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18 results on '"Yan, Yonghuan"'

3. Intermittent fasting boosts antitumor immunity by restricting CD11b +Ly6C low Ly6G low cell viability through glucose metabolism in murine breast tumor model

Author

Fu, Chenghao, primary, Liang, Zhehao, additional, Niu, Zemiao, additional, Chen, Ning, additional, Li, Yuemin, additional, Liang, Zhenhua, additional, Huo, Yanwei, additional, Xi, Hao, additional, Wang, Rong, additional, Yan, Yonghuan, additional, Gano, Xiaoru, additional, Wang, Mengtian, additional, Huang, Yun, additional, Zhang, Yan, additional, Gao, Mingming, additional, and Lü, Pin, additional

Published
2024
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6. Targeted delivery of food functional ingredients in precise nutrition: design strategy and application of nutritional intervention.

Author

Wang, Xu, Shi, Guohua, Fan, Sufang, Ma, Junmei, Yan, Yonghuan, Wang, Mengtian, Tang, Xiaozhi, Lv, Pin, and Zhang, Yan

Subjects
INFLAMMATORY bowel diseases, LOCAL delivery services, CONSTRUCTION materials, FUNCTIONAL foods, DISEASE incidence, NUTRITION
Abstract

With the high incidence of chronic diseases, precise nutrition is a safe and efficient nutritional intervention method to improve human health. Food functional ingredients are an important material base for precision nutrition, which have been researched for their application in preventing diseases and improving health. However, their poor solubility, stability, and bad absorption largely limit their effect on nutritional intervention. The establishment of a stable targeted delivery system is helpful to enhance their bioavailability, realize the controlled release of functional ingredients at the targeted action sites in vivo, and provide nutritional intervention approaches and methods for precise nutrition. In this review, we summarized recent studies about the types of targeted delivery systems for the delivery of functional ingredients and their digestion fate in the gastrointestinal tract, including emulsion-based delivery systems and polymer-based delivery systems. The building materials, structure, size and charge of the particles in these delivery systems were manipulated to fabricate targeted carriers. Finally, the targeted delivery systems for food functional ingredients have gained some achievements in nutritional intervention for inflammatory bowel disease (IBD), liver disease, obesity, and cancer. These findings will help in designing fine targeted delivery systems, and achieving precise nutritional intervention for food functional ingredients on human health. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Intermittent fasting boosts antitumor immunity by restricting CD11b+Ly6ClowLy6Glowcell viability through glucose metabolism in murine breast tumor model

Author

Fu, Chenghao, Liang, Zhehao, Niu, Zemiao, Chen, Ning, Li, Yuemin, Liang, Zhenhua, Huo, Yanwei, Xi, Hao, Wang, Rong, Yan, Yonghuan, Gan, Xiaoruo, Wang, Mengtian, Huang, Yun, Zhang, Yan, Gao, Mingming, and Lü, Pin

Abstract

Intermittent fasting can benefit breast cancer patients undergoing chemotherapy or immunotherapy. However, it is still uncertain how to select immunotherapy drugs to combine with intermittent fasting. Herein we observed that two cycles of fasting treatment significantly inhibited breast tumor growth and lung tissue metastasis, as well as prolonged overall survival in mice bearing 4T1 and 4T07 breast cancer. During this process, both the immunosuppressive monocytic- (M-) and granulocytic- (G-) myeloid-derived suppressor cell (MDSC) decreased, accompanied by an increase in interleukin (IL) 7R+and granzyme B+T cells in the tumor microenvironment. Interestingly, we observed that Ly6GlowG-MDSC sharply decreased after fasting treatment, and the cell surface markers and protein mass spectrometry data showed potential therapeutic targets. Mechanistic investigation revealed that glucose metabolism restriction suppressed the splenic granulocyte-monocyte progenitor and the generation of colony-stimulating factors and IL-6, which both contributed to the accumulation of G-MDSC. On the other hand, glucose metabolism restriction can directly induce the apoptosis of Ly6GlowG-MDSC, but not Ly6Ghighsubsets. In summary, these results suggest that glucose metabolism restriction induced by fasting treatment attenuates the immune-suppressive milieu and enhances the activation of CD3+T cells, providing potential solutions for enhancing immune-based cancer interventions.

Published
2024
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