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A millimeter-wave broadband metasurface-based antenna with a low profile is proposed. In order to guide the mode excitation, the characteristic mode analysis (CMA) is used for the design and optimization of the proposed antenna. Four sets of coplanar patches with different dimensions on a thin printed circuit board are used to generate four adjacent broadside modes, which are directly fed by a coaxial probe. Then, to expand low-frequency bandwidth, a new resonant mode is introduced by etching slots on the parasite patch. Meanwhile, the extra mode introduced does not significantly change the radiation performance of the original modes. Moreover, dual slots are etched on the mid patch fed by the coaxial probe, which moves the orthogonal modes of the chosen modes out of the operating band to reduce cross-polarization levels. The proposed antenna realized 25.02 % (30–38.58 GHz) impedance bandwidth with dimensions of 1.423 × 1.423 × 0.029 λ 0   3 ( λ 0 is the wavelength at 34 GHz in free space), and the realized gain in the band is 8.35–11.3 dB. [ABSTRACT FROM AUTHOR]

Aim: To explore the association of neurotensin receptor 1 (NTSR1) with inflammatory bowel diseases (IBD) and colitis-associated neoplasia., Methods: NTSR1 was detected by immunohistochemistry in clinical samples of colonic mucosa with IBD colitis, colitis-associated raised low-grade dysplasia (LGD) including dysplasia-associated lesions or masses (DALMs, n = 18) and adenoma-like dysplastic polyps (ALDPs, n = 4), colitis-associated high-grade dysplasia (HGD, n = 11) and colitis-associated colorectal carcinoma (CACRC, n = 13), sporadic colorectal adenomatous polyp (SAP, n = 17), and sporadic colorectal carcinoma (SCRC, n = 12). The immunoreactivity of NTSR1 was semiquantitated (as negative, 1+, 2+, and 3+) and compared among different conditions., Results: NTSR1 was not detected in normal mucosa but was expressed similarly in both active and inactive colitis. LGD showed a significantly stronger expression as compared with non-dysplastic colitic mucosa, with significantly more cases showing > 2+ intensity (68.75% in LGD vs 32.26% in nondysplastic mucosa, P = 0.001). However, no significant difference existed between DALMs and ALDPs. CACRC and HGD showed a further stronger expression, with significantly more cases showing 3+ intensity than that in LGD (61.54% vs 12.50% for CACRC vs LGD, P = 0.022; 58.33% vs 12.50% for CACRC/HGD vs LGD, P = 0.015). No significant difference existed between colitis-associated and non-colitic sporadic neoplasia., Conclusion: NTSR1 in colonic epithelial cells is overexpressed in IBD, in a stepwise fashion with sequential progress from inflammation to dysplasia and carcinoma.