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189 results on '"Yang, Jingzhi"'

4. Instruct-Code-Llama: Improving Capabilities of Language Model in Competition Level Code Generation by Online Judge Feedback

Author

Liu, Zhaofeng, Su, Jing, Cai, Jia, Yang, Jingzhi, Wu, Chenfan, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Huang, De-Shuang, editor, Si, Zhanjun, editor, and Zhang, Qinhu, editor

Published
2024
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21. Synergistic D‐Amino Acids Based Antimicrobial Cocktails Formulated via High‐Throughput Screening and Machine Learning.

Author

Yang, Jingzhi, Ran, Yami, Liu, Shaopeng, Ren, Chenhao, Lou, Yuntian, Ju, Pengfei, Li, Guoliang, Li, Xiaogang, and Zhang, Dawei

Subjects
*HIGH throughput screening (Drug development), *MACHINE learning, *DRUG efficacy, *DRUG dosage, *LUNG infections, *AMINO acids, *SCHIFF bases
Abstract

Antimicrobial resistance (AMR) from pathogenic bacterial biofilms has become a global health issue while developing novel antimicrobials is inefficient and costly. Combining existing multiple drugs with enhanced efficacy and/or reduced toxicity may be a promising approach to treat AMR. D‐amino acids mixtures coupled with antibiotics can provide new therapies for drug‐resistance infection with reduced toxicity by lower drug dosage requirements. However, iterative trial‐and‐error experiments are not tenable to prioritize credible drug formulations, owing to the extremely large number of possible combinations. Herein, a new avenue is provide to accelerate the exploration of desirable antimicrobial formulations via high‐throughput screening and machine learning optimization. Such an intelligent method can navigate the large search space and rapidly identify the D‐amino acid mixtures with the highest anti‐biofilm efficiency and also the synergisms between D‐amino acid mixtures and antibiotics. The optimized drug cocktails exhibit high antimicrobial efficacy while remaining non‐toxic, which is demonstrated not only from in vitro assessments but also the first in vivo study using a lung infection mouse model. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Didymella Segeticola is a new pathogen causing leaf spot disease on Zanthoxylum bungeanum.

Author

Yang, Jingzhi, Chen, Chunxu, Yin, Xianhui, Xu, Huayang, Long, Haijiang, Gu, Guifei, Shu, Ran, Yuan, Jun, and Zhou, Houying

Subjects
*LEAF spots, *ZANTHOXYLUM, *FOLIAGE plants, *FUNGICIDES, *RUTACEAE
Abstract

Zanthoxylum bungeanum (family Rutaceae) is an economically important deciduous shrub that is widely distributed across Asia. The leaves of this plant are rich in chemical compounds and have a variety of biological activities. However, a spot disease was discovered on Z. bungeanum leaves in Zunyi, China, in 2020. In the present study, a fungal isolate (YY-815) was obtained from Z. bungeanum leaves with leaf spot symptoms and identified as Didymella segeticola based on its morphological characteristics and phylogenetic analysis. This isolate could cause leaf spot disease and be re-isolated, fulfilling Koch's postulates. The fungicides boscalid, penthiopyrad and pydiflumetofen significantly inhibited hyphal growth of D. segeticola under in vitro conditions. This is the first study to report a leaf spot disease on Z. bungeanum caused by D. segeticola. [ABSTRACT FROM AUTHOR]

Published
2023
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25. SARS‐CoV‐2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species.

Author

Yu, Haiyun, Yang, Lu, Han, Zhennan, Zhou, Xiaoyu, Zhang, Zihan, Sun, Tianli, Zheng, Fang, Yang, Jingzhi, Guan, Fei, Xie, Jungang, and Liu, Chaohong

Subjects
SARS-CoV-2, REACTIVE oxygen species, OXYGEN consumption, COVID-19, CYTOSKELETAL proteins
Abstract

Coronavirus disease 2019 (COVID‐19) pathogenesis is influenced by reactive oxygen species (ROS). Nevertheless, the precise mechanisms implicated remain poorly understood. The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the main driver for this condition, is a structural protein indispensable for viral replication and assembly, and its role in ROS production has not been reported. This study shows that SARS‐CoV‐2 N protein expression enhances mitochondrial ROS level. Bulk RNA‐sequencing suggests of aberrant redox state of the electron transport chain. Accordingly, this protein hinders ATP production but simultaneously augments the activity of complexes I and III, and most mitochondrially encoded complex I and III proteins are upregulated by it. Mechanistically, N protein of SARS‐CoV‐2 shows significant mitochondrial localization. It interacts with mitochondrial transcription components and stabilizes them. Moreover, it also impairs the activity of antioxidant enzymes with or without detectable interaction. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Didymella Segeticolais a new pathogen causing leaf spot disease on Zanthoxylum bungeanum

Author

Yang, Jingzhi, Chen, Chunxu, Yin, Xianhui, Xu, Huayang, Long, Haijiang, Gu, Guifei, Shu, Ran, Yuan, Jun, and Zhou, Houying

Abstract

ABSTRACTZanthoxylum bungeanum(family Rutaceae) is an economically important deciduous shrub that is widely distributed across Asia. The leaves of this plant are rich in chemical compounds and have a variety of biological activities. However, a spot disease was discovered on Z. bungeanumleaves in Zunyi, China, in 2020. In the present study, a fungal isolate (YY-815) was obtained from Z. bungeanumleaves with leaf spot symptoms and identified as Didymella segeticolabased on its morphological characteristics and phylogenetic analysis. This isolate could cause leaf spot disease and be re-isolated, fulfilling Koch’s postulates. The fungicides boscalid, penthiopyrad and pydiflumetofen significantly inhibited hyphal growth of D. segeticolaunder in vitroconditions. This is the first study to report a leaf spot disease on Z. bungeanumcaused by D. segeticola.

Published
2023
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42. Bioinspired Carboxylate–Water Coordination Polymers with Hydrogen-Bond Clusters and Local Coordination Flexibility for Electrochemical Water Splitting

Author

Liya Wang, Chunying Duan, Cheng He, Bo Li, Yang Jingzhi, Junling Chen, Heng Zhang, Tiexin Zhang, and Li Xiongwen

Subjects
chemistry.chemical_classification, Materials science, Flexibility (anatomy), Hydrogen, Hydrogen bond, Oxygen evolution, Energy Engineering and Power Technology, chemistry.chemical_element, Polymer, Electrochemistry, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Chemical engineering, Materials Chemistry, medicine, Chemical Engineering (miscellaneous), Water splitting, Carboxylate, Electrical and Electronic Engineering
Abstract

Coordination polymers (CPs) have attracted considerable attention for use in noble-metal-free electrochemical water splitting, for example, by the hydrogen/oxygen evolution reactions (HER/OER). Tra...

Published
2020

50. Synthesis, characterization and magnetic properties of cobalt(II) and manganese(II) metal–organic frameworks assembled from 4,6-bis(imidazol-1-yl)isophthalic acid ligands

Author

Bo Li, Liya Wang, Zhou Ye, Li Xiongwen, and Yang Jingzhi

Subjects
010405 organic chemistry, Metals and Alloys, chemistry.chemical_element, Manganese, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Catalysis, Inorganic Chemistry, Isophthalic acid, Metal, Crystallography, chemistry.chemical_compound, chemistry, visual_art, Materials Chemistry, visual_art.visual_art_medium, Antiferromagnetism, Metal-organic framework, Cobalt, Organometallic chemistry
Abstract

Two metal–organic frameworks of 4,6-bis(imidazol-1-yl)isophthalic acid (H2biip), of general formula, {[M2(biip)2(H2O)]·EtOH2}n (M = Co (1), Mn (2)), have been synthesized under solvothermal conditions. Complexes 1 and 2 are isomorphic and exhibit three-dimensional metal–organic frameworks with a 2-nodal (4,8)-connected topological network, Point Symbol {416.612}{44.62}2. The magnetic properties of the complexes were examined, indicating antiferromagnetic interactions between the metal centers in the temperature range from 2 to 300 K.

Published
2018

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