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1. First joint oscillation analysis of Super-Kamiokande atmospheric and T2K accelerator neutrino data

Author

Super-Kamiokande, collaborations, T2K, Abe, S., Abe, K., Akhlaq, N., Akutsu, R., Alarakia-Charles, H., Ali, A., Hakim, Y. I. Alj, Monsalve, S. Alonso, Amanai, S., Andreopoulos, C., Anthony, L. H. V., Antonova, M., Aoki, S., Apte, K. A., Arai, T., Arihara, T., Arimoto, S., Asada, Y., Asaka, R., Ashida, Y., Atkin, E. T., Babu, N., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Bates, P., Batkiewicz-Kwasniak, M., Beauchêne, A., Berardi, V., Berns, L., Bhadra, S., Bhuiyan, N., Bian, J., Blanchet, A., Blondel, A., Bodur, B., Bolognesi, S., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bubak, A., Avanzini, M. Buizza, Burton, G. T., Caballero, J. A., Calabria, N. F., Cao, S., Carabadjac, D., Carter, A. J., Cartwright, S. L., Casado, M. P., Catanesi, M. G., Cervera, A., Chakrani, J., Chalumeau, A., Chen, S., Cherdack, D., Choi, K., Chong, P. S., Chvirova, A., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cormier, F., Cudd, A., Dalmazzone, C., Daret, T., Dasgupta, P., Davis, C., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Dharmapal, R., Di Lodovico, F., Lopez, G. Diaz, Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Duffy, K. E., Dumarchez, J., Dunne, P., Dygnarowicz, K., D'ago, D., Edwards, R., Eguchi, A., Elias, J., Emery-Schrenk, S., Erofeev, G., Ershova, A., Eurin, G., Fannon, J. E. P., Fedorova, D., Fedotov, S., Feltre, M., Feng, J., Feng, L., Ferlewicz, D., Fernandez, P., Finch, A. J., Aguirre, G. A. Fiorentini, Fiorillo, G., Fitton, M. D., Patiño, J. M. Franco, Friend, M., Fujii, Y., Fujisawa, C., Fujita, S., Fukuda, Y., Furui, Y., Gao, J., Gaur, R., Giampaolo, A., Giannessi, L., Giganti, C., Glagolev, V., Goldsack, A., Gonin, M., Rosa, J. González, Goodman, E. A. G., Gorin, A., Gorshanov, K., Gousy-Leblanc, V., Grassi, M., Griskevich, N. J., Guigue, M., Hadley, D., Haigh, J. T., Han, S., Harada, M., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hayato, Y., Heitkamp, I., Henaff, D., Hill, J., Hino, Y., Hiraide, K., Hogan, M., Holeczek, J., Holin, A., Holvey, T., Van, N. T. Hong, Honjo, T., Horiuchi, S., Hosokawa, K., Hu, Z., Hu, J., Iacob, F., Ichikawa, A. K., Ieki, K., Ikeda, M., Iovine, N., Ishida, T., Ishino, H., Ishitsuka, M., Ishizuka, T., Ito, H., Itow, Y., Izmaylov, A., Izumiyama, S., Jakkapu, M., Jamieson, B., Jang, M. C., Jang, J. S., Jenkins, S. J., Jesús-Valls, C., Ji, J. Y., Jia, M., Jiang, J., Jonsson, P., Joshi, S., Jung, C. K., Jung, S., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kanemura, Y., Kaneshima, R., Karpova, S., Kasetti, S. P., Kashiwagi, Y., Kasturi, V. S., Kataoka, Y., Katori, T., Kawamura, Y., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kim, S. B., King, S., Kiseeva, V., Kisiel, J., Kneale, L., Kobayashi, H., Kobayashi, T., Kobayashi, M., Koch, L., Kodama, S., Kolupanova, M., Konaka, A., Kormos, L. L., Koshio, Y., Koto, T., Kowalik, K., Kudenko, Y., Kudo, Y., Kuribayashi, S., Kurjata, R., Kurochka, V., Kutter, T., Kuze, M., Kwon, E., La Commara, M., Labarga, L., Lachat, M., Lachner, K., Lagoda, J., Lakshmi, S. M., LamersJames, M., Langella, A., Laporte, J. -F., Last, D., Latham, N., Laveder, M., Lavitola, L., Lawe, M., Learned, J. G., Lee, Y., Lee, S. H., Silverio, D. Leon, Levorato, S., Lewis, S., Li, X., Li, W., Lin, C., Litchfield, R. P., Liu, S. L., Liu, Y. M., Long, K. R., Longhin, A., Moreno, A. Lopez, Lu, X., Ludovici, L., Lux, T., Machado, L. N., Maekawa, Y., Magaletti, L., Mahn, K., Mahtani, K. K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Martens, K., Marti, Ll., Martin, D. G. R., Martin, J. F., Martin, D., Martini, M., Maruyama, T., Matsubara, T., Matsumoto, R., Mattiazzi, M., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., McCauley, N., McElwee, J. M., McFarland, K. S., McGrew, C., McKean, J., Mefodiev, A., Megias, G. D., Mehta, P., Mellet, L., Menjo, H., Metelko, C., Mezzetto, M., Migenda, J., Mijakowski, P., Miki, S., Miller, E., Minamino, A., Mine, S., Mineev, O., Mirabito, J., Miura, M., Bueno, L. Molina, Moon, D. H., Mori, M., Moriyama, S., Morrison, P., Muñoz, A., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, Y., Nagai, K., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, K., Nakamura, K. D., Nakamura, T., Nakanishi, F., Nakano, Y., Nakaya, T., Nakayama, S., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Nguyen, D. T., Nicholson, M., Niewczas, K., Ninomiya, K., Nishijima, K., Nishimori, S., Nishimura, Y., Noguchi, Y., Nosek, T., Nova, F., Novella, P., Nugent, J. C., Odagawa, T., Okazaki, R., Okazawa, H., Okinaga, W., Okumura, K., Okusawa, T., Ommura, Y., Onda, N., Ospina, N., Osu, L., Oyama, Y., O'Flaherty, M., O'Keeffe, H. M., O'Sullivan, L., Périssé, L., Paganini, P., Palladino, V., Paolone, V., Pari, M., Park, R. G., Parlone, J., Pasternak, J., Payne, D., Penn, G. C., de Perio, P., Pershey, D., Pfaff, M., Pickering, L., Pintaudi, G., Pistillo, C., Pointon, B. W., Popov, B., Yrey, A. Portocarrero, Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Prasad, H., Pronost, G., Prouse, N. W., Pupilli, F., Quilain, B., Quyen, P. T., Raaf, J. L., Radermacher, T., Radicioni, E., Radics, B., Ramirez, M. A., Ramsden, R. M., Ratoff, P. N., Reh, M., Riccio, C., Richards, B., Rogly, R., Rondio, E., Roth, S., Roy, N., Rubbia, A., Russo, L., Rychter, A., Saenz, W., Sakai, S., Sakashita, K., Samani, S., Santos, A. D., Sato, Y., Sato, K., Schefke, T., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Seo, J. W., Sgalaberna, D., Shaikhiev, A., Shi, W., Shiba, H., Shibayama, R., Shigeta, N., Shima, S., Shimamura, R., Shimizu, K., Shinoki, M., Shiozawa, M., Shiraishi, Y., Shvartsman, A., Skrobova, N., Skwarczynski, K., Smy, M. B., Smyczek, D., Sobczyk, J. T., Sobel, H. W., Soler, F. J. P., Sonoda, Y., Speers, A. J., Spina, R., Stroke, Y., Suslov, I. A., Suvorov, S., Suzuki, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sánchez, F., Tada, T., Tada, M., Tairafune, S., Takagi, Y., Takeda, A., Takemoto, Y., Takeuchi, Y., Takhistov, V., Takifuji, K., Tanaka, H., Tanaka, H. K., Tanigawa, H., Taniuchi, N., Tano, T., Tarrant, A., Tashiro, T., Teklu, A., Terada, K., Tereshchenko, V. V., Thamm, N., Thiesse, M. D., Thompson, L. F., Toki, W., Tomiya, T., Touramanis, C., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M. R., Vargas, D., Varghese, M., Vasseur, G., Villa, E., Vinning, W. G. S., Virginet, U., Vladisavljevic, T., Wachala, T., Wakabayashi, D., Wallace, H. T., Walsh, J. G., Walter, C. W., Wan, L., Wang, X., Wang, Y., Wark, D., Wascko, M. O., Watanabe, E., Weber, A., Wendell, R. A., Wester, T., Wilking, M. J., Wilkinson, C., Wilson, S. T., Wilson, J. R., Wood, K., Wret, C., Wu, Y., Xia, J., Xie, Z., Xu, B. D., Xu, Y. -H., Yamamoto, K., Yamamoto, T., Yamauchi, K., Yanagisawa, C., Yang, G., Yang, B. S., Yang, J. Y., Yankelevich, A., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoo, J., Yoshida, T., Yoshida, S., Yoshimoto, Y., Yoshimura, N., Yoshioka, Y., Yu, M., Yu, I., Zaki, R., Zaldivar, B., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhang, J., Zhang, A. Q., Zhang, B., Zhao, X. Y., Zhong, H., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zsoldos, S.

Subjects
High Energy Physics - Experiment
Abstract

The Super-Kamiokande and T2K collaborations present a joint measurement of neutrino oscillation parameters from their atmospheric and beam neutrino data. It uses a common interaction model for events overlapping in neutrino energy and correlated detector systematic uncertainties between the two datasets, which are found to be compatible. Using 3244.4 days of atmospheric data and a beam exposure of $19.7(16.3) \times 10^{20}$ protons on target in (anti)neutrino mode, the analysis finds a 1.9$\sigma$ exclusion of CP-conservation (defined as $J_{CP}=0$) and a preference for the normal mass ordering., Comment: 10 pages, 3 figures

Published
2024

2. PDS 70 unveiled by star-hopping: total intensity, polarimetry and mm-imaging modeled in concert

Author

Wahhaj, Z., Benisty, M., Ginski, C., Swastik, C., Arora, S., van Holstein, R. G., De Rosa, R. J., Yang, B., Bae, J., and Ren, B.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Context. Most ground-based planet search direct imaging campaigns use angular differential imaging, which distorts the signal from extended sources like protoplanetary disks. In the case PDS 70, a young system with two planets found within the cavity of a protoplanetary disk, obtaining a reliable image of both planets and disk is essential to understanding planet-disk interactions. Aims. Our goals are to reveal the true intensity of the planets and disk without self-subtraction effects for the first time, search for new giant planets beyond separations of 0.1" and to study the morphology of the disk shaped by two massive planets. Methods. We present YJHK-band imaging, polarimetry, and spatially resolved spectroscopy of PDS 70 using near-simultaneous reference star differential imaging, also known as star-hopping. We created a radiative transfer model of the system to match the near-infrared imaging and polarimetric data, along with sub-millimeter imaging from ALMA. Furthermore, we extracted the spectra of the planets and the disk and compared them. Results. We find that the disk is quite flared with a scale height of ~15% at the outer edge of the disk at ~90 au, similar to some disks in the literature. The gap inside of ~50 au is estimated to have ~1% of the dust density of the outer disk. The Northeast outer disk arc seen in previous observations is likely the outer lip of the flared disk. Abundance ratios of grains estimated by the modeling indicate a shallow grain-size index > -2.7, instead of the canonical -3.5. There is both vertical and radial segregation of grains. Planet c is well separated from the disk and has a spectrum similar to planet b, clearly redder than the disk spectra. Planet c is possibly associated with the sudden flaring of the disk starting at ~50 au. No new planets > 5 Mj were found., Comment: Accepted to A&A on April 11, 2024. 20 pages, 19 figures

Published
2024
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3. Development of a data overflow protection system for Super-Kamiokande to maximize data from nearby supernovae

Author

Mori, M., Abe, K., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Okamoto, K., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Megias, G. D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., Machado, L. N., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Edwards, R., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Kotsar, Y., Ozaki, H., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Bronner, C., Feng, J., Hu, J. R., Hu, Z., Kawaune, M., Kikawa, T., LiCheng, F., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Wilking, M. J., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Kitagawa, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Martens, K., Tsui, K. M., Vagins, M. R., Valls, C. J., Xia, J., Kuze, M., Izumiyama, S., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Yoshida, T., Martin, J. F., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Prouse, N. W., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Hadley, D., Nicholson, M., Flaherty, M. O', Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Suzuki, S., and Wada, K.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics, High Energy Physics - Experiment
Abstract

Neutrinos from very nearby supernovae, such as Betelgeuse, are expected to generate more than ten million events over 10\,s in Super-Kamokande (SK). At such large event rates, the buffers of the SK analog-to-digital conversion board (QBEE) will overflow, causing random loss of data that is critical for understanding the dynamics of the supernova explosion mechanism. In order to solve this problem, two new DAQ modules were developed to aid in the observation of very nearby supernovae. The first of these, the SN module, is designed to save only the number of hit PMTs during a supernova burst and the second, the Veto module, prescales the high rate neutrino events to prevent the QBEE from overflowing based on information from the SN module. In the event of a very nearby supernova, these modules allow SK to reconstruct the time evolution of the neutrino event rate from beginning to end using both QBEE and SN module data. This paper presents the development and testing of these modules together with an analysis of supernova-like data generated with a flashing laser diode. We demonstrate that the Veto module successfully prevents DAQ overflows for Betelgeuse-like supernovae as well as the long-term stability of the new modules. During normal running the Veto module is found to issue DAQ vetos a few times per month resulting in a total dead time less than 1\,ms, and does not influence ordinary operations. Additionally, using simulation data we find that supernovae closer than 800~pc will trigger Veto module resulting in a prescaling of the observed neutrino data., Comment: 28 pages, 18 figures. Submitted to PTEP

Published
2024
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4. Measurements of the charge ratio and polarization of cosmic-ray muons with the Super-Kamiokande detector

Author

Kitagawa, H., Tada, T., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Okamoto, K., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Megias, G. D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchêne, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Calabria, N. F., Catanesi, M. G., Radicioni, E., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Périssé, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Kotsar, Y., Ozaki, H., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Jesús-Valls, C., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Terada, K., Ishitsuka, M., Ito, H., Kinoshita, T., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Yoshida, T., Martin, J. F., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Suzuki, S., and Wada, K.

Subjects
High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present the results of the charge ratio ($R$) and polarization ($P^{\mu}_{0}$) measurements using the decay electron events collected from 2008 September to 2022 June by the Super-Kamiokande detector. Because of its underground location and long operation, we performed high precision measurements by accumulating cosmic-ray muons. We measured the muon charge ratio to be $R=1.32 \pm 0.02$ $(\mathrm{stat.}{+}\mathrm{syst.})$ at $E_{\mu}\cos \theta_{\mathrm{Zenith}}=0.7^{+0.3}_{-0.2}$ $\mathrm{TeV}$, where $E_{\mu}$ is the muon energy and $\theta_{\mathrm{Zenith}}$ is the zenith angle of incoming cosmic-ray muons. This result is consistent with the Honda flux model while this suggests a tension with the $\pi K$ model of $1.9\sigma$. We also measured the muon polarization at the production location to be $P^{\mu}_{0}=0.52 \pm 0.02$ $(\mathrm{stat.}{+}\mathrm{syst.})$ at the muon momentum of $0.9^{+0.6}_{-0.1}$ $\mathrm{TeV}/c$ at the surface of the mountain; this also suggests a tension with the Honda flux model of $1.5\sigma$. This is the most precise measurement ever to experimentally determine the cosmic-ray muon polarization near $1~\mathrm{TeV}/c$. These measurement results are useful to improve the atmospheric neutrino simulations., Comment: 29 pages, 45 figures

Published
2024

5. Second gadolinium loading to Super-Kamiokande

Author

Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Uchida, Y., Berardi, V., Calabria, N. F., Catanesi, M. G., Radicioni, E., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Shi, W., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Jesus-Valls, C., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Terada, K., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., Suzuki, S., Scovell, P. R., Meehan, E., Bandac, I., Pena-Garay, C., Perez, J., Gileva, O., Lee, E. K., Leonard, D. S., Sakakieda, Y., Sakaguchi, A., Sueki, K., Takaku, Y., and Yamasaki, S.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The first loading of gadolinium (Gd) into Super-Kamiokande in 2020 was successful, and the neutron capture efficiency on Gd reached 50\%. To further increase the Gd neutron capture efficiency to 75\%, 26.1 tons of $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ was additionally loaded into Super-Kamiokande (SK) from May 31 to July 4, 2022. As the amount of loaded $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ was doubled compared to the first loading, the capacity of the powder dissolving system was doubled. We also developed new batches of gadolinium sulfate with even further reduced radioactive impurities. In addition, a more efficient screening method was devised and implemented to evaluate these new batches of $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$. Following the second loading, the Gd concentration in SK was measured to be $333.5\pm2.5$ ppm via an Atomic Absorption Spectrometer (AAS). From the mean neutron capture time constant of neutrons from an Am/Be calibration source, the Gd concentration was independently measured to be 332.7 $\pm$ 6.8(sys.) $\pm$ 1.1(stat.) ppm, consistent with the AAS result. Furthermore, during the loading the Gd concentration was monitored continually using the capture time constant of each spallation neutron produced by cosmic-ray muons,and the final neutron capture efficiency was shown to become 1.5 times higher than that of the first loaded phase, as expected., Comment: 34 pages, 13 figures, submitted to Nuclear Inst. and Methods in Physics Research, A

Published
2024
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6. Performance of SK-Gd's Upgraded Real-time Supernova Monitoring System

Author

Kashiwagi, Y., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointn, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchêne, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Périssé, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarrant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Wilking, M. J., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Jesús-Valls, C., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Kuze, M., Izumiyama, S., Matsumoto, R., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., and Suzuki, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Among multi-messenger observations of the next galactic core-collapse supernova, Super-Kamiokande (SK) plays a critical role in detecting the emitted supernova neutrinos, determining the direction to the supernova (SN), and notifying the astronomical community of these observations in advance of the optical signal. On 2022, SK has increased the gadolinium dissolved in its water target (SK-Gd) and has achieved a Gd concentration of 0.033%, resulting in enhanced neutron detection capability, which in turn enables more accurate determination of the supernova direction. Accordingly, SK-Gd's real-time supernova monitoring system (Abe te al. 2016b) has been upgraded. SK_SN Notice, a warning system that works together with this monitoring system, was released on December 13, 2021, and is available through GCN Notices (Barthelmy et al. 2000). When the monitoring system detects an SN-like burst of events, SK_SN Notice will automatically distribute an alarm with the reconstructed direction to the supernova candidate within a few minutes. In this paper, we present a systematic study of SK-Gd's response to a simulated galactic SN. Assuming a supernova situated at 10 kpc, neutrino fluxes from six supernova models are used to characterize SK-Gd's pointing accuracy using the same tools as the online monitoring system. The pointing accuracy is found to vary from 3-7$^\circ$ depending on the models. However, if the supernova is closer than 10 kpc, SK_SN Notice can issue an alarm with three-degree accuracy, which will benefit follow-up observations by optical telescopes with large fields of view., Comment: 38 pages, 29 figures, 6 tables

Published
2024

7. Solar neutrino measurements using the full data period of Super-Kamiokande-IV

Author

Collaboration, Super-Kamiokande, Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Imaizumi, S., Iyogi, K., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Kato, Y., Kishimoto, Y., Miki, S., Mine, S., Miura, M., Mochizuki, T., Moriyama, S., Nagao, Y., Nakahata, M., Nakano, Y., Nakayama, S., Noguchi, Y., Okada, T., Okamoto, K., Orii, A., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, R., Wang, X., Yoshida, S., Bravo-Berguno, D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Blaszczyk, F. d. M., Kachulis, C., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Weatherly, P., Yankelevich, A., Ganezer, K. S., Hill, J., Jang, M. C., Kim, J. Y., Lee, S., Lim, I. T., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Bernard, L., Coffani, A., Drapier, O., Hedri, S. El, Giampaolo, A., Imber, J., Mueller, Th. A., Paganini, P., Rogly, R., Quilain, B., Santos, A., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Matsuno, S., Iovine, N., Choi, K., Cao, S., Anthony, L. H. V., Litchfield, R. P., Prouse, N., Marin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Intonti, R. A., Radicioni, E., Calabria, N. F., De Rosa, G., Langella, A., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Friend, M., Hasegawa, T., Ishida, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Bhuiyan, N., Burton, G. T., Gao, J., Goldsack, A., Katori, T., Di Lodovico, F., Migenda, J., Sedgwick, S. Molina, Ramsden, R. M., Taani, M., Xie, Z., Zsoldos, S., Abe, KE., Hasegawa, M., Isobe, Y., Kotsar, Y., Miyabe, H., Ozaki, H., Shiozawa, T., Sugimoto, T., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Yamamoto, S., Zhong, H., Ashida, Y., Feng, J., Feng, L., Hayashino, T., Hirota, S., Hu, J. R., Hu, Z., Jiang, M., Kawaue, M., Kikawa, T., Mori, M., Nakamura, KE., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Pritchard, A., Tarrant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Murase, M., Ninomiya, K., Niwa, T., Tsukada, M., Yoshioka, Y., Frankiewicz, K., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jiang, J., Jia, M., Jung, C. K., Palomino, J. L., Santucci, G., Shi, W., Vilela, C., Yanagisawa, C., Fukuda, D., Hagiwara, K., Harada, M., Hino, Y., Horai, T., Ishino, H., Ito, S., Kitagawa, H., Koshio, Y., Ma, W., Nakanishi, F., Piplani, N., Sakai, S., Sakuda, M., Tada, T., Tano, T., Xu, C., Yamaguchi, R., Ishizuka, T., Kuno, Y., Barr, G., Barrow, D., Cook, L., Samani, S., Simpson, C., Wark, D., Holin, A. M., Nova, F., Jung, S., Yang, B., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Choi, Y., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Tairahune, S., Nishijima, K., Eguchi, A., Iwamoto, K., Nakagiri, K., Nakajima, Y., Ogawa, N., Shima, S., Watanabe, E., Yokoyama, M., Calland, R. G., Fujita, S., Jesus-Valls, C., Junjie, X., Ming, T. K., de Perio, P., Martens, K., Murdoch, M., Vagins, M. R., Izumiyama, S., Kuze, M., Matsumoto, R., Okajima, Y., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Ohta, K., Ommura, Y., Shinoki, M., Shigeta, N., Suganuma, T., Yamaguchi, K., Martin, J. F., Nantais, C. M., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Berkman, S., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Walker, J., Amanai, S., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Sasaki, R., Suzuki, S., and Wada, K.

Subjects
High Energy Physics - Experiment
Abstract

An analysis of solar neutrino data from the fourth phase of Super-Kamiokande~(SK-IV) from October 2008 to May 2018 is performed and the results are presented. The observation time of the data set of SK-IV corresponds to $2970$~days and the total live time for all four phases is $5805$~days. For more precise solar neutrino measurements, several improvements are applied in this analysis: lowering the data acquisition threshold in May 2015, further reduction of the spallation background using neutron clustering events, precise energy reconstruction considering the time variation of the PMT gain. The observed number of solar neutrino events in $3.49$--$19.49$ MeV electron kinetic energy region during SK-IV is $65,443^{+390}_{-388}\,(\mathrm{stat.})\pm 925\,(\mathrm{syst.})$ events. Corresponding $\mathrm{^{8}B}$ solar neutrino flux is $(2.314 \pm 0.014\, \rm{(stat.)} \pm 0.040 \, \rm{(syst.)}) \times 10^{6}~\mathrm{cm^{-2}\,s^{-1}}$, assuming a pure electron-neutrino flavor component without neutrino oscillations. The flux combined with all SK phases up to SK-IV is $(2.336 \pm 0.011\, \rm{(stat.)} \pm 0.043 \, \rm{(syst.)}) \times 10^{6}~\mathrm{cm^{-2}\,s^{-1}}$. Based on the neutrino oscillation analysis from all solar experiments, including the SK $5805$~days data set, the best-fit neutrino oscillation parameters are $\rm{sin^{2} \theta_{12,\,solar}} = 0.306 \pm 0.013 $ and $\Delta m^{2}_{21,\,\mathrm{solar}} = (6.10^{+ 0.95}_{-0.81}) \times 10^{-5}~\rm{eV}^{2}$, with a deviation of about 1.5$\sigma$ from the $\Delta m^{2}_{21}$ parameter obtained by KamLAND. The best-fit neutrino oscillation parameters obtained from all solar experiments and KamLAND are $\sin^{2} \theta_{12,\,\mathrm{global}} = 0.307 \pm 0.012 $ and $\Delta m^{2}_{21,\,\mathrm{global}} = (7.50^{+ 0.19}_{-0.18}) \times 10^{-5}~\rm{eV}^{2}$., Comment: 47 pages, 61 figures

Published
2023
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8. Atmospheric neutrino oscillation analysis with neutron tagging and an expanded fiducial volume in Super-Kamiokande I-V

Author

Collaboration, Super-Kamiokande, Wester, T., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R., Xie, Z., Zsoldos, S., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarrant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Wilking, M. J., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Holin, A., Nova, F., Samani, S., Wark, D., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Koshiba, M., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., and Suzuki, S.

Subjects
High Energy Physics - Experiment
Abstract

We present a measurement of neutrino oscillation parameters with the Super-Kamiokande detector using atmospheric neutrinos from the complete pure-water SK I-V (April 1996-July 2020) data set, including events from an expanded fiducial volume. The data set corresponds to 6511.3 live days and an exposure of 484.2 kiloton-years. Measurements of the neutrino oscillation parameters $\Delta m^2_{32}$, $\sin^2\theta_{23}$, $\sin^2 \theta_{13}$, $\delta_{CP}$, and the preference for the neutrino mass ordering are presented with atmospheric neutrino data alone, and with constraints on $\sin^2 \theta_{13}$ from reactor neutrino experiments. Our analysis including constraints on $\sin^2 \theta_{13}$ favors the normal mass ordering at the 92.3% level., Comment: 24 pages, 18 figures

Published
2023
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9. Measurement of the neutrino-oxygen neutral-current quasielastic cross section using atmospheric neutrinos in the SK-Gd experiment

Author

Sakai, S., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Calabria, N. F., Catanesi, M. G., Radicioni, E., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Suzuki, A. T., Takagi, Y., Zhong, H., Takeuchi, Y., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Wilking, M. J., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., and Suzuki, S.

Subjects
High Energy Physics - Experiment
Abstract

We report the first measurement of the atmospheric neutrino-oxygen neutral-current quasielastic (NCQE) cross section in the gadolinium-loaded Super-Kamiokande (SK) water Cherenkov detector. In June 2020, SK began a new experimental phase, named SK-Gd, by loading 0.011% by mass of gadolinium into the ultrapure water of the SK detector. The introduction of gadolinium to ultrapure water has the effect of improving the neutron-tagging efficiency. Using a 552.2 day data set from August 2020 to June 2022, we measure the NCQE cross section to be 0.74 $\pm$ 0.22(stat.) $^{+0.85}_{-0.15}$ (syst.) $\times$ 10$^{-38}$ cm$^{2}$/oxygen in the energy range from 160 MeV to 10 GeV, which is consistent with the atmospheric neutrino-flux-averaged theoretical NCQE cross section and the measurement in the SK pure-water phase within the uncertainties. Furthermore, we compare the models of the nucleon-nucleus interactions in water and find that the Binary Cascade model and the Liege Intranuclear Cascade model provide a somewhat better fit to the observed data than the Bertini Cascade model. Since the atmospheric neutrino-oxygen NCQE reactions are one of the main backgrounds in the search for diffuse supernova neutrino background (DSNB), these new results will contribute to future studies - and the potential discovery - of the DSNB in SK., Comment: 8 pages, 3 figures

Published
2023

10. Search for Periodic Time Variations of the Solar $^8$B Neutrino Flux between 1996 and 2018 in Super-Kamiokande

Author

Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Lee, S. H., Moon, D. H., Park, R. G., Jang, M. C., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Xie, Z., Ramsden, R. M., Zsoldos, S., Suzuki, A. T., Takagi, Y., Zhong, H., Takeuchi, Y., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kikawa, T., Mori, M., Kawaue, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Wilking, M. J., Yanagisawa, C., Shi, W., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Yang, B. S., Yang, J. Y., Yoo, J., Jung, S., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., Flaherty, M. O, Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., and Suzuki, S.

Subjects
High Energy Physics - Experiment
Abstract

We report a search for time variations of the solar $^8$B neutrino flux using 5804 live days of Super-Kamiokande data collected between May 31, 1996, and May 30, 2018. Super-Kamiokande measured the precise time of each solar neutrino interaction over 22 calendar years to search for solar neutrino flux modulations with unprecedented precision. Periodic modulations are searched for in a dataset comprising five-day interval solar neutrino flux measurements with a maximum likelihood method. We also applied the Lomb-Scargle method to this dataset to compare it with previous reports. The only significant modulation found is due to the elliptic orbit of the Earth around the Sun. The observed modulation is consistent with astronomical data: we measured an eccentricity of (1.53$\pm$0.35)\%, and a perihelion shift of ($-$1.5$\pm$13.5) days., Comment: 8 pages, 5 figures, 2 tables, and data file: "sksolartimevariation5804d.txt" (the data file updated with additional 3 columns -- R^2 correction, upper-error, lower-error)

Published
2023

11. Morphological evidence for nanoflares heating warm loops in the solar corona

Author

Bi, Y., Yang, J. J., Qin, Y., Qiang, Z. P., Hong, J. C., Yang, B., Xu, Z., Liu, H., and Ji, K. F.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Nanoflares are impulsive energy releases by magnetic reconnection in the braided coronal magnetic field, which is a potential mechanism for heating the corona. However, there are still sporadic observations of the interchange of braiding structure segments and footpoints inside coronal loops, which is predicted to be the morphological evolution of the reconnecting magnetic bundles in the nanoflare picture. This work aims to detect the evolutions of the pairs of braiding strands within the apparent single coronal loops observed in Atmospheric Imaging Assembly (AIA) images. The loop strands are detected on two kinds of upsampled AIA 193 \AA\ images, which are obtained by upscaling the Point Spread Function matched AIA images via Bicubic interpolation and are generated using a super-resolution convolutional neural network, respectively. The architecture of the network is designed to map the AIA images to unprecedentedly high spatial resolution coronal images taken by High-resolution Coronal Imager (Hi-C) during its brief flight. At times, pairs of separate strands that appear braided together later evolved into pairs of almost parallel strands with completely exchanged parts. These evolutions offer morphological evidence that magnetic reconnections between the braiding strands have taken place, which is further supported by the appearance of transient hot emissions containing significant high-temperature components (T > 5MK) at the footpoints of the braiding structures. The brief appearances of the two rearranging strands support that magnetic reconnections have occurred within what appears to be a single AIA loop., Comment: Accepted for publication in Astronomy & Astrophysics

Published
2023
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12. Gender-Dependent Association of Pulmonary Hypertension with Adverse Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement

Author

Wang C, Yang B, Luo S, Zheng S, Sun Y, Chen J, Fan R, Luo J, and Li J

Subjects
transcatheter aortic valve replacement, gender, pulmonary hypertension, outcome, Medicine (General), R5-920
Abstract

Changjin Wang,1,* Bangyuan Yang,1,* Songyuan Luo,1 Shengneng Zheng,2 Yinghao Sun,1 Jiaohua Chen,1 Ruixin Fan,3 Jianfang Luo,1,* Jie Li1,* 1Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Radiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China; 3Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Li; Jianfang Luo, Email leomoku1981@163.com; jianfangluo@sina.comBackground: The relationship between pulmonary hypertension (PH) and outcomes after transcatheter aortic valve replacement (TAVR) has been shown to be unfavorable. The impact of gender on TAVR outcomes remains controversial. There have been no studies evaluating the simultaneous effects of both factors on TAVR outcomes.Methods: We retrospectively analyzed a prospective cohort of patients who underwent TAVR between January 2016 and December 2022. The patients were stratified by gender and the presence of PH. The primary outcome of the study was all-cause mortality. Secondary outcome was a composite of all-cause mortality and heart failure hospitalization.Results: We identified a total of 133 female patients without PH, 179 males without PH, 87 females with PH, and 122 males with PH. The median follow-up period was 18 months. Female patients without PH demonstrated a lower cumulative mortality rate compared to those with male gender and/or PH. Adjusted multivariate Cox proportional hazard analyses revealed that male gender and PH status, either individually or in combination, were independently associated with long-term mortality when compared to female patients without PH. Specifically, females with PH (HR 6.80, 95% confidence interval (CI): 1.49– 31.12, P=0.013), males without PH (HR 6.45, 95% CI: 1.47– 28.22, P=0.013), and males with PH (HR 7.2, 95% CI: 1.63– 31.81, P=0.009) demonstrated significantly higher risk for mortality.Conclusion: Patients who were male or had PH status had a higher risk of mortality. However, there was no synergistic effect between being male and having PH on the prognosis after TAVR.Keywords: transcatheter aortic valve replacement, gender, pulmonary hypertension, outcome

Published
2024

13. How Daily Job Insecurity Links to Next-Day Ingratiation: The Roles of Emotional Exhaustion and Power Distance Orientation

Author

Yang B, Zhao C, Zhu Y, and Li X

Subjects
job insecurity, emotional exhaustion, power distance, ingratiation, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract

Bo Yang, Chaoyue Zhao, Yao Zhu, Xianchun Li School of Psychology and Cognitive Science, East China Normal University, Shanghai, People’s Republic of ChinaCorrespondence: Bo Yang, School of Psychology and Cognitive Science, East China Normal University, Shanghai, People’s Republic of China, Email 52163200021@stu.ecnu.edu.cnPurpose: Numerous empirical studies consistently support the detrimental impact of job insecurity (JI) on employees. However, a new perspective suggests that individuals perceiving JI may proactively take measures to protect their positions. Drawing from the conservation of resources theory, this study argues that perceived resource loss due to JI motivates employees to engage in ingratiating behaviors for expanding their social capital. Additionally, this study empirically establishes the mediating role of emotional exhaustion and the moderating effect of power distance.Methods: A daily diary design was used to examine the relationship between daily JI and next-day ingratiation. Our analyses of data collected from 134 full‐time employees across 10 consecutive working days using multi-level model.Results: Our results showed that daily JI was found to affect next-day ingratiation (γ = 0.14, p < 0.01), and this relationship was mediated by emotional exhaustion (indirect effect = 0.07, p < 0.05, 95% CI [0.01, 0.13]). Power distance moderated the relationship between emotional exhaustion and ingratiation (γ = 0.25, p < 0.001), and further moderated the indirect effect of JI on ingratiation via emotional exhaustion.Conclusion: Our study has revealed that JI serves as a catalyst for employees to engage in resource creation behavior, thereby contributing to a deeper understanding of the implications of JI as an independent variable for both scholars and businesses.Keywords: job insecurity, emotional exhaustion, power distance, ingratiation

Published
2024

14. Analysis of Grip Strength and Its Explanatory Factors in Older Patients with Gastrointestinal Tumours

Author

Yu W, Qiu J, Jiang X, Xie H, Cai Z, and Yang B

Subjects
gastrointestinal tumour, grip strength, analysis of explanatory factors, nursing, Medicine (General), R5-920
Abstract

Weifei Yu,1,&ast; Jingxia Qiu,2,&ast; Ximing Jiang,2 Haofen Xie,2 Zejun Cai,2 Bin Yang2 1Ningbo Hospital of Traditional Chinese Medicine, Ningbo, 315000, People’s Republic of China; 2The First Affiliated Hospital of Ningbo University(Yuehu Courtyard), Ningbo, 315000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Haofen Xie, The First Affiliated Hospital of Ningbo University(Yuehu Courtyard), No. 59 of Liuting Street, Haishu District, Ningbo, 315010, People’s Republic of China, Tel +86 13867889859, Email xihfff2022@126.comAim: To investigate the grip strength of older patients with gastrointestinal tumours and analyse its explanatory factors.Methods: A total of 170 older patients with gastrointestinal tumours admitted to the Gastrointestinal Surgery Department of a Grade-III hospital in the Zhejiang province from January 2022 to December 2022 were selected as the investigation participants. Among them, there were 102 cases of gastric cancer (60.0%) and 68 cases of colon cancer (40.0%). There were 110 male patients (64.7%) and 60 female patients (35.3%), with patient ages ranging between 64 and 82 years old. A cross-sectional survey was conducted using a general data questionnaire, grip apparatus and the Nutritional Risk Screening 2002 (NRS-2002) score. Multiple linear regression was used to analyse the explanatory factors on the grip strength of older patients with gastrointestinal tumours.Results: The grip strength of older patients with gastrointestinal tumours was 25.3± 5.3 kg. Multiple linear regression analysis showed that gender, age, disease, body mass index (BMI), albumin concentration and the NRS-2002 score were the main explanatory factors on grip strength (P< 0.05).Conclusion: Grip strength was lower in older patients with gastrointestinal tumours and was lower in females, those aged ≥ 70 years, patients with colorectal cancer, individuals with a BMI of < 18.5, those with an albumin concentration of < 35g/l and those with an NRS2002 score of ≥ 3. Clinical staff should dynamically evaluate the level of grip strength in patients with gastrointestinal tumors and develop individualized interventions based on the related explanatory factors.Keywords: gastrointestinal tumour, grip strength, analysis of explanatory factors, nursing

Published
2024

15. Liquid-Based Cytology of Small Cell Carcinoma of the Cervix: A Multicenter Retrospective Study

Author

Liu Y, Li M, Wan Y, Yang B, Li D, and Wang S

Subjects
cervical cytology, small cell carcinoma, cervical cancer, diagnostic rate, neuroendocrine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Yun Liu,1,&ast; Meirong Li,2,&ast; Yan Liu,3 Yu Wan,1 Bo Yang,1 Dan Li,4 Shaohua Wang1 1Department of Pathology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, 646000, People’s Republic of China; 2Department of Pathology, Deyang People’s Hospital, Deyang, Sichuan Province, 618099, People’s Republic of China; 3Department of Pathology, Chengdu Women and Children’s Central Hospital, Chengdu, Sichuan Province, 610073, People’s Republic of China; 4Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, 646000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Shaohua Wang, Department of Pathology, the Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, Sichuan, 646000, People’s Republic of China, Email wangshaohua20006@163.comBackground/Aims: There are currently few reports describing the liquid-based cytological characteristics of small cell neuroendocrine carcinoma of the cervix. This study aimed to retrospectively analyze these features to reduce missed or misdiagnosis.Methods: A total of 11 patients with histologically diagnosed small cell carcinoma of the cervix from three hospitals between 2017 and 2023 were included in this study. The cytological morphology of small cell carcinoma of the cervix and causes of missed or misdiagnosis were analyzed and summarized through a review of clinical data, liquid-based cytology, histology, immunohistochemistry, and human papillomaviruses (HPV) test results.Results: In this study, the positivity rate of preliminary cytological screening was 63.6% (7/11); however, no cases were accurately diagnosed as small cell carcinoma of the cervix. A total of 36.4% (4/11) of small cell carcinoma of the cervix cases were cytologically negative; retrospective cytology found that two of these were false negatives. The main cytological features of small cell carcinoma of the cervix were summarized. Most of the liquid-based cytology smear cells were dense, and almost all cases showed clustered and scattered cytoplasm-scanty tumor cells. The tumor cells were all deeply stained and relatively consistent small cells. Most cases showed typical nuclear molding, chromatin stippling, and no obvious nucleoli. Mild nuclear smears, nuclear fragments, and mitotic figures were seen in most cases.Conclusion: Liquid-based cytology has a high rate of missed diagnosis and misdiagnosis in small cell carcinoma of the cervix. This study confirms that reviewing cytology results can effectively reduce this proportion and that increasing understanding of small cell carcinoma of the cervix morphology is conducive to improving the cytology-based diagnosis rate.Keywords: cervical cytology, small cell carcinoma, cervical cancer, diagnostic rate, neuroendocrine

Published
2024

16. Development and Validation of a Community–Based Prediction Model for Depression in Elderly Patients with Diabetes: A Cross–Sectional Study

Author

Li S, Zhang L, Yang B, Huang Y, Guan Y, Huang N, Wu Y, Wang W, Wang Q, Cai H, Sun Y, Xu Z, and Wu Q

Subjects
prediction model, depression, elderly, diabetes, community–based, Specialties of internal medicine, RC581-951
Abstract

Shanshan Li,1,2 Le Zhang,3 Boyi Yang,3 Yi Huang,3 Yuqi Guan,3 Nanbo Huang,1 Yingnan Wu,1 Wenshuo Wang,1 Qing Wang,1 Haochen Cai,1 Yong Sun,1 Zijun Xu,1 Qin Wu1,2 1Medical College, Jiangsu Vocational College of Medicine, Yancheng, People’s Republic of China; 2Jiangsu Engineering Research Centers for Cardiovascular and Cerebrovascular Disease and Cancer Prevention and Control, Jiangsu Vocational College of Medicine, Yancheng, People’s Republic of China; 3Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Qin Wu, Medical College, Jiangsu Vocational College of Medicine, No. 283, South Jiefang Road, Yancheng, 224005, People’s Republic of China, Tel +86-515-88159750, Email hhwuq@163.comBackground: In elderly diabetic patients, depression is often overlooked because professional evaluation requires psychiatrists, but such specialists are lacking in the community. Therefore, we aimed to create a simple depression screening model that allows earlier detection of depressive disorders in elderly diabetic patients by community health workers.Methods: The prediction model was developed in a primary cohort that consisted of 210 patients with diabetes, and data were gathered from December 2022 to February 2023. The independent validation cohort included 99 consecutive patients from February 2023 to March 2023. Multivariable logistic regression analysis was used to develop the predictive model. We incorporated common demographic characteristics, diabetes–specific factors, family structure characteristics, the self–perceived burden scale (SPBS) score, and the family APGAR (adaptation, partnership, growth, affection, resolution) score. The performance of the nomogram was assessed with respect to its calibration (calibration curve, the Hosmer–Lemeshow test), discrimination (the area under the curve (AUC)), and clinical usefulness (Decision curve analysis (DCA)).Results: The prediction nomogram incorporated 5 crucial factors such as glucose monitoring status, exercise status, monthly income, sleep disorder status, and the SPBS score. The model demonstrated strong discrimination in the primary cohort, with an AUC of 0.839 (95% CI, 0.781– 0.897). This discriminative ability was further validated in the validation cohort, with an AUC of 0.857 (95% CI, 0.779– 0.935). Moreover, the nomogram exhibited satisfactory calibration. DCA suggested that the prediction of depression in elderly patients with diabetes mellitus was of great clinical value.Conclusion: The prediction model provides precise and user–friendly guidance for community health workers in preliminary screenings for depression among elderly patients with diabetes.Keywords: prediction model, depression, elderly, diabetes, community–based

Published
2024

17. Search for astrophysical electron antineutrinos in Super-Kamiokande with 0.01wt% gadolinium-loaded water

Author

Harada, M., Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Okamoto, K., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Megias, G. D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., Machado, L. N., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Xie, Z., Zsoldos, S., Kotsar, Y., Ozaki, H., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarrant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Wilking, M. J., Yanagisawa, C., Hino, Y., Ishino, H., Kitagawa, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Kuze, M., Izumiyama, S., Matsumoto, R., Ishitsuka, M., Ito, H., Kinoshita, T., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Martin, J. F., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Prouse, N. W., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., Flaherty, M. O, Richards, B., Ali, A., Jamieson, B., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Suzuki, S., and Wada, K.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment, Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

We report the first search result for the flux of astrophysical electron antineutrinos for energies O(10) MeV in the gadolinium-loaded Super-Kamiokande (SK) detector. In June 2020, gadolinium was introduced to the ultra-pure water of the SK detector in order to detect neutrons more efficiently. In this new experimental phase, SK-Gd, we can search for electron antineutrinos via inverse beta decay with efficient background rejection and higher signal efficiency thanks to the high efficiency of the neutron tagging technique. In this paper, we report the result for the initial stage of SK-Gd with a $22.5\times552$ $\rm kton\cdot day$ exposure at 0.01% Gd mass concentration. No significant excess over the expected background in the observed events is found for the neutrino energies below 31.3 MeV. Thus, the flux upper limits are placed at the 90% confidence level. The limits and sensitivities are already comparable with the previous SK result with pure-water ($22.5 \times 2970 \rm kton\cdot day$) owing to the enhanced neutron tagging.

Published
2023
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18. Smart Construction Engineering and Management

Author

Yang, B., Hao, J., Ma, W., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Papadikis, Konstantinos, editor, Zhang, Cheng, editor, Tang, Shu, editor, Liu, Engui, editor, and Di Sarno, Luigi, editor

Published
2024
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19. Internal Crack Detection and Cross-Section Reconstruction of Reinforced Concrete Structure Based on Ultrasonic Tomography and Deep Learning

Author

Yang, H., Li, S. H., Wang, X. Y., Yang, B., Wang, S. X., Shu, J. P., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Gu, Xiang-Lin, editor, Motavalli, Masoud, editor, Ilki, Alper, editor, and Yu, Qian-Qian, editor

Published
2024
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20. STCF Conceptual Design Report: Volume 1 -- Physics & Detector

Author

Achasov, M., Ai, X. C., Aliberti, R., An, L. P., An, Q., Bai, X. Z., Bai, Y., Bakina, O., Barnyakov, A., Blinov, V., Bobrovnikov, V., Bodrov, D., Bogomyagkov, A., Bondar, A., Boyko, I., Bu, Z. H., Cai, F. M., Cai, H., Cao, J. J., Cao, Q. H., Cao, Z., Chang, Q., Chao, K. T., Chen, D. Y., Chen, H., Chen, H. X., Chen, J. F., Chen, K., Chen, L. L., Chen, P., Chen, S. L., Chen, S. M., Chen, S., Chen, S. P., Chen, W., Chen, X. F., Chen, X., Chen, Y., Chen, Y. Q., Cheng, H. Y., Cheng, J., Cheng, S., Dai, J. P., Dai, L. Y., Dai, X. C., Dedovich, D., Denig, A., Denisenko, I., Ding, D. Z., Dong, L. Y., Dong, W. H., Druzhinin, V., Du, D. S., Du, Y. J., Du, Z. G., Duan, L. M., Epifanov, D., Fan, Y. L., Fang, S. S., Fang, Z. J., Fedotovich, G., Feng, C. Q., Feng, X., Feng, Y. T., Fu, J. L., Gao, J., Ge, P. S., Geng, C. Q., Geng, L. S., Gilman, A., Gong, L., Gong, T., Gradl, W., Gu, J. L., Escalante, A. G., Gui, L. C., Guo, F. K., Guo, J. C., Guo, J., Guo, Y. P., Guo, Z. H., Guskov, A., Han, K. L., Han, L., Han, M., Hao, X. Q., He, J. B., He, S. Q., He, X. G., He, Y. L., He, Z. B., Heng, Z. X., Hou, B. L., Hou, T. J., Hou, Y. R., Hu, C. Y., Hu, H. M., Hu, K., Hu, R. J., Hu, X. H., Hu, Y. C., Hua, J., Huang, G. S., Huang, J. S., Huang, M., Huang, Q. Y., Huang, W. Q., Huang, X. T., Huang, X. J., Huang, Y. B., Huang, Y. S., Hüsken, N., Ivanov, V., Ji, Q. P., Jia, J. J., Jia, S., Jia, Z. K., Jiang, H. B., Jiang, J., Jiang, S. Z., Jiao, J. B., Jiao, Z., Jing, H. J., Kang, X. L., Kang, X. S., Ke, B. C., Kenzie, M., Khoukaz, A., Koop, I., Kravchenko, E., Kuzmin, A., Lei, Y., Levichev, E., Li, C. H., Li, C., Li, D. Y., Li, F., Li, G., Li, H. B., Li, H., Li, H. N., Li, H. J., Li, H. L., Li, J. M., Li, J., Li, L., Li, L. Y., Li, N., Li, P. R., Li, R. H., Li, S., Li, T., Li, W. J., Li, X. H., Li, X. Q., Li, Y., Li, Y. Y., Li, Z. J., Liang, H., Liang, J. H., Liao, G. R., Liao, L. Z., Liao, Y., Lin, C. X., Lin, X. S., Liu, B. J., Liu, C. W., Liu, D., Liu, F., Liu, G. M., Liu, H. B., Liu, J., Liu, J. J., Liu, J. B., Liu, K., Liu, K. Y., Liu, L., Liu, Q., Liu, S. B., Liu, T., Liu, X., Liu, Y. W., Liu, Y., Liu, Y. L., Liu, Z. Q., Liu, Z. Y., Liu, Z. W., Logashenko, I., Long, Y., Lu, C. G., Lu, N., Lü, Q. F., Lu, Y., Lv, Z., Lukin, P., Luo, F. J., Luo, T., Luo, X. F., Lyu, H. J., Lyu, X. R., Ma, J. P., Ma, P., Ma, Y., Maas, F., Malde, S., Matvienko, D., Meng, Z. X., Mitchell, R., Dias, J. M., Nefediev, A., Nefedov, Y., Olsen, S. L., Ouyang, Q., Pakhlov, P., Pakhlova, G., Pan, X., Pan, Y., Passemar, E., Pei, Y. P., Peng, H. P., Peng, L., Peng, X. Y., Peng, X. J., Peters, K., Pivovarov, S., Pyata, E., Qi, B. B., Qi, Y. Q., Qian, W. B., Qian, Y., Qiao, C. F., Qin, J. J., Qin, L. Q., Qin, X. S., Qiu, T. L., Rademacker, J., Redmer, C. F., Sang, H. Y., Saur, M., Shan, W., Shan, X. Y., Shang, L. L., Shao, M., Shekhtman, L., Shen, C. P., Shen, J. M., Shen, Z. T., Shi, H. C., Shi, X. D., Shwartz, B., Sokolov, A., Song, J. J., Song, W. M., Song, Y., Song, Y. X., Sukharev, A., Sun, J. F., Sun, L., Sun, X. M., Sun, Y. J., Sun, Z. P., Tang, J., Tang, S. S., Tang, Z. B., Tian, C. H., Tian, J. S., Tikhonov, Y., Todyshev, K., Uglov, T., Vorobyev, V., Wan, B. D., Wang, B. L., Wang, B., Wang, D. Y., Wang, G. Y., Wang, G. L., Wang, H. L., Wang, J., Wang, J. H., Wang, J. C., Wang, M. L., Wang, R., Wang, S. B., Wang, W., Wang, W. P., Wang, X. C., Wang, X. D., Wang, X. L., Wang, X. P., Wang, X. F., Wang, Y. D., Wang, Y. P., Wang, Y. Q., Wang, Y. L., Wang, Y. G., Wang, Z. Y., Wang, Z. L., Wang, Z. G., Wei, D. H., Wei, X. L., Wei, X. M., Wen, Q. G., Wen, X. J., Wilkinson, G., Wu, B., Wu, J. J., Wu, L., Wu, P. W., Wu, T. W., Wu, Y. S., Xia, L., Xiang, T., Xiao, C. W., Xiao, D., Xiao, M., Xie, Y. H., Xing, Y., Xing, Z. Z., Xiong, X. N., Xu, F. R., Xu, J., Xu, L. L., Xu, Q. N., Xu, X. C., Xu, X. P., Xu, Y. C., Xu, Y. P., Xu, Y., Xu, Z. Z., Xuan, D. W., Xue, F. F., Yan, L., Yan, M. J., Yan, W. B., Yan, W. C., Yan, X. S., Yang, B. F., Yang, C., Yang, H. J., Yang, H. R., Yang, H. T., Yang, J. F., Yang, S. L., Yang, Y. D., Yang, Y. H., Yang, Y. S., Yang, Y. L., Yang, Z. Y., Yao, D. L., Yin, H., Yin, X. H., Yokozaki, N., You, S. Y., You, Z. Y., Yu, C. X., Yu, F. S., Yu, G. L., Yu, H. L., Yu, J. S., Yu, J. Q., Yuan, L., Yuan, X. B., Yue, Y. F., Zeng, M., Zeng, S., Zhang, A. L., Zhang, B. W., Zhang, G. Y., Zhang, G. Q., Zhang, H. J., Zhang, H. B., Zhang, J. Y., Zhang, J. L., Zhang, J., Zhang, L., Zhang, L. M., Zhang, R., Zhang, S. L., Zhang, T., Zhang, X., Zhang, Y., Zhang, Y. X., Zhang, Y. T., Zhang, Y. F., Zhang, Y. C., Zhang, Y. M., Zhang, Y. L., Zhang, Z. H., Zhang, Z. Y., Zhao, H. Y., Zhao, J., Zhao, L., Zhao, M. G., Zhao, Q., Zhao, R. G., Zhao, R. P., Zhao, Z. G., Zhao, Z. X., Zhemchugov, A., Zheng, B., Zheng, L., Zheng, Q. B., Zheng, R., Zheng, Y. H., Zhong, X. H., Zhou, H. J., Zhou, H. Q., Zhou, H., Zhou, S. H., Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, Y. L., Zhou, Y., Zhou, Y. X., Zhou, Z. Y., Zhu, J. Y., Zhu, K., Zhu, R. D., Zhu, R. L., Zhu, S. H., Zhu, Y. C., Zhu, Z. A., Zhukova, V., Zhulanov, V., Zou, B. S., and Zuo, Y. B.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

The Super $\tau$-Charm facility (STCF) is an electron-positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of $0.5\times 10^{35}{\rm cm}^{-2}{\rm s}^{-1}$ or higher. The STCF will produce a data sample about a factor of 100 larger than that by the present $\tau$-Charm factory -- the BEPCII, providing a unique platform for exploring the asymmetry of matter-antimatter (charge-parity violation), in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions, as well as searching for exotic hadrons and physics beyond the Standard Model. The STCF project in China is under development with an extensive R\&D program. This document presents the physics opportunities at the STCF, describes conceptual designs of the STCF detector system, and discusses future plans for detector R\&D and physics case studies.

Published
2023
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21. Activity and composition of the hyperactive comet 46P/Wirtanen during its close approach in 2018

Author

Moulane, Y., Jehin, E., Manfroid, J., Hutsemékers, D., Opitom, C., Shinnaka, Y., Bodewits, D., Benkhaldoun, Z., Jabiri, A., Hmiddouch, S., Donckt, M. Vander, Pozuelos, F. J., and Yang, B.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Hyperactive comets are a small group of comets whose activity are higher than expected. They seem to emit more water than they should based on the size of their nucleus and comet 46P/Wirtanen is one of them. Investigating its activity and composition evolution could provide clues about its origins and formation region in the Solar nebulae. Given the exceptional close approach in 2018 of comet 46P to the Earth, we aim to study the evolution of its activity and composition as a function of heliocentric distances before and after perihelion. We used both TRAPPIST telescopes to monitor the comet for almost a year with broad-band and narrow-band filters. We derived the production rates of five gaseous species, e.g. OH, NH, CN, C$_3$ and C$_2$, using a Haser model as well as the A($\theta$)f$\rho$, dust proxy parameter. The comet was also observed with two optical high resolution spectrographs UVES and ESPRESSO mounted on the 8-m ESO VLT to measure the isotopic ratios of C and N, the oxygen forbidden lines ratios and the NH$_2$ ortho-to-para ratios. We followed during almost a year the rise and decline of the production rates of different species as well as the dust activity of 46P on both pre- and post-perihelion. Relative abundances with respect to CN and OH along the orbit of the comet show constant and symmetric abundance ratios and a typical coma composition. We determined the rotation period of the nucleus using high cadence observations and long series of CN images on several nights, and we obtained a value of (9.18$\pm$0.05) hr at perihelion. Using high resolution spectra of 46P coma, we derived C and N isotopic ratios of 100$\pm$20 and 150$\pm$30 and a green-to-red forbidden oxygen [OI] lines ratio of 0.23$\pm$0.02. We measured a NH$_2$ ortho-to-para ratio of 3.31$\pm$0.03 and derived an ammonia ratio of 1.19$\pm$0.03 corresponding to a spin temperature of 27$\pm$1 K., Comment: 10 pages, 10 figures

Published
2023
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22. The Association Between Sleep Problems and Attentional Network Functions in Patients with Self-Limited Epilepsy with Centrotemporal Spikes

Author

Jiang N, Yang CM, Wang JL, Ye XF, and Yang B

Subjects
selects, attention network function, sleep disorders, cshq, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Nan Jiang,1,2 Chun Mei Yang,1,2 Jia Le Wang,1,2 Xiao Fei Ye,1 Bin Yang1,2 1Children’s Medical Centre of Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2The Fifth Clinical College Affiliated to Anhui Medical University, Hefei, Anhui, People’s Republic of ChinaCorrespondence: Bin Yang, Children’s Medical Centre of Anhui Medical University, The Fifth Clinical College Affiliated to Anhui Medical University, Hefei, People’s Republic of China, Tel +86-13866127496, Email yangbin691202@163.comPurpose: To investigate sleep problems in children with self-limited epilepsy with central temporal spiking (SeLECTS) and to assess the relationship between sleep problems and attention network dysfunction.Patients and methods: 107 children 6– 14 years of age with SeLECTS and 90 age- and sex-matched healthy controls were recruited for this study. The sleep status of these participants was evaluated using the Children’s Sleep Habits Questionnaire (CSHQ), while attentional network function was assessed with the attention network function test (ANT).Results: Together, these analyses revealed that children with SeLECTS exhibited higher total CSHQ scores and sleep disorder incidence relative to healthy controls (P< 0.001). Children with SeLECTS had higher scores in delayed sleep onset, sleep duration, night awakenings, parasomnias, daytime sleepiness and sleep anxiety (P< 0.01). Total CSHQ scores were negatively correlated with average ANT correct rates (ρ= − 0.253, P< 0.01), while they were positively correlated with total reaction time (ρ=0.367, P< 0.01) and negatively correlated with the efficiency of the alerting and executive control networks (ρ=− 0.344 P< 0.01; ρ=− 0.418 P< 0.01).Conclusion: Children with SeLECTS face a higher risk of experiencing sleep disorders relative to age-matched healthy children, while also demonstrating that the magnitude of the impairment of attentional network function in these children is positively correlated with sleep disorder severity. Thus, the prognosis and quality of life of children with SeLECTS can be improved by interventions addressing sleep disorders.Keywords: SeLECTS, attention network function, sleep disorders, CSHQ

Published
2024

23. Identification of Potential Ferroptosis Biomarkers and Analysis of Immune Cell Infiltration in Psoriasis Using Machine Learning

Author

Wu X, Sun Y, Wei S, Hu H, and Yang B

Subjects
psoriasis, ferroptosis, biomarker, immune., Dermatology, RL1-803
Abstract

Xiaoyan Wu,1,2 Yuzhe Sun,2,3 Shuyi Wei,2,3 Huoyou Hu,1 Bin Yang2 1Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, People’s Republic of China; 2Department of Dermatology, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, People’s Republic of China; 3Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, 510091, People’s Republic of ChinaCorrespondence: Huoyou Hu, Shenzhen Second People’s Hospital, 3002 Sungang West Road, Shenzhen, Guangdong, 518035, People’s Republic of China, Tel +86-13554918106, Email huhuoyou1029@163.com Bin Yang, Jinan University, 601 West Huangpu Avenue, Guangzhou, Guangdong, 510632, People’s Republic of China, Tel +86-13922207231, Email yangbin1@smu.edu.cnBackground: Ferroptosis is a type of cell death characterized by the accumulation of iron-dependent lethal lipid peroxides, which is associated with various pathophysiological processes. Psoriasis is a chronic autoimmune skin disease accompanied by abnormal immune cell infiltration and excessive production of lipid reactive oxygen species (ROS). Currently, its pathogenesis remains elusive, especially the potential role of ferroptosis in its pathophysiological process.Methods: The microarrays GSE13355 (58 psoriatic skin specimens versus 122 healthy skin specimens) and the ferroptosis database were employed to identify the common differentially expressed genes (DEGs) associated with psoriasis and ferroptosis. The functions of common DEGs were investigated through functional enrichment analysis and protein-protein interaction analysis. The potential diagnostic markers for psoriasis among the common DEGs were identified using four machine-learning algorithms. DGIdb was utilized to explore potential therapeutic agents for psoriasis. Additionally, CIBERSORT was employed to investigate immune infiltration in psoriasis.Results: A total of 8 common DEGs associated with psoriasis and ferroptosis were identified, which are involved in intercellular signaling and affect pathways of cell response to stress and stimulation. Four machine-learning algorithms were employed to identify poly (ADP-ribose) polymerase 12 (PARP12), frizzled homolog 7 (FZD7), and arachidonate 15-lipoxygenase (ALOX15B) among the eight common DEGs as potential diagnostic markers for psoriasis. A total of 18 drugs targeting the five common DEGs were identified as potential candidates for treating psoriasis. Additionally, significant changes were observed in the immune microenvironment of patients with psoriasis.Conclusion: This study has contributed to our enhanced comprehension of ferroptosis-related genes as potential biomarkers for psoriasis diagnosis, as well as the alterations in the immune microenvironment associated with psoriasis. Our findings offer valuable insights into the diagnosis and treatment of psoriasis.Keywords: psoriasis, ferroptosis, biomarker, immune

Published
2024

24. Identification of Long Noncoding RNAs Expression Profiles Between Gallstone and Gallbladder Cancer Using Next-Generation Sequencing Analysis

Author

Wang Q, Bi P, Luo D, Cao P, Chen W, and Yang B

Subjects
gallstone, gallbladder cancer, long non-coding rna, next-generation sequencing analysis, computational biology, Medicine (General), R5-920
Abstract

Qiang Wang,&ast; Pinduan Bi,&ast; Ding Luo, Pingli Cao, Weihong Chen, Bin Yang Department of Hepatobiliary Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Bin Yang, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Wuhua District, Kunming, People’s Republic of China, Tel +86 013987642890, Email yangbin@kmmu.edu.cnBackground: Gallstone disease (GS) is an important risk factor for Gallbladder cancer (GBC). However, the mechanisms of the progression of GS to GBC remain unclear. Long non-coding RNA (lncRNA), modulates DNA/RNA/proteins at epigenetic, pre-transcriptional, transcriptional and posttranscriptional levels, and plays a potential therapeutic role in various diseases. This study aims to identify lncRNAs that have a potential impact on GS-promoted GBC progression.Methods and Results: Six GBC patients without GS, six normal gallbladder tissues, nine gallstones and nine GBC patients with GS were admitted to our hospital. The next-generation RNA-sequencing was performed to analyze differentially expressed (DE) lncRNA and messenger RNA (mRNA) in four groups. Then overlapping and specific molecular signatures were analyzed. We identified 29 co-DEGs and 500 co-DElncRNAs related to gallstone or GBC. The intersection and concatenation of co-DEGs and co-DElncRNA functionally involved in focal adhesion, Transcriptional misregulation in cancers, Protein digestion and absorption, and ECM-receptor interaction signaling pathways may contribute to the development of gallbladder cancer. Further exploration is necessary for early diagnosis and the potential treatment of GBC. FXYD2, MPZL1 and PAH were observed in both co-DEGs and co-DElncRNA and validated by qRT-PCR.Conclusion: Our data identified a series of DEGs and DElncRNAs, which were involved in the progression of GBC and GS-related metabolism pathways. Compared to GBC, the GS profile was more similar to para-tumor tissues in transcriptome level and lower risk of cancer. Further exploration is necessary from GBC patients with different periods of follow-up gallstone.Keywords: gallstone, gallbladder cancer, long non-coding RNA, next-generation sequencing analysis, computational biology

Published
2024

25. A Diagnostic Nomogram for Predicting Hypercapnic Respiratory Failure in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Author

Zhou Z, Wang Y, Yang B, Xu C, Wang S, and Yang W

Subjects
acute exacerbation of chronic obstructive pulmonary disease, hypercapnic respiratory failure, nomogram, prediction model, Diseases of the respiratory system, RC705-779
Abstract

Zihan Zhou,1,2,&ast; Yuhui Wang,2,3,&ast; Yongsheng Wang,1,2 Bo Yang,4 Chuchu Xu,1,2 Shuqin Wang,1,2 Wanchun Yang1,2 1Department of Respiratory and Critical Care Medicine, Hefei Hospital Affiliated to Anhui Medical University, The Second People’s Hospital of Hefei, Hefei, Anhui, 230011, People’s Republic of China; 2The Fifth Clinical College of Anhui Medical University, Hefei, Anhui, 230032, People’s Republic of China; 3Department of Cardiology, Hefei Hospital Affiliated to Anhui Medical University, Hefei, The Second People’s Hospital of Hefei, Hefei, Anhui, 230011, People’s Republic of China; 4Affiliated Hospital of West Anhui Health Vocational College, The Second People’s Hospital of Lu’an City, Lu’an, 237005, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wanchun Yang, Department of Respiratory and Critical Care Medicine, Hefei Hospital Affiliated to Anhui Medical University, The Second People’s Hospital of Hefei, Hefei, Anhui, 230011, People’s Republic of China, Email hfey2023@163.comPurpose: To develop and validate a nomogram for assessing the risk of developing hypercapnic respiratory failure (HRF) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Patients and Methods: From January 2019 to August 2023, a total of 334 AECOPD patients were enrolled in this research. We employed the Least Absolute Shrinkage and Selection Operator (LASSO) regression and multivariate logistic regression to determine independent predictors and develop a nomogram. This nomogram was appraised by the area under the receiver operating characteristic curve (AUC), calibration curve, Hosmer–Lemeshow goodness-of-fit test (HL test), decision curve analysis (DCA), and clinical impact curve (CIC). The enhanced bootstrap method was used for internal validation.Results: Sex, prognostic nutritional index (PNI), hematocrit (HCT), and activities of daily living (ADL) were independent predictors of HRF in AECOPD patients. The developed nomogram based on the above predictors showed good performance. The AUCs for the training, internal, and external validation cohorts were 0.841, 0.884, and 0.852, respectively. The calibration curves and HL test showed excellent concordance. The DCA and CIC showed excellent clinical usefulness. Finally, a dynamic nomogram was developed (https://a18895635453.shinyapps.io/dynnomapp/).Conclusion: This nomogram based on sex, PNI, HCT, and ADL demonstrated high accuracy and clinical value in predicting HRF. It is a less expensive and more accessible approach to assess the risk of developing HRF in AECOPD patients, which is more suitable for primary hospitals, especially in developing countries with high COPD-related morbidity and mortality.Keywords: acute exacerbation of chronic obstructive pulmonary disease, hypercapnic respiratory failure, nomogram, prediction model

Published
2024

26. Chinese Chronic Mucocutaneous Candidiasis: A Case Report Series

Author

Qian G, Zhang J, Shi L, Li D, Yang B, Chen B, and Shi D

Subjects
chronic mucocutaneous candidiasis, candida spp., diagnosis, treatment, Infectious and parasitic diseases, RC109-216
Abstract

Guocheng Qian,1 Jiaying Zhang,2 Leyao Shi,1 Dongmei Li,3 Biao Yang,4,5 Biao Chen,4 Dongmei Shi4,5 1The Second Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 2School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, People’s Republic of China; 3Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC, USA; 4Laboratory of Medical Mycology, Jining No. 1 People’s Hospital, Jining, Shandong Province, People’s Republic of China; 5Department of Dermatology, Jining No. 1 People’s Hospital, Jining, Shandong Province, People’s Republic of ChinaCorrespondence: Biao Chen; Dongmei Shi, Laboratory of Medical Mycology, Jining No. 1 People’s Hospital, No. 6, Jiankang Road, Jining, Shandong Province, 272067, People’s Republic of China, Email cbjn@mail.jnmc.edu.cn; shidongmei28@163.comAbstract: Chronic Mucocutaneous Candidiasis (CMC) is a rare immunodeficiency disease characterized by chronic or recurrent superficial Candida infections on the skin, nail, and mucous membranes. Here, we present four Chinese patients with CMC who manifested oral mucosal leukoplakia and nail thickening during early childhood, all displaying fissured tongue lines. The causative pathogens isolated from their oral mucosa and nails were identified as C. albicans and C. parapsilosis through morphology and molecular sequencing. Notably, among the four patients, one presented with vitiligo, while another had hypothyroidism. We have also conducted a review of reported cases of CMC in China and worldwide over the last five years, highlighting potential approaches for diagnosis and treatment. The current molecular evidence in the literature suggests potential for the development of early diagnosis methods, such as screening genetic variables on STAT1 and STAT3. Additionally, potential treatment avenues, including gene-targeted analogues and GM-CSF analogues, could be explored in conjunction with traditional antifungal therapy.Keywords: chronic mucocutaneous candidiasis, Candida spp., diagnosis, treatment

Published
2024

27. Assess the Outcomes of Transcatheter Aortic Valve Replacement in Bicuspid Valve with Mixed Disease versus Predominant Aortic Stenosis

Author

Wang C, Hu X, Luo S, Sun Y, Yang B, Zheng S, Chen J, Fu M, Fan R, Li J, and Luo J

Subjects
transcatheter aortic valve replacement, mixed aortic valve disease, bicuspid aortic valve, device success, propensity score match, Geriatrics, RC952-954.6
Abstract

Changjin Wang,1,&ast; Xiaolu Hu,1,2,&ast; Songyuan Luo,1,&ast; Yinghao Sun,1 Bangyuan Yang,1 Shengneng Zheng,3 Jiaohua Chen,1 Ming Fu,1 Ruixin Fan,4 Jie Li,1 Jianfang Luo1,2 1Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China; 2School of Medicine South China University of Technology, Guangzhou, People’s Republic of China; 3Department of Radiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China; 4Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jie Li; Jianfang Luo, Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, &num;96 Dongchuan Road, Yuexiu District, Guangzhou, Guangdong, 510080, People’s Republic of China, Tel +86-20-83827812, Fax +86-20-83875453, Email leomoku1981@163.com; jianfangluo@sina.comPurpose: In mixed aortic valve disease (MAVD), the results of transcatheter aortic valve replacement (TAVR) are conflicting. There is limited data on the outcomes of TAVR in patients with bicuspid aortic valve (BAV) and MAVD. The objective of this study is to compare outcomes after TAVR in BAV patients with MAVD and predominant aortic stenosis (PAS).Patients and Methods: Patients with BAV who underwent TAVR between January 2016 and April 2023 were included. The primary outcome was device success. The secondary endpoints were periprocedural mortality and other complications as defined by the Valve Academic Research Consortium-3 (VARC-3). Propensity score matching was used to minimize potential confounding.Results: A total of 262 patients were included in this study, 83 of whom had MAVD. The median age was 72 years, and 55.7% were male. The baseline comorbidity risk files were comparable between the two groups. Patients with MAVD had more mitral regurgitation, tricuspid regurgitation and pulmonary hypertension, larger annular and left ventricular outflow tract dimensions, and more severe calcification than PAS. In the unmatched population, MAVD patients had similar device success rate (69.9% vs 79.9%, P=0.075) and 30-day mortality (3.6% vs 3.4%, P=1) compared to PAS. Propensity score matching resulted in 66 patient pairs. Device success rate were still comparable in the matched population. Other clinical outcomes, including stroke, bleeding (type 2– 4), major vascular complications, acute kidney injury (stage 2– 4) and permanent pacemaker implantation, were comparable between the two groups. Multivariable logistic regression analysis did not show MAVD to be an independent negative predictor of device success. At one year, survival was similar between patients with MAVD and those with PAS.Conclusion: For the bicuspid valve, patients with MAVD had a more challenging anatomy. MAVD patients associated with comparable 30-day clinical outcomes after TAVR compared to PAS patients in patients with BAV.Keywords: transcatheter aortic valve replacement, mixed aortic valve disease, bicuspid aortic valve, device success, propensity score match

Published
2024

28. Long Non-Coding RNA B3GALT5-AS1 Suppresses Keloid Progression by Regulating the β-Trcp1-Mediated Ubiquitination of HuR

Author

Ye W, Lu J, Yang Z, Yang B, Zhu G, and Xue C

Subjects
b3galt5-as1, keloid, fibroblast, hur, β-trcp1, Dermatology, RL1-803
Abstract

Wei Ye,1,&ast; Junwen Lu,1,&ast; Zuxian Yang,2 Ben Yang,2 Guanya Zhu,2 Chunli Xue2 1Department of Burn Surgery, the First Clinical Medical College of Guangdong Medical University, Huizhou, 516001, People’s Republic of China; 2Department of Burn Surgery, Huizhou Municipal Central Hospital, Huizhou, 516001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chunli Xue, Department of Burn Surgery, Huizhou Municipal Central Hospital, No. 41, Eiling North Road, Huicheng District, Huizhou, 516001, People’s Republic of China, Email xuechunli2001@163.comBackground: lncRNA β‑1,3‑galactosyltransferase 5‑AS1 (B3GALT5-AS1) plays a vital regulatory role in colon and gastric cancers. However, the biological functions and regulatory mechanisms of B3GALT5-AS1 in keloid progression remain unknown. This study aims to investigate the molecular mechanisms in the B3GALT5-AS1-regulated keloid proliferation and invasion.Methods: Secondary mining of the lncRNA sequencing data from GSE158395 was conducted to screen differentially expressed lncRNAs between keloid and normal tissues. MTT, cell migration and invasion assays were performed to detect the effects of B3GALT5-AS1 on keloid fibroblasts (KFs) proliferation and metastasis. The extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) were also determined to evaluate glycolysis in KFs. RNA pull-down and RNA-protein immunoprecipitation assays were used to confirm the interaction between B3GALT5-AS1 and Hu-Antigen R (HuR). Further ubiquitination and rescue experiments were performed to elucidate the regulatory relationship between B3GALT5-AS1 and HuR.Results: B3GALT5-AS1 was significantly down-regulated in keloid tissues and fibroblasts. B3GALT5-AS1 overexpression significantly inhibited KFs proliferation, glycolysis, invasion, and migration and promoted cell apoptosis, whereas silencing B3GALT5-AS1 inhibited these effects. Moreover, B3GALT5-AS1 binds to HuRand reduces its stability through β-Transducin repeats-containing protein 1 (β-Trcp1)-mediated ubiquitination. Overexpression of HuR reversed the inhibition of B3GALT5-AS1 on cell proliferation, migration, and invasion in KFs, where glycolysis pathway was involved.Conclusion: Our findings illustrate that B3GALT5-AS1 has great effect on inhibition of keloid formation, which provides a potential target for keloid therapy.Keywords: B3GALT5-AS1, keloid, fibroblast, HuR, β-Trcp1

Published
2024

29. Analyzing Korean Public Health Centers’ Infectious Disease Disaster Response Experiences with a Focus on Business Continuity

Author

Yun EK, Han JW, Kim JO, Jung S, Cha J, Yoo K, Min S, and Yang B

Subjects
public health, disaster crisis, qualitative research, Public aspects of medicine, RA1-1270
Abstract

Eun Kyoung Yun, Jeong-Won Han, Jung Ok Kim, Sungmo Jung, Jeongeun Cha, Keunhee Yoo, Soyoon Min, Boeun Yang College of nursing science, Kyung Hee University, Seoul, Republic of KoreaCorrespondence: Jeong-Won Han, College of Nursing Science, Kyung Hee University, 26, Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Republic of Korea, Tel/Fax +82-2-961-2123, Email hjw0721@naver.comObjective: This study aims to provide basic data for establishing strategies to maintain the core functions of health centers, and enable an effective response to emergency tasks in the event of future infectious disease disasters.Methods: The participants were 41 workers from two public health centers in Seoul. They all had prior experience in responding to the early and middle stages of the COVID-19 pandemic. Data were collected through Focus Group Discussions, and then analyzed using the deductive method of content analysis.Results: The participants’ experiences during the infectious disease disaster crisis were examined through ten categories: governance and coordination, information management, human resources, essential medical supplies and equipment, infrastructure, administration, finance and logistics, community engagement and risk communication, delivery of essential services, security, and additional considerations for vulnerable populations. The analysis of the results made it apparent that new systems and policies were imperative for responding appropriately to the concerns and experiences of the public healthcare center staff, and for improving the response to future epidemics.Conclusion: We found that to prepare for infectious disaster situations in the future, it is necessary for health centers to establish a mid- to long-term business continuity plan to ensure the continuation and stability of their operations. Additionally, it was found that health professionals in public health centers also believe in the necessity of education and training programs on disaster preparedness, based on Business Continuity Planning proposed by the World Health Organization. They deem these essential to sustain routine tasks for the management of the health of local community residents during outbreaks of novel infectious diseases in the future.Keywords: public health, disaster crisis, qualitative research

Published
2024

30. Measurement of the cosmogenic neutron yield in Super-Kamiokande with gadolinium loaded water

Author

Collaboration, Super-Kamiokande, Shinoki, M., Abe, K., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Okamoto, K., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Megias, G. D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchêne, A., Bernard, L., Coffani, A., Drapier, O., Hedri, S. El, Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Choi, K., Cao, S., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., Machado, L. N., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Boschi, T., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Taani, M., Xie, Z., Zsoldos, S., Kotsar, Y., Ozaki, H., Suzuki, A. T., Takeuchi, Y., Bronner, C., Feng, J., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarrant, A., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Wilking, M. J., Yanagisawa, C., Harada, M., Ishino, H., Ito, S., Kitagawa, H., Koshio, Y., Nakanishi, F., Sakai, S., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Yang, J. Y., Yang, B. S., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Koshiba, M., Iwamoto, K., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Yokoyama, M., Martens, K., de Perio, P., Vagins, M. R., Xia, J., Kuze, M., Izumiyama, S., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ommura, Y., Shigeta, N., Suganuma, T., Yamauchi, K., Martin, J. F., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Prouse, N. W., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Suzuki, S., and Wada, K.

Subjects
High Energy Physics - Experiment
Abstract

Cosmic-ray muons that enter the Super-Kamiokande detector cause hadronic showers due to spallation in water, producing neutrons and radioactive isotopes. Those are a major background source for studies of MeV-scale neutrinos and searches for rare events. Since 2020, gadolinium was introduced in the ultra-pure water in the Super-Kamiokande detector to improve the detection efficiency of neutrons. In this study, the cosmogenic neutron yield was measured using data acquired during the period after the gadolinium loading. The yield was found to be $(2.76 \pm 0.02\,\mathrm{(stat.) \pm 0.19\,\mathrm{(syst.)}}) \times 10^{-4}\,\mu^{-1} \mathrm{g^{-1} cm^{2}}$ at 259 GeV of average muon energy at the Super-Kamiokande detector., Comment: 10 pages, 10 figures, 3 tables

Published
2022

31. The equilibrium shape of (65) Cybele: primordial or relic of a large impact?

Author

Marsset, M., Brož, M., Vermersch, J., Rambaux, N., Ferrais, M., Viikinkoski, M., Hanuš, J., Jehin, E., Podlewska-Gaca, E., Bartczak, P., Dudzinski, G., Carry, B., Vernazza, P., Szakáts, R., Duffard, R., Jones, A., Molina, D., Santana-Ros, T., Benkhaldoun, Z., Birlan, M., Dumas, C., Fétick, R., Fusco, T., Jorda, L., Marchis, F., Vachier, F., and Yang, B.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Cybele asteroids constitute an appealing reservoir of primitive material genetically linked to the outer Solar System, and the physical properties of the largest members can be readily accessed by large telescopes. We took advantage of the bright apparition of (65) Cybele in July and August 2021 to acquire high-angular-resolution images and optical light curves of the asteroid with which we aim to analyse its shape and bulk properties. 7 series of images acquired with VLT/SPHERE were combined with optical light curves to reconstruct the shape of the asteroid using the ADAM, MPCD, and SAGE algorithms. The origin of the shape was investigated by means of N-body simulations. Cybele has a volume-equivalent diameter of 263+/-3km and a bulk density of 1.55+/-0.19g.cm-3. Notably, its shape and rotation state are closely compatible with those of a Maclaurin equilibrium figure. The lack of a collisional family associated with Cybele and the higher bulk density of that body with respect to other large P-type asteroids suggest that it never experienced any large disruptive impact followed by rapid re-accumulation. This would imply that its present-day shape represents the original one. However, numerical integration of the long-term dynamical evolution of a hypothetical family shows that it is dispersed by gravitational perturbations and chaotic diffusion over Gyrs of evolution. The very close match between Cybele and an equilibrium figure opens up the possibility that D>260km small bodies from the outer Solar System all formed at equilibrium. However, we cannot rule out an old impact as the origin of the equilibrium shape. Cybele itself is found to be dynamically unstable, implying that it was recently (<1Ga) placed on its current orbit either through slow diffusion from a relatively stable orbit in the Cybele region or, less likely, from an unstable, JFC orbit in the planet-crossing region., Comment: 19 pages, 14 figures, 4 tables, accepted for publication in A&A

Published
2022
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32. Direct dark matter searches with the full data set of XMASS-I

Author

XMASS Collaboration, Abe, K., Hiraide, K., Kato, N., Moriyama, S., Nakahata, M., Sato, K., Sekiya, H., Suzuki, T., Suzuki, Y., Takeda, A., Yang, B. S., Kim, N. Y., Kim, Y. D., Kim, Y. H., Itow, Y., Martens, K., Mason, A., Yamashita, M., Miuchi, K., Takeuchi, Y., Lee, K. B., Lee, M. K., Fukuda, Y., Ogawa, H., Ichimura, K., Kishimoto, Y., Nishijima, K., Fushimi, K., Xu, B. D., Kobayashi, K., and Nakamura, S.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment, Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

Various WIMP dark matter searches using the full data set of XMASS-I, a single-phase liquid xenon detector, are reported in this paper. Stable XMASS-I data taking accumulated a total live time of 1590.9 days between November 20, 2013 and February 1, 2019 with an analysis threshold of ${\rm 1.0\,keV_{ee}}$. In the latter half of data taking a lower analysis threshold of ${\rm 0.5\,keV_{ee}}$ was also available through a new low threshold trigger. Searching for a WIMP signal in the detector's 97~kg fiducial volume yielded a limit on the WIMP-nucleon scattering cross section of ${\rm 1.4\times 10^{-44}\, cm^{2}}$ for a ${\rm 60\,GeV/c^{2}}$ WIMP at the 90$\%$ confidence level. We also searched for WIMP induced annual modulation signatures in the detector's whole target volume, containing 832~kg of liquid xenon. For nuclear recoils of a ${\rm 8\,GeV/c^{2}}$ WIMP this analysis yielded a 90\% CL cross section limit of ${\rm 2.3\times 10^{-42}\, cm^{2}}$. At a WIMP mass of ${\rm 0.5\, GeV/c^{2}}$ the Migdal effect and Bremsstrahlung signatures were evaluated and lead to 90\% CL cross section limits of ${\rm 1.4\times 10^{-35}\, cm^{2}}$ and ${\rm 1.1\times 10^{-33}\, cm^{2}}$ respectively.

Published
2022
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34. Search for neutrinoless quadruple beta decay of $^{136}$Xe in XMASS-I

Author

XMASS Collaboration, Abe, K., Hiraide, K., Ichimura, K., Kato, N., Kishimoto, Y., Kobayashi, K., Kobayashi, M., Moriyama, S., Nakahata, M., Sato, K., Sekiya, H., Suzuki, T., Takeda, A., Tasaka, S., Yamashita, M., Yang, B. S., Kim, N. Y., Kim, Y. D., Kim, Y. H., Ishii, R., Itow, Y., Kanzawa, K., Masuda, K., Martens, K., Mason, A., Suzuki, Y., Miuchi, K., Takeuchi, Y., Lee, K. B., Lee, M. K., Fukuda, Y., Ogawa, H., Nishijima, K., Fushimi, K., Xu, B. D., and Nakamura, S.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

A search for the neutrinoless quadruple beta decay of $^{136}$Xe was conducted with the liquid-xenon detector XMASS-I using $\rm 327\; kg \times 800.0 \; days$ of the exposure. The pulse shape discrimination based on the scintillation decay time constant which distinguishes $\gamma$-rays including the signal and $\beta$-rays was used to enhance the search sensitivity. No significant signal excess was observed from the energy spectrum fitting with precise background evaluation, and we set a lower limit of the half life of 3.7 $\times$ 10$^{24}$ years at 90$\%$ confidence level. This is the first experimental constraint of the neutrinoless quadruple beta decay of $^{136}$Xe.

Published
2022
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35. Measurement of cosmogenic $^9$Li and $^8$He production rates at RENO

Author

Lee, H. G., Choi, J. H., Jang, H. I., Jang, J. S., Jeon, S. H., Joo, K. K., Jung, D. E., Kim, J. G., Kim, J. H., Kim, J. Y., Kim, S. B., Kim, S. Y., Kim, W., Kwon, E., Lee, D. H., Lee, W. J., Lim, I. T., Moon, D. H., Pac, M. Y., Park, J. S., Park, R. G., Seo, H., Seo, J. W., Shin, C. D., Yang, B. S., Yoo, J., Yoon, S. G., Yeo, I. S., and Yu, I.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

We report the measured production rates of unstable isotopes $^9$Li and $^8$He produced by cosmic muon spallation on $^{12}$C using two identical detectors of the RENO experiment. Their beta-decays accompanied by a neutron make a significant contribution to backgrounds of reactor antineutrino events in precise determination of the smallest neutrino mixing angle. The mean muon energy of its near (far) detector with an overburden of 120 (450) m.w.e. is estimated as 33.1 +- 2.3 (73.6 +- 4.4) GeV. Based on roughly 3100 days of data, the cosmogenic production rate of $^9$Li ($^8$He) isotope is measured to be 44.2 +- 3.1 (10.6 +- 7.4) per day at near detector and 10.0 +- 1.1 (2.1 +- 1.5) per day at far detector. This corresponds to yields of $^9$Li ($^8$He), 4.80 +- 0.36 (1.15 +- 0.81) and 9.9 +- 1.1 (2.1 +- 1.5) at near and far detectors, respectively, in a unit of 10$^{-8}$ $\mu^{-1}$ g${^-1}$ cm${^2}$. Combining the measured $^9$Li yields with other available underground measurements, an excellent power-law relationship of the yield with respect to the mean muon energy is found to have an exponent of $\alpha$ = 0.75 +- 0.05., Comment: 11 pages, 14 figures

Published
2022
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36. STCF conceptual design report (Volume 1): Physics & detector

Author

Achasov, M., Ai, X. C., An, L. P., Aliberti, R., An, Q., Bai, X. Z., Bai, Y., Bakina, O., Barnyakov, A., Blinov, V., Bobrovnikov, V., Bodrov, D., Bogomyagkov, A., Bondar, A., Boyko, I., Bu, Z. H., Cai, F. M., Cai, H., Cao, J. J., Cao, Q. H., Cao, X., Cao, Z., Chang, Q., Chao, K. T., Chen, D. Y., Chen, H., Chen, H. X., Chen, J. F., Chen, K., Chen, L. L., Chen, P., Chen, S. L., Chen, S. M., Chen, S., Chen, S. P., Chen, W., Chen, X., Chen, X. F., Chen, X. R., Chen, Y., Chen, Y. Q., Cheng, H. Y., Cheng, J., Cheng, S., Cheng, T. G., Dai, J. P., Dai, L. Y., Dai, X. C., Dedovich, D., Denig, A., Denisenko, I., Dias, J. M., Ding, D. Z., Dong, L. Y., Dong, W. H., Druzhinin, V., Du, D. S., Du, Y. J., Du, Z. G., Duan, L. M., Epifanov, D., Fan, Y. L., Fang, S. S., Fang, Z. J., Fedotovich, G., Feng, C. Q., Feng, X., Feng, Y. T., Fu, J. L., Gao, J., Gao, Y. N., Ge, P. S., Geng, C. Q., Geng, L. S., Gilman, A., Gong, L., Gong, T., Gou, B., Gradl, W., Gu, J. L., Guevara, A., Gui, L. C., Guo, A. Q., Guo, F. K., Guo, J. C., Guo, J., Guo, Y. P., Guo, Z. H., Guskov, A., Han, K. L., Han, L., Han, M., Hao, X. Q., He, J. B., He, S. Q., He, X. G., He, Y. L., He, Z. B., Heng, Z. X., Hou, B. L., Hou, T. J., Hou, Y. R., Hu, C. Y., Hu, H. M., Hu, K., Hu, R. J., Hu, W. H., Hu, X. H., Hu, Y. C., Hua, J., Huang, G. S., Huang, J. S., Huang, M., Huang, Q. Y., Huang, W. Q., Huang, X. T., Huang, X. J., Huang, Y. B., Huang, Y. S., Hüsken, N., Ivanov, V., Ji, Q. P., Jia, J. J., Jia, S., Jia, Z. K., Jiang, H. B., Jiang, J., Jiang, S. Z., Jiao, J. B., Jiao, Z., Jing, H. J., Kang, X. L., Kang, X. S., Ke, B. C., Kenzie, M., Khoukaz, A., Koop, I., Kravchenko, E., Kuzmin, A., Lei, Y., Levichev, E., Li, C. H., Li, C., Li, D. Y., Li, F., Li, G., Li, G., Li, H. B., Li, H., Li, H. N., Li, H. J., Li, H. L., Li, J. M., Li, J., Li, L., Li, L., Li, L. Y., Li, N., Li, P. R., Li, R. H., Li, S., Li, T., Li, W. J., Li, X., Li, X. H., Li, X. Q., Li, X. H., Li, Y., Li, Y. Y., Li, Z. J., Liang, H., Liang, J. H., Liang, Y. T., Liao, G. R., Liao, L. Z., Liao, Y., Lin, C. X., Lin, D. X., Lin, X. S., Liu, B. J., Liu, C. W., Liu, D., Liu, F., Liu, G. M., Liu, H. B., Liu, J., Liu, J. J., Liu, J. B., Liu, K., Liu, K. Y., Liu, K., Liu, L., Liu, Q., Liu, S. B., Liu, T., Liu, X., Liu, Y. W., Liu, Y., Liu, Y. L., Liu, Z. Q., Liu, Z. Y., Liu, Z. W., Logashenko, I., Long, Y., Lu, C. G., Lu, J. X., Lu, N., Lü, Q. F., Lu, Y., Lu, Y., Lu, Z., Lukin, P., Luo, F. J., Luo, T., Luo, X. F., Lyu, H. J., Lyu, X. R., Ma, J. P., Ma, P., Ma, Y., Ma, Y. M., Maas, F., Malde, S., Matvienko, D., Meng, Z. X., Mitchell, R., Nefediev, A., Nefedov, Y., Olsen, S. L., Ouyang, Q., Pakhlov, P., Pakhlova, G., Pan, X., Pan, Y., Passemar, E., Pei, Y. P., Peng, H. P., Peng, L., Peng, X. Y., Peng, X. J., Peters, K., Pivovarov, S., Pyata, E., Qi, B. B., Qi, Y. Q., Qian, W. B., Qian, Y., Qiao, C. F., Qin, J. J., Qin, J. J., Qin, L. Q., Qin, X. S., Qiu, T. L., Rademacker, J., Redmer, C. F., Sang, H. Y., Saur, M., Shan, W., Shan, X. Y., Shang, L. L., Shao, M., Shekhtman, L., Shen, C. P., Shen, J. M., Shen, Z. T., Shi, H. C., Shi, X. D., Shwartz, B., Sokolov, A., Song, J. J., Song, W. M., Song, Y., Song, Y. X., Sukharev, A., Sun, J. F., Sun, L., Sun, X. M., Sun, Y. J., Sun, Z. P., Tang, J., Tang, S. S., Tang, Z. B., Tian, C. H., Tian, J. S., Tian, Y., Tikhonov, Y., Todyshev, K., Uglov, T., Vorobyev, V., Wan, B. D., Wang, B. L., Wang, B., Wang, D. Y., Wang, G. Y., Wang, G. L., Wang, H. L., Wang, J., Wang, J. H., Wang, J. C., Wang, M. L., Wang, R., Wang, R., Wang, S. B., Wang, W., Wang, W. P., Wang, X. C., Wang, X. D., Wang, X. L., Wang, X. L., Wang, X. P., Wang, X. F., Wang, Y. D., Wang, Y. P., Wang, Y. Q., Wang, Y. L., Wang, Y. G., Wang, Z. Y., Wang, Z. Y., Wang, Z. L., Wang, Z. G., Wei, D. H., Wei, X. L., Wei, X. M., Wen, Q. G., Wen, X. J., Wilkinson, G., Wu, B., Wu, J. J., Wu, L., Wu, P., Wu, T. W., Wu, Y. S., Xia, L., Xiang, T., Xiao, C. W., Xiao, D., Xiao, M., Xie, K. P., Xie, Y. H., Xing, Y., Xing, Z. Z., Xiong, X. N., Xu, F. R., Xu, J., Xu, L. L., Xu, Q. N., Xu, X. C., Xu, X. P., Xu, Y. C., Xu, Y. P., Xu, Y., Xu, Z. Z., Xuan, D. W., Xue, F. F., Yan, L., Yan, M. J., Yan, W. B., Yan, W. C., Yan, X. S., Yang, B. F., Yang, C., Yang, H. J., Yang, H. R., Yang, H. T., Yang, J. F., Yang, S. L., Yang, Y. D., Yang, Y. H., Yang, Y. S., Yang, Y. L., Yang, Z. W., Yang, Z. Y., Yao, D. L., Yin, H., Yin, X. H., Yokozaki, N., You, S. Y., You, Z. Y., Yu, C. X., Yu, F. S., Yu, G. L., Yu, H. L., Yu, J. S., Yu, J. Q., Yuan, L., Yuan, X. B., Yuan, Z. Y., Yue, Y. F., Zeng, M., Zeng, S., Zhang, A. L., Zhang, B. W., Zhang, G. Y., Zhang, G. Q., Zhang, H. J., Zhang, H. B., Zhang, J. Y., Zhang, J. L., Zhang, J., Zhang, L., Zhang, L. M., Zhang, Q. A., Zhang, R., Zhang, S. L., Zhang, T., Zhang, X., Zhang, Y., Zhang, Y. J., Zhang, Y. X., Zhang, Y. T., Zhang, Y. F., Zhang, Y. C., Zhang, Y., Zhang, Y., Zhang, Y. M., Zhang, Y. L., Zhang, Z. H., Zhang, Z. Y., Zhang, Z. Y., Zhao, H. Y., Zhao, J., Zhao, L., Zhao, M. G., Zhao, Q., Zhao, R. G., Zhao, R. P., Zhao, Y. X., Zhao, Z. G., Zhao, Z. X., Zhemchugov, A., Zheng, B., Zheng, L., Zheng, Q. B., Zheng, R., Zheng, Y. H., Zhong, X. H., Zhou, H. J., Zhou, H. Q., Zhou, H., Zhou, S. H., Zhou, X., Zhou, X. K., Zhou, X. P., Zhou, X. R., Zhou, Y. L., Zhou, Y., Zhou, Y. X., Zhou, Z. Y., Zhu, J. Y., Zhu, K., Zhu, R. D., Zhu, R. L., Zhu, S. H., Zhu, Y. C., Zhu, Z. A., Zhukova, V., Zhulanov, V., Zou, B. S., and Zuo, Y. B.

Published
2024
Full Text
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37. White Paper on Light Sterile Neutrino Searches and Related Phenomenology

Author

Acero, M. A., Argüelles, C. A., Hostert, M., Kalra, D., Karagiorgi, G., Kelly, K. J., Littlejohn, B., Machado, P., Pettus, W., Toups, M., Ross-Lonergan, M., Sousa, A., Surukuchi, P. T., Wong, Y. Y. Y., Abdallah, W., Abdullahi, A. M., Akutsu, R., Alvarez-Ruso, L., Alves, D. S. M., Aurisano, A., Balantekin, A. B., Berryman, J. M., Bertólez-Martínez, T., Brunner, J., Blennow, M., Bolognesi, S., Borusinski, M., Cianci, D., Collin, G., Conrad, J. M., Crow, B., Denton, P. B., Duvall, M., Fernández-Martinez, E., Fong, C. S., Foppiani, N., Forero, D. V., Friend, M., García-Soto, A., Giganti, C., Giunti, C., Gandhi, R., Ghosh, M., Hardin, J., Heeger, K. M., Ishitsuka, M., Izmaylov, A., Jones, B. J. P., Jordan, J. R., Kamp, N. W., Katori, T., Kim, S. B., Koerner, L. W., Lamoureux, M., Lasserre, T., Leach, K. G., Learned, J., Li, Y. F., Link, J. M., Louis, W. C., Mahn, K., Meyers, P. D., Maricic, J., Marko, D., Maruyama, T., Mertens, S., Minakata, H., Mocioiu, I., Mooney, M., Moulai, M. H., Nunokawa, H., Ochoa-Ricoux, J. P., Oh, Y. M., Ohlsson, T., Päs, H., Pershey, D., Robertson, R. G. H., Rosauro-Alcaraz, S., Rott, C., Roy, S., Salvado, J., Scott, M., Seo, S. H., Shaevitz, M. H., Smiley, M., Spitz, J., Stachurska, J., Thakore, T., Ternes, C. A., Thompson, A., Tseng, S., Vogelaar, B., Weiss, T., Wendell, R. A., Wright, T., Xin, Z., Yang, B. S., Yoo, J., Zennamo, J., Zettlemoyer, J., Zornoza, J. D., Ahmad, S., Basto-Gonzalez, V. S., Bowden, N. S., Cañas, B. C., Caratelli, D., Chang, C. V., Chen, C., Classen, T., Convery, M., Davies, G. S., Dennis, S. R., Djurcic, Z., Dorrill, R., Du, Y., Evans, J. J., Fahrendholz, U., Formaggio, J. A., Foust, B. T., Gatti, H. Frandini, Garcia-Gamez, D., Gariazzo, S., Gehrlein, J., Grant, C., Gomes, R. A., Hansell, A. B., Halzen, F., Ho, S., Zink, J. Hoefken, Jones, R. S., Kunkle, P., Li, J. -Y., Li, S. C., Luo, X., Malyshkin, Yu., Massaro, D., Mastbaum, A., Mohanta, R., Mumm, H. P., Nebot-Guinot, M., Neilson, R., Ni, K., Nieves, J., Gann, G. D. Orebi, Pandey, V., Pascoli, S., Qian, X., Rajaoalisoa, M., Roca, C., Roskovec, B., Saul-Sala, E., Saldaña, L., Scholberg, K., Shakya, B., Slocum, P. L., Snider, E. L., Steiger, H. Th. J., Steklain, A. F., Stock, M. R., Sutanto, F., Takhistov, V., Tsai, Y. -D., Tsai, Y. -T., Venegas-Vargas, D., Wallbank, M., Wang, E., Weatherly, P., Westerdale, S., Worcester, E., Wu, W., Yang, G., and Zamorano, B.

Subjects
High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract

This white paper provides a comprehensive review of our present understanding of experimental neutrino anomalies that remain unresolved, charting the progress achieved over the last decade at the experimental and phenomenological level, and sets the stage for future programmatic prospects in addressing those anomalies. It is purposed to serve as a guiding and motivational "encyclopedic" reference, with emphasis on needs and options for future exploration that may lead to the ultimate resolution of the anomalies. We see the main experimental, analysis, and theory-driven thrusts that will be essential to achieving this goal being: 1) Cover all anomaly sectors -- given the unresolved nature of all four canonical anomalies, it is imperative to support all pillars of a diverse experimental portfolio, source, reactor, decay-at-rest, decay-in-flight, and other methods/sources, to provide complementary probes of and increased precision for new physics explanations; 2) Pursue diverse signatures -- it is imperative that experiments make design and analysis choices that maximize sensitivity to as broad an array of these potential new physics signatures as possible; 3) Deepen theoretical engagement -- priority in the theory community should be placed on development of standard and beyond standard models relevant to all four short-baseline anomalies and the development of tools for efficient tests of these models with existing and future experimental datasets; 4) Openly share data -- Fluid communication between the experimental and theory communities will be required, which implies that both experimental data releases and theoretical calculations should be publicly available; and 5) Apply robust analysis techniques -- Appropriate statistical treatment is crucial to assess the compatibility of data sets within the context of any given model., Comment: Contribution to Snowmass 2021 by the NF02 Topical Group (Understanding Experimental Neutrino Anomalies). Submitted to J. Phys. G as a Major Report

Published
2022

38. Observation of the $\pi^2\sigma^2$-bond linear-chain molecular structure in $^{16}$C

Author

Han, J. X., Liu, Y., Ye, Y. L., Lou, J. L., Yang, X. F., Baba, T., Kimura, M., Yang, B., Li, Z. H., Li, Q. T., Xu, J. Y., Ge, Y. C., Hua, H., Yang, Z. H., Wang, J. S., Yang, Y. Y., Ma, P., Bai, Z., Hu, Q., Liu, W., Ma, K., Tao, L. C., Jiang, Y., Hu, L. Y., Zang, H. L., Feng, J., Wu, H. Y., Bai, S. W., Li, G., Yu, H. Z., Huang, S. W., Chen, Z. Q., Sun, X. H., Li, J. J., Tan, Z. W., Gao, Z. H., Duan, F. F., Tan, J. H., Sun, S. Q., and Song, Y. S.

Subjects
Nuclear Experiment
Abstract

Measurements of the $^2$H($^{16}$C,$^{16}$C$^{*}$$\rightarrow^4$He+$^{12}$Be or $^6$He+$^{10}$Be)$^2$H inelastic excitation and cluster-decay reactions have been carried out at a beam energy of about 23.5 MeV/u. A specially designed detection system, including one multi-layer silicon-strip telescope at around zero degrees, has allowed the high-efficiency three-fold coincident detection and therefore the event-by-event determination of the energy of the unstable nucleus beam. The decay paths from the $^{16}$C resonances to various states of the final $^{10}$Be or $^{12}$Be nucleus are recognized thanks to the well-resolved $Q$-value spectra. The reconstructed resonances at 16.5(1), 17.3(2), 19.4(1) and 21.6(2) MeV are assigned as the $0^+$, $2^+$, $4^+$ and $6^+$ members, respectively, of the positive-parity $(3/2_\pi^-)^2(1/2_\sigma^-)^2$-bond linear-chain molecular band in $^{16}$C, based on the angular correlation analysis for the 16.5 MeV state and the excellent agreement of decay patterns between the measurements and theoretical predictions. Moreover, another intriguing high-lying state was observed at 27.2(1) MeV which decays almost exclusively to the $\sim$6 MeV states of $^{10}$Be, in line with the newly predicted pure $\sigma$-bond linear-chain configuration., Comment: 13 pages, 10 figures

Published
2022
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39. Spectrum Sharing for Secrecy Performance Enhancement in D2D-enabled UAV Networks

Author

Yang, B., Taleb, T., Wu, Z., and Ma, L.

Subjects
Computer Science - Networking and Internet Architecture, Electrical Engineering and Systems Science - Signal Processing
Abstract

With the assistance of device-to-device (D2D) communications, unmanned aerial vehicle (UAV) networks are anticipated to support widespread applications in the fifth generation (5G) and beyond wireless systems, by providing seamless coverage, flexible deployment, and high channel rate. However, the networks face significant security threats from malicious eavesdroppers due to the inherent broadcast and openness nature of wireless channels. To ensure secure communications of such networks, physical layer security is a promising technique, which utilizes the randomness and noise of wireless channels to enhance secrecy performance. This article investigates physical layer security performance via spectrum sharing in D2D-enabled UAV networks. We first present two typical network architectures where each UAV serves as either a flying base station or an aerial user equipment. Then, we propose a spectrum sharing strategy to fully exploit interference incurred by spectrum reuse for improving secrecy performance. We further conduct two case studies to evaluate the spectrum sharing strategy in these two typical network architectures, and also show secrecy performance gains compared to traditional spectrum sharing strategy. Finally, we discuss some future research directions in D2D-enabled UAV networks.

Published
2022

40. Deep Learning for GPS Spoofing Detection in Cellular Enabled Unmanned Aerial Vehicle Systems

Author

Dang, Y., Benzaid, C., Yang, B., and Taleb, T.

Subjects
Computer Science - Cryptography and Security, Computer Science - Networking and Internet Architecture
Abstract

Cellular-based Unmanned Aerial Vehicle (UAV) systems are a promising paradigm to provide reliable and fast Beyond Visual Line of Sight (BVLoS) communication services for UAV operations. However, such systems are facing a serious GPS spoofing threat for UAV's position. To enable safe and secure UAV navigation BVLoS, this paper proposes a cellular network assisted UAV position monitoring and anti-GPS spoofing system, where deep learning approach is used to live detect spoofed GPS positions. Specifically, the proposed system introduces a MultiLayer Perceptron (MLP) model which is trained on the statistical properties of path loss measurements collected from nearby base stations to decide the authenticity of the GPS position. Experiment results indicate the accuracy rate of detecting GPS spoofing under our proposed approach is more than 93% with three base stations and it can also reach 80% with only one base station.

Published
2022

44. Improvement in Cutaneous Conditions Can Benefit Some Health Conditions in the Elderly

Author

Yang B and Man MQ

Subjects
aging, stratum corneum hydration, inflammaging, epidermis, diabetes, obesity, cardiovascular diseases, Geriatrics, RC952-954.6
Abstract

Bin Yang,1 Mao-Qiang Man1,2 1Dermatology Hospital of Southern Medical University, Guangzhou, 510091, People’s Republic of China; 2Dermatology Services, Veterans Affairs Medical Center and University of California, San Francisco, CA, 94121, USACorrespondence: Mao-Qiang Man, Dermatology Service, 4150 Clement Street, San Francisco, CA, 94121, USA, Tel +1 415 575-0539, Fax +1 415 750-2106, Email mqman@hotmail.comAbstract: As we are aging, a number of cutaneous and extracutaneous disorders will be developed. Although the pathogenesis of these aging-associated disorders is not clear yet, abnormalities in the skin are linked to some aging-associated disorders at least to some extent. Inflammatory dermatoses such as psoriasis and atopic dermatitis predispose to the development of cardiovascular diseases, obesity and type 2 diabetes. In addition, both chronologically aged skin and individuals with some aging-associated systemic conditions display altered epidermal function, such as reduced stratum corneum hydration levels, which can provoke cutaneous inflammation. Because aged skin exhibits higher expression levels of inflammatory cytokines, which play a pathogenic role in a variety of aging-associated health condition, the association of the skin with some aging-associated disorders is likely mediated by inflammation. This postulation is supported by the evidence that improvement in either epidermal function or inflammatory dermatoses can mitigate some aging-associated disorders such as mild cognitive impairment and insulin sensitivity. This perspective discusses the association of the skin with aging-associated disorders and highlights the potential of improvement in cutaneous conditions in the management of some health conditions in the elderly.Keywords: aging, stratum corneum hydration, inflammaging, epidermis, diabetes, obesity, cardiovascular diseases

Published
2023

45. Diabetic Retinopathy and Cardiovascular Disease: A Literature Review

Author

Yu W, Yang B, Xu S, Gao Y, Huang Y, and Wang Z

Subjects
diabetic retinopathy；cardiovascular disease；pathophysiological mechanism；optical coherence tomography angiography ；biomarkers, Specialties of internal medicine, RC581-951
Abstract

Wenhua Yu,1 Bo Yang,1 Siting Xu,1 Yun Gao,2 Yan Huang,3 Zhongqun Wang1 1Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2Department of Pathology, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 3Department of Ophthalmology, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of ChinaCorrespondence: Zhongqun Wang; Yan Huang, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China, Tel +86-15262919468, Email wangtsmc@126.com; wangzhongqun@ujs.edu.cn; 0511syj@163.comAbstract: Diabetic complications can be divided into macrovascular complications such as cardiovascular disease and cerebrovascular disease and microvascular complications such as diabetic retinopathy, diabetic nephropathy and diabetic neuropathy. Among them, cardiovascular disease (CVD) is an important cause of death in diabetic patients. Diabetes retinopathy (DR) is one of the main reasons for the increasing disability rate of diabetes. In recent years, some studies have found that because DR and CVD have a common pathophysiological basis, the occurrence of DR and CVD are inseparable, and to a certain extent, DR can predict the occurrence of CVD. With the development of technology, the fundus parameters of DR can be quantitatively analyzed as an independent risk factor of CVD. In addition, the cytokines related to DR can also be used for early screening of DR. Although many advances have been made in the treatment of CVD, its situation of prevention and treatment is still not optimistic. This review hopes to discuss the feasibility of DR in predicting CVD from the common pathophysiological mechanism of DR and CVD, the new progress of diagnostic techniques for DR, and the biomarkers for early screening of DR.Keywords: diabetic retinopathy, cardiovascular disease, pathophysiological mechanism, optical coherence tomography angiography, biomarkers

Published
2023

46. Risk Factors and Dynamic Nomogram Development for Surgical Site Infection Following Open Wedge High Tibial Osteotomy for Varus Knee Osteoarthritis: A Retrospective Cohort Study

Author

Guo H, Song B, Zhou R, Yu J, Chen P, Yang B, Pan N, Li C, Zhu Y, and Wang J

Subjects
open wedge high tibial osteotomy, surgical site infection, risk factors, nomogram., Geriatrics, RC952-954.6
Abstract

Haichuan Guo,1,&ast; Bixuan Song,2,&ast; Ruijuan Zhou,3 Jiahao Yu,1 Pengzhao Chen,1 Bin Yang,1 Naihao Pan,1 Chengsi Li,1 Yanbin Zhu,1,4 Juan Wang1,4 1Department of Orthopedic Surgery, The 3rd Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, People’s Republic of China; 2Division of Medical Sciences, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China; 3College of Education, Hebei Normal University, Shijiazhuang, Hebei, 050010, People’s Republic of China; 4Orthopedic Research Institute of Hebei Province, Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, 050051, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Juan Wang; Yanbin Zhu, Department of Orthopaedics, the 3rd Hospital, Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, 050051, People’s Republic of China, Tel +86-311-88602015, Email wangj_heb3y@163.com; zhuyanbin111@126.comBackground: As the worldwide population ages, the population receiving open wedge high tibial osteotomy (OWHTO) is growing, and surgical site infection (SSI) is a rare but fatal surgical complication. This study aimed to identify risk factors independently associated with SSI following OWHTO and develop a predictive nomogram.Methods: Clinical data of patients who received OWHTO and followed up for more than 12 months in our hospital were retrospectively reviewed. Multivariable logistic regression was performed to determine independent risk factors for SSI and to construct predictive nomograms. The study further illustrated the predictive performance of the model by using the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA).Results: A total of 1294 eligible patients were included in the study. Multivariate analysis revealed tobacco consumption (OR=3.44, p=0.010), osteotomy size ≥ 12 mm (OR=3.3, p=0.015), the use of allogeneic bone or artificial bone graft substitutes (allogeneic bone vs none, OR=4.08, p=0.037; artificial bone vs none, OR=5.16, p=0.047), Kellgren-Lawrence (K-L) grade IV (OR=2.5, p=0.046), systemic immune-inflammation index (SII) > 423.62 (OR=6.2, p< 0.001), high-sensitivity C-reactive protein (HCRP) > 2.6 mg/L (OR=2.42, p=0.044), and a higher level of fasting blood glucose (FBG) (OR=1.32, p=0.022) were the independent predictors of SSI. The cutoff score of the model was 148, with a sensitivity of 76.0% and specificity of 81.0%. The concordance index (C-index) and Brier score of the nomogram were 0.856 and 0.017, and the corrected values after 1000 bootstrapping validations were 0.820 and 0.018, respectively. Furthermore, the ROC curve, calibration curve, and DCA exhibited excellent predictive accuracy and clinical applicability of the model.Conclusion: This study developed a dynamic nomogram based on seven predictors, which allowed surgeons to individualize risk stratification of patients and intervene promptly to reduce SSI rates.Keywords: open wedge high tibial osteotomy, surgical site infection, risk factors, nomogram

Published
2023

47. Enhancing the Biopharmacological Characteristics of Asperosaponin VI: Unveiling Dynamic Self-Assembly Phase Transitions in the Gastrointestinal Environment

Author

Mo Y, Yang Y, Zeng J, Ma W, Guan Y, Guo J, Wu X, Liu D, Feng L, Jia X, and Yang B

Subjects
asperosaponin vi, dynamic self-assembled structure, gastrointestinal environment, biopharmacological characteristics, oral bioavailability, Medicine (General), R5-920
Abstract

Yulin Mo,1,&ast; Yanjun Yang,1,&ast; Jingqi Zeng,1 Weikun Ma,1 Yuxin Guan,1 Jingxi Guo,1 Xiaochun Wu,1 Dingkun Liu,1 Liang Feng,1,2 Xiaobin Jia,1,2 Bing Yang1,2 1School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, People’s Republic of China; 2State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaobin Jia; Bing Yang, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, People’s Republic of China, Email jiaxiaobin2015@163.com; 15751151582@163.comPurpose: Asperosaponin VI (ASP VI) as an active ingredient of Dipsacus asperoides, which has a wide range of biological and pharmacological activity. However, its development and application are restricted due to the poor gastrointestinal permeability and oral bioavailability. This investigation aims to reveal the influence of the self-assembled structure by the interaction between ASP VI and endogenous components NaTC and/or DOPC in the gastrointestinal environment on its biopharmaceutical properties, and novelty elucidated the molecular mechanism for the formation of self-assembled nanomicelles.Methods: This change in phase state in gastrointestinal fluids is characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM). UPLC-Q-TOF-MS was used to analyze the composition of phase components and the exposure of nanomicelles in vivo. Molecular dynamics simulation (MDS) was applied to preliminarily elucidate the self-assembly mechanism of ASP VI in the gastrointestinal environment. Furthermore, theS8 promoting absorption mechanism of nanomicelles were investigated through in vivo pharmacokinetic experiments, parallel artificial membrane permeability assay (PAMPA), quadruple single-pass intestinal perfusion in rats, and Caco-2 cell monolayer model.Results: We demonstrated that the ASP VI could spontaneously form dynamic self-assembled structures with sodium taurocholate (NaTC) and dipalmitoyl phosphatidylcholine (DOPC) during gastrointestinal solubilization, which promoted the gastrointestinal absorption and permeability of ASP VI and increased its exposure in vivo, thus improving the biopharmacological characteristics of ASP VI. Moreover, ASP VI-NaTC-DOPC-self-assembled nanostructures (ASP VI-NaTC-DOPC-SAN) manifested higher cellular uptake in Caco-2 cells as evidenced by flow cytometry and confocal microscopy, and this study also preliminarily revealed the mechanism of self-assembly formation of ASP VI with endogenous components NaTC and DOPC driven by electrostatic and hydrogen bonding interactions.Conclusion: This study provides evidence that the dynamic self-assembled phase transition may play a key role in improving the biopharmacological characteristics of insoluble or low permeability active ingredients during the gastrointestinal dissolution of Chinese medicines. Keywords: Asperosaponin VI, dynamic self-assembled structure, gastrointestinal environment, biopharmacological characteristics, oral bioavailability

Published
2023

48. Mitigation of Sepsis-Induced Acute Lung Injury by BMSC-Derived Exosomal miR-125b-5p Through STAT3-Mediated Suppression of Macrophage Pyroptosis

Author

Tao Y, Xu X, Yang B, Zhao H, and Li Y

Subjects
mesenchymal stem cells, exosomes, acute lung injury, machine learning, mir-125b-5p, stat3, Medicine (General), R5-920
Abstract

Yiming Tao,1,2 Xinxin Xu,1,2 Bin Yang,1,2 Hui Zhao,1,2 Yongsheng Li1,2 1Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Emergency Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Yongsheng Li, Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, People’s Republic of China, Email tjh_ysli@163.comIntroduction: Sepsis is a syndrome characterized by high morbidity and mortality rates. One of its most severe complications is acute lung injury, which exhibits a multitude of clinical and biological features, including macrophage pyroptosis. This study investigates the regulatory effects of exosomes derived from Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs) on sepsis-associated acute lung injury (ALI) and explores the potential mechanisms mediated by exosomal miRNAs.Methods: Exosomes were isolated from primary BMSCs of adult C57BL/6J mice using differential centrifugation. Their uptake and distribution in both in vitro and in vivo contexts were validated. Key sepsis-associated hub gene signal transducer and activator of transcription 3 (STAT3) and its upstream non-coding miR-125b-5p were elucidated through a combination of bioinformatics, machine learning, and miRNA sequencing. Subsequently, the therapeutic potential of BMSC-derived exosomes in alleviating sepsis-induced acute lung injury was substantiated. Moreover, the functionalities of miR-125b-5p and STAT3 were corroborated through miR-125b-5p inhibitor and STAT3 agonist interventions, employing gain and loss-of-function strategies both in vitro and in vivo. Finally, a dual-luciferase reporter assay reaffirmed the interaction between miR-125b-5p and STAT3.Results: We isolated exosomes from primary BMSCs and confirmed their accumulation in the mouse lung as well as their uptake by macrophages in vitro. This study identified the pivotal sepsis-associated hub gene STAT3 and demonstrated that exosomes derived from BMSCs can target STAT3, thereby inhibiting macrophage pyroptosis. MiR-125b-5p inhibition experiments showed that exosomes mitigate macrophage pyroptosis and lung injury by delivering miR-125b-5p. STAT3 overexpression experiments validated that miR-125b-5p reduces macrophage pyroptosis and lung injury by suppressing STAT3. Furthermore, a dual-luciferase reporter assay confirmed the binding interaction between miR-125b-5p and STAT3.Conclusion: Exosomes derived from BMSCs, serving as carriers for delivering miR-125b-5p, can downregulate STAT3, thereby inhibiting macrophage pyroptosis and alleviating sepsis-associated ALI. These significant findings provide valuable insights into the potential development of ALI therapies centred around exosomes derived from BMSC.Keywords: mesenchymal stem cells, exosomes, acute lung injury, machine learning, miR-125b-5p, STAT3

Published
2023

49. A Multi-Component Nano-Co-Delivery System Utilizing Astragalus Polysaccharides as Carriers for Improving Biopharmaceutical Properties of Astragalus Flavonoids

Author

Yang B, Wu X, Zeng J, Song J, Qi T, Yang Y, Liu D, Mo Y, He M, Feng L, and Jia X

Subjects
astragalus polysaccharides, flavonoids, self-assembly, solubility, permeability, natural carrier, Medicine (General), R5-920
Abstract

Bing Yang,1,&ast; Xiaochun Wu,1,&ast; Jingqi Zeng,1 Jinjing Song,1 Tianhao Qi,1 Yanjun Yang,1 Dingkun Liu,1 Yulin Mo,1 Miao He,2 Liang Feng,1 Xiaobin Jia1 1School of Traditional Chinese Pharmacy, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, People’s Republic of China; 2College of Pharmacy, Dali University, Dali, Yunnan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaobin Jia; Liang Feng, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, People’s Republic of China, Email jiaxiaobin2015@163.com; wenmoxiushi@163.comPurpose: Enhancing the dissolution, permeation and absorption of active components with low solubility and poor permeability is crucial for maximizing therapeutic efficacy and optimizing functionality. The objective of this study is to investigate the potential of natural polysaccharides as carriers to improve the biopharmaceutical properties of active components.Methods: In this study, we employed four representative flavonoids in Astragali Radix, namely Calycosin-7-O-β-D-glucoside (CAG), Ononin (ON), Calycosin (CA) and Formononetin (FMN), as a demonstration to evaluate the potential of Astragalus polysaccharides (APS) as carriers to improve the biopharmaceutical properties, sush as solubility, permeability, and absorption in vivo. In addition, the microstructure of the flavonoids-APS complexes was characterized, and the interaction mechanism between APS and flavonoids was investigated using multispectral technique and molecular dynamics simulation.Results: The results showed that APS can self-assemble into aggregates with a porous structure and large surface area in aqueous solutions. These aggregates can be loaded with flavonoids through weak intermolecular interactions, such as hydrogen bonding, thereby improving their gastrointestinal stability, solubility, permeability and absorption in vivo.Conclusion: We discovered the self-assembly properties of APS and its potential as carriers. Compared with introducing external excipients, the utilization of natural polysaccharides in plants as carriers may have a unique advantage in enhancing dissolution, permeation and absorption. Keywords: astragalus polysaccharides, flavonoids, self-assembly, solubility, permeability, natural carrier

Published
2023

50. Characterization of Epidermal Function in Individuals with Primary Cutaneous Amyloidosis

Author

Huang F, Zhang Y, Guo J, Pan H, Liao Z, Yang B, and Lu P

Subjects
cutaneous amyloidosis, epidermis, biophysical properties, pruritus., Dermatology, RL1-803
Abstract

Fujuan Huang,1,&ast; Yuling Zhang,2,&ast; Junyi Guo,3 Hongju Pan,4 Zhigang Liao,4 Bin Yang,1 Ping Lu1 1Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Dermatology, The First Hospital of Jilin University, Changchun, People’s Republic of China; 3Department of Dermatology, Guangdong Provincial Dermatology Hospital, Guangzhou, People’s Republic of China; 4Guangdong Provincial Engineering Technology Research and Development Center for External Drugs, Foshan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ping Lu; Bin Yang, Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, People’s Republic of China, Email lvping75@163.com; yangbin101@hotmail.comPurpose: To compare epidermal biophysical properties, indicators of epidermal function, in individuals with and without primary cutaneous amyloidosis (PCA).Patients and Methods: This study incorporated 189 patients with PCA and 166 healthy individuals. The GPSkin Barrier was employed to measure transepidermal water loss (TEWL) rates and hydration levels of the stratum corneum. The Sebumeter and the Skin pH Meter were utilized to determine the skin surface’s sebum content and pH, respectively. The severity of pruritus in participants was evaluated using the visual analog scale (VAS).Results: Compared to the control group without PCA, individuals with PCA displayed a notable increase in skin surface pH and TEWL and a decrease in the hydration levels of the stratum corneum (p< 0.0001 for all parameters). Additionally, the sebum content was markedly lower in those with PCA than in the controls (p< 0.0001). Of particular note, both TEWL and skin surface pH at the lesion sites on the back and the shin were more elevated in lichenoid amyloidosis (LA) and in macular amyloidosis (MA), whereas hydration levels of the stratum corneum and sebum levels were diminished in LA compared to MA (p< 0.05). In conclusion, both hydration levels of the stratum corneum and sebum content exhibited an inverse relationship with pruritus severity, whereas TEWL and skin surface pH demonstrated a positive correlation with pruritus intensity.Conclusion: The function of the epidermis is compromised in individuals diagnosed with PCA. However, the mechanisms underlying these changes await further investigation.Keywords: cutaneous amyloidosis, epidermis, biophysical properties, pruritus

Published
2023

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