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Approximately one third of the population is prone to motion sickness (MS), which is associated with the dysfunction in the integration of sensory inputs. Transcranial alternating current stimulation (tACS) has been widely used to modulate neurological functions by affecting neural oscillation. However, it has not been applied in the treatment of motion sickness. This study aims to investigate changes in brain oscillations during exposure to MS stimuli and to further explore the potential impact of tACS with the corresponding frequency and site on MS symptoms. A total of 19 subjects were recruited to be exposed to Coriolis stimuli to complete an inducing session. After that, they were randomly assigned to tACS stimulation group or sham stimulation group to complete a stimulation session. Electroencephalography (EEG), electrocardiogram, and galvanic skin response were recorded during the experiment. All the subjects suffering from obvious MS symptoms after inducing session were observed that alpha power of four channels of parieto-occipital lobe significantly decreased (P7: t =3.589, p <0.001; P8: t =2.667, p <0.05; O1: t =3.556, p <0.001; O2: t =2.667, p <0.05). Based on this, tACS group received the tACS stimulation at 10Hz from Oz to CPz. Compared to sham group, tACS stimulation significantly improved behavioral performance and entrained the alpha oscillation in individuals whose alpha power decrease during the inducing session. The findings show that parieto-occipital alpha oscillation plays a critical role in the integration of sensory inputs, and alpha tACS on parieto-occipital can become a potential method to mitigate MS symptoms.

Autonomous driving offers significant potential for changes in the automotive industry. However, sensory conflict during autonomous driving can lead to motion sickness. Quantitative evaluation and effective preventions to predict and reduce motion sickness are needed. The goal of this study is to verify the objective indicator of motion sickness level based on encephalography (EEG) that we proposed before and investigate the influence of attenuating sensory conflict on motion sickness. A 6-degree of freedom (DOF) driving simulator platform was used to provide an autonomous driving environment to the subjects, and the subjective motion sickness level (MSL), as well as the EEG signals of 15 healthy subjects, were collected simultaneously during 3 conditions, i) autonomous driving, ii) autonomous driving with eyes blindfolded and iii) active driving. The MSLs were reported by the subjects every two minutes, providing a reference to the recorded EEG signals. The EEG signals were analyzed and compared among different conditions. Average MSLs were higher in autonomous driving than in autonomous driving with eyes blindfolded and active driving, together with the increase of the mean EEG frequency of theta band in the central, parietal and occipital areas (FC5, Cz, CP5, P3, and POz). These findings validated that EEG mean frequency of theta band could be an indicator of motion sickness, besides an attenuated visual input or active control of the vehicle can effectively reduce the generation of motion sickness.

Objective: To develop a quick quantitative detecting method for luteinizing hormone(LH) based on superparamagnetic particles labeled immunochromatography technology., Methods: Magnetic particles were catalyzed by EDC/NHS, LH monoclonal antibody were coupled with magnetic particles, another antibody were coated with the NC membrane, established a quantitative detecting method combined sand wish assay format with immunochromatography. The performance of this method was evaluated by linear range, precision, accuracy, specificity and stability. Detecting the serum sample that were tested by chemiluminescence immunoassay (CLIA) which was high credibility to verify the reliability., Results: The reaction time of LH antibody coupled magnetic particles, LH and LH antibody coated in nitrocellulose membrane was 20 min; the coefficient of variation (CV) values for low, median, high were 8%-12%, the bias was less than 10%, recovery rate was 90%-120%, the minimum detection limit was 0.63 mIU/ml, no obvious cross reaction with human chorionic gonadotropin (HCG), thyroid stimulating hormone (TSH), follicle-stimulating hormone (FSH). Test results of clinical sample had good correlation with CLIA (R² =0.96, P<0.05)., Conclusion: The superparamagnetic particles labeled immuno-chromatography method is simple and rapid, and is expected to become a direction in the development for point-of-care test (POCT) quantitative detection of micro components in biological sample.