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379 results on '"Yang, L.-J."'

4. Differentially expressed homologous genes reveal interspecies differences of Paragonimus proliferus based on transcriptome analysis

Author

Li S. H., Li S. D., Li H. J., Li J. Y., Xu J. J., Chang G. J., Yang L. J., Wang W. Q., Zhang Y. L., Ma Z. Q., He S. M., Wang W. L., and Huang H. L.

Subjects
paragonimus proliferus, transcriptome, homologous genes, interspecies differences, Microbiology, QR1-502
Abstract

Paragonimus proliferus (P. proliferus), one of 46 Paragonimus species registered in the National Center for Biotechnology Information database, may be much more widely distributed in Southeast Asia than previously thought, as its reported natural foci have increased in the past decades. However, very little is known about its molecular biology, especially at the transcriptome level. For the first time, the transcriptome of this species was sequenced and compared with four other common Paragonimus species, namely Paragonimus skrjabini, Paragonimus kellicotti, Paragonimus miyazakii, and Paragonimus westermani, to predict homologous genes and differentially expressed homologous genes to explore interspecies differences of Paragonimus proliferus.

Published
2020
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11. OP0163 A MATRIX PREDICTION MODEL FOR THE SIX-MONTH MORTALITY RISK IN PATIENTS WITH ANTI-MELANOMA DIFFERENTIATION-ASSOCIATED PROTEIN-5 POSITIVE DERMATOMYOSITIS

Author

Tang, A. J., primary, Tang, F. Y., additional, Ouyang, Z. M., additional, Lin, J., additional, Yang, Z. H., additional, Yang, L. J., additional, Wei, X. N., additional, Li, Q. H., additional, Liang, J. J., additional, Zheng, D. H., additional, Dai, L., additional, and Mo, Y. Q., additional

Published
2022
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19. A CLINICAL INVESTIGATION INTO THE USEFULNESS OF FRACTIONAL EXHALED NITRIC OXIDE IN GUIDING GLUCOCORTICOID THERAPY IN CHILDREN WITH BRONCHIAL ASTHMA.

Author

FANG, C., YANG, L.-J., CHEN, X.-J., LI, D.-M., LI, D.-X., LIANG, L.-T., LU, Z.-N., and LI, Q.

Abstract

The present study aims to investigate the value of fractional exhaled nitric oxide (FeNO) combined with pulmonary function in guiding the dose adjustment of inhaled glucocorticosteroids (ICSs) in children with asthma. A total of 133 children aged 6-12 years with newly diagnosed asthma were enrolled as the study subjects and randomly divided into the experimental group (n=68) and the control group (n=65). After three months of ICS treatment, in the experimental group, the dose of ICSs was adjusted based on the control status of the children and the results of the pulmonary function tests and FeNO assays, and in the control group, the dose was adjusted based on the control status of the children and the results of the pulmonary function tests. After another three months of treatment, the number of acute asthma attacks and the Childhood Asthma Control Test (C-ACT) scores were compared between the two groups, and the outcome of pulmonary function tests and FeNO assays during treatment were analyzed. When examining pulmonary function and FeNO levels, when compared with before treatment, there were no statistically significant differences in either group or between the groups after three months of ICS treatment (P>0.05). After dose adjustment and another three months of treatment, when compared with the control group, the improvement in pulmonary function in the experimental group was greater, the reduction in FeNO levels was greater, the incidence of acute asthma attacks was lower, and the C-ACT score was higher (P<0.05). We concluded that the combination of FeNO assays and pulmonary function tests to guide the ICS dose adjustment in children with asthma could improve asthma control and reduce the risk of acute asthma attacks. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Problem 75-19

Author

Stolarsky, K. B. and Yang, L. J.

Published
1977

42. Real-time stall detection of centrifugal fan based on the analysis of symmetrized dot pattern and wavelet packet transform

Author

Xu, X. G., Liu, H. X., Wang, S. L., Fan, Z. Y., Yang, L. J., Liu, S. T., Xu, X. G., Liu, H. X., Wang, S. L., Fan, Z. Y., Yang, L. J., and Liu, S. T.

Abstract

This paper presents a novel stall detection method based on symmetrized dot pattern (SDP) analysis, which detects the starting point of rotating stall timely and accurately during operations of centrifugal fans. To demonstrate the proposed method, experiments were first performed on a G4-73 No. 8D centrifugal fan to measure the aerodynamic pressure signals of the air flow inside the fan during the gradual development of rotating stall. Then, the SDP technique was used to analyze the pressure signals and extract the time-domain characteristics of the pressure signal during the gradual development of rotation stall. Finally, a comprehensive autocorrelation coefficient was defined and employed as the index for real-time stall detection. In addition, to verify the accuracy of detection results, the tested signals were also analyzed off-line by wavelet transform to detect the actual starting point of rotating stall. The comparison results show that the stall detection method based on the symmetrized dot pattern (SDP) analysis can accurately detect the starting point of rotating stall in centrifugal fans within a short period of 0.05 s.

Published
2017

50. Pancreatic and duodenal homeobox gene 1 (Pdx1) down-regulates hepatic transcription factor 1 alpha (HNF1α) expression during reprogramming of human hepatic cells into insulin-producing cells

Author

Donelan, W., Li, S., Wang, H., Lu, S., Chao Xie, Tang, D., Chang, L. -J, and Yang, L. -J

Subjects
endocrine system, Original Article, digestive system
Abstract

Ectopic expression of Pdx1 triggers rapid hepatocyte dedifferentiation by down-regulating liver-enriched transcription factors and liver-specific functional genes such as hepatic nuclear factor-1α (HNF1α), albumin, and AAT. However, the links between Pdx1 over-expression and hepatic gene down-regulation are incompletely understood. HNF1α and HNF4α are important transcription factors that establish and maintain the hepatocyte phenotype. The human HNF4α gene contains two promoters (P1 and P2) that drive expression of P1-(HNF4α 1-6) or P2-(HNF4α 7-9)-derived isoforms, which are used in different tissues and at different times during development. We hypothesized that the relative expression of HNF1α and HNF4α following ectopic Pdx1 expression may promote hepatic cell dedifferentiation and transdifferentiation toward pancreatic beta-cells. We produced lentiviruses expressing Pdx1, Pdx1-VP16, and Ngn3, along with dual-color reporter genes to indicate hepatic and pancreatic beta-cell phenotype changes. Using these PTF alone or in combinations, we demonstrated that Pdx1 not only activates specific beta-cell genes but down-regulates HNF1α. Pdx1-mediated reduction of HNF1α is accompanied by altered expression of its major activator, HNF4α isoforms, down-regulating hepatic genes ALB and AAT. Pdx1 up-regulates HNF4α via the P2 promoter. These P2-driven isoforms compete with P1-driven isoforms to suppress target gene transcription. In Huh7 cells, the AF-1 activation domain is more important for transactivation, whereas in INS1 cells, the F inhibitory domain is more important. The loss and gain of functional activity strongly suggests that Pdx1 plays a central role in reprogramming hepatocytes into beta-cells by suppressing the hepatic phenotype.

Published
2015

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