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The objective of this study was to explore the potential genetic link between Crohn's disease and breast cancer, with a focus on identifying druggable genes that may have therapeutic relevance. We assessed the causal relationship between these diseases through Mendelian randomization and investigated gene-drug interactions using computational predictions. This study sought to identify common genetic pathways possibly involved in immune responses and cancer progression, providing a foundation for future targeted treatment research. The dataset comprises single nucleotide polymorphisms used as instrumental variables for Crohn's disease, analyzed to explore their possible impact on breast cancer risk. Gene ontology and pathway enrichment analyses were conducted to identify genes shared between the two conditions, supported by protein–protein interaction networks, colocalization analyses, and deep learning-based predictions of gene-drug interactions. The identified hub genes and predicted gene-drug interactions offer preliminary insights into possible therapeutic targets for breast cancer and immune-related conditions. This dataset may be valuable for researchers studying genetic links between autoimmune diseases and cancer and for those interested in the early identification of potential drug targets. [ABSTRACT FROM AUTHOR]

The author team attended a group which visited University of Nebraska Medical Center and experienced their medical education system in 2016, sponsored by China Scholarship Council. Some education reformations and trials were carried out in the authors’ affiliations after the program finished. In this work, an analysis of the differences in medical education of the USA and of China was made, combining the published perspectives and our own experiences. The critical comments raised in this work may contribute to the remodeling of our medical education system and teaching mode.