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Your search keyword '"Yang, Hai-Jiao"' showing total 11 results
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11 results on '"Yang, Hai-Jiao"'

1. CD147-specific chimeric antigen receptor T cells effectively inhibit T cell acute lymphoblastic leukemia

Author

Zheng, Nai-Shan, primary, Zhao, Xiang-Yu, additional, Wei, Ding, additional, Miao, Jin-Lin, additional, Liu, Ze-Kun, additional, Yong, Yu-Le, additional, Zhang, Ren-Yu, additional, Guo, Yi-Xiao, additional, He, Lin, additional, Wang, Bin, additional, Sun, Xiu-Xuan, additional, Yang, Hai-Jiao, additional, Zhang, Tian-Jiao, additional, He, Qian, additional, Li, Xiao-Min, additional, Zhang, Hai, additional, Hou, Rong, additional, Lin, Peng, additional, Xu, Ying-Ming, additional, Huang, Xiao-Jun, additional, Chen, Zhi-Nan, additional, and Bian, Huijie, additional

Published
2022
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11. Programmed Death Ligand 1 Indicates Pre-Existing Adaptive Immune Response by Tumor-Infiltrating CD8 + T Cells in Non-Small Cell Lung Cancer.

Author

Li YM, Yu JM, Liu ZY, Yang HJ, Tang J, and Chen ZN

Subjects
Adaptive Immunity, Aged, B7-H1 Antigen genetics, CD8-Positive T-Lymphocytes metabolism, Carcinoma, Non-Small-Cell Lung metabolism, Cell Line, Tumor, Female, Humans, Interferon-gamma physiology, Male, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Regression Analysis, Signal Transduction, Tumor Cells, Cultured, B7-H1 Antigen metabolism, CD8-Positive T-Lymphocytes immunology, Carcinoma, Non-Small-Cell Lung immunology
Abstract

Aberrant expression of programmed death ligand 1 (PD-L1) on tumor cells impedes antitumor immunity and instigates immune evasion. The remarkable efficacy of immune checkpoint blockade has been confirmed in various solid tumors. However, the correlation between PD-L1 expression and host immunological landscape remains of considerable controversy in non-small cell lung cancer (NSCLC). In the present study, PD-L1 expression and CD8 + tumor-infiltrating lymphocyte (TIL) infiltration levels were determined by immunohistochemistry (IHC) in tumor sections of 138 NSCLC patients. The expression level of PD-L1 was positively correlated with the abundance of CD8 + TILs ( p < 0.0001). Furthermore, no constitutive expression of PD-L1 was observed in the majority of six NSCLC cell lines detected by Western blot; but exposure to interferon-γ (IFN-γ), a primary cytokine secreted by activated CD8 + T cells, prominently increased PD-L1 expression. Notably, a significantly positive association was determined within PD-L1, CD8 and IFN-γ gene expression by qRT-PCR, which was corroborated by RNA-sequencing from TCGA lung cancer dataset. These findings demonstrate that PD-L1 expression indicates an adaptive immune resistance mechanism adopted by tumor cells in the aversion of immunogenic destruction by CD8 + TILs. Both higher expression of PD-L1 and infiltration of CD8 + TILs were correlated with superior prognosis ( p = 0.044 for PD-L1; p = 0.002 for CD8). Moreover, Cox multivariate regression analysis showed that the combination of PD-L1 and CD8 were independent prognostic factors, which was more accurate in prediction of prognosis in NSCLC than individually. Finally, we found that IFN-γ induced the upregulation of PD-L1 in NSCLC cells, mainly through the JAK/STAT1 signaling pathway. In conclusion, PD-L1 expression is mainly induced by activated CD8 + TILs via IFN-γ in the immune milieu and indicates pre-existing adaptive immune response in NSCLC.

Published
2019
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