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12 results on '"Yang, Ende"'

1. Tislelizumab combined with chemotherapy as neoadjuvant therapy for surgically resectable esophageal cancer: A prospective, single-arm, phase II study (TD-NICE)

Author

Yan, Xiaolong, Duan, Hongtao, Ni, Yunfeng, Zhou, Yongan, Wang, Xiaoping, Qi, Haini, Gong, Li, Liu, Honggang, Tian, Feng, Lu, Qiang, Sun, Jianyong, Yang, Ende, Zhong, Daixing, Wang, Tao, Huang, Lijun, Wang, Jian, chaoyang Wang, Wang, Yuanyong, Wan, Zhiyi, Lei, Jie, Zhao, Jinbo, and Jiang, Tao

Published
2022
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4. Neoadjuvant Camrelizumab Plus Platinum-Based Chemotherapy vs Chemotherapy Alone for Chinese Patients With Resectable Stage IIIA or IIIB (T3N2) Non–Small Cell Lung Cancer

Author

Lei, Jie, primary, Zhao, Jinbo, additional, Gong, Li, additional, Ni, Yunfeng, additional, Zhou, Yongan, additional, Tian, Feng, additional, Liu, Honggang, additional, Gu, Zhongping, additional, Huang, Lijun, additional, Lu, Qiang, additional, Wang, Xiaoping, additional, Sun, Jianyong, additional, Yang, Ende, additional, Wang, Tao, additional, Zhong, Daixing, additional, Wang, Jian, additional, Zhao, Zhengwei, additional, Liu, Zhigang, additional, Wang, Cheng, additional, Wang, Xiaojing, additional, Lei, Guangyan, additional, Yan, Xiaolong, additional, and Jiang, Tao, additional

Published
2023
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7. Pyroptosis and Inflammasome-Related Genes-NLRP3, NLRC4 and NLRP7 Polymorphisms Were Associated with Risk of Lung Cancer

Author

Jing,Xin, Yun,Yuhui, Ji,Xiang, Yang,Ende, Li,Pei, Jing,Xin, Yun,Yuhui, Ji,Xiang, Yang,Ende, and Li,Pei

Abstract

Xin Jing,&ast; Yuhui Yun,&ast; Xiang Ji, Ende Yang, Pei Li Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710038, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Pei Li; Ende Yang, Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710038, People’s Republic of China, Email yanglinglipei@163.com; endeyangfmmu@163.comBackground: Cancer development and tumor immune microenvironment remodeling are closely linked to pyroptosis and inflammasome activation. However, little information is available in single nucleotide polymorphisms (SNPs) in pyroptosis and inflammasome-related genes in patients with lung cancer. This study aims to evaluate the associations between pyroptosis-related gene (NLRP3, NLRC4, and NLRP7) polymorphisms and the risk of lung cancer.Methods: The MassARRAY platform was used to genotype six SNPs of the NLRP3, NLRC4, and NLRP7 genes in 660 lung cancer cases and 660 controls.Results: Individuals with rs35829419-A, rs385076-C, and rs775882-T alleles exhibited a higher risk of lung cancer (p < 0.01), while rs212704-T appears protective (p = 0.006). The rs35829419-AA, rs385076-TC/CC, and rs775882-CT/TT genotypes were associated with various degrees of elevated risk of lung cancer (p< 0.02), whereas rs212704-TT was associated with a reduced risk of the disease (p=0.014). Genetic models analysis showed that rs35829419, rs385076, and rs775882 was associated with an increased risk of lung cancer, while rs212704 was related to a reduced risk in all three models (p < 0.05). The four SNPs remained significant in smoker and nonsmoker subgroups (p < 0.05). However, rs35829419 was correlated with risk of adenocarcinoma and small cell lung cancer, and rs212704 was only protective for squamous cell carcinoma. The rs385076 and rs775882 were associated with all three pathological types

Published
2023

9. Cuproptosis-Related Gene – SLC31A1, FDX1 and ATP7B – Polymorphisms are Associated with Risk of Lung Cancer

Author

Yun,Yuhui, Wang,Yun, Yang,Ende, and Jing,Xin

Subjects
Pharmacogenomics and Personalized Medicine
Abstract

Yuhui Yun,1,&ast; Yun Wang,2,&ast; Ende Yang,1 Xin Jing1 1Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710038, People’s Republic of China; 2Department of Medical Oncology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710038, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xin Jing; Ende Yang, Email jingxintd2014@163.com; endeyangfmmu@163.comBackground: Cuproptosis is a novel copper-dependent cell death, and the copper level was increased in lung cancer patients. However, few studies evaluated the association between single-nucleotide polymorphisms (SNPs) in cuproptosis-related genes and lung cancer risk.Methods: Six SNPs of the SLC31A1, FDX1 and ATP7B genes were genotyped in a case–control cohort including 650 lung cancer cases and 650 controls using the MassARRAY platform.Results: The minor alleles of SLC31A1-rs10981694 and FDX1-rs10488764 were associated with an increased risk of lung cancer (rs10981694: OR=1.455, 95% CI: 1.201– 1.763, p< 0.001; rs10488764: OR=1.483, 95% CI: 1.244– 1.768, p< 0.001). In contrast, the minor alleles of rs9535826 and rs9535828 in ATP7B were related to a decreased risk of the disease (rs9535826: OR=0.714, 95% CI: 0.608– 0.838 p< 0.001; rs9535828: OR=0.679, 95% CI: 0.579– 0.796, p< 0.001). The frequencies of rs10981694-TG/GG and rs10488764-GA/AA genotypes were significantly higher in lung cancer cases than that in controls, making them risk genotypes for the disease (p < 0.001); while the rs9535826-TG/GG and rs9535828-GA/AA genotypes were protective genotypes and associated with a reduced risk of the disease (p< 0.001). Genetic model evaluation revealed that SLC31A1-rs10981694 and FDX1-rs10488764 were associated with a growing risk of lung cancer in dominant, recessive and log-additive models (p< 0.001). Moreover, rs9535826 and rs9535828 in ATP7B were related to a declining risk of the disease in three genetic models (p< 0.001). In addition, stratification analysis showed that FDX1-rs10488764 was risk variant for lung cancer in both smokers and nonsmokers, and was associated with risk of each pathological type of lung cancer (p< 0.008).Conclusion: The results shed new light on the correlation between cuproptosis-related genes and risk of lung cancer.Keywords: lung cancer, single-nucleotide polymorphisms, SNPs, solute carrier family 31 member 1, SLC31A1, ferredoxin 1, FDX1, ATPase copper transporting beta, ATP7B

Published
2022

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