Search

Your search keyword '"Yang, Ming-Jie"' showing total 324 results
Start Over Author "Yang, Ming-Jie"
324 results on '"Yang, Ming-Jie"'

5. Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro

Author

Hsia, Kai, Yang, Ming-Jie, Chen, Wei-Min, Yao, Chao-Ling, Lin, Chih-Hsun, Loong, Che-Chuan, Huang, Yi-Long, Lin, Ya-Ting, Lander, Arthur D, Lee, Hsinyu, and Lu, Jen-Her

Subjects
Engineering, Biomedical and Clinical Sciences, Biomedical Engineering, Stem Cell Research, Stem Cell Research - Nonembryonic - Human, Stem Cell Research - Umbilical Cord Blood/ Placenta - Human, Stem Cell Research - Umbilical Cord Blood/ Placenta, Hematology, Cardiovascular, Regenerative Medicine, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Blood Coagulation, Blood Vessel Prosthesis, Cell Adhesion, Endothelial Progenitor Cells, Endothelium, Vascular, Fluorescent Antibody Technique, Glycocalyx, Human Umbilical Vein Endothelial Cells, Humans, Kinetics, Lysophospholipids, Matrix Metalloproteinase 7, Models, Biological, Platelet Adhesiveness, Sphingosine, Syndecan-1, Thrombosis, Tissue Scaffolds, Umbilical Veins, Sphingosine-l-phosphate, Endothelial cell, Endothelial progenitor, Platelet adhesion, Sphingosine-1-phosphate
Abstract

Sphingosine-1-phosphate (S1P) has been known to promote endothelial cell (EC) proliferation and protect Syndecan-1 (SDC1) from shedding, thereby maintaining this antithrombotic signal. In the present study, we investigated the effect of S1P in the construction of a functional tissue-engineered blood vessel by using human endothelial cells and decellularized human umbilical vein (DHUV) scaffolds. Both human umbilical vein endothelial cells (HUVEC) and human cord blood derived endothelial progenitor cells (EPC) were seeded onto the scaffold with or without the S1P treatment. The efficacy of re-cellularization was determined by using the fluorescent marker CellTracker CMFDA and anti-CD31 immunostaining. The antithrombotic effect of S1P was examined by the anti-aggregation tests measuring platelet adherence and clotting time. Finally, we altered the expression of SDC1, a major glycocalyx protein on the endothelial cell surface, using MMP-7 digestion to explore its role using platelet adhesion tests in vitro. The result showed that S1P enhanced the attachment of HUVEC and EPC. Based on the anti-aggregation tests, S1P-treated HUVEC recellularized vessels when grafted showed reduced thrombus formation compared to controls. Our results also identified reduced SDC1 shedding from HUVEC responsible for inhibition of platelet adherence. However, no significant antithrombogenic effect of S1P was observed on EPC. In conclusion, S1P is an effective agent capable of decreasing thrombotic risk in engineered blood vessel grafts.Statement of significanceSphingosine-1phosphate (S1P) is a low molecular-weight phospholipid mediator that regulates diverse biological activities of endothelial cell, including survival, proliferation, cell barrier integrity, and also influences the development of the vascular system. Based on these characters, we the first time to use it as an additive during the process of a small caliber blood vessel construction by decellularized human umbilical vein and endothelial cell/endothelial progenitor. We further explored the function and mechanism of S1P in promoting revascularization and protection against thrombosis in this tissue engineered vascular grafts. The results showed that S1P could not only accelerate the generation but also reduce thrombus formation of small caliber blood vessel.

Published
2017

43. Design och implementering av en kompilator för ett XML-baserat hårdvarubeskrivande språk med support för energioptimering

Author

Yang, Ming-Jie

Subjects
XML, Electrical Engineering, Electronic Engineering, Information Engineering, Elektroteknik och elektronik, hardware description language, compiler
Abstract

GPU-based heterogeneous system architectures are popular as they combine the advantages of CPU with the benefits of GPU. Development of high-performance and power-efficient software for heterogeneous system architecture needs to take both hardware and software specifications into consideration, which leads the software development process to be more complicated. To simplify the software development process, Architecture Description Languages (ADLs) came out. By modeling the target architecture components into structural formats, programmers can adapt their software to the platforms which they used. XPDL is a modular and extensible XML-based platform description language which is mainly designed to support optimization.The purposes of this thesis are to design the query API (Application Programming Interface) and develop a compiler which translates the XPDL descriptors to libraries that implement the API to support programmers for the development of adaptive high-performance and energy-optimized software. In this thesis, we design and develop a compiler to generate the API according to the XPDL descriptors.The main workflow of the designed compiler is following: first, the toolchain validates the XPDL descriptors against XSDs. Second, it parses the descriptors into DOM trees and transforms them into XPDL model trees. Next, the compiler links all XPDL model trees together, which results in the intermediate representation (IR). Then, any unspecified node values which means the unknown attributes, are handled by microbenchmark generator and executor. In the end, the code generator generates the libraries which expose the API according to the information in the IR. Finally, a few example codes are discussed to show how the API can be used to develop performance adaptive applications on heterogeneous systems.

Published
2017

47. Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro

Author

Hsia, Kai, primary, Yang, Ming-Jie, additional, Chen, Wei-Min, additional, Yao, Chao-Ling, additional, Lin, Chih-Hsun, additional, Loong, Che-Chuan, additional, Huang, Yi-Long, additional, Lin, Ya-Ting, additional, Lander, Arthur D., additional, Lee, Hsinyu, additional, and Lu, Jen-Her, additional

Published
2017
Full Text
View/download PDF

48. Study on the Pattern Matching Technology and Its Application in Network Security

Author

Zheng Yi, Ma Zhi-Cheng, Zhang Lei, and Yang Ming-Jie

Subjects
Database, Network security, business.industry, Computer science, Computer security model, Web application security, computer.software_genre, Internet security, SQL injection, Network Access Control, Pattern matching, Data mining, business, computer, Vulnerability (computing)
Abstract

In this paper, we concentrate on the problem of network security protection, and we proposed a novel pattern matching algorithm to tackle this problem. Particularly, we focus on the problem SQL Injection, which is a typical network security problem, and it means a type of web application security vulnerability. Afterwards, a typical pattern matching based network security system is illustrated. Additionally, we define that a pattern is a set of specific ternary strings in the traffic which illustrates the probability of potential intrusion or abnormality of the network. Furthermore, a novel pattern matching algorithm is given. In the end, to demonstrate the effectiveness of our method, experiments are conducted to maker performance.

Published
2015
Full Text
View/download PDF

49. Design and Implementation of a Compiler for an XML-based Hardware Description Language to Support Energy Optimization

Author

Yang, Ming-Jie and Yang, Ming-Jie

Abstract

GPU-based heterogeneous system architectures are popular as they combine the advantages of CPU with the benefits of GPU. Development of high-performance and power-efficient software for heterogeneous system architecture needs to take both hardware and software specifications into consideration, which leads the software development process to be more complicated. To simplify the software development process, Architecture Description Languages (ADLs) came out. By modeling the target architecture components into structural formats, programmers can adapt their software to the platforms which they used. XPDL is a modular and extensible XML-based platform description language which is mainly designed to support optimization.The purposes of this thesis are to design the query API (Application Programming Interface) and develop a compiler which translates the XPDL descriptors to libraries that implement the API to support programmers for the development of adaptive high-performance and energy-optimized software. In this thesis, we design and develop a compiler to generate the API according to the XPDL descriptors.The main workflow of the designed compiler is following: first, the toolchain validates the XPDL descriptors against XSDs. Second, it parses the descriptors into DOM trees and transforms them into XPDL model trees. Next, the compiler links all XPDL model trees together, which results in the intermediate representation (IR). Then, any unspecified node values which means the unknown attributes, are handled by microbenchmark generator and executor. In the end, the code generator generates the libraries which expose the API according to the information in the IR. Finally, a few example codes are discussed to show how the API can be used to develop performance adaptive applications on heterogeneous systems.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results