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Civil aero-engine is the scientific and technological highland of modern industry and a symbol of the comprehensive national strength of a country; it is also crucial for constructing a new development pattern of dual circulation in China. The development of civil aero-engine industry in China started late and now it is in a critical period of development. Therefore, it is necessary to explore a strategic path for the independent development of the industry, thereby strengthening the transportation, manufacturing, and aviation sectors of China. Through field investigation and further discussion, experiences of other countries regarding aero-engine development are summarized and development status of aero-engines in China is analyzed. Moreover, existing problems of the aero-engine industry in China are examined while considering the development situation in China and abroad and focusing on market demand. The independent development of China’s aero-engine industry can be achieved by three steps and the three-step targets can be realized by promoting scientific and technological innovation capabilities, improving the industrial and supply chains, and encouraging international cooperation. Furthermore, the following suggestions are proposed: promoting the research and development of green power, establishing an aircraft – engine coordination mechanism, developing a multiple support mode, and strengthening policy support and guidance.

Excessive fat deposition leads to obesity and cardiovascular diseases with abnormal metabolism. Pantothenic acid (PA) is a major B vitamin required for energy metabolism. However, the effect of PA on lipid metabolism and obesity has not been explored. We investigated the effects and molecular mechanism of PA on fat accumulation as well as the influence of adipogenic marker genes in both adult male mice and primary adipocytes. First, we demonstrated that PA attenuates weight gain in mice fed high-fat diet (HFD). Besides, PA supplementation substantially improved glucose tolerance and lipid metabolic disorder in obese mice. Furthermore, PA significantly inhibited white adipose tissue (WAT) deposition as well as fat droplets visualized by magnification in both chow and HFD group. More importantly, PA obviously suppressed the mRNA levels of CD36 , IL-6 , and TNF-α to alleviate inflammation and reduced the levels of PPARγ , aP2 , and C/EBPα genes that are related to lipid metabolism in inguinal white adipose tissue (ing-WAT) and epididymal white adipose tissue (ei-WAT). In vitro, PA supplementation showed a lower lipid droplet aggregation as well as reduced expression levels of adipogentic genes. Finally, we identified that PA inhibits the phosphorylation levels of p38 and JNK in murine primary adipocytes. Collectively, our data demonstrated for the first time that PA attenuates lipid metabolic disorder as well as fat deposition by JNK/p38 MAPK signaling pathway.