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An extensive investigation of the interaction of thermoplastic olefin (TPO) compounds with high frequency radar wave has been conducted to understand how TPO materials affect radar sensor efficiency, an important function for vehicle safety and especially the advancement of autonomous vehicles. In this article, the effect of major ingredients of a TPO on its dielectric properties was studied, and then a wide range of TPO compounds were evaluated for their radar transmittance or attenuation. It was demonstrated that the characteristics of polypropylene (PP) resin and rubber have little impact on the dielectric properties of a TPO, thus minimal influence on TPO's radar transparency, while increasing the talc loading in the compound increases the dielectric constant of the TPO. The TPO materials containing talc from 7% up to 34% were found to have dielectric constants ranging from 2.30 to 2.70 and nearly zero dielectric loss. Experiments confirmed that parts molded with these materials are transparent to high frequency radar wave at optimized thicknesses. Some pigments for coloring the materials also affect dielectric properties of TPOs, thus radar transmittance, with metal pigments showing the most impact. Finally, commercial TPO products are shown to have great batch to batch consistency in radar transmittance at a selected part thickness. [ABSTRACT FROM AUTHOR]

The results of the Phase III DESTINY-Breast04 trial of trastuzumab deruxtecan (T-DXd) are leading to a shift in both the classification and treatment of human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer. In this trial, T-DXd was associated with a substantial survival benefit among patients with hormone receptor-positive and hormone receptor-negative disease and low expression of HER2, a biomarker previously considered unactionable in this treatment setting. Herein, we discuss the evolving therapeutic pathway for HER2-low disease, ongoing clinical trials, and the potential challenges and evidence gaps arising with treatment of this patient population. [ABSTRACT FROM AUTHOR]

Significant performance improvements may be obtained in digital communication systems if error control coding is properly applied. However, selection of a coding scheme for specific applications is often a complicated task. The choice is affected by a set of system design goals. Some of these goals impose case-dependent conflicting requirements. Similar scheme selection problems exist in many engineering system design processes. Here, a knowledge-combined neural network approach is developed and applied to optimum coding selection. The proposed approach utilizes a neural network trained not only by precedent examples but also by knowledge rules to draw conclusions. It is shown that artificial neural networks can provide effective solutions to the problems encountered in building systems that emulate a coding specialist's expertise.

Background: Synovial fluid aspiration is a routine practice used by most orthopaedic surgeons to aid in the diagnosis of joint infection. In patients for whom there is a low pretest probability of infection, a positive culture-particularly if it is a broth-only culture-may be considered a contaminant, especially if the bacterial species are skin pathogens. To our knowledge no study has evaluated the incidence of contamination of aspirations from the native knee.Questions/purposes: What is the frequency of false-positive cultures among knee aspirations of the native knee?Methods: Two hundred patients, with a total of 200 knees, with the diagnosis of degenerative osteoarthritis undergoing a total knee arthroplasty (TKA) were identified for this study. None of these patients had symptoms, signs, or laboratory studies to suggest the presence of joint infection; a positive culture in this population therefore would be considered contaminated. Thirty-two (16%) patients were excluded secondary to a dry aspiration. One patient was enrolled in the study but did not have the knee aspirated and another patient's specimen was accidentally discarded. Each knee was aspirated under sterile conditions before performing the TKA. The fluid was sent for cell count and culture. If insufficient fluid was obtained for both cell count and culture, culture was performed rather than cell count.Results: There were no false-positive cultures (zero of 166 [0%]) in aspirations of native knees.Conclusions: Our study would indicate that when done properly under sterile technique, cultures taken from knee arthrocentesis in patients without prosthetic joints should not be affected by perceived contaminant species. A positive specimen finding on culture should raise a strong suspicion of bacterial septic arthritis. Future studies should include more specimens as well as knees with prior TKA to help further identify the rate of false-positive cultures in knee arthrocentesis in both populations.Level Of Evidence: Level I, diagnostic study. [ABSTRACT FROM AUTHOR]

Background: The risk of early complications is high after monoblock acetabular metal-on-metal (MoM) THA revisions. However, there is a paucity of evidence regarding clinical complications after isolated head-liner exchange of modular MoM THA.Questions/purposes: The purposes of this study were (1) to describe the frequency of early complications after an isolated head-liner exchange revision of modular MoM THA; and (2) to determine whether patients who experienced complications or dislocation after head-liner exchanges had higher serum chromium (Cr) or cobalt (Co) ion levels than those who did not.Methods: A review of our institution's total joint registry retrospectively identified 53 patients who underwent 54 liner exchange revisions of a modular acetabular MoM THA. The study period was from April 2008 to April 2016 at a single tertiary care center. During this period, isolated head-liner exchanges (rather than more extensive revisions) were performed in patients if they did not have evidence of loosening of the acetabular or femoral components. Reasons for revision surgery included pain, mechanical symptoms, radiographic evidence of osteolysis, elevated serum metal ions, and MRI abnormalities with 40 of the 54 hips having pain or mechanical symptoms and 38 of 54 hips having multiple reasons for revision before surgery. Patients were excluded if they did not meet the minimum postrevision followup or had the modular liner exchange secondary to infection. All revisions were from a single manufacturer with one head-liner exchange of a MoM THA from another manufacturer excluded during the study period. The mean time from index MoM THA to modular exchange was 96 (SD ± 36) months. Because the focus of this study was early complications, we had a minimum 90-day followup duration for inclusion. Mean followup after revision was 15 months (SD ± 12); a total of 56% (30 of 54) had followup of at least 12 months' duration. Complications (dislocation, infection) and reoperations were obtained by chart review performed by individuals other than the treating physician(s). Serum metal ion levels were obtained before head-liner exchange. The median serum Cr and Co levels were 6 µg/L (range, 0-76 µg/L) and 12 µg/L (range, 0-163 µg/L), respectively.Results: Of the 54 revision THAs, 15 (28%) developed complications. Nine (17%) occurred within 90 days of the revision surgery and 11 (20%) resulted in reoperation. The most common complication was dislocation (12 of 54 [22%]) with recurrent dislocation noted in eight of these 12 patients. All patients with recurrent dislocation continued to dislocate and underwent repeat revision. Patients with dislocation had higher median serum Cr and Co ion levels than those without dislocation (Cr: 24 [range, 11-76] versus 4 [range, 0-70], p = 0.001 [95% confidence interval {CI}, 10-57]; Co: 41 [range, 6-163] versus 8 [range, 0-133], p = 0.016 [95% CI, 6-141]). Three (6%) of the 54 patients underwent repeat surgery for deep space infection.Conclusions: Complications and reoperations are common after modular head-liner exchange in the setting of a failed MoM THA. Our study likely underestimates the frequency of complications and revisions because the followup period in this report was relatively short. Dislocation is the most common complication and elevated serum metal ion levels may be a predictor of dislocation. These findings are concerning and surgeons should be aware of the high complication risk associated with this procedure.Level Of Evidence: Level IV, therapeutic study. [ABSTRACT FROM AUTHOR]