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1. Clinical Characteristics and Outcomes of Patients with Asthma–COPD Overlap in Japanese Patients with COPD

Author

Kobayashi S, Hanagama M, Ishida M, Ono M, Sato H, Yamanda S, and Yanai M

Subjects
asthma, asthma–copd overlap, copd, exacerbations, mortality, Diseases of the respiratory system, RC705-779
Abstract

Seiichi Kobayashi,1 Masakazu Hanagama,1 Masatsugu Ishida,1 Manabu Ono,1 Hikari Sato,1 Shinsuke Yamanda,1,2 Masaru Yanai1 1Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan; 2Department of Pulmonary Medicine, Sendai Kosei Hospital, Sendai, Miyagi, JapanCorrespondence: Seiichi KobayashiDepartment of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichishita, Hebita, Ishinomaki 986-8522, JapanTel +81 225 21 7220Fax +81 225 96 0122Email skoba-thk@umin.ac.jpPurpose: Asthma–COPD overlap (ACO) has been reported as an association with a lower quality of life, frequent exacerbations, and higher mortality than those with COPD alone. However, clinical characteristics and outcomes of ACO remain controversial.Patients and Methods: We conducted a prospective observational study analyzing data of patients with stable COPD enrolled from the Ishinomaki COPD Network Registry. Patients with features of asthma who had a history of respiratory symptoms that vary over time and intensity, together with documented variable expiratory airflow limitation, were identified, and then defined as having ACO. The characteristics, frequency of exacerbations, and mortality during the 3-year follow-up were compared between patients with ACO and patients with COPD alone.Results: Among 387 patients with COPD, 41 (10.6%) were identified as having ACO. Patients with ACO tended to be younger, have higher BMI, have a shorter smoking history, and use more respiratory medications, especially inhaled corticosteroids. Inflammatory biomarkers including fractional exhaled nitric oxide, blood eosinophil count, total immunoglobulin E (IgE) level, and presence of antigen-specific IgE were significantly higher in patients with ACO than in those with COPD alone. Lung function, mMRC score, CAT score, and comorbidity index were not different between the groups. The annual rate of all exacerbations and severe exacerbations required hospital admission were not different between ACO and COPD alone (0.20 vs 0.14, 0.12 vs 0.10, events per person, respectively). Mortality was significantly higher in patients with COPD alone compared with those with ACO during the study period (P=0.037).Conclusion: The results of our study indicate that ACO is not associated with poor clinical features nor outcomes in an outpatient COPD cohort receiving appropriate treatment.Keywords: asthma, asthma–COPD overlap, COPD, exacerbations, mortality

Published
2020

2. Clinical characteristics and outcomes in Japanese patients with COPD according to the 2017 GOLD classification: the Ishinomaki COPD Network Registry

Author

Kobayashi S, Hanagama M, Ishida M, Sato H, Ono M, Yamanda S, Yamada M, Aizawa H, and Yanai M

Subjects
COPD, GOLD, GOLD 2017, exacerbations, mortality, Diseases of the respiratory system, RC705-779
Abstract

Seiichi Kobayashi,1 Masakazu Hanagama,1 Masatsugu Ishida,1 Hikari Sato,1 Manabu Ono,1 Shinsuke Yamanda,1 Mitsuhiro Yamada,2 Hiroyuki Aizawa,1 Masaru Yanai1 1Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan; 2Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan Purpose: The GOLD report provides a framework for classifying COPD in a way that reflects its clinical impact and allows treatment recommendations. The GOLD 2017 proposes a new classification whereby patients are grouped as A–D according to their symptoms and history of exacerbations. However, the clinical characteristics and outcomes in these patients are not well documented.Patients and methods: In this prospective observational study, we analyzed data from the Ishinomaki COPD Network Registry. All patients with stable COPD were classified into the four groups defined by GOLD 2017. The patient demographics, clinical characteristics, number of exacerbations, and mortality rate during 1 year of follow-up were compared between the groups.Results: Four hundred and one patients with stable COPD were identified. There were 240 patients (59.9%) in group A, 122 (30.4%) in group B, 16 (4.0%) in group C, and 23 (5.7%) in group D. Patients in groups B, C, and D had ORs of 2.95, 3.92, and 5.45, respectively, for risk of exacerbation relative to group A. Groups C and D experienced exacerbations more frequently, including exacerbations leading to hospital admission, than groups A and B (both P

Published
2018

3. Inflammatory biomarkers in asthma-COPD overlap syndrome

Author

Kobayashi S, Hanagama M, Yamanda S, Ishida M, and Yanai M

Subjects
asthma, asthma-COPD overlap syndrome, COPD, biomarkers, Diseases of the respiratory system, RC705-779
Abstract

Seiichi Kobayashi, Masakazu Hanagama, Shinsuke Yamanda, Masatsugu Ishida, Masaru YanaiDepartment of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, JapanBackground: The clinical phenotypes and underlying mechanisms of asthma-COPD overlap syndrome (ACOS) remain elusive. This study aimed to investigate a comparison of COPD patients with and without ACOS, focusing on inflammatory biomarkers, in an outpatient COPD cohort.Methods: We conducted a cross-sectional study analyzing prospectively collected data from the Ishinomaki COPD Network registry. All participants were diagnosed with COPD, confirmed by using spirometry, and were aged 40–90 years and former smokers. Patients with features of asthma including both variable respiratory symptoms and variable expiratory airflow limitation were identified and defined as having ACOS. Then, the inflammatory biomarkers such as fractional exhaled nitric oxide level, blood eosinophil count and percentage, total immunoglobulin E (IgE) level, and presence of antigen-specific IgE were evaluated.Results: A total of 257 patients with COPD were identified, including 37 (14.4%) with ACOS. Patients with ACOS tended to be younger, have a shorter smoking history, and use more respiratory medications, especially inhaled corticosteroids and theophylline. Mean fractional exhaled nitric oxide level was significantly higher in those with ACOS than in those without ACOS (38.5 parts per billion [ppb] vs 20.3 ppb, P

Published
2016

4. Rikkunshito, a traditional Japanese medicine, suppresses cisplatin-induced anorexia in humans

Author

Ohno T, Yanai M, Ando H, Toyomasu Y, Ogawa A, Morita H, Ogata K, Mochiki E, Asao T, and Kuwano H

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Tetsuro Ohno, Mitsuhiro Yanai, Hiroyuki Ando, Yoshitaka Toyomasu, Atsushi Ogawa, Hiroki Morita, Kyoichi Ogata, Erito Mochiki, Takayuki Asao, Hiroyuki KuwanoDepartment of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, JapanBackground: The aim of this study was to investigate the effects of Rikkunshito on ghrelin secretion and on cisplatin-induced anorexia in humans.Methods: The study was performed as a crossover design, and ten unresectable or relapsed gastric cancer patients were randomly divided into two groups. Group A (n = 5) was started on Rikkunshito (2.5 g three times daily, orally) from the first course of chemotherapy and followed by a second course without Rikkunshito. A treatment with reversed order was performed for Group B (n = 5). All patients received combined chemotherapy with S-1 plus cisplatin. The primary endpoint was the amount of oral intake, and the categories of scales of anorexia, nausea, and vomiting; secondary endpoints included the plasma concentration of acylated ghrelin.Results: In the Rikkunshito-on period, no decrease of the plasma concentration of acylated ghrelin induced by cisplatin was observed. The average oral intake in the Rikkunshito-on period was significantly larger than that in the Rikkunshito-off period, and the grade of anorexia was significantly lower in the Rikkunshito-on period than in the Rikkunshito-off period.Conclusion: Rikkunshito appeared to prevent anorexia induced by cisplatin, resulting in effective prophylactic administration of chemotherapy with cisplatin, and patients could continue their treatments on schedule.Keywords: Rikkunshito, cisplatin, ghrelin, anorexia, stomach cancer

Published
2011

7. Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus -- the 'D-shuttle' project --

Author

Adachi, N., Adamovitch, V., Adjovi, Y., Aida, K., Akamatsu, H., Akiyama, S., Akli, A., Ando, A., Andrault, T., Antonietti, H., Anzai, S., Arkoun, G., Avenoso, C., Ayrault, D., Banasiewicz, M., Banaśkiewicz, M., Bernandini, L., Bernard, E., Berthet, E., Blanchard, M., Boreyko, D., Boros, K., Charron, S., Cornette, P., Czerkas, K., Dameron, M., Date, I., De Pontbriand, M., Demangeau, F., Dobaczewski, Ł., Dobrzyński, L., Ducouret, A., Dziedzic, M., Ecalle, A., Edon, V., Endo, K., Endo, T., Endo, Y., Etryk, D., Fabiszewska, M., Fang, S., Fauchier, D., Felici, F., Fujiwara, Y., Gardais, C., Gaul, W., Guérin, L., Hakoda, R., Hamamatsu, I., Handa, K., Haneda, H., Hara, T., Hashimoto, M., Hashimoto, T., Hashimoto, K., Hata, D., Hattori, M., Hayano, R., Hayashi, R., Higasi, H., Hiruta, M., Honda, A., Horikawa, Y., Horiuchi, H., Hozumi, Y., Ide, M., Ihara, S., Ikoma, T., Inohara, Y., Itazu, M., Ito, A., Janvrin, J., Jout, I., Kanda, H., Kanemori, G., Kanno, M., Kanomata, N., Kato, T., Kato, S., Katsu, J., Kawasaki, Y., Kikuchi, K., Kilian, P., Kimura, N., Kiya, M., Klepuszewski, M., Kluchnikov, E., Kodama, Y., Kokubun, R., Konishi, F., Konno, A., Kontsevoy, V., Koori, A., Koutaka, A., Kowol, A., Koyama, Y., Kozioł, M., Kozue, M., Kravtchenko, O., Kruczała, W., Kudła, M., Kudo, H., Kumagai, R., Kurogome, K., Kurosu, A., Kuse, M., Lacombe, A., Lefaillet, E., Magara, M., Malinowska, J., Malinowski, M., Maroselli, V., Masui, Y., Matsukawa, K., Matsuya, K., Matusik, B., Maulny, M., Mazur, P., Miyake, C., Miyamoto, Y., Miyata, K., Miyazaki, M., Molęda, M., Morioka, T., Morita, E., Muto, K., Nadamoto, H., Nadzikiewicz, M., Nagashima, K., Nakade, M., Nakayama, C., Nakazawa, H., Nihei, Y., Nikul, R., Niwa, S., Niwa, O., Nogi, M., Nomura, K., Ogata, D., Ohguchi, H., Ohno, J., Okabe, M., Okada, M., Okada, Y., Omi, N., Onodera, H., Onodera, K., Ooki, S., Oonishi, K., Oonuma, H., Ooshima, H., Oouchi, H., Orsucci, M., Paoli, M., Penaud, M., Perdrisot, C., Petit, M., Piskowski, A., Płocharski, A., Polis, A., Polti, L., Potsepnia, T., Przybylski, D., Pytel, M., Quillet, W., Remy, A., Robert, C., Sadowski, M., Saito, M., Sakuma, D., Sano, K., Sasaki, Y., Sato, N., Schneider, T., Schneider, C., Schwartzman, K., Selivanov, E., Sezaki, M., Shiroishi, K., Shustava, I., Śniecińska, A., Stalchenko, E., Staroń, A., Stromboni, M., Studzińska, W., Sugisaki, H., Sukegawa, T., Sumida, M., Suzuki, Y., Suzuki, K., Suzuki, R., Suzuki, H., Świderski, W., Szudejko, M., Szymaszek, M., Tada, J., Taguchi, H., Takahashi, K., Tanaka, D., Tanaka, G., Tanaka, S., Tanino, K., Tazbir, K., Tcesnokova, N., Tgawa, N., Toda, N., Tsuchiya, H., Tsukamoto, H., Tsushima, T., Tsutsumi, K., Umemura, H., Uno, M., Usui, A., Utsumi, H., Vaucelle, M., Wada, Y., Watanabe, K., Watanabe, S., Watase, K., Witkowski, M., Yamaki, T., Yamamoto, J., Yamamoto, T., Yamashita, M., Yanai, M., Yasuda, K., Yoshida, Y., Yoshida, A., Yoshimura, K., Żmijewska, M., and Zuclarelli, E.

Subjects
Physics - Medical Physics
Abstract

Twelve high schools in Japan (of which six are in Fukushima Prefecture), four in France, eight in Poland and two in Belarus cooperated in the measurement and comparison of individual external doses in 2014. In total 216 high-school students and teachers participated in the study. Each participant wore an electronic personal dosimeter "D-shuttle" for two weeks, and kept a journal of his/her whereabouts and activities. The distributions of annual external doses estimated for each region overlap with each other, demonstrating that the personal external individual doses in locations where residence is currently allowed in Fukushima Prefecture and in Belarus are well within the range of estimated annual doses due to the background radiation level of other regions/countries.

Published
2015
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12. Regional rheological differences in locomoting neutrophils

Author

Yanai, M., Butler, J.P., Suzuki, T., Sasaki, H., and Higuchi, H.

Subjects
Neutrophils, Leukocytes, Biological sciences
Abstract

Intracellular theology is a useful probe of the mechanisms underlying spontaneous or chemotactic locomotion and transcellular migration of leukocytes. We characterized regional rheological differences between the leading, body, and trailing regions of isolated, adherent, and spontaneously locomoting human neutrophils. We optically trapped intracellular granules and measured their displacement for 500 ms after a 100-nm step change in the trap position. Results were analyzed in terms of simple viscoelasticity and with the use of structural damping (stress relaxation follows a power law in time). Structural damping fit the data better than did viscoelasticity. Regional viscoelastic stiffness and viscosity or structural damping storage and loss moduli were all significantly lower in leading regions than in pooled body and/or trailing regions (the latter were not significantly different). Structural damping showed similar levels of elastic and dissipative stresses in body and/or trailing regions; leading regions were significantly more fluidlike (increased power law exponent). Cytoskeletal disruption with cytochalasin D or nocodazole made body and/or trailing regions ~50% less elastic and less viscous. Cytochalasin D completely suppressed pseudopodial formation and locomotion; nocodazole had no effect on leading regions. Neither drug changed the dissipation-storage energy ratio, These results differ from those of studies of neutrophils and other cell types probed at the cell membrane via [[beta].sub.2]-integrin receptors, which suggests a distinct role for the cell cortex or focal adhesion complexes. We conclude that 1) structural damping well describes intracellular rheology, and 2) while not conclusive, the significantly more fluidlike behavior of the leading edge supports the idea that intracellular pressure may be the origin of motive force in neutrophil locomotion. structural damping; power law; viscoelasticity; optical trap

Published
2004

14. Climate of South Asia

Author

Xue, Y and Yanai, M

Subjects
Science
Abstract

Summary: This comprehensive volume covers all the main subfields of climatology, supplies information on climates in major continental areas, and explains the intricacies of climatic processes.

Published
2005

28. 562 Development of a group/organization-focused diagnostic sheet for occupational health nursing

Author

Ito, M, primary, Akimoto, F, additional, Hara, K, additional, Masuzawa, K, additional, Ito, M, additional, Nakamur, H, additional, Yanai, M, additional, Murakami, K, additional, Nagano, A, additional, Seto, M, additional, Yamaguchi, Y, additional, Yoshida, R, additional, Kono, K, additional, Chiba, A, additional, Ochiai, N, additional, Tachikawa, M, additional, and Inomata, K, additional

Published
2018
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29. 571 Construction of occupational health nursing diagnosis system for group and organisation in mental health in japan

Author

Yamaguchi, Y, primary, Ito, M, additional, Akimoto, F, additional, Hara, K, additional, Masuzawa, K, additional, Nakamur, H, additional, Yanai, M, additional, Murakami, xxx, additional, Nagano, A, additional, Seto, M, additional, Yoshida, R, additional, Kono, K, additional, Chiba, A, additional, Ochiai, N, additional, Tachikawa, M, additional, and Inomata, K, additional

Published
2018
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34. Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus—the ‘D-shuttle’ project—

Author

Adachi, N, primary, Adamovitch, V, additional, Adjovi, Y, additional, Aida, K, additional, Akamatsu, H, additional, Akiyama, S, additional, Akli, A, additional, Ando, A, additional, Andrault, T, additional, Antonietti, H, additional, Anzai, S, additional, Arkoun, G, additional, Avenoso, C, additional, Ayrault, D, additional, Banasiewicz, M, additional, Banaśkiewicz, M, additional, Bernardini, L, additional, Bernard, E, additional, Berthet, E, additional, Blanchard, M, additional, Boreyko, D, additional, Boros, K, additional, Charron, S, additional, Cornette, P, additional, Czerkas, K, additional, Dameron, M, additional, Date, I, additional, De Pontbriand, M, additional, Demangeau, F, additional, Dobaczewski, ł, additional, Dobrzyński, L, additional, Ducouret, A, additional, Dziedzic, M, additional, Ecalle, A, additional, Edon, V, additional, Endo, K, additional, Endo, T, additional, Endo, Y, additional, Etryk, D, additional, Fabiszewska, M, additional, Fang, S, additional, Fauchier, D, additional, Felici, F, additional, Fujiwara, Y, additional, Gardais, C, additional, Gaul, W, additional, Gurin, L, additional, Hakoda, R, additional, Hamamatsu, I, additional, Handa, K, additional, Haneda, H, additional, Hara, T, additional, Hashimoto, M, additional, Hashimoto, T, additional, Hashimoto, K, additional, Hata, D, additional, Hattori, M, additional, Hayano, R, additional, Hayashi, R, additional, Higasi, H, additional, Hiruta, M, additional, Honda, A, additional, Horikawa, Y, additional, Horiuchi, H, additional, Hozumi, Y, additional, Ide, M, additional, Ihara, S, additional, Ikoma, T, additional, Inohara, Y, additional, Itazu, M, additional, Ito, A, additional, Janvrin, J, additional, Jout, I, additional, Kanda, H, additional, Kanemori, G, additional, Kanno, M, additional, Kanomata, N, additional, Kato, T, additional, Kato, S, additional, Katsu, J, additional, Kawasaki, Y, additional, Kikuchi, K, additional, Kilian, P, additional, Kimura, N, additional, Kiya, M, additional, Klepuszewski, M, additional, Kluchnikov, E, additional, Kodama, Y, additional, Kokubun, R, additional, Konishi, F, additional, Konno, A, additional, Kontsevoy, V, additional, Koori, A, additional, Koutaka, A, additional, Kowol, A, additional, Koyama, Y, additional, Kozioł, M, additional, Kozue, M, additional, Kravtchenko, O, additional, Kruczała, W, additional, Kudła, M, additional, Kudo, H, additional, Kumagai, R, additional, Kurogome, K, additional, Kurosu, A, additional, Kuse, M, additional, Lacombe, A, additional, Lefaillet, E, additional, Magara, M, additional, Malinowska, J, additional, Malinowski, M, additional, Maroselli, V, additional, Masui, Y, additional, Matsukawa, K, additional, Matsuya, K, additional, Matusik, B, additional, Maulny, M, additional, Mazur, P, additional, Miyake, C, additional, Miyamoto, Y, additional, Miyata, K, additional, Miyazaki, M, additional, Molȩda, M, additional, Morioka, T, additional, Morita, E, additional, Muto, K, additional, Nadamoto, H, additional, Nadzikiewicz, M, additional, Nagashima, K, additional, Nakade, M, additional, Nakayama, C, additional, Nakazawa, H, additional, Nihei, Y, additional, Nikul, R, additional, Niwa, S, additional, Niwa, O, additional, Nogi, M, additional, Nomura, K, additional, Ogata, D, additional, Ohguchi, H, additional, Ohno, J, additional, Okabe, M, additional, Okada, M, additional, Okada, Y, additional, Omi, N, additional, Onodera, H, additional, Onodera, K, additional, Ooki, S, additional, Oonishi, K, additional, Oonuma, H, additional, Ooshima, H, additional, Oouchi, H, additional, Orsucci, M, additional, Paoli, M, additional, Penaud, M, additional, Perdrisot, C, additional, Petit, M, additional, Piskowski, A, additional, Płocharski, A, additional, Polis, A, additional, Polti, L, additional, Potsepnia, T, additional, Przybylski, D, additional, Pytel, M, additional, Quillet, W, additional, Remy, A, additional, Robert, C, additional, Sadowski, M, additional, Saito, M, additional, Sakuma, D, additional, Sano, K, additional, Sasaki, Y, additional, Sato, N, additional, Schneider, T, additional, Schneider, C, additional, Schwartzman, K, additional, Selivanov, E, additional, Sezaki, M, additional, Shiroishi, K, additional, Shustava, I, additional, Śniecińska, A, additional, Stalchenko, E, additional, Staroń, A, additional, Stromboni, M, additional, Studzińska, W, additional, Sugisaki, H, additional, Sukegawa, T, additional, Sumida, M, additional, Suzuki, Y, additional, Suzuki, K, additional, Suzuki, R, additional, Suzuki, H, additional, Świderski, W, additional, Szudejko, M, additional, Szymaszek, M, additional, Tada, J, additional, Taguchi, H, additional, Takahashi, K, additional, Tanaka, D, additional, Tanaka, G, additional, Tanaka, S, additional, Tanino, K, additional, Tazbir, K, additional, Tcesnokova, N, additional, Tgawa, N, additional, Toda, N, additional, Tsuchiya, H, additional, Tsukamoto, H, additional, Tsushima, T, additional, Tsutsumi, K, additional, Umemura, H, additional, Uno, M, additional, Usui, A, additional, Utsumi, H, additional, Vaucelle, M, additional, Wada, Y, additional, Watanabe, K, additional, Watanabe, S, additional, Watase, K, additional, Witkowski, M, additional, Yamaki, T, additional, Yamamoto, J, additional, Yamamoto, T, additional, Yamashita, M, additional, Yanai, M, additional, Yasuda, K, additional, Yoshida, Y, additional, Yoshida, A, additional, Yoshimura, K, additional, Żmijewska, M, additional, and Zuclarelli, E, additional

Published
2015
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35. Immunohistochemical analysis of extramammary Paget's disease with Bowenoid features: case report and review of the literature

Author

Kikuchi, K., primary, Moriuchi, R., additional, Inokuma, D., additional, Ito, T., additional, Kawashima, K., additional, Yoshida, T., additional, Nozaki, A., additional, Horiuchi, K., additional, Nakayama, C., additional, Itami, H., additional, Yanai, M., additional, Fukasawa, Y., additional, Kimura, T., additional, and Shimizu, S., additional

Published
2015
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38. Long-term outcome in Japanese patients with lupus nephritis

Author

Kono, M, primary, Yasuda, S, additional, Kato, M, additional, Kanetsuka, Y, additional, Kurita, T, additional, Fujieda, Y, additional, Otomo, K, additional, Horita, T, additional, Oba, K, additional, Kondo, M, additional, Mukai, M, additional, Yanai, M, additional, Fukasawa, Y, additional, and Atsumi, T, additional

Published
2014
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40. Erythromycin and common cold in COPD.

Author

Suzuki T, Yanai M, Yamaya M, Satoh-Nakagawa T, Sekizawa K, Ishida S, Sasaki H, Suzuki, T, Yanai, M, Yamaya, M, Satoh-Nakagawa, T, Sekizawa, K, Ishida, S, and Sasaki, H

Abstract

Study Objectives: To investigate whether erythromycin therapy lowers the frequency of the common cold and subsequent exacerbation in patients with COPD.Design: Prospective, randomized, controlled, but not blinded, trial.Patients: One hundred nine patients with COPD were enrolled into the study. Patients were randomly assigned to erythromycin therapy or to no active treatment in September 1997. Patients then were observed for 12 months, starting in October, during which time the risk and frequency of catching common colds and COPD exacerbations were investigated. Fifty-five patients received erythromycin at study entry (erythromycin group). The remaining 54 patients received no active treatment (control group).Measurements and Results: The mean (+/- SE) number of common colds for 12 months was significantly lower in the erythromycin group than in the control group (1.24 +/- 0.07 vs 4.54 +/- 0.02, respectively, per person; p = 0.0002). Forty-one patients (76%) in the control group experienced common colds more than once, compared to 7 patients (13%) in the erythromycin group. The relative risk of developing two or more common colds in the control group compared with that in the erythromycin group was 9.26 (95% confidence interval [CI], 3.92 to 31.74; p = 0.0001). Thirty patients (56%) in the control group and 6 patients (11%) in the erythromycin group had one or more exacerbations. The relative risk of experiencing an exacerbation in the control group compared with that in the erythromycin group was 4.71 (95% CI, 1.53 to 14.5; p = 0.007). Significantly more patients were hospitalized due to exacerbations in the control group than in the erythromycin group (p = 0.0007).Conclusion: Erythromycin therapy has beneficial effects on the prevention of exacerbations in COPD patients. [ABSTRACT FROM AUTHOR]

Published
2001
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42. Clinical Nephrology - Epidemiology II

Author

Agnes, H., primary, Kalman, P., additional, Jozsef, A., additional, Henrik, B., additional, Mucsi, I., additional, Kamata, K., additional, Sano, T., additional, Naito, S., additional, Okamoto, T., additional, Okina, C., additional, Kamata, M., additional, Murano, J., additional, Kobayashi, K., additional, Uchida, M., additional, Aoyama, T., additional, Takeuchi, Y., additional, Nagaba, Y., additional, Sakamoto, H., additional, Torino, C., additional, Panuccio, V., additional, Clementi, A., additional, Garozzo, M., additional, Bonanno, G., additional, Boito, R., additional, Natale, G., additional, Cicchetti, T., additional, Chippari, A., additional, Logozzo, D., additional, Alati, G., additional, Cassani, S., additional, Sellaro, A., additional, D'arrigo, G., additional, Tripepi, G., additional, Roberta, A., additional, Postorino, M., additional, Mallamaci, F., additional, Zoccali, C., additional, Buonanno, E., additional, Brancaccio, S., additional, Fimiani, V., additional, Napolitano, P., additional, Spadola, R., additional, Morrone, L., additional, DI Iorio, B., additional, Russo, D., additional, Betriu, A., additional, Martinez-Alonso, M., additional, Vidal, T., additional, Valdivielso, J., additional, Fernandez, E., additional, Bernadette, F., additional, Jean-Baptiste, B., additional, Frimat, L., additional, Madala, N. D., additional, Thusi, G. P., additional, Sibisi, N., additional, Mazibuko, B. G., additional, Assounga, A. G. H., additional, Tsai, N.-C., additional, Wang, H.-H., additional, Chen, Y.-C., additional, Hung, C.-C., additional, Hwang, S.-J., additional, Chen, H.-C., additional, Branco, P., additional, Adragao, T., additional, Birne, R., additional, Martins, A. R., additional, Vizinho, R., additional, Gaspar, A., additional, Grilo, M. J., additional, Barata, J. D., additional, Bonhorst, D., additional, Adragao, P., additional, Kim, J. S., additional, Yang, J. W., additional, Kim, M. K., additional, Choi, S. O., additional, Han, B. G., additional, Nathalie, N., additional, Sunny, E., additional, Glorieux, G., additional, Daniela, B., additional, Fellype, B., additional, Sophie, L., additional, Horst D, L., additional, Ziad, M., additional, Raymond, V., additional, Yanai, M., additional, Okada, K., additional, Takeuchi, K., additional, Nitta, K., additional, Takahashi, S., additional, Morena, M., additional, Jaussent, I., additional, Halkovich, A., additional, Dupuy, A.-M., additional, Bargnoux, A.-S., additional, Chenine, L., additional, Leray-Moragues, H., additional, Klouche, K., additional, Vernhet, H., additional, Canaud, B., additional, Cristol, J.-P., additional, Shutov, A., additional, Serov, V., additional, Kuznetsova, J., additional, Menzorov, M., additional, Serova, D., additional, Petrescu, L., additional, Zugravu, A., additional, Capusa, C., additional, Stancu, S., additional, Cinca, S., additional, Anghel, C., additional, Timofte, D., additional, Medrihan, L., additional, Ionescu, D., additional, Mircescu, G., additional, Hsu, T.-W., additional, Kuo, K.-L., additional, Hung, S.-C., additional, Tarng, D.-C., additional, Lee, S., additional, Kim, I., additional, Lee, D., additional, Rhee, H., additional, Song, S., additional, Seong, E., additional, Kwak, I., additional, Holzmann, M., additional, Gardell, C., additional, Jeppsson, A., additional, Sartipy, U., additional, Solak, Y., additional, Yilmaz, M. I., additional, Caglar, K., additional, Saglam, M., additional, Yaman, H., additional, Sonmez, A., additional, Unal, H. U., additional, Gok, M., additional, Gaipov, A., additional, Kayrak, M., additional, Eyileten, T., additional, Turk, S., additional, Vural, A., additional, DI Lullo, L., additional, Floccari, F., additional, Rivera, R., additional, Granata, A., additional, D'amelio, A., additional, Logias, F., additional, Otranto, G., additional, Malaguti, M., additional, Santoboni, A., additional, Fiorini, F., additional, Connor, T., additional, Oygar, D., additional, Nitsch, D., additional, Gale, D., additional, Steenkamp, R., additional, Neild, G. H., additional, Maxwell, P., additional, Louise Hogsbro, I., additional, Redal-Baigorri, B., additional, Sautenet, B., additional, Halimi, J. M., additional, Caille, A., additional, Goupille, P., additional, Giraudeau, B., additional, Oguz, Y., additional, Yenicesu, M., additional, Cetinkaya, H., additional, Ishimoto, Y., additional, Ohki, T., additional, Sugahara, M., additional, Kanemitsu, T., additional, Kobayashi, M., additional, Uchida, L., additional, Kotera, N., additional, Tanaka, S., additional, Sugimoto, T., additional, Mise, N., additional, Miyazaki, N., additional, Matsumoto, J., additional, Murata, I., additional, Yoshida, G., additional, Morishita, K., additional, Ushikoshi, H., additional, Nishigaki, K., additional, Ogura, S., additional, Minatoguchi, S., additional, Harvey, R., additional, Ala, A., additional, Banerjee, D., additional, Farmer, C., additional, Irving, J., additional, Hobbs, H., additional, Wheeler, T., additional, Klebe, B., additional, Stevens, P., additional, Selim, G., additional, Stojceva-Taneva, O., additional, Tozija, L., additional, Stojcev, N., additional, Gelev, S., additional, Dzekova-Vidimliski, P., additional, Pavleska, S., additional, Sikole, A., additional, Qureshi, A. R., additional, Evans, M., additional, Stendahl, M., additional, Prutz, K. G., additional, Elinder, C. G., additional, Tamagaki, K., additional, Kado, H., additional, Nakata, M., additional, Kitani, T., additional, Ota, N., additional, Ishida, R., additional, Matsuoka, E., additional, Shiotsu, Y., additional, Ishida, M., additional, Mori, Y., additional, Christelle, M., additional, Rognant, N., additional, Evelyne, D., additional, Sophie, F., additional, Laurent, J., additional, Maurice, L., additional, Silverwood, R., additional, Pierce, M., additional, Kuh, D., additional, Savage, C., additional, Ferro, C., additional, Moniek, D. G., additional, De Goeij, M., additional, Nynke, H., additional, Gurbey, O., additional, Joris, R., additional, Friedo, D., additional, Clayton, P., additional, Grace, B., additional, Cass, A., additional, Mcdonald, S., additional, Lorenzo, V., additional, Martin Conde, M., additional, Dusso, A., additional, Valdivielso, J. M., additional, Roggeri, D. P., additional, Cannella, G., additional, Cozzolino, M., additional, Mazzaferro, S., additional, Messa, P., additional, Brancaccio, D., additional, De Souza Faria, R., additional, Fernandes, N., additional, Lovisi, J., additional, Moura Marta, M., additional, Reboredo, M., additional, Do Vale Pinheiro, B., additional, Bastos, M., additional, Hundt, F., additional, Pabst, S., additional, Hammerstingl, C., additional, Gerhardt, T., additional, Skowasch, D., additional, Woitas, R., additional, Lopes, A. A., additional, Silva, L. F., additional, Matos, C. M., additional, Martins, M. S., additional, Silva, F. A., additional, Lopes, G. B., additional, Pizzarelli, F., additional, Dattolo, P., additional, Michelassi, S., additional, Rossi, C., additional, Bandinelli, S., additional, Mieth, M., additional, Mass, R., additional, Ferrucci, L., additional, Parisi, S., additional, Arduino, S., additional, Attini, R., additional, Fassio, F., additional, Biolcati, M., additional, Pagano, A., additional, Bossotti, C., additional, Ferraresi, M., additional, Gaglioti, P., additional, Todros, T., additional, Piccoli, G. B., additional, Salgado, T. M., additional, Arguello, B., additional, Benrimoj, S. I., additional, Fernandez-Llimos, F., additional, Bailey, P., additional, Tomson, C., additional, Ben-Shlomo, Y., additional, Santoro, A., additional, Rucci, P., additional, Mandreoli, M., additional, Caruso, F., additional, Corradini, M., additional, Flachi, M., additional, Gibertoni, D., additional, Rigotti, A., additional, Russo, G., additional, Fantini, M., additional, Mahapatra, H. S., additional, Choudhury, S., additional, Buxi, G., additional, Sharma, N., additional, Gupta, Y., additional, Sekhar, V., additional, Yanagisawa, N., additional, Ando, M., additional, Ajisawa, A., additional, Tsuchiya, K., additional, Janusz, O., additional, Mikolaj, M., additional, Jacek, M., additional, Boleslaw, R., additional, Prakash, S., additional, Coffin, R., additional, Schold, J., additional, Einstadter, D., additional, Stark, S., additional, Rodgers, D., additional, Howard, M., additional, Sehgal, A., additional, Palmer, S., additional, Tong, A., additional, Manns, B., additional, Craig, J., additional, Ruospo, M., additional, Gargano, L., additional, Strippoli, G., additional, Vecchio, M., additional, Petruzzi, M., additional, De Benedictis, M., additional, Pellegrini, F., additional, Ohno, Y., additional, Ishimura, E., additional, Naganuma, T., additional, Kondo, K., additional, Fukushima, W., additional, Mui, K., additional, Inaba, M., additional, Hirota, Y., additional, Sun, X., additional, Jiang, S., additional, Gu, H., additional, Chen, Y., additional, XI, C., additional, Qiao, X., additional, Chen, X., additional, Daher, E., additional, Junior, G. S., additional, Jacinto, C. N., additional, Pimentel, R. S., additional, Aguiar, G. B. R., additional, Lima, C. B., additional, Borges, R. C., additional, Mota, L. P. C., additional, Melo, J. V. L., additional, Melo, S. A., additional, Canamary, V. T., additional, Alves, M., additional, Araujo, S. M. H. A., additional, Huang, Y. K., additional, Rogacev, K., additional, Cremers, B., additional, Zawada, A., additional, Seiler, S., additional, Binder, N., additional, Ege, P., additional, Grosse-Dunker, G., additional, Heisel, I., additional, Hornof, F., additional, Jeken, J., additional, Rebling, N., additional, Ulrich, C., additional, Scheller, B., additional, Bohm, M., additional, Fliser, D., additional, Heine, G. H., additional, Robinson, B., additional, Wang, M., additional, Bieber, B., additional, Fluck, R., additional, Kerr, P. G., additional, Wikstrom, B., additional, Krishnan, M., additional, Nissenson, A., additional, Pisoni, R. L., additional, Mykleset, S., additional, Osthus, T. B., additional, Waldum, B., additional, Os, I., additional, Buttigieg, J., additional, Cassar, A., additional, Farrugia Agius, J., additional, Hara, M., additional, Yamato, M., additional, Yasuda, K., additional, and Sasaki, K., additional

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2012
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