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28 results on '"Yanai, Hirotsugu"'

3. Possible Case of IgG4-related Mastitis : A Case Report and Review of the Literature

Author

ENDO, Kayoko, ISHIDA, Mitsuaki, KIKAWA, Yuichiro, HIRAI, Chie, TADA, Manami, YANAI, Hirotsugu, KAN, Naoki, SEKIMOTO, Mitsugu, and SUGIE, Tomoharu

Subjects
integumentary system, 乳腺炎, fungi, parasitic diseases, IgG4-positive plasma cells, IgG4 関連疾患, IgG4-related mastitis, IgG4 陽性形質細胞, skin and connective tissue diseases, mastitis
Abstract

IgG4-related disease (IgG4-RD) has been recognized as a distinct disease entity, and the occurrence of IgG4-RD in the breast, is extremely rare. In this report, we describe a possible case of IgG4-related mastitis. A 55-year-old Japanese female presented with a left breast tumor. Ultrasound examination demonstrated a hypoechoic tumor in the left upper outer quadrant and lymph node swelling. The tumor had become larger, and a right breast tumor was also noted. Accordingly, surgical resection of the left breast tumor was performed. After the surgery, parotid gland tumors and multiple lung nodules were noted, and the serum IgG4 level was elevated (144 mg/dL). A histopathological study demonstrated dense lymphoplasmacytic infiltration with lymphoid follicle formation, fibrosclerosis and obliterative phlebitis. Immunohistochemical analyses revealed substantial IgG4-positive plasma cell infiltration ; however, the IgG4/IgG-positive plasma cell ratio was 23.6%. Accordingly, this patient was considered to have a possible case of IgG4-related mastitis. Additional studies are needed to clarify the clinicopathological features of IgG4-related mastitis because the diagnostic criteria for this disease have not yet been established., IgG4 関連疾患（IgG4-RD）は，一疾患として認識されており，乳腺におけるIgG4-RD は極めて珍しい．乳房におけるIgG4 関連疾患疑診群と診断した症例について報告する．症例は，55 歳の日本人女性で，左乳房腫瘤を自覚した．超音波検査では，左C 区域の低エコーと両側の腋窩リンパ節腫大を示した．その後左乳房腫瘤の増大と右乳房腫瘍が指摘されたため，左乳房腫瘤に対して腫瘤摘出術が行われた．術後，耳下腺腫瘍と複数の肺結節が出現し，血清IgG4 レベルが上昇していた（144mg/dL）．手術標本の病理結果は，リンパ濾胞周囲を主体に多数形質細胞が浸潤し，一部で線維化・硝子化を伴い静脈炎も観察された．免疫染色では，IgG4 陽性の形質細胞浸潤を認めたが，IgG4/IgG 陽性形質細胞比は23.6％であったため，IgG4 関連疾患疑診群の診断となった．この疾患の乳腺における診断基準がまだ確立されていないため，IgG4 関連乳腺炎の臨床病理学的特徴を明らかにするために症例の蓄積が必要である．

Published
2021

15. Maintenance of sweat glands by stem cells located in the acral epithelium

Author

Ohe, Shuichi, Tanaka, Toshihiro, Yanai, Hirotsugu, Komai, Yoshihiro, Omachi, Taichi, Kanno, Shohei, Tanaka, Kiyomichi, Ishigaki, Kazuhiko, Saiga, Kazuho, Nakamura, Naohiro, Ohsugi, Haruyuki, Tokuyama, Yoko, Atsumi, Naho, Hisha, Hiroko, Yoshida, Naoko, Kumano, Keiki, Yamazaki, Fumikazu, Okamoto, Hiroyuki, and Ueno, Hiroo

Subjects
Male, Polycomb Repressive Complex 1, integumentary system, Multipotent Stem Cells, Stem Cells, Body Weight, Mice, Transgenic, Epithelium, Receptors, G-Protein-Coupled, Sweat Glands, Mice, Inbred C57BL, Mice, Imaging, Three-Dimensional, Gene Expression Regulation, Proto-Oncogene Proteins, Animals, Cell Lineage, Female, Epidermis, Cell Proliferation, Skin
Abstract

平成30年度, The skin is responsible for a variety of physiological functions and is critical for wound healing and repair. Therefore, the regenerative capacity of the skin is important. However, stem cells responsible for maintaining the acral epithelium had not previously been identified. In this study, we identified the specific stem cells in the acral epithelium that participate in the long-term maintenance of sweat glands, ducts, and interadnexal epidermis and that facilitate the regeneration of these structures following injury. Lgr6-positive cells and Bmi1-positive cells were found to function as long-term multipotent stem cells that maintained the entire eccrine unit and the interadnexal epidermis. However, while Lgr6-positive cells were rapidly cycled and constantly supplied differentiated cells, Bmi1-positive cells were slow to cycle and occasionally entered the cell cycle under physiological conditions. Upon irradiation-induced injury, Bmi1-positive cells rapidly proliferated and regenerated injured epithelial tissue. Therefore, Bmi1-positive stem cells served as reservoir stem cells. Lgr5-positive cells were rapidly cycled and maintained only sweat glands; therefore, we concluded that these cells functioned as lineage-restricted progenitors. Taken together, our data demonstrated the identification of stem cells that maintained the entire acral epithelium and supported the different roles of three cellular classes.

Published
2015

16. Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity

Author

Yanai, Hirotsugu, primary, Atsumi, Naho, additional, Tanaka, Toshihiro, additional, Nakamura, Naohiro, additional, Komai, Yoshihiro, additional, Omachi, Taichi, additional, Tanaka, Kiyomichi, additional, Ishigaki, Kazuhiko, additional, Saiga, Kazuho, additional, Ohsugi, Haruyuki, additional, Tokuyama, Yoko, additional, Imahashi, Yuki, additional, Ohe, Shuichi, additional, Hisha, Hiroko, additional, Yoshida, Naoko, additional, Kumano, Keiki, additional, Kon, Masanori, additional, and Ueno, Hiroo, additional

Published
2017
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17. Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion

Author

Yanai, Hirotsugu, primary, Atsumi, Naho, additional, Tanaka, Toshihiro, additional, Nakamura, Naohiro, additional, Komai, Yoshihiro, additional, Omachi, Taichi, additional, Tanaka, Kiyomichi, additional, Ishigaki, Kazuhiko, additional, Saiga, Kazuho, additional, Ohsugi, Haruyuki, additional, Tokuyama, Yoko, additional, Imahashi, Yuki, additional, Ohe, Shuichi, additional, Hisha, Hiroko, additional, Yoshida, Naoko, additional, Kumano, Keiki, additional, Kon, Masanori, additional, and Ueno, Hiroo, additional

Published
2017
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18. Bmi1-positive cells in the lingual epithelium could serve as cancer stem cells in tongue cancer

Author

Tanaka, Toshihiro, primary, Atsumi, Naho, additional, Nakamura, Naohiro, additional, Yanai, Hirotsugu, additional, Komai, Yoshihiro, additional, Omachi, Taichi, additional, Tanaka, Kiyomichi, additional, Ishigaki, Kazuhiko, additional, Saiga, Kazuho, additional, Ohsugi, Haruyuki, additional, Tokuyama, Yoko, additional, Imahashi, Yuki, additional, Hisha, Hiroko, additional, Yoshida, Naoko, additional, Kumano, Keiki, additional, Okazaki, Kazuichi, additional, and Ueno, Hiroo, additional

Published
2016
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20. Corrigendum to “Maintenance of sweat glands by stem cells located in the acral epithelium” [Biochem. Biophys. Res. Commun. 466 (3) (2015) 333–338]

Author

Ohe, Shuichi, primary, Tanaka, Toshihiro, additional, Yanai, Hirotsugu, additional, Komai, Yoshihiro, additional, Omachi, Taichi, additional, Kanno, Shohei, additional, Tanaka, Kiyomichi, additional, Ishigaki, Kazuhiko, additional, Saiga, Kazuho, additional, Nakamura, Naohiro, additional, Ohsugi, Haruyuki, additional, Tokuyama, Yoko, additional, Atsumi, Naho, additional, Hisha, Hiroko, additional, Yoshida, Naoko, additional, Kumano, Keiki, additional, Yamazaki, Fumikazu, additional, Okamoto, Hiroyuki, additional, and Ueno, Hiroo, additional

Published
2016
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21. Long-term germ stem cells express Bmi1

Author

Komai, Yoshihiro, primary, Tanaka, Toshihiro, additional, Tokuyama, Yoko, additional, Yanai, Hirotsugu, additional, Ohe, Shuichi, additional, Omachi, Taichi, additional, Atsumi, Naho, additional, Yoshida, Naoko, additional, Kumano, Keiki, additional, Hisha, Hiroko, additional, Matsuda, Tadashi, additional, and Ueno, Hiroo, additional

Published
2016
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22. Bmi1 expression in long-term germ stem cells

Author

Komai, Yoshihiro, primary, Tanaka, Toshihiro, additional, Tokuyama, Yoko, additional, Yanai, Hirotsugu, additional, Ohe, Shuichi, additional, Omachi, Taichi, additional, Atsumi, Naho, additional, Yoshida, Naoko, additional, Kumano, Keiki, additional, Hisha, Hiroko, additional, Matsuda, Tadashi, additional, and Ueno, Hiroo, additional

Published
2014
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27. [Locally Advanced Breast Cancer Treated with Mohs' Paste and Neoadjuvant Chemotherapy-A Case Report].

Author

Hirai C, Tada M, Yanai H, Hasuo H, Sakuma H, Matsumori E, and Sugie T

Subjects
Chlorides, Humans, Mastectomy, Quality of Life, Zinc Compounds, Breast Neoplasms therapy, Neoadjuvant Therapy
Abstract

Cutaneous infiltration by breast cancer significantly reduces patient quality of life(QOL)due to bleeding, exudate, and pain. We report a case of combined treatment using Mohs' paste and neoadjuvant chemotherapy for locally advanced breast cancer. Mohs' paste decreased bleeding and exudate from the tumor and neoadjuvant chemotherapy combined with bevacizumab down-staged a large tumor to a volume that permitted mastectomy. Good local control using Mohs' paste and neoadjuvant chemotherapy can improve patient QOL and reduce the physical burden.

Published
2019

28. [The Clinical Utility of Pegfilgrastim in Combination with Adjuvant FEC(100)and TC Chemotherapy for Breast Cancer].

Author

Yanai H, Endo K, Matsumoto M, Kon M, and Sugie T

Subjects
Adult, Aged, Chemotherapy, Adjuvant, Filgrastim, Granulocyte Colony-Stimulating Factor administration & dosage, Humans, Middle Aged, Polyethylene Glycols, Recombinant Proteins administration & dosage, Recombinant Proteins adverse effects, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy, Granulocyte Colony-Stimulating Factor adverse effects
Abstract

Background: More than 20%of breast cancer patients who undergo myelosuppressive chemotherapy involving FEC(100) or TC experience febrile neutropenia(FN), and pegfilgrastim is commonly recommended as the primary prophylaxis. Delays and/or dose-reductions in chemotherapy should be avoided as much as possible to maximize the clinical benefits of these adjuvant chemotherapies., Purpose: This study assessed the relative dose intensity(RDI), efficacy, and safety of pegfilgrastim in patients with breast cancer. The incidence of FN was also evaluated., Methods: Twenty-six patients with breast cancer undergoing FEC(100)or TC were included in this retrospective study., Results: Of the 26 patients, 19 patients who underwent FEC(100)and 7 patients who underwent TC received 3.6 mg of pegfilgrastim 24 hours after administration of the myelosuppressive chemotherapy. Four and 14 patients who underwent FEC(100)achieved 85-99% and 100% RDI, respectively. All 7 patients who underwent TC achieved 100% RDI. Grade 3 and 4 adverse events, as assessed using the CTCAE, were observed in 11 patients who underwent FEC(100): 2 patients experienced leukocytopenia, 7 experienced neutropenia, 1 experienced thrombocytopenia, and 1 experienced FN. Four patients who underwent TC experienced Grade 3 and 4 adverse events: 1 patient each experienced bone pain, neutropenia, anemia, and FN., Conclusions: Pegfilgrastim can reduce the incidence of FN and maintain RDI in patients with breast cancer undergoing myelosuppressive chemotherapy.

Published
2016

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