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Geophysical surveying is crucial in the investigation of mineral resources in poorly exposed areas such as SE-Cameroon, a region known for its gold mineral potential. In this paper, gravity survey is carried out in the Batouri area, SE-Cameroon based on land gravity data from the Centre-south Cameroon. Therefore, an analytical polynomial separation program, based on least-square fitting of a third-degree polynomial surface to the Bouguer anomaly map, was used to separate the regional/residual components in gravity data. This technique permitted to better understand the disposition of the deep and near surface structures responsible of the observed anomalies in the Batouri area. Spectral analysis and 2.5D modelling of two profiles P1 (SW-NE) and P2 (N-S) selected from the residual anomaly map provided depths to basement. These depths constrain the gravity models along the profiles, indicating a variable thickness of the sedimentary infill with an approximate anomaly of -33 mGal. The 2.5D model of the basement shows a gravity body, with a signature suggesting two close and similar masses, which characterize the quartz-bearing formations associated here to granite and gneiss. Our work highlights a main heavy gravity: Gwe-Batouri anomaly, containing the major part of auriferous deposits located along the NE-SW direction. Further, three tectonic sub-basins bounded by normal faults have been highlighted at Guedal, Gwe, and Belimban, in the south of Guedal-Belimban depression. They are associated with the extension tectonics, more or less vertical tangential cuts and accidents that have affected the region. A correlation with previous results from tectonic, lithological and gold mineralization activities proves the relevance of the study and the need to intensify geophysical surveying in the area.