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Convolutional Neural Networks (CNNs) have been widely applied in various edge computing devices based on intelligent sensors. However, due to the high computational demands of CNN tasks, the limited computing resources of edge intelligent terminal devices, and significant architectural differences among these devices, it is challenging for edge devices to independently execute inference tasks locally. Collaborative inference among edge terminal devices can effectively utilize idle computing and storage resources and optimize latency characteristics, thus significantly addressing the challenges posed by the computational intensity of CNNs. This paper targets efficient collaborative execution of CNN inference tasks among heterogeneous and resource-constrained edge terminal devices. We propose a pre-partitioning deployment method for CNNs based on critical operator layers, and optimize the system bottleneck latency during pipeline parallelism using data compression, queuing, and "micro-shifting" techniques. Experimental results demonstrate that our method achieves significant acceleration in CNN inference within heterogeneous environments, improving performance by 71.6% compared to existing popular frameworks. [ABSTRACT FROM AUTHOR]

Y-box-binding protein 1 (YB-1) is a multifunctional RNA binding protein involved in virtually every step of RNA metabolism. However, the functions and mechanisms of YB-1 in one of the most aggressive cancers, glioblastoma, are not well understood. In this study, we found that YB-1 protein was markedly overexpressed in glioblastoma and acted as a critical activator of both mTORC1 and mTORC2 signaling. Mechanistically, YB-1 bound the 5'UTR of CCT4 mRNA to promote the translation of CCT4, a component of the CCT chaperone complex, that in turn activated the mTOR signaling pathway by promoting mLST8 folding. In addition, YB-1 autoregulated its own translation by binding to its 5'UTR, leading to sustained activation of mTOR signaling. In patients with glioblastoma, high protein expression of YB-1 correlated with increased expression of CCT4 and mLST8 and activated mTOR signaling. Importantly, the administration of RNA decoys specifically targeting YB-1 in a mouse xenograft model resulted in slower tumor growth and better survival. Taken together, these findings uncover a disrupted proteostasis pathway involving a YB-1/CCT4/mLST8/mTOR axis in promoting glioblastoma growth, suggesting that YB-1 is a potential therapeutic target for the treatment of glioblastoma., Introduction Recent large-scale surveys of proteins identified more than 1500 RNA binding proteins that bind to single- or double-stranded RNAs (1-4). RNA binding proteins together with different classes of RNAs [...]

In the simulation process for multi-body systems, the generated redundant constraints will result in ill-conditioned dynamic equations, which are not good for stable simulations when the system motion proceeds near a singular configuration. In order to overcome the singularity problems, the paper presents a regularization method with an explicit expression based on Gauss principle, which does not need to eliminate the constraint violation after each iteration step compared with the traditional methods. Then the effectiveness and stability are demonstrated through two numerical examples, a slider-crank mechanism and a planar four-bar linkage. Simulation results obtained with the proposed method are analyzed and compared with augmented Lagrangian formulation and the null space formulation in terms of constraints violation, drift mechanical energy and computational efficiency, which shows that the proposed method is suitable to perform efficient and stable dynamic simulations for multi-body systems with singular configurations. [ABSTRACT FROM AUTHOR]

Redundancy in the constrained mechanical systems often occurs in complex multibody mechanic systems in the existence of excessive constraints and singular positions due to system motion. In this work, Gauss principle of least constraint (GPLC) is applied to solve the dynamic motion of system with redundant constraints without changing the physics of system. Furthermore, the particle swarm optimization method is used to handle the minimization optimization problem. Eventually, the effectiveness of GPLC is validated through the dynamic modelling and simulation of two numerical examples (a planar four-bar mechanism and a spatial parallelogram mechanism). The simulation results are analyzed and compared with those obtained from Udwaia-Phohomsiri formulation and augmented Lagrangian formulation, in terms of constraint violation, computational efficiency and variation of the mechanical energy. From the viewpoint of computational efficiency and accuracy, GPLC can be regarded as a practical real-time simulation method for multibody systems with redundant constraints. [ABSTRACT FROM AUTHOR]

Abstract: A CeO2 -modified aluminide coating was obtained by composite electro-deposition Ni and CeO2 particles on 20 steel with different holding time using pack cementation. The growth kinetics curve was given with computer fitting by measuring the thickness of the layer. Scanning electronic microscopy and X-ray energy dispersive spectrometry were used to analyze the microstructure and components of the layer. The results showed that the content of CeO2 was up to 5.21wt.% in the rich area of NiAl coatings, which restrain the interdiffusion between the coating and the base during the oxidation process at high temperature. Meanwhile, the growth curve obtained could offer an important basis to forecasting and controlling the depth of the coating. [Copyright &y& Elsevier]

Benign fibrous histiocytoma (BFH) within the intracerebral region is remarkably rare. Our report details 2 cases of unusual BFH instances that exhibit no adhesion to the dura mater or cerebral falx, accompanied by a comprehensive literature review. While magnetic resonance imaging demonstrates specific characteristics for BFH, it does not readily differentiate BFH from more common brain neoplasms like gliomas and metastatic tumors. The definitive diagnosis of BFH depends primarily on histopathological and immunohistochemical examinations. Total surgical resection is considered an efficacious therapeutic approach, emphasizing the necessity for prolonged postoperative surveillance to detect any potential tumor recurrence or metastasis., (Copyright: © Neurosciences.)

Torcular meningiomas intimately involving major dural sinuses such as superior sagittal sinuses, transverse sinuses, and straight sinuses and the confluence are a great challenge for neurosurgeons. Simpson grade I total resection, which can bring complete cure, is the ultimate goal, but under many circumstances, it is difficult to achieve. The patency of the sinuses around these tumors is the key factor for successful tumor resection, and decides the surgical strategy. We report the experience of complete resection of a huge recurrent torcular meningioma. Related literature is reviewed., (Georg Thieme Verlag KG Stuttgart · New York.)