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16 results on '"Yang, Dong ‐ Bo"'

15. Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/ GLI1 Signaling Pathway in Vitro and Vivo.

Author

Du, Wen ‐ Zhong, Feng, Yan, Wang, Xiao ‐ Feng, Piao, Xing ‐ Yin, Cui, Yu ‐ Qiong, Chen, Ling ‐ Chao, Lei, Xu ‐ Hui, Sun, Xu, Liu, Xing, Wang, Han ‐ Bing, Li, Xian ‐ Feng, Yang, Dong ‐ Bo, Sun, Ying, Zhao, Zhe ‐ Feng, Jiang, Tao, Li, Yong ‐ Li, and Jiang, Chuan ‐ Lu

Subjects
GLIOMAS, CURCUMIN, CANCER cell growth, APOPTOSIS, CELLULAR signal transduction, ENZYME inhibitors, CANCER cell proliferation, LABORATORY mice
Abstract

Aims To study the role of curcumin on glioma cells via the SHH/ GLI1 pathway in vitro and vivo. Methods The effects of curcumin on proliferation, migration, apoptosis, SHH/ GLI1 signaling, and GLI1 target genes expression were evaluated in multiple glioma cell lines in vitro. A U87-implanted nude mice model was used to study the role of curcumin on tumor volume and the suppression efficacy of GLI1. Results Curcumin showed cytotoxic effects on glioma cell lines in vitro. Both mRNA and protein levels of SHH/ GLI1 signaling ( Shh, Smo, GLI1) were downregulated in a dose- and time-dependent manner. Several GLI1-dependent target genes ( Cyclin D1, Bcl-2, Foxm1) were also downregulated. Curcumin treatment prevented GLI1 translocating into the cell nucleus and reduced the concentration of its reporter. Curcumin suppressed cell proliferation, colony formation, migration, and induced apoptosis which was mediated partly through the mitochondrial pathway after an increase in the ratio of Bax to Bcl2. Intraperitoneal injection of curcumin in vivo reduced tumor volume, GLI1 expression, the number of positively stained cells, and prolonged the survival period compared with the control group. Conclusion This study shows that curcumin holds a great promise for SHH/ GLI1 targeted therapy against gliomas. [ABSTRACT FROM AUTHOR]

Published
2013
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16. Life Cycle Analysis on Energy Efficiency and CO2 Emissions of China’s New Energy City Bus

Author

Yang, Dong Bo, Liu, Li, Zeng, Ceng, and Han, Li Bo

Abstract

Life cycle analysis provides global research methods for the assessment of life cycle performance. In this research, a WTW（well to wheel）model was introduced to study and compare the energy efficiency and CO2 emissions from diesel bus, CNG bus and electric bus. The results show that the WTW total energy efficiency of diesel bus is 1790MJ/100km. The energy efficiency of CNG bus is 6% lower than that of diesel bus, while the energy efficiency of electric bus is 36% higher than that of diesel bus. Both CNG bus and electric bus show good potential of oil replacement with oil consumption decrease of 98% and 90%. As more than 80% of China’s electricity is produced by coal, electric bus has equal effect as CNG bus on CO2 reduction. Compared to diesel bus, CO2 emissions from new energy bus are reduced by 14%.

Published
2012
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