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Background Gastrointestinal symptoms in gastric cancer patients treated with postoperative chemotherapy are diverse and interconnected, without effective intervention targets. In recent years, network analysis has emerged as a prominent approach to identify intervention targets. Objective To construct a network of gastrointestinal symptoms in gastric cancer patients treated with postoperative chemotherapy, identify core symptoms and analyze the factors influencing core symptoms, so as to provide a reference for precise symptom management. Methods Postoperative chemotherapy patients with gastric cancer were selected in the medical oncology and surgical oncology department of four tertiary A-level Chinese medicine hospitals (Jiangsu Provincial Hospital of Traditional Chinese Medicine, Suzhou Hospital of Traditional Chinese Medicine, Wuxi Hospital of Traditional Chinese Medicine, and Xuzhou Hospital of Traditional Chinese Medicine) in South, Central, and North of Jiangsu Province, from March to December 2022 via convenience sampling method, as the study subjects. The MD Anderson Symptom Inventory Gastrointestinal Cancer (MDASI-GI) was used for evaluating gastrointestinal symptoms and their severity among patients receiving postoperative chemotherapy for gastric cancer, as well as assessing the classification of traditional Chinese medicine constitution among patients. The network of gastrointestinal symptoms was constructed using an R package to identify the centrality indexes. The univariate analysis and multiple linear regression analysis were conducted to investigate factors influencing core gastrointestinal symptoms in patients undergoing postoperative chemotherapy for gastric cancer. Results A total of 362 electronic questionnaires were collected, 355 were valid, with a valid recovery rate of 98.1%. The highest incidence of gastrointestinal symptoms in patients with postoperative chemotherapy for gastric cancer was lack of appetite (83.1%), taste alteration (81.7%) and nausea (71.0%), and the top three in terms of severity were lack of appetite (2.77 points), taste alteration (2.50 points) and nausea (2.27 points). Network analysis showed that taste alteration had the highest intensity (rS=1.27) and the highest tight centrality (rC=1.50) ; vomiting had the highest betweenness centrality (rB=1.76). The results of multiple linear regression analysis showed that gender (B=0.809, 95%CI=0.319-1.298), smoking history (B=0.706, 95%CI=0.185-1.228) and phlegm-damp constitution (B=1.703, 95%CI=0.538-2.868) were the factors influencing the severity of taste alteration symptoms in patients with gastric cancer after chemotherapy (P

One of the major challenges arising in internet of military things (IoMT) is accommodating massive connectivity while providing guaranteed quality of service (QoS) in terms of ultra-high reliability. In this regard, this paper presents a class of code-domain nonorthogonal multiple accesses (NOMAs) for uplink ultra reliable networking of massive IoMT based on tactical datalink such as Link-16 and joint tactical information distribution system (JTIDS). In the considered scenario, a satellite equipped with Nr antennas servers K devices including vehicles, drones, ships, sensors, handset radios, etc. Nonorthogonal coded modulation, a special form of multiple input multiple output (MIMO)-NOMA is proposed. The discussion starts with evaluating the output signal to interference-plus-noise (SINR) of receiver filter, leading to the unveiling of a closed-form expression for overloading systems as the number of users is significantly larger than the number of devices admitted such that massive connectivity is rendered. The expression allows for the development of simple yet successful interference suppression based on power allocation and phase shaping techniques that maximizes the sum rate since it is equivalent to fixed-point programming as can be proved. The proposed design is exemplified by nonlinear modulation schemes such as minimum shift keying (MSK) and Gaussian MSK (GMSK), two pivotal modulation formats in IoMT standards such as Link-16 and JITDS. Numerical results show that near capacity performance is offered. Fortunately, the performance is obtained using simple forward error corrections (FECs) of higher coding rate than existing schemes do, while the transmit power is reduced by 6 dB. The proposed design finds wide applications not only in IoMT but also in deep space communications, where ultra reliability and massive connectivity is a keen concern.

Cancer risk is modulated by hereditary and somatic mutations, exposures, age, sex, and gender. The mechanisms by which sex and gender work alone and in combination with other cancer risk factors remain underexplored. In general, cancers that occur in both the male and female sexes occur more commonly in XY compared with XX individuals, regardless of genetic ancestry, geographic location, and age. Moreover, XY individuals are less frequently cured of their cancers, highlighting the need for a greater understanding of sex and gender effects in oncology. This will be necessary for optimal laboratory and clinical cancer investigations. To that end, we review the epigenetics of sexual differentiation and its effect on cancer hallmark pathways throughout life. Specifically, we will touch on how sex differences in metabolism, immunity, pluripotency, and tumor suppressor functions are patterned through the epigenetic effects of imprinting, sex chromosome complement, X inactivation, genes escaping X inactivation, sex hormones, and life history., In humans, cancer occurs more commonly in males, and males die more rapidly of their disease compared with females (1). When we observe significant sex differences such as these, they [...]

Objective To explore the role of G protein pathway suppressor 2(GPS2)in regulating proliferation, migration and invasion in hepatocellular carcinoma cell line MHCC-97H.Methods The expression of GPS2 in hepatocellular carcinoma (HCC) cells were detected using quantitative PCR or Western blot; GPS2 was either over-expressed or knocked down in HCC cells using over-expression vectors or short hairpin RNAs (shRNAs) for GPS2, respectively. Clone formation assay, scratch assay and Transwell assay were used to detect the effects of GPS2 on proliferation, migration and invasion of HCC cells. Results In HCC cells, over-expression of GPS2 was found to inhibit the proliferation, migration and invasion of HCC cells MHCC-97H, while knockdown of GPS2 up-regulated proliferation, migration and invasion of MHCC-97H(P＜0.05). The over-expression of GPS2 in MHCC-97H cells was found to inhibit the expression of cell proliferation, migration and invasion-related factors such as EGFR, MMP1, MMP3 and MMP9, while knockdown of GPS2 upregulated the expression of these factors(P＜0.05). Conclusions GPS2 is a novel HCC regulatory factor that inhibits proliferation, migration and invasion of HCC cells.