilities but also playing crucial roles in angiogenesis and tissue repair. While exosomes derived from human umbilical cord mesenchymal stem cells (HucMSC-Exo) have emerged as a promising therapeutic tool, their exact mechanisms of action remain partly elusive. We hypothesize that HucMSC-Exo treatment may modulate neutrophil phenotypes, thereby significantly influencing wound healing outcomes.Methods: HucMSC-Exo were isolated via ultracentrifugation and subsequently administered through subcutaneous injection into full-thickness cutaneous wounds in mice. To determine the impact of host neutrophils on the healing effects of HucMSC-Exo in skin injuries, strategies including neutrophil depletion and adoptive transfer were employed. Flow cytometry was used to evaluate the proportion of N2 subtype neutrophils in both normal and diabetic wounds, and the effect of HucMSC-Exo on this proportion was assessed. Furthermore, the mitochondrial metabolic reprogramming driven by HucMSC-Exo during N2 polarization was investigated through JC1 staining, ATP quantification, fatty acid uptake assays, and assessment of FAO-related genes (Cpt1b, Acadm, and Acadl).Results: Depleting host neutrophils strikingly dampened prohealing effect of HucMSC-Exo on skin injury, while adoptive transfer of bone marrow neutrophils rescued this process. During normal healing process, some neutrophils expressed N2 markers, in contrast, diabetic wounds exhibited a reduced expression of N2 markers. After treatment with HucMSC-Exo, most neutrophils increased the phosphorylation of STAT6, leading to mitochondrial metabolic reprogramming and thus acquired an N2 phenotype. These N2 neutrophils, polarized by HucMSC-Exo, boosted the release of proangiogenic factors, particularly BV8, a myeloid cell-derived proangiogenic factor, and induced angiogenesis thereby favoring tissue restoration.Conclusion: This research uniquely demonstrates the identification of N2 neutrophils in skin injury and shows that HucMSC-Exo could skew neutrophils toward N2 phenotype, enhancing our insight into how cells react to HucMSC-Exo. Keywords: HucMSC-Exo, neutrophils, phenotype switching, cutaneous wound healing, tissue restoration

Published
2024

37. The Emerging Roles of Nanocarrier Drug Delivery System in Treatment of Intervertebral Disc Degeneration-Current Knowledge, Hot Spots, Challenges and Future Perspectives

Author

Hu Y, Yang R, Liu S, Song Z, and Wang H

Subjects
lumbar disc herniation, intervertebral disc degeneration, nanocarrier drug delivery system, targeted therapy, regenerative medicine., Therapeutics. Pharmacology, RM1-950
Abstract

Yunxiang Hu,1,2,&ast; Rui Yang,1,2,&ast; Sanmao Liu,1,2,&ast; Zefeng Song,3 Hong Wang1,2 1Department of Orthopedics, Central Hospital of Dalian University of Technology, Dalian City, Liaoning Province, People’s Republic of China; 2School of Graduates, Dalian Medical University, Dalian City, Liaoning Province, People’s Republic of China; 3School of Graduates, Dalian University of Technology, Dalian City, Liaoning Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hong WangDepartment of Orthopedics, Central Hospital of Dalian University of Technology, No. 826, Southwestern Road, Shahekou District, Dalian City, Liaoning Province, People’s Republic of China, Email wanghong@dmu.edu.cnAbstract: Low back pain (LBP) is a common condition that has substantial consequences on individuals and society, both socially and economically. The primary contributor to LBP is often identified as intervertebral disc degeneration (IVDD), which worsens and leads to significant spinal problems. The conventional treatment approach for IVDD involves physiotherapy, drug therapy for pain management, and, in severe cases, surgery. However, none of these treatments address the underlying cause of the condition, meaning that they cannot fundamentally reverse IVDD or restore the mechanical function of the spine. Nanotechnology and regenerative medicine have made significant advancements in the field of healthcare, particularly in the area of nanodrug delivery systems (NDDSs). These approaches have demonstrated significant potential in enhancing the efficacy of IVDD treatments by providing benefits such as high biocompatibility, biodegradability, precise drug delivery to targeted areas, prolonged drug release, and improved therapeutic results. The advancements in different NDDSs designed for delivering various genes, cells, proteins and therapeutic drugs have opened up new opportunities for effectively addressing IVDD. This comprehensive review provides a consolidated overview of the recent advancements in the use of NDDSs for the treatment of IVDD. It emphasizes the potential of these systems in overcoming the challenges associated with this condition. Meanwhile, the insights and ideas presented in this review aim to contribute to the advancement of precise IVDD treatment using NDDSs.Keywords: lumbar disc herniation, intervertebral disc degeneration, nanocarrier drug delivery system, targeted therapy, regenerative medicine

Published
2024

38. Emerging Strategies to Overcome Current CAR-T Therapy Dilemmas - Exosomes Derived from CAR-T Cells

Author

Hu D, Yang R, Wang G, Li H, Fan X, and Liang G

Subjects
tumor, car-t cells, immune escape, exosome, Medicine (General), R5-920
Abstract

Dong Hu,1 Ruyue Yang,1 Guidan Wang,2 Hao Li,1 Xulong Fan,1 Gaofeng Liang1 1School of Basic Medicine and Forensic Medicine, Henan University of Science & Technology, Luoyang, 471023, People’s Republic of China; 2School of Medical Technology and Engineering, Henan University of Science & Technology, Luoyang, 471023, People’s Republic of ChinaCorrespondence: Gaofeng Liang, School of Basic Medicine and Forensic Medicine, Henan University of Science & Technology, Luoyang, 471023, People’s Republic of China, Email lgfeng990448@163.comAbstract: Adoptive T cells immunotherapy, specifically chimeric antigen receptor T cells (CAR-T), has shown promising therapeutic efficacy in the treatment of hematologic malignancies. As extensive research on CAR-T therapies has been conducted, various challenges have emerged that significantly hampered their clinical application, including tumor recurrence, CAR-T cell exhaustion, and cytokine release syndrome (CRS). To overcome the hurdles of CAR-T therapy in clinical treatment, cell-free emerging therapies based on exosomes derived from CAR-T cells have been developed as an effective and promising alternative approach. In this review, we present CAR-T cell-based therapies for the treatment of tumors, including the features and benefits of CAR-T therapies, the limitations that exist in this field, and the measures taken to overcome them. Furthermore, we discuss the notable benefits of utilizing exosomes released from CAR-T cells in tumor treatment and anticipate potential issues in clinical trials. Lastly, drawing from previous research on exosomes from CAR-T cells and the characteristics of exosomes, we propose strategies to overcome these restrictions. Additionally, the review discusses the plight in large-scale preparation of exosome and provides potential solutions for future clinical applications.Keywords: tumor, CAR-T cells, immune escape, exosome

Published
2024

39. Efficacy and Safety of HepaSphere Drug-Eluting Bead Transarterial Chemoembolization Combined with Hepatic Arterial Infusion Chemotherapy as the Second-Line Treatment in Advanced Hepatocellular Carcinoma

Author

Liu B, Gao S, Guo J, Kou F, Liu S, Zhang X, Feng A, Wang X, Cao G, Chen H, Liu P, Xu H, Gao Q, Yang R, Xu L, and Zhu X

Subjects
transarterial chemoembolization, advanced hepatocellular carcinoma, hepatic arterial infusion chemotherapy, propensity score matching, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Baojiang Liu,&ast; Song Gao,&ast; Jianhai Guo, Fuxin Kou, Shaoxing Liu, Xin Zhang, Aiwei Feng, Xiaodong Wang, Guang Cao, Hui Chen, Peng Liu, Haifeng Xu, Qinzong Gao, Renjie Yang, Liang Xu, Xu Zhu Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Interventional Therapy, Peking University Cancer Hospital & Institute, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xu Zhu, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Interventional Therapy, Peking University Cancer Hospital & Institute, Beijing, People’s Republic of China, Tel + 86-10-8819-6059, Email drzhuxu@163.comPurpose: Recently, hepatic arterial infusion chemotherapy (HAIC) has also gained popularity for hepatocellular carcinoma (HCC). Several studies have compared HAIC and Transarterial chemoembolization (TACE). However, comparisons between TACE plus HAIC and HAIC are rarely reported. Here, we evaluated the performance of HepaSphere DEB-TACE combined with HAIC (Hepa-HAIC) compared to HAIC in patients with advanced HCC.Patients and Methods: In this retrospective study, we enrolled 167 patients diagnosed with advanced HCC and treated at Peking University Cancer Hospital from May 2018 to May 2022. The cohort comprised 74 patients who received HepaSphere DEB-TACE combined with HAIC-FOLFOX (Hepa-HAIC) and 93 patients who received HAIC-FOLFOX. Over 60% of patients received prior treatments. To avoid selection bias, propensity score matching was applied to the efficacy and safety analyses. The primary endpoints are progression-free survival (PFS) and overall survival (OS); the secondary endpoints include objective response rate (ORR), disease control rate (DCR), and safety.Results: Propensity-matching yielded 48 pairs, and group baselines were almost equal after matching. Median PFS and median OS were both higher in the matched Hepa-HAIC cohort (median PFS: 8.9 vs 5.8 months, p = 0.035; median OS: 22.4 vs 9.5 months, p = 0.027), which was consistent with pre-matching analysis. The ORR in the Hepa-HAIC and HAIC cohorts was 75.0% and 37.5%, respectively; the DCR was 93.8% after Hepa-HAIC and 81.3% after HAIC. There was no treatment-related death. Grade 3– 4 ALT elevation was more frequent in the Hepa-HAIC group (33.3% vs 8.3%, p = 0.003), while vomiting was more frequent in the HAIC group (29.2% vs 12.5%, p = 0.084).Conclusion: The Hepa-HAIC group is superior to the HAIC group in metrics of PFS, OS, ORR, and DCR, which indicates the combination of HepaSphere DEB-TACE and HAIC may lead to improved outcomes with a comparable safety profile in advanced HCC.Keywords: transarterial chemoembolization, advanced hepatocellular carcinoma, hepatic arterial infusion chemotherapy, propensity score matching

Published
2024

40. Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy

Author

Xiang D, Zhou L, Yang R, Yuan F, Xu Y, Yang Y, Qiao Y, and Li X

Subjects
cancers, ferroptosis, nano-drug delivery system, target, Medicine (General), R5-920
Abstract

Debiao Xiang,1– 3 Lili Zhou,4 Rui Yang,1,4 Fang Yuan,1– 3 Yilin Xu,4 Yuan Yang,1,4 Yong Qiao,1– 3 Xin Li1– 3 1Department of Pharmacy, The Third Hospital of Changsha, Changsha, Hunan Province, People’s Republic of China; 2Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs, Changsha, Hunan Province, People’s Republic of China; 3The Clinical Application Research Institute of Antibiotics in Changsha, Changsha, Hunan Province, People’s Republic of China; 4College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan Province, People’s Republic of ChinaCorrespondence: Xin Li, 176 Laodong West Road, Tianxin District, Changsha, Hunan Province, People’s Republic of China, Tel +86 0731-85171320, Email xin-li@cssdsyy.comAbstract: Currently, cancer remains one of the most significant threats to human health. Treatment of most cancers remains challenging, despite the implementation of diverse therapies in clinical practice. In recent years, research on the mechanism of ferroptosis has presented novel perspectives for cancer treatment. Ferroptosis is a regulated cell death process caused by lipid peroxidation of membrane unsaturated fatty acids catalyzed by iron ions. The rapid development of bio-nanotechnology has generated considerable interest in exploiting iron-induced cell death as a new therapeutic target against cancer. This article provides a comprehensive overview of recent advancements at the intersection of iron-induced cell death and bionanotechnology. In this respect, the mechanism of iron-induced cell death and its relation to cancer are summarized. Furthermore, the feasibility of a nano-drug delivery system based on iron-induced cell death for cancer treatment is introduced and analyzed. Secondly, strategies for inducing iron-induced cell death using nanodrug delivery technology are discussed, including promoting Fenton reactions, inhibiting glutathione peroxidase 4, reducing low glutathione levels, and inhibiting system Xc−. Additionally, the article explores the potential of combined treatment strategies involving iron-induced cell death and bionanotechnology. Finally, the application prospects and challenges of iron-induced nanoagents for cancer treatment are discussed.Keywords: cancers, ferroptosis, nano-drug delivery system, target

Published
2024

41. Flux Variations of Cosmic Ray Air Showers Detected by LHAASO-KM2A During a Thunderstorm on 10 June 2021

Author

LHAASO Collaboration, Aharonian, F., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Zhe, Cao, Zhen, Chang, J., Chang, J. F., Chen, E. S., Chen, Liang, Chen, Long, Chen, M. J., Chen, M. L., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, X. J., Chen, Y., Cheng, H. L., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Duan, K. K., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Gu, F. L., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, W. H., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Li, B. B., Li, Cheng, Li, Cong, Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Long, W. J., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Min, Z., Mitthumsiri, W., Nan, Y. C., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Sáiz, A., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. Y., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R., Wang, R. N., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Z. H. Wang. Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., W, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yan, J. Z., Yang, C. W., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, Lu, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Y. L., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

The Large High Altitude Air Shower Observatory (LHAASO) has three sub-arrays, KM2A, WCDA and WFCTA. The flux variations of cosmic ray air showers were studied by analyzing the KM2A data during the thunderstorm on 10 June 2021. The number of shower events that meet the trigger conditions increases significantly in atmospheric electric fields, with maximum fractional increase of 20%. The variations of trigger rates (increases or decreases) are found to be strongly dependent on the primary zenith angle. The flux of secondary particles increases significantly, following a similar trend with that of the shower events. To better understand the observed behavior, Monte Carlo simulations are performed with CORSIKA and G4KM2A (a code based on GEANT4). We find that the experimental data (in saturated negative fields) are in good agreement with simulations, assuming the presence of a uniform upward electric field of 700 V/cm with a thickness of 1500 m in the atmosphere above the observation level. Due to the acceleration/deceleration and deflection by the atmospheric electric field, the number of secondary particles with energy above the detector threshold is modified, resulting in the changes in shower detection rate., Comment: 18 pages, 11 figures

Published
2022
Full Text
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42. Low-$p_T$ direct-photon production in Au$+$Au collisions at $\sqrt{s_{_{NN}}}=39$ and 62.4 GeV

Author

Abdulameer, N. J., Acharya, U., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Ta'ani, H., Alexander, J., Alfred, M., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bannier, B., Barish, K. N., Bassalleck, B., Bathe, S., Baublis, V., Baumgart, S., Bazilevsky, A., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Roman, V. Canoa, Castera, P., Chen, C. -H., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Corliss, R., Morales, Y. Corrales, Csanád, M., Csörgő, T., D'Orazio, L., Dairaku, S., Datta, A., Daugherity, M. S., David, G., Dean, C. T., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Doomra, V., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Edwards, S., Efremenko, Y. V., Engelmore, T., Enokizono, A., Esha, R., Eyser, K. O., Fadem, B., Fan, W., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Giles, M., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hanks, J., Harvey, M., Hasegawa, S., Hashimoto, K., Haslum, E., Hayano, R., Hemmick, T. K., Hester, T., He, X., Hill, J. C., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Huang, J., Ichihara, T., Iinuma, H., Ikeda, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Issah, M., Ivanishchev, D., Jacak, B. V., Javani, M., Jiang, X., Ji, Z., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kawall, D., Kazantsev, A. V., Kempel, T., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kijima, K. M., Kim, B. I., Kim, C., Kim, D. J., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, T., Kim, Y. -J., Kim, Y. K., Kincses, D., Kingan, A., Kinney, E., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Komatsu, Y., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Kovacs, L., Krizek, F., Král, A., Kunde, G. J., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lai, Y. S., Lajoie, J. G., Larionova, D., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Lewis, B., Lewis, N. A., Lim, S. H., Levy, L. A. Linden, Liu, M. X., Li, X., Loomis, D. A., Love, B., Lökös, S., Maguire, C. F., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., Masumoto, S., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Mohapatra, S., Mondal, M. M., Moon, H. J., Moon, T., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Muhammad, A., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Nelson, S., Nihashi, M., Nouicer, R., Novák, T., Novitzky, N., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oh, J., Okada, K., Orosz, M., Osborn, J. D., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J. S., Park, S., Park, S. K., Patel, L., Patel, M., Pate, S. F., Pei, H., Peng, J. -C., Peng, W., Pereira, H., Perepelitsa, D. V., Peressounko, D. Yu., PerezLara, C. E., Petti, R., Pinkenburg, C., Pisani, R. P., Potekhin, M., Proissl, M., Pun, A., Purschke, M. L., Qu, H., Radzevich, P. V., Rak, J., Ramasubramanian, N., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Runchey, J., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sano, M., Sarsour, M., Sato, S., Sawada, S., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sharma, D., Shein, I., Shi, Z., Shibata, M., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sun, Z., Sziklai, J., Takagui, E. M., Takahama, R., Takahara, A., Taketani, A., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tennant, E., Themann, H., Todoroki, T., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Ueda, Y., Ujvari, B., Vale, C., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Vértesi, R., Velkovska, J., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Wang, X. R., Wang, Z., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., White, S. N., Winter, D., Wolin, S., Wong, C. P., Woody, C. L., Wysocki, M., Xia, B., Yamaguchi, Y. L., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Younus, I., You, Z., Yushmanov, I. E., Zajc, W. A., Zelenski, A., and Zou, L.

Subjects
Nuclear Experiment
Abstract

The measurement of direct photons from Au$+$Au collisions at $\sqrt{s_{_{NN}}}=39$ and 62.4 GeV in the transverse-momentum range $0.4

Published
2022
Full Text
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43. Equilibrium Particle Shape and Surface Chemistry of Disordered Li-Excess, Mn-Rich Li-ion Cathodes through First-Principles Modeling,

Author

Burns, J, Ouyang, B, Cheng, J, Horton, MK, Siron, M, Andriuc, O, Yang, R, Ceder, G, and Persson, KA

Subjects
Engineering, Materials Engineering, Chemical Sciences, Physical Chemistry, Affordable and Clean Energy, Materials, Chemical sciences
Abstract

A novel methodology for calculating the surface energy of a disordered material was developed and is described here. The method was used to calculate the range of surface energies for {100}, {110}, {111}, and {112} type facets of the disordered rock salt (DRX) cathode material Li2MnO2F, as a function of surface cation and anion decoration. Boltzmann averaging was used to determine average surface energies for each facet which were then used to calculate the equilibrium particle shape. It was found that Li2MnO2F displays predominantly {100} type lithium/fluorine-rich facets favoring a cubic particle shape. The density of states along with electronic structure-based bonding analyses are calculated to rationalize differences observed in surface energy. Importantly, it is found that surface lithium and fluorine lower the surface energy of the majority facets, suggesting that surfaces of Li2MnO2F are likely enriched in lithium and fluorine and display less oxygen and manganese, which has implications for capacity and rate retention.

Published
2022

44. Prediction of Non-Transplantable Recurrence After Liver Resection for Solitary Hepatocellular Carcinoma

Author

Zhang C, Tao Y, Yang R, Wang Y, Yu Y, and Zhou Y

Subjects
hepatocellular carcinoma, salvage liver transplantation, non-transplantable recurrence, treatment, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Chunhui Zhang,1,&ast; Yuqing Tao,1,&ast; Rui Yang,1 Yueqi Wang,1 Yanyan Yu,2 Yang Zhou2 1Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150010, People’s Republic of China; 2Department of Radiology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150010, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yang Zhou, Department of Radiology, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, Heilongjiang, 150010, People’s Republic of China, Email zhouyang094@126.comPurpose: Using a combination model of preoperative imaging and clinical factors to predict non-transplantable recurrence (NTR) after liver resection and assist solitary hepatocellular carcinoma (HCC) patients in the selection of early treatment options.Patients and Methods: A retrospective analysis was conducted on 253 solitary HCC patients who underwent radical resection and had preoperative MRI. NTR patients were defined as those exceeding the University of California, San Francisco (UCSF) criteria at the time of recurrence. Cox regression analysis was employed to identify preoperative factors associated with NTR based on clinical and tumor imaging characteristics. A risk scoring model (NTRScore) was developed and validated.Results: Among the 253 patients, 86 (33.9%) experienced recurrence, and among those with recurrence, 34 patients (39.5%) developed NTR. In multivariate analysis, factors associated with NTR included alpha-fetoprotein (AFP) [> 10 ng/mL] [HR: 3.42, 95% confidence interval (CI): 1.54– 7.63, P: 0.003], arterial phase hyperenhancement (APHE) [HR: 2.23, 95% CI: 1.03– 4.81, P: 0.041], washout[HR: 0.35, 95% CI: 0.15– 0.84, P: 0.019], and capsule [HR: 0.44, 95% CI: 0.22– 0.88, P: 0.021]. The β-coefficients of these variables were utilized to develop the weighted NTRScore(c-index 0.72, 95% CI: 0.65– 0.79). The NTR occurrence increased across the three categories (low: 5.6%, medium: 13.6%, high: 35.1%, p < 0.001), and the Kaplan-Meier curves of recurrence-free survival(RFS) and overall survival(OS) show significant differences (p = 0.004 and p< 0.001). Furthermore, the higher NTR categories may be associated with an increased risk of extrahepatic recurrence.Conclusion: The NTRScore demonstrated strong discriminatory ability and may serve as a clinically useful tool to assist in risk stratification and potential to guide treatment and optimal surveillance for patients of solitary hepatocellular carcinoma within UCSF criteria.Keywords: hepatocellular carcinoma, salvage liver transplantation, non-transplantable recurrence, treatment, prognosis

Published
2024

45. Clinical and Genomic Characteristics of a Clinical Listeria Monocytogenes ST120 Isolate Recovered from a Pregnant Woman

Author

Zhang J, Liu Z, Li Z, Xu C, Wang H, Yang R, and Liu L

Subjects
listeria monocytogenes, whole genome sequence, st120, plasmid, Infectious and parasitic diseases, RC109-216
Abstract

Jingrui Zhang,1,&ast; Zengbin Liu,2,&ast; Zhirong Li,2 Caihong Xu,1 Hongbin Wang,3 Rugang Yang,1 Li Liu1 1Department of Clinical Laboratory, The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Gynecology and Obstetrics, The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jingrui Zhang; Li Liu, The Fourth Hospital of Shijiazhuang, Shijiazhuang, 050000, People’s Republic of China, Email jingrui20005@163.com; liuliok2012@163.comBackground: Maternal–fetal listeriosis, caused by Listeria monocytogenes, is a rare but serious infection. Herein, we report the clinical and genomic characteristics of a clinical L. monocytogenes ST120 isolate recovered from a pregnant woman.Methods: The clinical symptoms and treatment in pregnant woman were described in detail. Whole genome sequencing (WGS) was performed on the L. monocytogenes isolate SJZ_LM001, and the genomic characterization of the isolate was deeply analyzed.Results: The clinical symptoms in pregnant women were mainly fever, and the placenta experienced severe inflammation. The pregnant woman was treated with ampicillin for effective anti-infective therapy. Genomic analysis showed that isolate SJZ_LM001 is sequence type (ST) 120, belong to clonal complex (CC)8 and lineage II of L. monocytogenes. Additionally, the isolates SJZ_LM001 harbored a novel plasmid pSJZ_LM001, which carried arsenical resistance genes (arsACD and acr3), and cadmium resistance genes (cadAC). Drug susceptibility testing showed that the isolate SJZ-LM001 was susceptible to ampicillin, meropenem, penicillin, and cotrimoxazole.Conclusion: This is the first to identify a clinical case of infection in a pregnant woman caused by ST120 L. monocytogenes in China. These findings could benefit our understanding of the genomic characteristics of L. monocytogenes, and the pregnancy-related listeriosis and providing early diagnosis and effective targeted treatment.Keywords: Listeria monocytogenes, whole genome sequence, ST120, plasmid

Published
2024

46. Integrated Bioinformatics Analysis Reveals Diagnostic Biomarkers and Immune Cell Infiltration Characteristics of Solar Lentigines

Author

Yang X, Xia Z, Fan Y, Xie Y, Ge G, Lang D, Ao J, Yue D, Wu J, Chen T, Zou Y, Zhang M, and Yang R

Subjects
solar lentigines, photoaging, diagnostic biomarkers, immune infiltration, artificial neural network, Dermatology, RL1-803
Abstract

Xin Yang,1,2,&ast; Zhikuan Xia,1,&ast; Yunlong Fan,1 Yitong Xie,1 Ge Ge,1 Dexiu Lang,3 Junhong Ao,1 Danxia Yue,1 Jiamin Wu,1 Tong Chen,1 Yuekun Zou,1 Mingwang Zhang,4 Rongya Yang1,2 1Department of Dermatology, The Seventh Medical Center of PLA General Hospital, Beijing, People’s Republic of China; 2Department of Dermatology, Yanbian University Hospital, Yanji, People’s Republic of China; 3Department of Dermatology, XingYi People’s Hospital, Xingyi, People’s Republic of China; 4Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Mingwang Zhang; Rongya Yang, Email mingwangzhang2@163.com; yangrya@sina.comBackground: Solar lentigines (SLs), serving as a prevalent characteristic of skin photoaging, present as cutaneous aberrant pigmentation. However, the underlying pathogenesis remains unclear and there is a dearth of reliable diagnostic biomarkers.Objective: The aim of this study was to identify diagnostic biomarkers for SLs and reveal its immunological features.Methods: In this study, gene expression profiling datasets (GSE192564 and GSE192565) of SLs were obtained from the GEO database. The GSE192564 was used as the training group for screening of differentially expressed genes (DEGs) and subsequent depth analysis. Gene set enrichment analysis (GSEA) was employed to explore the biological states associated with SLs. The weighted gene co-expression network analysis (WGCNA) was employed to identify the significant modules and hub genes. Then, the feature genes were further screened by the overlapping of hub genes and up-regulated differential genes. Subsequently, an artificial neural network was constructed for identifying SLs samples. The GSE192565 was used as the test group for validation of feature genes expression level and the model’s classification performance. Furthermore, we conducted immune cell infiltration analysis to reveal the immune infiltration landscape of SLs.Results: The 9 feature genes were identified as diagnostic biomarkers for SLs in this study. And an artificial neural network based on diagnostic biomarkers was successfully constructed for identification of SLs. GSEA highlighted potential role of immune system in pathogenesis of SLs. SLs samples had a higher proportion of several immune cells, including activated CD8 T cell, dendritic cell, myeloid-derived suppressor cell and so on. And diagnostic biomarkers exhibited a strong relationship with the infiltration of most immune cells.Conclusion: Our study identified diagnostic biomarkers for SLs and explored its immunological features, enhancing the comprehension of its pathogenesis.Keywords: solar lentigines, photoaging, diagnostic biomarkers, immune infiltration, artificial neural network

Published
2024

47. Peculiar disk behaviors of the black hole candidate MAXI J1348-630 in the hard state observed by Insight-HXMT and Swift

Author

Zhang, W., Tao, L., Soria, R., Qu, J. L., Zhang, S. N., Weng, S. S., zhang, L., Wang, Y. N., Huang, Y., Ma, R. C., Zhang, S., Ge, M. Y., Song, L. M., Ma, X., Bu, Q. C., Cai, C., Cao, X. L., Chang, Z., Chen, L., Chen, T. X., Chen, Y. B., Chen, Y., Chen, Y. P., Cui, W. W., Du, Y. Y., Gao, G. H., Gao, H., Gu, Y. D., Guan, J., Guo, C. C., Han, D. W., Huo, J., Jia, S. M., Jiang, W. C., Jin, J., Kong, L. D., Li, B., Li, C. K., Li, G., Li, T. P., Li, W., Li, X., Li, X. B., Li, X. F., Li, Z. W., Liang, X. H., Liao, J. Y., Liu, B. S., Liu, C. Z., Liu, H. X., Liu, H. W., Liu, X. J., Lu, F. J., Lu, X. F., Luo, Q., Luo, T., Meng, B., Nang, Y., Nie, J. Y., Ou, G., Ren, X. Q., Sai, N., Song, X. Y., Sun, L., Tan, Y., Tuo, Y. L., Wang, C., Wang, L. J., Wang, P. J., Wang, W. S., Wang, Y. S., Wen, X. Y., Wu, B. Y., Wu, B. B., Wu, M., Xiao, G. C., Xiao, S., Xiong, S. L., Yang, R. J., Yang, S., Yang, Y. J., Yang, Y. R., Yi, Q. B., Yin, Q. Q., Yuan, Y., Zhang, F., Zhang, H. M., Zhang, P., Zhang, W. C., Zhang, Y. F., Zhang, Y. H., Zhao, H. S., Zhao, X. F., Zheng, S. J., Zheng, Y. G., and Zhou, D. K.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present a spectral study of the black hole candidate MAXI J1348-630 during its 2019 outburst, based on monitoring observations with Insight-HXMT and Swift. Throughout the outburst, the spectra are well fitted with power-law plus disk-blackbody components. In the soft-intermediate and soft states, we observed the canonical relation L ~ T_in^4 between disk luminosity L and peak colour temperature T_in, with a constant inner radius R_in (traditionally identified with the innermost stable circular orbit). At other stages of the outburst cycle, the behaviour is more unusual, inconsistent with the canonical outburst evolution of black hole transients. In particular, during the hard rise, the apparent inner radius is smaller than in the soft state (and increasing), and the peak colour temperature is higher (and decreasing). This anomalous behaviour is found even when we model the spectra with self-consistent Comptonization models, which take into account the up-scattering of photons from the disk component into the power-law component. To explain both those anomalous trends at the same time, we suggest that the hardening factor for the inner disk emission was larger than the canonical value of ~1.7 at the beginning of the outburst. A more physical trend of radii and temperature evolution requires a hardening factor evolving from ~3.5 at the beginning of the hard state to ~1.7 in the hard intermediate state. This could be evidence that the inner disk was in the process of condensing from the hot, optically thin medium and had not yet reached a sufficiently high optical depth for its emission spectrum to be described by the standard optically-thick disk solution., Comment: 20 pages, 10 figures, 4 tables, accepted by ApJ

Published
2022
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49. Urinary PART1 and PLA2R1 Could Potentially Serve as Diagnostic Markers for Diabetic Kidney Disease Patients

Author

Ye Q, Xu G, Yuan H, Mi J, Xie Y, Li H, Li Z, Huang G, Chen X, Li W, and Yang R

Subjects
diabetic kidney disease, urine, non-invasive, diagnosis, biomarker, Specialties of internal medicine, RC581-951
Abstract

Qinglin Ye,1,&ast; Guiling Xu,1,&ast; Hao Yuan,2,3 Junhao Mi,2,3 Yuli Xie,2,3 Haoyu Li,1 Zhejun Li,1 Guanwen Huang,1 Xuesong Chen,1 Wei Li,1 Rirong Yang2,3 1Department of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530005, People’s Republic of China; 2Centre for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, 530021, People’s Republic of China; 3Department of Immunology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Rirong Yang, Centre for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Department of Immunology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of China, Fax +86 0771 5317061, Email yangrirong@sr.gxmu.edu.cn; 520yrr@163.com Wei Li, Department of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530005, People’s Republic of China, Email liwei030514@126.comBackground: Diabetic kidney disease (DKD) is a chronic renal disease which could eventually develop into renal failure. Though albuminuria and estimated glomerular filtration rate (eGFR) are helpful for the diagnosis of DKD, the lack of specific biomarkers reduces the efficiency of therapeutic interventions.Methods: Based on bulk-seq of 56 urine samples collected at different time points (including 11 acquired from DKD patients and 11 from healthy controls), in corporation of scRNA-seq data of urine samples and snRNA-seq data of renal punctures from DKD patients (retrieved from NCBI GEO Omnibus), urine-kidney specific genes were identified by Multiple Biological Information methods.Results: Forty urine-kidney specific genes/differentially expressed genes (DEGs) were identified to be highly related to kidney injury and proteinuria for the DKD patients. Most of these genes participate in regulating glucagon and apoptosis, among which, urinary PART1 (mainly derived from distal tubular cells) and PLA2R1 (podocyte cell surface marker) could be used together for the early diagnosis of DKD. Moreover, urinary PART1 was significantly associated with multiple clinical indicators, and remained stable over time in urine.Conclusion: Urinary PART1 and PLA2R1 could be shed lights on the discovery and development of non-invasive diagnostic method for DKD, especially in early stages. Keywords: diabetic kidney disease, urine, non-invasive, diagnosis, biomarker

Published
2023

50. Campaign Governance and Partnerships: Unraveling COVID-19 Vaccine Promotion Efforts in China’s Neighborhoods

Author

Yang R and Sun S

Subjects
campaign governance, partnerships, covid-19 vaccine promotion, neighborhood, china, Public aspects of medicine, RA1-1270
Abstract

Ronghui Yang, Sirui Sun Department of Public Administration, College of Humanities, Donghua University, Shanghai, 200051, People’s Republic of ChinaCorrespondence: Sirui Sun, Department of Public Administration, College of Humanities, Donghua University, 1882 West Yan’an Road, Shanghai, 200051, People’s Republic of China, Tel +8618521057816, Email sirui_sun@dhu.edu.cnBackground: COVID-19 vaccine promotion helps counter vaccine hesitancy and raise vaccine acceptance. Therefore, the Chinese state created collaborative infrastructures of COVID-19 vaccine promotion programs to promote stakeholder engagement and unload the burden of policy practitioners. However, partnerships in COVID-19 vaccine promotion programs have been underrepresented.Methods: To address this lacuna, we qualitatively explored how partnerships in the COVID-19 vaccine promotion campaign (CVPC) were organized in China’s neighborhoods. Specifically, we recruited participants via personal networks, referrals from acquaintances, and snowballing approaches, and conducted the qualitative thematic analysis following interviews with 62 Chinese stakeholders.Results: This study indicates that to promote partnerships in CVPCs, neighborhood managers formed leadership in CVPCs, expanded the collaborative network, trained Health Promotion Practitioners (HPPs), and coordinated with HPPs to shape partnership agreements, produced COVID-19 vaccine promotional materials and advertised COVID-19 vaccines via diverse media tools. Although coproduction of CVPCs to a certain extent promoted state-society interaction in neighborhoods and state responsiveness to public demands, partners’ disagreements on strategies applied by states for promoting COVID-19 vaccines eroded partnerships in CVPCs.Conclusion: To construct a robust partnership in CVPCs, depoliticizing CVPCs and creating shared values among stakeholders in CVPCs are expected. Our study will not only deepen global audiences’ understanding of CVCPs in China but also offer potential neighborhood-level solutions for implementing local and global health promotion efforts.Keywords: campaign governance, partnerships, COVID-19 vaccine promotion, neighborhood, China

Published
2023

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