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Objective: An evaluation of the prognostic factors of patients with surgically treated high-grade neuroendocrine carcinoma of the cervix (NECC). Design: A multi-center, retrospective analysis Setting and Population: 58 cases Methods: 58 patients with stage IIA1-IIIC cervical cancer who had high-grade NECC and were initially treated with surgery between 2009 and 2022 was conducted. We divided them into two groups based on pathology: the pure cohort (only one histological type) and the mixed group (≥2 histological types). All clinicopathological characteristics of patients were reviewed retrospectively using electronic medical records. Main Outcome Measures: Survival outcomes of NECC, clinicopathological characteristics and various related factors were analysed. Results: The median overall survival (OS) was 32.5 months (range: 4.1–60.9). The mixed pathology was a protective factor impacting survival outcomes in NECC (HR,0.02; 95% CI, 0.00~0.45, P=0.014). In contrast, uterus invasion (HR, 24.5; 95%CI, 1.37~439.31, P=0.03) was a poor prognostic factor affecting the survival outcomes in NECC. In addition, among all postoperative adjuvant chemotherapy options, etoposide + platinum (EP) showed better survival outcome (HR,0.04; 95% CI, 0.00~0.89, P=0.041). According to the Kaplan-Meier survival curves, significant differences were observed with respect to mixed pathology (P=0.044), uterus invasion (P＜0.0001), parametrium invasion (P=0.025), surgical margin (P=0.035), and distant metastasis (P＜0.0001). Conclusions: Patients with mixed pathological subtypes who undergo surgery for NECC have a better prognosis. Meanwhile, uterus invasion is a poor predictor of prognosis. In terms of postoperative adjuvant chemotherapy, the EP regimen is superior to other regimens. (The trial registration number: ChiCTR2200063023)

Backgrounds and aims Increased arterial stiffness may increase cardiovascular morbidity and mortality. Angiotensin II type 1 receptor blocker losartan is potentially useful in controlling the central blood pressure and arterial stiffness in mild to moderate essential hypertension, while the effects of losartan in aged patients with essential hypertension are not entirely investigated. Methods The carotid-femoral arterial pulse wave velocity (PWV) was measured in aged patients with essential hypertension. Results In a cross-sectional study, PWV value was significantly higher in these old patients with essential hypertension, compared with patients without essential hypertension. Logistic regression analysis indicated that age, hypertension duration, and losartan treatment are risk factors of arterial stiffness. In a perspective study, long-term administration of losartan (50 mg/d) remarkably reduced PWV in aged patients with essential hypertension. In a longitudinal study, PWV is an independent predictor of the occurrence of acute coronary syndrome (ACS) in elderly patients with essential hypertension by using multivariate analysis. Further, the ACS occurrence was reduced by long-term administration of losartan in aged patients with essential hypertension, compared with the old hypertensive patients without taking losartan. Conclusion Losartan treatment is a negative risk factor of arterial stiffness and reduces the risk of ACS in aged patients with essential hypertension.

Fusion of output information from different sets of INS can effectively improve the navigation accuracy and fault tolerance. Hence, vehicles are usually equipped with two or more than two sets of inertial navigation systems (INS). However, due to the misalignment angles, the coordinate axes of different systems are usually not absolutely coincide with each other, which would cause serious problems when integrating the attitudes information. Therefore, it is necessary to precisely calibrate and compensate the misalignment angles between systems. In this study, a mathematical model of misalignment angles between INSs is established, and a fast and highly accurate calibration method for misalignment angles between the two systems is proposed. To verify the validity of the method, a turntable experiment was carried out. Experiment results show when turntable’s X axis swings the biggest attitude difference can be inhibited from 550” peak- peak value to 15” peak#peak value, when turntable’s Y axis swings the biggest attitude difference can be inhibited from 500” peak#peak value to S” peak- peak value, when turntable’s Z axis swings the biggest attitude difference can be inhibited from 1900” peak - peak value to 2” peak- peak value.

To study the impacts of structural change of SiO2 aerogel on its insulating properties, the samples were treated in long time (0-12h) at 500°C, 600°C, 700°C and 800°C. The results show that with the time increased, the shrink extends in thickness, the weight loss and the density is basically unchanged under the 500°Cand 600°C. As for 700°C and 800°C, the results were treated with 0-12h, the shrink extends in thickness, the weight loss and density increases considerably. Besides, the structure and composition of SiO2 aerogel after the different temperature treaded with 0.5h were tested. The results show that when the heat treatment temperature is between 200-800°C, the small pores in SiO2 aerogel collapses and large pores increase, and the density is stil1 able to maintain the 1ow value due to the unbroken skeleton. When the heat temperature is between 800-1000°C, the secondary particle size increases and the rnutual integration of the secondary particles occurs, the density will be significantly increased.

Stress is increasingly present in everyday life in our fast-paced society and involved in the pathogenesis of many psychiatric diseases. Corticotrophin-releasing-hormone (CRH) plays a pivotal role in regulating the stress responses. The tree shrews are highly vulnerable to stress which makes them the promising animal models for studying stress responses. However, the mechanisms underlying their high stress-susceptibility remained unknown. Here we confirmed that cortisol was the dominate corticosteroid in tree shrew and was significantly increased after acute stress. Our study showed that the function of tree shrew CRH - hypothalamic-pituitary-adrenal (HPA) axis was nearly identical to human that contributed little to their hyper-responsiveness to stress. Using CRH transcriptional regulation analysis we discovered a peculiar active glucocorticoid receptor response element (aGRE) site within the tree shrew CRH promoter, which continued to recruit co-activators including SRC-1 (steroid receptor co-activator-1) to promote CRH transcription under basal or forskolin/dexamethasone treatment conditions. Basal CRH mRNA increased when the aGRE was knocked into the CRH promoter in human HeLa cells using CAS9/CRISPR. The aGRE functioned critically to form the “Stress promoter” that contributed to the higher CRH expression and susceptibility to stress. These findings implicated novel molecular bases of the stress-related diseases in specific populations.

Cu-doped anatase TiO2 films grown by magnetron sputtering at room temperature showed the unexpected observation of room-temperature ferromagnetism, which was enhanced or destroyed corresponding to low or high impurity concentration via vacuum annealing. On the basis of the analysis of composition and structure, the most important factor for activating ferromagnetism can be identified as the creation of grain boundary defects. In addition, oxygen defects can be the dominating factor for increasing the saturation moment of the 0.19 at. % Cu-doped TiO2 film from 0.564 to 26.41 emu/cm(3). These results help elucidate the origin of ferromagnetism and emphasize the role of oxygen defects for the application of ferromagnetic films.

To investigate the relationship between the extracellular matrix (ECM) and neoplastic progression in hamster with tongue cancer.Forty-eight specimens of hamster tongue cancer were divided into control group (n=6) and experimental group (n=42). The pathological grade of the specimens was assessed (including 3 stages, namely atypical hyperplasia, carcinoma in situ and early invasive carcinoma). The sections of the tongue were stained with Masson and aldehyde-fuchsin (AF) staining for microscopic observation of the elastic fiber and collagen fiber changes.Within the connective tissue cores (CTC) of the papillae in the control group was a framework of numerous and fine Gomrori's aldehyde fuchsin-positive elastic fibers. But in the stages of dysplasia and carcinoma in situ, these elastic fibers decreased and further diminished in the CTC in early invasive carcinoma. In dysplasia and carcinoma in situ stages, most of the elastic fibers collapsed with scattered elastic fibers, and the elastic fibers decreased significantly in early invasive carcinoma. The control group showed a significantly greater number of elastic fibers in the experimental group. The collagen fiber was obviously increased and irregularly arranged in dysplasia and carcinoma in situ stage; in early invasive carcinoma, the collagen fibers became thicker with deposition in the lamina propria.An excessive deposition of collagen fiber and reduction of the elastic fibers is an important factor contributing to the development of tongue carcinoma in hamsters.

To find out the rate of repeated induced abortion among unmarried abortion women and to study the relevant risk factors.From July to September 2005, we used the method of hospital based descriptive epidemiological study to investigate 2295 abortion women below 25 years of age in Beijing, Shanghai and Zhengzhou. Case-control study was used as the method. We considered the women with history of repeated abortion as case group (736 women) and considered the women without history of repeated abortion as control group (1559 women).The mean age of respondents was 21.92 years with minimal age as 15 years. 17.2 % aborted women aged below 20 years with 32. 1% of them were ever having a history of previous induced abortion. Among 736 women with repeated abortion, 75.3 % of them had one time of induced abortion previously, 18.1% having two times, 4.2% having 3 times, 13 women having 4 times and 4 women having 5 times and one even with the maximum of having 8 times of previous abortion. In comparison with control group, the case group had higher rate among women whose first sex was below 18 years (16.2% vs. 9.4% , P0.01). There were higher rates of women under following conditions: having exposed to sexual behavior for more than 3 years (33.6% vs. 6.6 % , P0.01), having cohabited with male partner for over 1 year (64.6% vs. 23.9%, P0.01), having regular sexual life (48.5 % vs. 37. 1%, P0.05), having multiple sexual partners (36.0% vs. 15.0%,P0.01) having unwanted sex (6.0% vs. 3.9%, P0.05), whose current pregnancy resulted from contraceptive failure (39.3% vs. 31.6%, P0.01), having a history of high-risk abortion (30.8% vs. 3.1%, P0.01) etc. In comparison with the control group, the case group showed higher rates of male partners not supporting this induced abortion, male partner not participating in decision-making on abortion and male partner not accompanying the female partners to seek for abortion service (rates of the three major factors in case group and in control group were 10.3% vs. 5.9%, P0.01, 30.3% vs. 24.0%, and 27.5% vs. 23.5%, P0.01, respectively).The rate of repeated induced abortion among unmarried abortion women was relatively high. The risk factors for females would include: younger age of sex debut, longer duration from the beginning of first sex to the current abortion, cohabitation, regular sexual life, multiple sexual partners, unwanted sex, contraceptive failure and high risk induced abortion. Meanwhile, unmarried but repeated abortion was related to the differences of gender between males and females and male partner's concern on induced abortion.