8,443 results on '"Yan, Rong"'
Search Results
2. Spectroastrometry and Reverberation Mapping (SARM) of Active Galactic Nuclei. I. The H$\beta$ Broad-line Region Structure and Black Hole Mass of Five Quasars
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Li, Yan-Rong, Hu, Chen, Yao, Zhu-Heng, Chen, Yong-Jie, Bai, Hua-Rui, Yang, Sen, Du, Pu, Fang, Feng-Na, Fu, Yi-Xin, Liu, Jun-Rong, Peng, Yue-Chang, Songsheng, Yu-Yang, Wang, Yi-Lin, Xiao, Ming, Zhai, Shuo, Winkler, Hartmut, Bai, Jin-Ming, Ho, Luis C., Petrov, Romain G., Aceituno, Jesus, and Wang, Jian-Min
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Astrophysics - Astrophysics of Galaxies - Abstract
We conduct a reverberation mapping (RM) campaign to spectroscopically monitor a sample of selected bright active galactic nuclei with large anticipated broad-line region (BLR) sizes adequate for spectroastrometric observations by the GRAVITY instrument on the Very Large Telescope Interferometer. We report the first results for five objects, IC 4329A, Mrk 335, Mrk 509, Mrk 1239, and PDS 456, among which Mrk 1239 and PDS 456 are for the first time spectroscopically monitored. We obtain multi-year monitoring data and perform multi-component spectral decomposition to extract the broad H$\beta$ profiles. We detect significant time lags between the H$\beta$ and continuum variations, generally obeying the previously established BLR size-luminosity relation. Velocity-resolved H$\beta$ time lags illustrate diverse, possibly evolving BLR kinematics. We further measure the H$\beta$ line widths from mean and rms spectra and the resulting virial products show good consistency among different seasons. Adopting a unity virial factor and the full width at half maximum of the broad H$\beta$ line from the mean spectrum as the measure of velocity, the obtained black hole mass averaged over seasons is $\log M_\bullet/M_\odot=8.02_{-0.14}^{+0.09}$, $6.92_{-0.12}^{+0.12}$, $8.01_{-0.25}^{+0.16}$, $7.44_{-0.14}^{+0.13}$, and $8.59_{-0.11}^{+0.07}$ for the five objects, respectively. The black hole mass estimations using other line width measures are also reported (up to the virial factors). For objects with previous RM campaigns, our mass estimates are in agreement with earlier results. In a companion paper, we will employ BLR dynamical modeling to directly infer the black hole mass and thereby determine the virial factors., Comment: 32 pages, 6 tables, 20 figures. To appear in ApJ
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- 2024
3. m-QMDS codes over mixed alphabets via orthogonal arrays
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Pang, Shanqi, Chen, Mengqian, Yan, Rong, and Zhu, Yan
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Quantum Physics - Abstract
The construction of quantum error-correcting codes (QECCs) with good parameters is a hot topic in the area of quantum information and quantum computing. Quantum maximum distance separable (QMDS) codes are optimal because the minimum distance cannot be improved for a given length and code size. The QMDS codes over mixed alphabets are rarely known even if the existence and construction of QECCs over mixed alphabets with minimum distance more than or equal to three are still an open question. In this paper, we define an $m$-QMDS code over mixed alphabets, which is a generalization of QMDS codes. We establish a relation between $m$-QMDS codes over mixed alphabets and asymmetrical orthogonal arrays (OAs) with orthogonal partitions. Using this relation, we propose a general method to construct $m$-QMDS codes. As applications of this method, numerous infinite families of $m$-QMDS codes over mixed alphabets can be constructed explicitly. Compared with existing codes, the constructed codes have more flexibility in the choice of parameters, such as the alphabet sizes, length and dimension of the encoding state.
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- 2024
4. Monitoring AGNs with H$\beta$ Asymmetry. IV. First Reverberation Mapping Results of 14 AGNs
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Zastrocky, T. E., Brotherton, Michael S., Du, Pu, McLane, Jacob N., Olson, Kianna A., Dale, D. A., Kobulnicky, H. A., Maithil, Jaya, Nguyen, My L., Chick, William T., Kasper, David H., Hand, Derek, Adelman, C., Carter, Z., Murphree, G., Oeur, M., Roth, T., Schonsberg, S., Caradonna, M. J., Favro, J., Ferguson, A. J., Gonzalez, I. M., Hadding, L. M., Hagler, H. D., Rogers, C. J., Stack, T. R., Chapman, Franklin, Bao, Dong-Wei, Fang, Feng-Na, Zhai, Shuo, Yang, Sen, Chen, Yong-Jie, Bai, Hua-Rui, Fu, Yi-Xin, Liu, Jun-Rong, Yao, Zhu-Heng, Peng, Yue-Chang, Songsheng, Yu-Yang, Li, Yan-Rong, Bai, Jin-Ming, Hu, Chen, Xiao, Ming, Ho, Luis C., and Wang, Jian-Min
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Astrophysics - Astrophysics of Galaxies - Abstract
We report first-time reverberation mapping results for 14 AGNs from the ongoing Monitoring AGNs with H$\beta$ Asymmetry campaign (MAHA). These results utilize optical spectra obtained with the Long Slit Spectrograph on the Wyoming Infrared 2.3m Telescope between 2017 November-2023 May. MAHA combines long-duration monitoring with high cadence. We report results from multiple observing seasons for 9 of the 14 objects. These results include H$\beta$ time lags, supermassive black hole masses, and velocity-resolved time lags. The velocity-resolved lags allow us to investigate the kinematics of the broad-line region., Comment: 35 pages, 19 figures, accepted for publication in ApJ Supplement
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- 2024
5. Event-triggered Hybrid Force Feedback Architecture With Tank-based Stabilization Method for Complicated Bilateral Teleoperation Tasks
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Gao, Zhitao, Peng, Fangyu, Chen, Chen, Zhang, Yukui, Wang, Yu, Yan, Rong, and Tang, Xiaowei
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- 2024
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6. Adaptive Tuning of Robotic Polishing Skills based on Force Feedback Model
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Wang, Yu, Zheng, Zhouyi, Chen, Chen, Wang, Zezheng, Gao, Zhitao, Peng, Fangyu, Tang, Xiaowei, and Yan, Rong
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Computer Science - Robotics - Abstract
Acquiring human skills offers an efficient approach to tackle complex task planning challenges. When performing a learned skill model for a continuous contact task, such as robot polishing in an uncertain environment, the robot needs to be able to adaptively modify the skill model to suit the environment and perform the desired task. The environmental perturbation of the polishing task is mainly reflected in the variation of contact force. Therefore, adjusting the task skill model by providing feedback on the contact force deviation is an effective way to meet the task requirements. In this study, a phase-modulated diagonal recurrent neural network (PMDRNN) is proposed for force feedback model learning in the robotic polishing task. The contact between the tool and the workpiece in the polishing task can be considered a dynamic system. In comparison to the existing feedforward neural network phase-modulated neural network (PMNN), PMDRNN combines the diagonal recurrent network structure with the phase-modulated neural network layer to improve the learning performance of the feedback model for dynamic systems. Specifically, data from real-world robot polishing experiments are used to learn the feedback model. PMDRNN demonstrates a significant reduction in the training error of the feedback model when compared to PMNN. Building upon this, the combination of PMDRNN and dynamic movement primitives (DMPs) can be used for real-time adjustment of skills for polishing tasks and effectively improve the robustness of the task skill model. Finally, real-world robotic polishing experiments are conducted to demonstrate the effectiveness of the approach., Comment: This paper has been accepted by The 2023 IEEE International Conference on Robotics and Biomimetics (IEEE ROBIO 2023)
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- 2023
7. AGN STORM 2. VI. Mapping Temperature Fluctuations in the Accretion Disk of Mrk 817
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Neustadt, Jack M. M., Kochanek, Christopher S., Montano, John, Gelbord, Jonathan, Barth, Aaron J., De Rosa, Gisella, Kriss, Gerard A., Cackett, Edward M., Horne, Keith, Kara, Erin A., Landt, Hermine, Netzer, Hagai, Arav, Nahum, Bentz, Misty C., Bonta, Elena Dalla, Dehghanian, Maryam, Du, Pu, Edelson, Rick, Ferland, Gary J., Fian, Carina, Fischer, Travis, Goad, Michael R., Buitrago, Diego H. Gonzalez, Gorjian, Varoujan, Grier, Catherine J., Hall, Patrick B., Homayouni, Y., Hu, Chen, Ilic, Dragana, Joner, Michael D., Kaastra, Jelle, Kaspi, Shai, Korista, Kirk T., Kovacevic, Andjelka B., Lewin, Collin, Li, Yan-Rong, McHardy, Ian M., Mehdipour, Missagh, Miller, Jake A., Panagiotou, Christos, Partington, Ethan, Plesha, Rachel, Pogge, Richard W., Popovic, Luka C., Proga, Daniel, Storchi-Bergmann, Thaisa, Sanmartim, David, Siebert, Matthew R., Signorini, Matilde, Vestergaard, Marianne, Zaidouni, Fatima, and Zu, Ying
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
We fit the UV/optical lightcurves of the Seyfert 1 galaxy Mrk 817 to produce maps of the accretion disk temperature fluctuations $\delta T$ resolved in time and radius. The $\delta T$ maps are dominated by coherent radial structures that move slowly ($v \ll c$) inwards and outwards, which conflicts with the idea that disk variability is driven only by reverberation. Instead, these slow-moving temperature fluctuations are likely due to variability intrinsic to the disk. We test how modifying the input lightcurves by smoothing and subtracting them changes the resulting $\delta T$ maps and find that most of the temperature fluctuations exist over relatively long timescales ($\sim$100s of days). We show how detrending AGN lightcurves can be used to separate the flux variations driven by the slow-moving temperature fluctuations from those driven by reverberation. We also simulate contamination of the continuum emission from the disk by continuum emission from the broad line region (BLR), which is expected to have spectral features localized in wavelength, such as the Balmer break contaminating the $U$ band. We find that a disk with a smooth temperature profile cannot produce a signal localized in wavelength and that any BLR contamination should appear as residuals in our model lightcurves. Given the observed residuals, we estimate that only $\sim$20% of the variable flux in the $U$ and $u$ lightcurves can be due to BLR contamination. Finally, we discus how these maps not only describe the data, but can make predictions about other aspects of AGN variability., Comment: 23 pages, 18 figures, submitting to ApJ, comments welcome
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- 2023
8. Research Advance of Chinese Medicine in Treating Atherosclerosis: Focus on Lipoprotein-Associated Phospholipase A2
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Wang, Lu-ming, Zhang, Wen-lan, Lyu, Nuan, Suo, Yan-rong, Yang, Lin, Yu, Bin, and Jiang, Xi-juan
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- 2024
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9. AGN STORM 2: V. Anomalous Behavior of the CIV Light Curve in Mrk 817
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Homayouni, Y., Kriss, Gerard A., De Rosa, Gisella, Plesha, Rachel, Cackett, Edward M., Goad, Michael R., Korista, Kirk T., Horne, Keith, Fischer, Travis, Waters, Tim, Barth, Aaron J., Kara, Erin A., Landt, Hermine, Arav, Nahum, Boizelle, Benjamin D., Bentz, Misty C., Brotherton, Michael S., Chelouche, Doron, Bonta, Elena Dalla, Dehghanian, Maryam, Du, Pu, Ferland, Gary J., Fian, Carina, Gelbord, Jonathan, Grier, Catherine J., Hall, Patrick B., Hu, Chen, Ilic, Dragana, Joner, Michael D., Kaastra, Jelle, Kaspi, Shai, Kovacevic, Andjelka B., Kynoch, Daniel, Li, Yan-Rong, Mehdipour, Missagh, Miller, Jake A., Mitchell, Jake, Montano, John, Netzer, Hagai, Neustadt, J. M. M., Partington, Ethan, Popovic, Luka C., Proga, Daniel, Storchi-Bergmann, Thaisa, Sanmartim, David, Siebert, Matthew R., Treu, Tommaso, Vestergaard, Marianne, Wang, Jian-Min, Ward, Martin J., Zaidouni, Fatima, and Zu, Ying
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Astrophysics - Astrophysics of Galaxies - Abstract
An intensive reverberation mapping campaign on the Seyfert 1 galaxy Mrk817 using the Cosmic Origins Spectrograph (COS) on the Hubble Space Telescope (HST) revealed significant variations in the response of the broad UV emission lines to fluctuations in the continuum emission. The response of the prominent UV emission lines changes over a $\sim$60-day duration, resulting in distinctly different time lags in the various segments of the light curve over the 14 months observing campaign. One-dimensional echo-mapping models fit these variations if a slowly varying background is included for each emission line. These variations are more evident in the CIV light curve, which is the line least affected by intrinsic absorption in Mrk817 and least blended with neighboring emission lines. We identify five temporal windows with distinct emission line response, and measure their corresponding time delays, which range from 2 to 13 days. These temporal windows are plausibly linked to changes in the UV and X-ray obscuration occurring during these same intervals. The shortest time lags occur during periods with diminishing obscuration, whereas the longest lags occur during periods with rising obscuration. We propose that the obscuring outflow shields the ultraviolet broad lines from the ionizing continuum. The resulting change in the spectral energy distribution of the ionizing continuum, as seen by clouds at a range of distances from the nucleus, is responsible for the changes in the line response., Comment: 20 pages, 8 figures, Accepted for publication in ApJ
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- 2023
10. AGN STORM 2. IV. Swift X-ray and ultraviolet/optical monitoring of Mrk 817
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Cackett, Edward M., Gelbord, Jonathan, Barth, Aaron J., De Rosa, Gisella, Edelson, Rick, Goad, Michael R., Homayouni, Yasaman, Horne, Keith, Kara, Erin A., Kriss, Gerard A., Korista, Kirk T., Landt, Hermine, Plesha, Rachel, Arav, Nahum, Bentz, Misty C., Boizelle, Benjamin D., Bonta, Elena Dalla, Dehghanian, Maryam, Donnan, Fergus, Du, Pu, Ferland, Gary J., Fian, Carina, Filippenko, Alexei V., Buitrago, Diego H. Gonzalez, Grier, Catherine J., Hall, Patrick B., Hu, Chen, Ilic, Dragana, Kaastra, Jelle, Kaspi, Shai, Kochanek, Christopher S., Kovacevic, Andjelka B., Kynoch, Daniel, Li, Yan-Rong, McLane, Jacob N., Mehdipour, Missagh, Miller, Jake A., Montano, John, Netzer, Hagai, Panagiotou, Christos, Partington, Ethan, Popovic, Luka C., Proga, Daniel, Rogantini, Daniele, Sanmartim, David, Siebert, Matthew R., Storchi-Bergmann, Thaisa, Vestergaard, Marianne, Wang, Jian-Min, Waters, Tim, and Zaidouni, Fatima
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
The AGN STORM 2 campaign is a large, multiwavelength reverberation mapping project designed to trace out the structure of Mrk 817 from the inner accretion disk to the broad emission line region and out to the dusty torus. As part of this campaign, Swift performed daily monitoring of Mrk 817 for approximately 15 months, obtaining observations in X-rays and six UV/optical filters. The X-ray monitoring shows that Mrk 817 was in a significantly fainter state than in previous observations, with only a brief flare where it reached prior flux levels. The X-ray spectrum is heavily obscured. The UV/optical light curves show significant variability throughout the campaign and are well correlated with one another, but uncorrelated with the X-rays. Combining the Swift UV/optical light curves with Hubble UV continuum light curves, we measure interband continuum lags, $\tau(\lambda)$, that increase with increasing wavelength roughly following $\tau(\lambda) \propto \lambda^{4/3}$, the dependence expected for a geometrically thin, optically thick, centrally illuminated disk. Modeling of the light curves reveals a period at the beginning of the campaign where the response of the continuum is suppressed compared to later in the light curve - the light curves are not simple shifted and scaled versions of each other. The interval of suppressed response corresponds to a period of high UV line and X-ray absorption, and reduced emission line variability amplitudes. We suggest that this indicates a significant contribution to the continuum from the broad line region gas that sees an absorbed ionizing continuum., Comment: 20 pages, 13 figures, 3 tables, accepted for publication in ApJ
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- 2023
11. Long-term optical spectral monitoring of a changing-look active galactic nucleus NGC 3516 -- II. Broad-line profile variability
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Popović, Luka C., Ilić, Dragana, Burenkov, Alexander, Álvarez, Victor Manuel Patiño, Marceta-Mandić, Sladjana, Dojcinović, Jelena Kovacević, Shablovinskaya, Elena, Kovacević, Andjelka B., Marziani, Paola, Chavushyan, Vahram, Wang, Jian-Min, Li, Yan-Rong, and Mediavilla, Evencio G.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We analyze the broad H$\beta$ line profile variability of the "changing look" active galactic nucleus (CL-AGN) NGC 3516 over a long period of 25 years. The observed change in the broad line profile may indicate a change in the geometry of the broad line region (BLR). Using spectral line profiles, we aim to explore changes in the kinematics and dimensions of the BLR in NGC 3516. We consider two possible scenarios, i.e. changes in the broad-line emission are caused by a decrease of ionization continuum emission or by the BLR obscuration by outer dusty regions. With this investigation we aim to clarify the CL mechanism of this AGN. We analyze the spectral band around the H$\beta$ line as well as the broad H$\beta$ line parameters, and how they change in time. We model the broad-line profiles assuming that there is an emission from the accretion disc superposed with an emission from a surrounding region that is outside the disc. We find that in the Type 1 activity phase, the BLR is very complex. There is a clear disc-like BLR that contributes to the broad line wings and an additional intermediate line region (ILR) that contributes to the line core. In the high activity phase, the ILR emission is close to the center of the line (in some cases slightly shifted to the red), whereas in the low activity phase (i.e., Type 2 phase), the ILR component has a significant shift to the blue, indicating an outflow. We propose that the changing look mechanism in NGC 3516 is rather connected with the intrinsic effects than with an outer obscuring region. It may still be possible that the dust has an important role in the low activity phase when it is coming inside of the BLR, making a dusty BLR. In this way, it causes a decrease in the ionization and recombination rates., Comment: 16 pages, accepted in A&A
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- 2023
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12. Transcription factor TaNF-YB2 interacts with partners TaNF-YA7/YC7 and transcriptionally activates distinct stress-defensive genes to modulate drought tolerance in T. Aestivum
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Ying-Jia Zhao, Chun-Ying Ma, Meng-Jing Zheng, Yan-Rong Yao, Li-Hua Lv, Li-Hua Zhang, Xiao-Xin Fu, Jing-Ting Zhang, and Kai Xiao
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Wheat (Triticum aestivum L.) ,Nuclear factor-YB gene ,Protein interaction ,transcriptional activation ,Transgene analysis ,Stress-associated physiological parameter ,Botany ,QK1-989 - Abstract
Abstract Background Drought stress limits significantly the crop productivity. However, plants have evolved various strategies to cope with the drought conditions by adopting complex molecular, biochemical, and physiological mechanisms. Members of the nuclear factor Y (NF-Y) transcription factor (TF) family constitute one of the largest TF classes and are involved in plant responses to abiotic stresses. Results TaNF-YB2, a NY-YB subfamily gene in T. aestivum, was characterized in this study focusing on its role in mediating plant adaptation to drought stress. Yeast two-hybrid (Y-2 H), biomolecular fluoresence complementation (BiFC), and Co-immunoprecipitation (Co-IP) assays indicated that TaNF-YB2 interacts with the NF-YA member TaNF-YA7 and NF-YC family member TaNF-YC7, which constitutes a heterotrimer TaNF-YB2/TaNF-YA7/TaNF-YC7. The TaNF-YB2 transcripts are induced in roots and aerial tissues upon drought signaling; GUS histochemical staining analysis demonstrated the roles of cis-regulatory elements ABRE and MYB situated in TaNF-YB2 promoter to contribute to target gene response to drought. Transgene analysis on TaNF-YB2 confirmed its functions in regulating drought adaptation via modulating stomata movement, osmolyte biosynthesis, and reactive oxygen species (ROS) homeostasis. TaNF-YB2 possessed the abilities in transcriptionally activating TaP5CS2, the P5CS family gene involving proline biosynthesis and TaSOD1, TaCAT5, and TaPOD5, the genes encoding antioxidant enzymes. Positive correlations were found between yield and the TaNF-YB2 transcripts in a core panel constituting 45 wheat cultivars under drought condition, in which two types of major haplotypes including TaNF-YB2-Hap1 and -Hap2 were included, with the former conferring more TaNF-YB2 transcripts and stronger plant drought tolerance. Conclusions TaNF-YB2 is transcriptional response to drought stress. It is an essential regulator in mediating plant drought adaptation by modulating the physiological processes associated with stomatal movement, osmolyte biosynthesis, and reactive oxygen species (ROS) homeostasis, depending on its role in transcriptionally regulating stress response genes. Our research deepens the understanding of plant drought stress underlying NF-Y TF family and provides gene resource in efforts for molecular breeding the drought-tolerant cultivars in T. aestivum.
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- 2024
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13. An exploration of the self-similarity of traditional settlements: the case of Xiaoliangjiang Village in Jingxing, Hebei, China
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Peng Peng, Xiangyun Zhou, Shaopu Wu, Yuechen Zhang, Jiajie Zhao, Limin Zhao, Jinyu Wu, and Yan Rong
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Traditional settlements ,Self-similarity ,Space syntax ,Fractal theory ,Fine Arts ,Analytical chemistry ,QD71-142 - Abstract
Abstract In order to retain the characteristics and style of traditional settlements and respect their layout and structure, it is necessary to carry out original planning and expansion of traditional settlements. This model of planning and expansion aims to protect the unique character of the settlement, maintain its original historical and cultural value, and integrate with the surrounding environment. Early research on the space complexity of settlements was dominated by qualitative analysis, and the depth of quantitative research on the spatial form of traditional settlements was insufficient. This article takes Xiaoliangjiang Village in Jingxing County, Shijiazhuang City, Hebei Province, which entered the fifth batch of the list of Chinese traditional villages list, as the research object. The spatial relationship of the settlement was obtained through field surveys and drone oblique photography, and the spatial morphological elements of Xiaoliangjiang Village were analyzed and extracted. Based on three quantitative theories of spatial form, namely topology theory, fractal theory, and space syntax, the self-similarity of settlements is analyzed from the perspectives of buildings, streets, and spaces. The research uses Matlab and DepthMap software to quantitatively analyze the spatial form of Xiaoliangjiang Village and obtains data. Through the analysis of data, it was found that Xiaoliangjiang Village has self-similarity at three levels: buildings, roads and settlement spaces. The buildings iteratively generate various forms of architectural courtyards through the basic “L”-shaped pattern. The spatial structures at all levels of roads and settlement space in Xiaoliangjiang Village are relatively similar, in line with the bottom-up traditional settlement evolutionary law. By studying settlement self-similarity, people can better understand the formation mechanism of traditional settlement space structure and its evolution law. At the same time, it enriches the research perspective of traditional settlements and provides technical support for analyzing the self-similarity of traditional settlements and settlement protection planning.
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- 2024
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14. Revisiting Emission-Line Measurement Methods for Narrow-Line Active Galactic Nuclei
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Khatu, Viraja C., Gallagher, Sarah C., Horne, Keith, Cackett, Edward M., Hu, Chen, Du, Pu, Wang, Jian-Min, Bian, Wei-Hao, Bai, Jin-Ming, Chen, Yong-Jie, Hall, Patrick, Jiang, Bo-Wei, Li, Sha-Sha, Li, Yan-Rong, Pasquini, Sofia, Songsheng, Yu-Yang, Wang, Chan, Xiao, Ming, and Yu, Zhe
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Measuring broad emission-line widths in active galactic nuclei (AGN) is not straightforward owing to the complex nature of flux variability in these systems. Line-width measurements become especially challenging when signal-to-noise is low, profiles are narrower, or spectral resolution is low. We conducted an extensive correlation analysis between emission-line measurements from the optical spectra of Markarian 142 (Mrk 142; a narrow-line Seyfert galaxy) taken with the Gemini North Telescope (Gemini) at a spectral resolution of 185.6+\-10.2 km/s and the Lijiang Telescope (LJT) at 695.2+\-3.9 km/s to investigate the disparities in the measured broad-line widths from both telescope data. Mrk~142 posed a challenge due to its narrow broad-line profiles, which were severely affected by instrumental broadening in the lower-resolution LJT spectra. We discovered that allowing the narrow-line flux of permitted lines having broad and narrow components to vary during spectral fitting caused a leak in the narrow-line flux to the broad component, resulting in broader broad-line widths in the LJT spectra. Fixing the narrow-line flux ratios constrained the flux leak and yielded the Hydrogen-beta broad-line widths from LJT spectra $\sim$54\% closer to the Gemini Hydrogen-beta widths than with flexible narrow-line ratios. The availability of spectra at different resolutions presented this unique opportunity to inspect how spectral resolution affected emission-line profiles in our data and adopt a unique method to accurately measure broad-line widths. Reconsidering line-measurement methods while studying diverse AGN populations is critical for the success of future reverberation-mapping studies. Based on the technique used in this work, we offer recommendations for measuring line widths in narrow-line AGN., Comment: 14 pages, 9 figures, accepted for publication in PASP
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- 2023
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15. Causal Relationship Extraction Combined Boundary Detection and Information Interaction
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Zhang, Honglei, Yan, Rong, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Cao, Cungeng, editor, Chen, Huajun, editor, Zhao, Liang, editor, Arshad, Junaid, editor, Asyhari, Taufiq, editor, and Wang, Yonghao, editor
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- 2024
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16. Chinese Medical Intent Recognition Based on Multi-feature Fusion
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Zhang, Xiliang, Zhang, Tong, Yan, Rong, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Luo, Biao, editor, Cheng, Long, editor, Wu, Zheng-Guang, editor, Li, Hongyi, editor, and Li, Chaojie, editor
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- 2024
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17. Does the reading acceleration program improve reading fluency and comprehension in emergent bilingual children?
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Li, Miao, Xi, Yueming, Geva, Esther, Yan, Rong, and Zhao, Wei
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- 2024
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18. The Multipolar Contribution and Plasmon Hybridization in Core–Shell Clusters
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Liu, Jiayi, Yan, Rong, Gao, Nan, Chen, Yongqi, and Fang, Yurui
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- 2024
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19. In-situ prediction of machining errors of thin-walled parts: an engineering knowledge based sparse Bayesian learning approach
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Sun, Hao, Zhao, Shengqiang, Peng, Fangyu, Yan, Rong, Zhou, Lin, Zhang, Teng, and Zhang, Chi
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- 2024
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20. Comparison of the Novel Digital Multi-dimension Botong Score with the Brief Pain Inventory for Evaluating Cancer-Related Pain: A Randomized Crossover Trial
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Yan, Rong, Fan, Bifa, Luo, Suxia, Wang, Kun, Xie, Guanglun, Wang, Yong, and Wang, Jiejun
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- 2023
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21. AGN STORM 2: II. Ultraviolet Observations of Mrk817 with the Cosmic Origins Spectrograph on the Hubble Space Telescope
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Homayouni, Y., De Rosa, Gisella, Plesha, Rachel, Kriss, Gerard A., Barth, Aaron J., Cackett, Edward M., Horne, Keith, Kara, Erin A., Landt, Hermine, Arav, Nahum, Boizelle, Benjamin D., Bentz, Misty C., Brink, Thomas G., Brotherton, Michael S., Chelouche, Doron, Bonta, Elena Dalla, Dehghanian, Maryam, Du, Pu, Ferland, Gary J., Ferrarese, Laura, Fian, Carina, Filippenko, Alexei V., Fischer, Travis, Foley, Ryan J., Gelbord, Jonathan, Goad, Michael R., Buitrago, Diego H. Gonzalez, Gorjian, Varoujan, Grier, Catherine J., Hall, Patrick B., Santisteban, Juan V. Hernandez, Hu, Chen, Ilic, Dragana, Joner, Michael D., Kaastra, Jelle, Kaspi, Shai, Kochanek, Christopher S., Korista, Kirk T., Kovacevic, Andjelka B., Kynoch, Daniel, Li, Yan-Rong, McHardy, Ian M., McLane, Jacob N., Mehdipour, Missagh, Miller, Jake A., Mitchell, Jake, Montano, John, Netzer, Hagai, Panagiotou, Christos, Partington, Ethan, Pogge, Richard W., Popovic, Luka C., Proga, Daniel, Rogantini, Daniele, Storchi-Bergmann, Thaisa, Sanmartim, David, Siebert, Matthew R., Treu, Tommaso, Vestergaard, Marianne, Wang, Jian-Min, Ward, Martin J., Waters, Tim, Williams, Peter R., Zaidouni, Fatima, and Zu, Ying
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Astrophysics - Astrophysics of Galaxies - Abstract
We present reverberation mapping measurements for the prominent ultraviolet broad emission lines of the active galactic nucleus Mrk817 using 165 spectra obtained with the Cosmic Origins Spectrograph on the Hubble Space Telescope. Our ultraviolet observations are accompanied by X-ray, optical, and near-infrared observations as part of the AGN Space Telescope and Optical Reverberation Mapping Program 2 (AGN STORM 2). Using the cross-correlation lag analysis method, we find significant correlated variations in the continuum and emission-line light curves. We measure rest-frame delayed responses between the far-ultraviolet continuum at 1180 A and Ly$\alpha$ $\lambda1215$ A ($10.4_{-1.4}^{+1.6}$ days), N V $\lambda1240$ A ($15.5_{-4.8}^{+1.0}$days), SiIV + OIV] $\lambda1397$ A ($8.2_{-1.4}^{+1.4}$ days), CIV $\lambda1549$ A ($11.8_{-2.8}^{+3.0}$ days), and HeII $\lambda1640$ A ($9.0_{-1.9}^{+4.5}$ days) using segments of the emission-line profile that are unaffected by absorption and blending, which results in sampling different velocity ranges for each line. However, we find that the emission-line responses to continuum variations are more complex than a simple smoothed, shifted, and scaled version of the continuum light curve. We also measure velocity-resolved lags for the Ly$\alpha$, and CIV emission lines. The lag profile in the blue wing of Ly$\alpha$ is consistent with virial motion, with longer lags dominating at lower velocities, and shorter lags at higher velocities. The CIV lag profile shows the signature of a thick rotating disk, with the shortest lags in the wings, local peaks at $\pm$ 1500 $\rm km\,s^{-1}$, and a local minimum at line center. The other emission lines are dominated by broad absorption lines and blending with adjacent emission lines. These require detailed models, and will be presented in future work., Comment: Submitted to ApJ. 25 pages, 8 figures, and 6 tables
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- 2023
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22. Testing Super-Eddington Accretion onto a Supermassive Black Hole: Reverberation Mapping of PG 1119+120
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Donnan, Fergus R., Santisteban, Juan V. Hernández, Horne, Keith, Hu, Chen, Du, Pu, Li, Yan-Rong, Xiao, Ming, Ho, Luis C., Aceituno, Jesús, Wang, Jian-Min, Guo, Wei-Jian, Yang, Sen, Jiang, Bo-Wei, and Yao, Zhu-Heng
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We measure the black hole mass and investigate the accretion flow around the local ($z=0.0502$) quasar PG 1119+120. Spectroscopic monitoring with Calar Alto provides H$\beta$ lags and linewidths from which we estimate a black hole mass of $\log \left(M_{\bullet}/\mathrm{M}_{\odot} \right) = 7.0$, uncertain by $\sim0.4$ dex. High cadence photometric monitoring over two years with the Las Cumbres Observatory provides lightcurves in 7 optical bands suitable for intensive continuum reverberation mapping. We identify variability on two timescales. Slower variations on a 100-day timescale exhibit excess flux and increased lag in the $u'$ band and are thus attributable to diffuse bound-free continuum emission from the broad line region. Faster variations that we attribute to accretion disc reprocessing lack a $u'$-band excess and have flux and delay spectra consistent with either $\tau \propto \lambda^{4/3}$, as expected for a temperature structure of $T(R) \propto R^{-3/4}$ for a thin accretion disc, or $\tau \propto \lambda^{2}$ expected for a slim disc. Decomposing the flux into variable (disc) and constant (host galaxy) components, we find the disc SED to be flatter than expected with $f_{\nu} \sim \rm{const}$. Modelling the SED predicts an Eddington ratio of $\lambda_{\rm Edd} > 1$, where the flat spectrum can be reproduced by a slim disc with little dust extinction or a thin disc which requires more dust extinction. While this accretion is super-Eddington, the geometry is still unclear, however a slim disc is expected due to the high radiation pressure at these accretion rates, and is entirely consistent with our observations., Comment: 23 pages, 16 figures, 10 tables. Accepted for publication in MNRAS
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- 2023
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23. UV/Optical disk reverberation lags despite a faint X-ray corona in the AGN Mrk 335
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Kara, Erin, Barth, Aaron J., Cackett, Edward M., Gelbord, Jonathan, Montano, John, Li, Yan-Rong, Santana, Lisabeth, Horne, Keith, Alston, William N., Buisson, Douglas, Chelouche, Doron, Du, Pu, Fabian, Andrew C., Fian, Carina, Gallo, Luigi, Goad, Michael R., Grupe, Dirk, Buitrago, Diego H. Gonzalez, Santisteban, Juan V. Hernandez, Kaspi, Shai, Hu, Chen, Komossa, S., Kriss, Gerard A., Lewin, Collin, Lewis, Tiffany, Loewenstein, Michael, Lohfink, Anne, Masterson, Megan, McHardy, Ian M., Mehdipour, Missagh, Miller, Jake, Panagiotou, Christos, Parker, Michael L., Pinto, Ciro, Remillard, Ron, Reynolds, Christopher, Rogantini, Daniele, Wang, Jian-Min, Wang, Jingyi, and Wilkins, Dan
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
We present the first results from a 100-day Swift, NICER and ground-based X-ray/UV/optical reverberation mapping campaign of the Narrow-Line Seyfert 1 Mrk 335, when it was in an unprecedented low X-ray flux state. Despite dramatic suppression of the X-ray variability, we still observe UV/optical lags as expected from disk reverberation. Moreover, the UV/optical lags are consistent with archival observations when the X-ray luminosity was >10 times higher. Interestingly, both low- and high-flux states reveal UV/optical lags that are 6-11 times longer than expected from a thin disk. These long lags are often interpreted as due to contamination from the broad line region, however the u band excess lag (containing the Balmer jump from the diffuse continuum) is less prevalent than in other AGN. The Swift campaign showed a low X-ray-to-optical correlation (similar to previous campaigns), but NICER and ground-based monitoring continued for another two weeks, during which the optical rose to the highest level of the campaign, followed ~10 days later by a sharp rise in X-rays. While the low X-ray countrate and relatively large systematic uncertainties in the NICER background make this measurement challenging, if the optical does lead X-rays in this flare, this indicates a departure from the zeroth-order reprocessing picture. If the optical flare is due to an increase in mass accretion rate, this occurs on much shorter than the viscous timescale. Alternatively, the optical could be responding to an intrinsic rise in X-rays that is initially hidden from our line-of-sight., Comment: Accepted for publication in the Astrophysical Journal. 15 pages, 8 figures, 3 tables
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- 2023
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24. Broad-line region in NGC 4151 monitored by two decades of reverberation mapping campaigns. I. Evolution of structure and kinematics
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Chen, Yong-Jie, Bao, Dong-Wei, Zhai, Shuo, Fang, Feng-Na, Hu, Chen, Du, Pu, Yang, Sen, Yao, Zhu-Heng, Li, Yan-Rong, Brotherton, Michael S., McLane, Jacob N., Zastrocky, T. E., Olson, Kianna A., Bon, Edi, Bai, Hua-Rui, Fu, Yi-Xin, Liu, Jun-Rong, Wang, Yi-Lin, Maithil, Jaya, Kobulnicky, H. A., Dale, D. A., Adelman, C., Caradonna, M. J., Carter, Z., Favro, J., Ferguson, A. J., Gonzalez, I. M., Hadding, L. M., Hagler, H. D., Murphree, G., Oeur, M., Rogers, C. J., Roth, T., Schonsberg, S., Stack, T. R., and Wang, Jian-Min
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Astrophysics - Astrophysics of Galaxies - Abstract
We report the results of long-term reverberation mapping (RM) campaigns of the nearby active galactic nuclei (AGN) NGC 4151, spanning from 1994 to 2022, based on archived observations of the FAST Spectrograph Publicly Archived Programs and our new observations with the 2.3m telescope at the Wyoming Infrared Observatory. We reduce and calibrate all the spectra in a consistent way, and derive light curves of the broad H$\beta$ line and 5100\,{\AA} continuum. Continuum light curves are also constructed using public archival photometric data to increase sampling cadences. We subtract the host galaxy contamination using {\it HST} imaging to correct fluxes of the calibrated light curves. Utilizing the long-term archival photometric data, we complete the absolute flux-calibration of the AGN continuum. We find that the H$\beta$ time delays are correlated with the 5100\,{\AA} luminosities as $\tau_{\rm H\beta}\propto L_{5100}^{0.46\pm0.16}$. This is remarkably consistent with Bentz et al. (2013)'s global size-luminosity relationship of AGNs. Moreover, the data sets for five of the seasons allow us to obtain the velocity-resolved delays of the H$\beta$ line, showing diverse structures (outflows, inflows and disks). Combining our results with previous independent measurements, we find the measured dynamics of the H$\beta$ broad-line region (BLR) are possibly related to the long-term trend of the luminosity. There is also a possible additional $\sim$1.86 years time lag between the variation in BLR radius and luminosity. These results suggest that dynamical changes in the BLR may be driven by the effects of radiation pressure., Comment: Accepted for publication in MNRAS; comments welcome!
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- 2023
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25. Scattering-induced entropy boost for highly-compressed optical sensing and encryption
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Bian, Liheng, Zhan, Xinrui, Chang, Xuyang, Li, Daoyu, Yan, Rong, Zhang, Yinuo, Ruan, Haowen, and Zhang, Jun
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Image classification often relies on a high-quality machine vision system with a large view field and high resolution, demanding fine imaging optics, heavy computational costs, and large communication bandwidths between an image sensor and a computing unit. Here, we report a novel image-free sensing framework for resource efficient image classification where the required number of measurements can be reduced by up to two orders of magnitude. In the proposed framework of single-pixel detection, the optical field from a target is first scattered by an optical diffuser and then two-dimensionally modulated by a spatial light modulator. The optical diffuser simultaneously serves as a compressor and an encryptor for the target information, effectively narrowing the view field and improving the system's security. The one-dimensional sequence of intensity values, measured with time-varying patterns on the spatial light modulator, is then used to extract semantic information based on end-to-end deep learning. The proposed sensing framework is shown to provide over 95 percentage accuracy with the sampling rate of 1 percentage and 5 percentage, respectively, for the classification of MNIST dataset and the recognition of Chinese license plate, which was up to 24 percentage more efficient compared with the case without an optical diffuser. The proposed framework represents a significant breakthrough in realizing high-throughput machine intelligence for scene analysis, with low-bandwidth, low cost, and strong encryption.
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- 2022
26. A new species of Eusirus Krøyer, 1845 (Amphipoda, Amphilochidea, Eusiridae) from the seamount of the Caroline Plate, with redescription of Meteusiroides keyensis Pirlot, 1934
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Yan-Rong Wang, Zhong-Li Sha, and Xian-Qiu Ren
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Biology (General) ,QH301-705.5 - Abstract
A new Eusirus Krøyer, 1845 species within the family Eusiridae Stebbing, 1888 is described based on specimens collected from seamounts of the Caroline Plate. Eusirus carolinus sp. nov. is characterized by having large, well-pigmented eyes, the distomiddorsal mediodorsal pointed process only present on pleonites 1 and 2, epimeral plate 3 with a smooth posterior margin, the elongated telson only cleft 20%, and the rami of uropod 3 being equal in length. A rare eusirid species, Meteusiroides keyensis Pirlot, 1934, is redescribed as providing the living coloration based on one female specimen. Sequences of two genes (16S rRNA and COI) were used to analyze their relationships with other species in the family Eusiridae and confirm the taxonomic placement. The result supports the monophyly of Cleonardo Stebbing, 1888; Eusirus and Rhachotropis S.I. Smith, 1883; and is consistent with morphological classification.
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- 2024
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27. FAT1 inhibits the proliferation of DLBCL cells via increasing the m6A modification of YAP1 mRNA
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Tian-long Wang, Xiao-juan Miao, Yan-rong Shuai, Hao-ping Sun, Xiao Wang, Min Yang, and Nan Zhang
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FAT atypical cadherin 1 (FAT1) ,Diffuse large B cell lymphoma (DLBCL) ,Yes1 associated transcriptional regulator (YAP1) ,Heterogeneous nuclear ribonucleoprotein D (HNRNPD) ,m6A ,ALKBH5 ,Medicine ,Science - Abstract
Abstract Emerging evidence shows that FAT atypical cadherin 1 (FAT1) mutations occur in lymphoma and are associated with poorer overall survival. Considering that diffuse large B cell lymphoma (DLBCL) is the category of lymphoma with the highest incidence rate, this study aims to explore the role of FAT1 in DLBCL. The findings demonstrate that FAT1 inhibits the proliferation of DLBCL cell lines by downregulating the expression of YAP1 rather than by altering its cellular localization. Mechanistic analysis via meRIP-qPCR/luciferase reporter assays showed that FAT1 increases the m6A modification of YAP1 mRNA 3′UTR and the subsequent binding of heterogeneous nuclear ribonucleoprotein D (HNRNPD) to the m6A modified YAP1 mRNA, thus decreasing the stability of YAP1 mRNA. Furthermore, FAT1 increases YAP1 mRNA 3′UTR m6A modification by decreasing the activity of the TGFβ-Smad2/3 pathway and the subsequent expression of ALKBH5, which is regulated at the transcriptional level by Smad2/3. Collectively, these results reveal that FAT1 inhibits the proliferation of DLBCL cells by increasing the m6A modification of the YAP1 mRNA 3’UTR via the TGFβ-Smad2/3-ALKBH5 pathway. The findings of this study therefore indicate that FAT1 exerts anti-tumor effects in DLBCL and may represent a novel target in the treatment of this form of lymphoma.
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- 2024
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28. Type 1 diabetes human enteroid studies reveal major changes in the intestinal epithelial compartment
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Vishwesh Bharadiya, Yan Rong, Zixin Zhang, Ruxian Lin, Anthony Lawrence Guerrerio, C. Ming Tse, Mark Donowitz, and Varsha Singh
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Medicine ,Science - Abstract
Abstract Lack of understanding of the pathophysiology of gastrointestinal (GI) complications in type 1 diabetes (T1D), including altered intestinal transcriptomes and protein expression represents a major gap in the management of these patients. Human enteroids have emerged as a physiologically relevant model of the intestinal epithelium but establishing enteroids from individuals with long-standing T1D has proven difficult. We successfully established duodenal enteroids using endoscopic biopsies from pediatric T1D patients and compared them with aged-matched enteroids from healthy subjects (HS) using bulk RNA sequencing (RNA-seq), and functional analyses of ion transport processes. RNA-seq analysis showed significant differences in genes and pathways associated with cell differentiation and proliferation, cell fate commitment, and brush border membrane. Further validation of these results showed higher expression of enteroendocrine cells, and the proliferating cell marker Ki-67, significantly lower expression of NHE3, lower epithelial barrier integrity, and higher fluid secretion in response to cAMP and elevated calcium in T1D enteroids. Enteroids established from pediatric T1D duodenum identify characteristics of an abnormal intestinal epithelium and are distinct from HS. Our data supports the use of pediatric enteroids as an ex-vivo model to advance studies of GI complications and drug discovery in T1D patients.
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- 2024
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29. Inhibition of acyl-CoA binding protein (ACBP) by means of a GABAARγ2-derived peptide
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Gerasimos Anagnostopoulos, Ester Saavedra, Flavia Lambertucci, Omar Motiño, Jordan Dimitrov, David Roiz-Valle, Victor Quesada, Karla Alvarez-Valadez, Hui Chen, Allan Sauvat, Yan Rong, Uxía Nogueira-Recalde, Sijing Li, Léa Montégut, Mojgan Djavaheri-Mergny, Maria Castedo, Carlos Lopez-Otin, Maria Chiara Maiuri, Isabelle Martins, and Guido Kroemer
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Cytology ,QH573-671 - Abstract
Abstract Acyl-CoA binding protein (ACBP) encoded by diazepam binding inhibitor (DBI) is an extracellular inhibitor of autophagy acting on the gamma-aminobutyric acid A receptor (GABAAR) γ2 subunit (GABAARγ2). Here, we show that lipoanabolic diets cause an upregulation of GABAARγ2 protein in liver hepatocytes but not in other major organs. ACBP/DBI inhibition by systemically injected antibodies has been demonstrated to mediate anorexigenic and organ-protective, autophagy-dependent effects. Here, we set out to develop a new strategy for developing ACBP/DBI antagonists. For this, we built a molecular model of the interaction of ACBP/DBI with peptides derived from GABAARγ2. We then validated the interaction between recombinant and native ACBP/DBI protein and a GABAARγ2-derived eicosapeptide (but not its F77I mutant) by pull down experiments or surface plasmon resonance. The GABAARγ2-derived eicosapeptide inhibited the metabolic activation of hepatocytes by recombinant ACBP/DBI protein in vitro. Moreover, the GABAARγ2-derived eicosapeptide (but not its F77I-mutated control) blocked appetite stimulation by recombinant ACBP/DBI in vivo, induced autophagy in the liver, and protected mice against the hepatotoxin concanavalin A. We conclude that peptidomimetics disrupting the interaction between ACBP/DBI and GABAARγ2 might be used as ACBP/DBI antagonists. This strategy might lead to the future development of clinically relevant small molecules of the ACBP/DBI system.
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- 2024
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30. KRT23 promotes the proliferation of liver cancer by activating AKT signaling pathway
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Liang Xinghua, Liu Foqiu, Yan Rong, Hu Juan
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krt23 ,akt signaling pathway ,liver cancer ,proliferation ,Medicine - Abstract
Objective To investigate the effect of high keratin 23 (KRT23) expression promoting cell proliferation on liver cancer. Methods The expression of KRT23 in liver cancer was analyzed by bioinformatics. After overexpression and inhibition of KRT23, the effect of KRT23 on the proliferation of liver cancer cells was analyzed by MTT and clone formation assay. The regulatory relationship between KRT23 and AKT signaling pathway was analyzed by software prediction, qPCRand Western blot. Results The expression level of KRT23 in liver cancer was significantly higher than that in normal control tissues. MTT and clone formation assay showed that overexpression of KRT23 promoted cell proliferation, while downregulation of KRT23 inhibited cell proliferation. GSEA analysis, qPCR and Western blot showed that KRT23 could activate the AKT signaling pathway and promote cell proliferation. Meanwhile, inhibition of AKT signaling pathway in overexpressing KRT23 cells significantly reduced cell proliferation. Conclusions KRT23 affects the proliferation of liver cancer cells by regulating the AKT signaling pathway. These results suggest that KRT23 exerts significant effects upon the malignant procession of liver cancer and may play an important role in the occurrence and development of liver cancer.
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- 2024
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31. Spectroastrometric Reverberation Mapping of Broad-line Regions
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Li, Yan-Rong and Wang, Jian-Min
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Spectroastrometry measures source astrometry as a function of wavelength/velocity. Reverberations of spectroastrometric signals naturally arise in broad-line regions (BLRs) of active galactic nuclei (AGNs) as a result of the continuum variations that drive responses of the broad emission lines with time delays. Such signals provide a new diagnostic for mapping BLR kinematics and geometry, complementary to the traditional intensity reverberation mapping (RM) technique. We present the generic mathematical formalism for spectroastrometric RM and show that under realistic parameters of a phenomenological BLR model, the spectroastrometric reverberation signals vary on a level of several to tens of microarcseconds, depending on the BLR size, continuum variability, and angular-size distance. We also derive the analytical expressions of spectroastrometric RM for an inclined ring-like BLR. We develop a Bayesian framework with a sophisticated Monte Carlo sampling technique to analyze spectroastrometric data and infer the BLR properties, including the central black hole mass and angular-size distance. We demonstrate the potential of spectroastrometric RM in spatially resolving BLR kinematics and geometry through a suite of simulation tests. The application to realistic observation data of 3C~273 obtains tentative, but enlightening results, reinforcing the practical feasibility of conducting spectroastrometric RM experiments on bright AGNs with the operating Very Large Telescope Interferometer as well as possibly with the planned next-generation 30 m class telescopes., Comment: 22 pages, 17 figures, 2 tables; matched to ApJ published version; The code BRAINS available at https://github.com/LiyrAstroph/BRAINS
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- 2022
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32. Final stage of merging binaries of supermassive black holes: observational signatures
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Wang, Jian-Min, Songsheng, Yu-Yang, Li, Yan-Rong, and Du, Pu
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
There are increasing interests in binary supermassive black holes (SMBHs), but merging binaries with separations smaller than ~1 light days (~10^2 gravitational radii for 10^8 Msun), which are rapidly evolving under control of gravitational waves, are elusive in observations. In this paper, we discuss fates of mini-disks around component SMBHs for three regimes: 1) low rates (advection-dominated accretion flows: ADAFs); 2) intermediate rates; 3) super-Eddington accretion rates. Mini-disks with intermediate rates are undergoing evaporation through thermal conduction of hot corona forming a hybrid radial structure. When the binary orbital periods are shorter than sound propagation timescales of the evaporated mini-disks, a new instability, denoted as sound instability, arises because the disks will be highly twisted so that they are destroyed. We demonstrate a critical separation of A_{crit}~10^2 Rg from the sound instability of the mini-disks and the cavity is full of hot gas. For those binaries, component SMBHs are accreting with Bondi mode in the ADAF regime, showing periodic variations resulting from Doppler boosting effects in radio from the ADAFs due to orbital motion. In the mean while, the circumbinary disks (CBDs) are still not hot enough (ultraviolet deficit) to generate photons to ionize gas for broad emission lines. For slightly super-Eddington accretion of the CBDs, MgII line appears with decreases of UV deficit, and for intermediate super-Eddington Balmer lines appear, but CIV line never unless CBD accretion rates are extremely high. Moreover, if the CBDs are misaligned with the binary plane, it is then expected to have optical periodical variations with about ten times radio periods., Comment: 10 pages, 3 figures; accepted to MNRAS
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- 2022
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33. Supermassive Black Hole and Broad-line Region in NGC~5548: Results from Five-season Reverberation Mapping
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Lu, Kai-Xing, Bai, Jin-Ming, Wang, Jian-Min, Hu, Chen, Li, Yan-Rong, Du, Pu, Xiao, Ming, Feng, Hai-Cheng, Li, Sha-Sha, Wang, Jian-Guo, Zhang, Zhi-Xiang, and Huang, Ying-Ke
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
NGC 5548 is one of the active galactic nuclei (AGN) selected for our long-term spectroscopic monitoring with the Lijiang 2.4~m telescope, aiming at investigating the origin and evolution of the broad-line regions (BLRs), accurately measuring the mass of the supermassive black holes (SMBHs), and understanding structure and evolution of the AGN. We have performed five-season observations for NGC~5548 with the median sampling interval ranging from 1.25 to 3 days. The light curves of the 5100~\AA\ continuum and broad emission lines are measured after subtracting contamination of the host galaxy starlight. The time lags of the broad He~{\sc ii}, He~{\sc i}, H$\gamma$, and H$\beta$ lines with respect to the 5100~\AA\ continuum are obtained for each season and their mean time lags over the five seasons are 0.69, 4.66, 4.60, 8.43 days, respectively. The H$\gamma$ and H$\beta$ velocity-resolved lag profiles in the seasons of 2015, 2018, 2019, and 2021 are constructed, from which an ``M-shaped'' structure is found in 2015 but disappears after 2018. Our five-season reverberation mapping (RM) yields an averaged virial SMBH mass of $M_\bullet/10^7M_\odot=14.22$, with a small standard deviation of $1.89$. By combining the previous 18 RM campaigns and our five-season campaign for NGC~5548, we find that there exists a time lag of 3.5~years between the changes in the BLR size and optical luminosity. In addition, we also construct the BLR radius$-$luminosity relation and the virial relation for NGC~5548., Comment: 23 pages, 15 figures, accepted for publication in ApJS
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- 2022
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34. Corrigendum to 'Salidroside improves the hypoxic tumor microenvironment and reverses the drug resistance of platinum drugs via HIF-1α signaling pathway' [EBioMedicine 38 (2018) 25–36]
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Yuan Qin, Hui-juan Liu, Meng Li, Deng-hui Zhai, Yuan-hao Tang, Lan Yang, Kai-liang Qiao, Jia-huan Yang, Wei-long Zhong, Qiang Zhang, Yan-rong Liu, Guang Yang, Tao Sun, and Cheng Yang
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Medicine ,Medicine (General) ,R5-920 - Published
- 2024
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35. Genome-wide sRNA and mRNA transcriptomic profiling insights into carbapenem-resistant Acinetobacter baumannii
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Yong Wei, Xuli Xin, Jiachun Zhang, Qifeng Liao, Yan Rong, Ying Zhong, Meiying Zhao, Jianping Ma, and Song He
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Acinetobacter baumannii ,carbapenem resistance ,transcriptomic profiling ,small RNA (sRNA) ,target gene ,Microbiology ,QR1-502 - Abstract
IntroductionAcinetobacter baumannii (AB) is rising as a human pathogen of critical priority worldwide as it is the leading cause of opportunistic infections in healthcare settings and carbapenem-resistant AB is listed as a “super bacterium” or “priority pathogen for drug resistance” by the World Health Organization.MethodsClinical isolates of A. baumannii were collected and tested for antimicrobial susceptibility. Among them, carbapenem-resistant and carbapenem-sensitive A. baumannii were subjected to prokaryotic transcriptome sequencing. The change of sRNA and mRNA expression was analyzed by bioinformatics and validated by quantitative reverse transcription-PCR.ResultsA total of 687 clinical isolates were collected, of which 336 strains of A. baumannii were resistant to carbapenem. Five hundred and six differentially expressed genes and nineteen differentially expressed sRNA candidates were discovered through transcriptomic profile analysis between carbapenem-resistant isolates and carbapenem-sensitive isolates. Possible binding sites were predicted through software for sRNA21 and adeK, sRNA27 and pgaC, sRNA29 and adeB, sRNA36 and katG, indicating a possible targeting relationship. A negative correlation was shown between sRNA21 and adeK (r = -0.581, P = 0.007), sRNA27 and pgaC (r = -0.612, P = 0.004), sRNA29 and adeB (r = -0.516, P = 0.020).DiscussionThis study preliminarily screened differentially expressed mRNA and sRNA in carbapenem-resistant A. baumannii, and explored possible targeting relationships, which will help further reveal the resistance mechanism and provide a theoretical basis for the development of drugs targeting sRNA for the prevention and treatment of carbapenem-resistant A. baumannii infection.
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- 2024
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36. The profile and prognostic significance of bone marrow T-cell differentiation subsets in adult AML at diagnosis
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Kai Sun, Zong-Yan Shi, Ya-Zhe Wang, Dai-Hong Xie, Yan-Rong Liu, Qian Jiang, Hao Jiang, Xiao-Jun Huang, and Ya-Zhen Qin
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AML ,memory T cell ,naive T cell ,DNMT3A mutation ,prognosis ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundT lymphocytes in tumor microenvironment play a pivotal role in the anti-tumor immunity, and the memory of T cells contributes to the long-term protection against tumor antigens. Compared to solid tumors, studies focusing on the T-cell differentiation in the acute myeloid leukemia (AML) bone marrow (BM) microenvironment remain limited.Patients and methodsFresh BM specimens collected from 103 adult AML patients at diagnosis and 12 healthy donors (HDs) were tested T-cell differentiation subsets by multi-parameter flow cytometry.ResultsCD4 and CD8 T-cell compartments had different constituted profiles of T-cell differentiated subsets, which was similar between AML patients and HDs. Compared to HDs, AML patients as a whole had a significantly higher proportion of CD8 effector T cells (Teff, P = 0.048). Moreover, the T-cell compartment of AML patients with no DNMT3A mutations skewed toward terminal differentiation at the expense of memory T cells (CD4 Teff: P = 0.034; CD8 Teff: P = 0.030; CD8 memory T: P = 0.017), whereas those with mutated DNMT3A had a decrease in CD8 naïve T (Tn) and CD4 effector memory T cells (Tem) as well as an increase in CD4 central memory T cells (Tcm) (P = 0.037, 0.053 and 0.053). Adverse ELN genetic risk correlated with a lower proportion of CD8 Tn. In addition, the low proportions of CD4 Tem and CD8 Tn independently predicted poorer relapse-free survival (RFS, HR [95%CI]: 5.7 (1.4–22.2), P = 0.017 and 4.8 [1.3–17.4], P = 0.013) and event-free survival (EFS, HR [95% CI]: 3.3 (1.1–9.5), P = 0.029; 4.0 (1.4–11.5), P = 0.010), respectively.ConclusionsAML patients had abnormal profiles of BM T-cell differentiation subsets at diagnosis, which was related to DNMT3A mutations. The low proportions of CD4 Tem and CD8 Tn predicted poor outcomes.
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- 2024
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37. The interplay of psychological resilience and adolescent mobile phone addiction in Henan province, China: insights from latent class analysis
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Jun Xiao Wu, Lin Jia, Yan Li, Qian Liu, Ying Ying Zhang, Jin Zhang, Yan Rong Jia, and Zhen Fan
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adolescent ,resilience ,mobile phone addiction ,DASS-21 ,ROC curve ,cut-off point ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundThe aim of this study was to classify distinct subgroups of adolescents based on the severity levels of their mobile phone addiction and to investigate how these groups differed in terms of their psychosocial characteristics. We surveyed a total of 2,230 adolescents using three different questionnaires to assess the severity of their mobile phone addiction, stress, anxiety, depression, psychological resilience, and personality. Latent class analysis was employed to identify the subgroups, and we utilized Receiver Operating Characteristic (ROC) curves and multinomial logistic regression for statistical analysis. All data analyses were conducted using SPSS 26.0 and Mplus 8.5.MethodsWe classified the subjects into subgroups based on their mobile phone addiction severity, and the results revealed a clear pattern with a three-class model based on the likelihood level of mobile phone addiction (p 14, which corresponded to the maximum Youden index (Youden index = 0.751).ResultsThe latent classification process in this research confirmed the existence of three distinct mobile phone user groups. We also examined the psychosocial characteristics that varied in relation to the severity levels of addiction.ConclusionThis study provides valuable insights into the categorization of adolescents based on the severity of mobile phone addiction and sheds light on the psychosocial characteristics associated with different addiction levels. These findings are expected to enhance our understanding of mobile phone addiction traits and stimulate further research in this area.
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- 2024
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38. The LSST era of supermassive black holes accretion-disk reverberation mapping
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Kovacevic, Andjelka B., Radovic, Viktor, Ilic, Dragana, Popovic, Luka C., Assef, Roberto J., Sanchez-Saez, Paula, Nikutta, Robert, Raiteri, Claudia M., Yoon, Ilsang, Homayouni, Yasaman, Li, Yan-Rong, Caplar, Neven, Czerny, Bozena, Panda, Swayamtrupta, Ricci, Claudio, Jankov, Isidora, Landt, Hermine, Wolf, Christian, Kovacevic-Dojcinovic, Jelena, Lakicevic, Masa, Savic, Djorđe, Vince, Oliver, Simic, Sasa, Cvorovic-Hajdinjak, Iva, and Marceta-Mandic, Sladjana
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) will detect an unprecedentedly large sample of actively accreting supermassive black holes with typical accretion disk (AD) sizes of a few light days. This brings us to face challenges in the reverberation mapping (RM) measurement of AD sizes in active galactic nuclei (AGNs) using interband continuum delays. We examine the effect of LSST cadence strategies on AD RM using our metric AGNTimeLagMetric. It accounts for redshift, cadence, the magnitude limit, and magnitude corrections for dust extinction. Running our metric on different LSST cadence strategies, we produce an atlas of the performance estimations for LSST photometric RM measurements. We provide an upper limit on the estimated number of quasars for which the AD time lag can be computed within 0
1000 sources in each Deep Drilling field (DDF, 10 sq. deg) in any filter, with the redshift distribution of these sources peaking at z~1. We find the LSST observation strategies with a good cadence (~ 5 days) and a long cumulative season (~9 yr), as proposed for LSST DDF, are favored for the AD size measurement. We create synthetic LSST light curves for the most suitable DDF cadences and determine RM time lags to demonstrate the impact of the best cadences based on the proposed metric., Comment: accepted for publication in the Astrophysical Journal Focus Issue on Rubin LSST cadence and survey strategy - Published
- 2022
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39. Revisiting the Continuum Reverberation Lags in the AGN PKS 0558-504
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González-Buitrago, D. H., Santisteban, J. V. Hernández, Barth, A. J., Jimenez-Bailón, E., Li, Yan-Rong, García-Díaz, Ma. T., Vargas, A. Lopez, and Herrera-Endoqui, M.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present a revised analysis of the photometric reverberation mapping campaign of the narrow-line Seyfert 1 galaxy PKS 0558-504 carried out with the Swift Observatory during 2008--2010. Previously, Gliozzi et al.\ found using the Discrete Correlation Function (DCF) method that the short-wavelength continuum variations lagged behind variations at longer wavelengths, the opposite of the trend expected for thermal reprocessing of X-rays by the accretion disc, and they interpreted their results as evidence against the reprocessing model. We carried out new DCF measurements that demonstrate that the inverted lag-wavelength relationship found by Gliozzi et al.\ resulted from their having interchanged the order of the driving and responding light curves when measuring the lags. To determine the inter-band lags and uncertainties more accurately, we carried out new measurements with four independent methods. These give consistent results showing time delays increasing as a function of wavelength, as expected for the disc reprocessing scenario. The slope of the re-analysed delay spectrum appears to be roughly compatible with the predicted $\tau \propto \lambda^{4/3}$ relationship for reprocessing by an optically thick and geometrically thin accretion disc, although the data points exhibit a large scatter about the fitted power-law trend., Comment: 12 pages, 7 figures, 2 tables
- Published
- 2022
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40. Monitoring AGNs with H$\beta$ Asymmetry. III. Long-term Reverberation Mapping Results of 15 Palomar-Green Quasars
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Bao, Dong-Wei, Brotherton, Michael S., Du, Pu, McLane, Jacob N., Zastrocky, T. E., Olson, Kianna A., Fang, Feng-Na, Zhai, Shuo, Huang, Zheng-Peng, Wang, Kai, Zhao, Bi-Xuan, Li, Sha-Sha, Yang, Sen, Chen, Yong-Jie, Liu, Jun-Rong, Yao, Zhu-Heng, Peng, Yue-Chang, Guo, Wei-Jian, Songsheng, Yu-Yang, Li, Yan-Rong, Jiang, Bo-Wei, Kasper, David H., Chick, William T., Nguyen, My L., Maithil, Jaya, Kobulnicky, H. A., Dale, D. A., Hand, Derek, Adelman, C., Carter, Z., Murphree, A. M., Oeur, M., Schonsberg, S., Roth, T., Winkler, Hartmut, Marziani, Paola, D'Onofrio, Mauro, Hu, Chen, Xiao, Ming, Xue, Suijian, Czerny, Bożena, Aceituno, Jesús, Ho, Luis C., Bai, Jin-Ming, and Wang, Jian-Min
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
In this third paper of the series reporting on the reverberation mapping (RM) campaign of active galactic nuclei with asymmetric H$\beta$ emission-line profiles, we present results for 15 Palomar-Green (PG) quasars using spectra obtained between the end of 2016 to May 2021. This campaign combines long time spans with relatively high cadence. For 8 objects, both the time lags obtained from the entire light curves and the measurements from individual observing seasons are provided. Reverberation mapping of 9 of our targets has been attempted for the first time, while the results for 6 others can be compared with previous campaigns. We measure the H$\beta$ time lags over periods of years and estimate their black hole masses. The long duration of the campaign enables us to investigate their broad line region (BLR) geometry and kinematics for different years by using velocity-resolved lags, which demonstrate signatures of diverse BLR geometry and kinematics. The BLR geometry and kinematics of individual objects are discussed. In this sample, the BLR kinematics of Keplerian/virialized motion and inflow is more common than outflow., Comment: 35 pages, 18 figures, 8 tables, accepted for publication in The Astrophysical Journal Supplement
- Published
- 2022
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41. Searching for quasar candidates with periodic variations from the Zwicky Transient Facility: results and implications
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Chen, Yong-Jie, Zhai, Shuo, Liu, Jun-Rong, Guo, Wei-Jian, Peng, Yue-Chang, Li, Yan-Rong, SongSheng, Yu-Yang, Du, Pu, Hu, Chen, and Wang, Jian-Min
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Astrophysics - Astrophysics of Galaxies - Abstract
We conduct a systematic search for quasars with periodic variations from the archival photometric data of the Zwicky Transient Facility by cross-matching with the quasar catalogs of the Sloan Digital Sky Survey and V{\'e}ron-Cetty \& V{\'e}ron. We first select out 184 primitive periodic candidates using the generalized Lomb-Scargle periodogram and auto-correlation function and then estimate their statistical significance of periodicity based on two red-noise models, i.e., damped random walk (DRW) and single power-law (SPL) models. As such, we finally identify 106 (DRW) and 86 (SPL) candidates with the most significant periodic variations out of 143,700 quasars. We further compare DRW and SPL models using Bayes factors, which indicate a relative preference of the SPL model for our primitive sample. We thus adopt the candidates identified with SPL as the final sample and summarize its basic properties. We extend the light curves of the selected candidates by supplying other archival survey data to verify their periodicity. However, only three candidates (with 6-8 cycles of periods) meet the selection criteria. This result clearly implies that, instead of being strictly periodic, the variability must be quasi-periodic or caused by stochastic red-noise. This exerts a challenge to the existing search approaches and calls for developing new effective methods., Comment: Accepted in MNRAS. Comments welcome
- Published
- 2022
42. Effect of frozen-thawed embryo transfer with a poor-quality embryo and a good-quality embryo on pregnancy and neonatal outcomes
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Cheng Zeng, Rui-Hui Lu, Xin Li, Sheng Wang, Yan-Rong Kuai, and Qing Xue
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Embryo quality ,Double embryo transfer ,Single good quality embryo transfer ,Live birth rate ,Neonatal outcomes ,Gynecology and obstetrics ,RG1-991 ,Reproduction ,QH471-489 - Abstract
Abstract Background To evaluate the impact of embryo quality and quantity, specifically a poor quality embryo (PQE) in combination with a good quality embryo (GQE), by double embryo transfer (DET) on the live birth rate (LBR) and neonatal outcomes in patients undergoing frozen-thawed embryo transfer (FET) cycles. Methods A study on a cohort of women who underwent a total of 1462 frozen-thawed cleavage or blastocyst embryo transfer cycles with autologous oocytes was conducted between January 2018 and December 2021. To compare the outcomes between single embryo transfer (SET) with a GQE and DET with a GQE and a PQE, propensity score matching (PSM) was applied to control for potential confounders, and a generalized estimating equation (GEE) model was used to determine the association between the effect of an additional PQE and the outcomes. Subgroup analysis was also performed for patients stratified by female age. Results After PS matching, DET-GQE + PQE did not significantly alter the LBR (adjusted odds ratio [OR] 1.421, 95% CI 0.907–2.228) compared with SET-GQE in cleavage-stage embryo transfer but did increase the multiple birth rate (MBR, [OR] 3.917, 95% CI 1.189–12.911). However, in patients who underwent blastocyst-stage embryo transfer, adding a second PQE increased the live birth rate by 7.8% ([OR] 1.477, 95% CI 1.046–2.086) and the multiple birth rate by 19.6% ([OR] 28.355, 95% CI 3.926–204.790), and resulted in adverse neonatal outcomes. For patients who underwent cleavage-stage embryo transfer, transferring a PQE with a GQE led to a significant increase in the MBR ([OR] 4.724, 95% CI 1.121–19.913) in women under 35 years old but not in the LBR ([OR] 1.227, 95% CI 0.719–2.092). The increases in LBR and MBR for DET-GQE + PQE compared with SET-GQE in women older than 35 years were nonsignificant toward. For patients who underwent blastocyst-stage embryo transfer, DET-GQE + PQE had a greater LBR ([OR] 1.803, 95% CI 1.165–2.789), MBR ([OR] 24.185, 95% CI 3.285–178.062) and preterm birth rate (PBR, [OR] 4.092, 95% CI 1.153–14.518) than did SET-GQE in women under 35 years old, while no significant impact on the LBR ([OR] 1.053, 95% CI 0.589–1.884) or MBR (0% vs. 8.3%) was observed in women older than 35 years. Conclusions The addition of a PQE has no significant benefit on the LBR but significantly increases the MBR in patients who underwent frozen-thawed cleavage-stage embryo transfer. However, for patients who underwent blastocyst-stage embryo transfer, DET-GQE + PQE resulted in an increase in both the LBR and MBR, which may lead to adverse neonatal outcomes. Thus, the benefits and risks of double blastocyst-stage embryo transfer should be balanced. In patients younger than 35 years, SET-GQE achieved satisfactory LBR either in cleavage-stage embryo transfer or blastocyst-stage embryo transfer, while DET-GQE + PQE resulted in a dramatically increased MBR. Considering the low LBR in women older than 35 years who underwent single cleavage-stage embryo transfer, selective single blastocyst-stage embryo transfer appears to be a more promising approach for reducing the risk of multiple live births and adverse neonatal outcomes.
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- 2024
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43. Novel and Advanced Ultrasound Techniques for Thyroid Thermal Ablation
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Wai-Kin Chan, Jui-Hung Sun, Miaw-Jene Liou, Chia-Jung Hsu, Yu-Ling Lu, Wei-Yu Chou, Yan-Rong Li, and Feng-Hsuan Liu
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ablation techniques ,microwaves ,radiofrequency ablation ,thyroid nodule ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Thyroid radiofrequency ablation and microwave ablation are widely adopted minimally invasive treatments for diverse thyroid conditions worldwide. Fundamental skills such as the trans-isthmic approach and the moving shot technique are crucial for performing thyroid ablation, and advanced techniques, including hydrodissection and vascular ablation, improve safety and efficacy and reduce complications. Given the learning curve associated with ultrasound-guided therapeutic procedures, operators need training and experience. While training models exist, limited attention has been given to ultrasound maneuvers in ablation needle manipulation. This article introduces two essential maneuvers, the zigzag moving technique and the alienate maneuver, while also reviewing the latest ultrasound techniques in thyroid ablation, contributing valuable insights into this evolving field.
- Published
- 2024
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44. External evaluation of the predictive performance of published population pharmacokinetic models of linezolid in adult patients
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Yan Qin, Zheng Jiao, Yan-Rong Ye, Yun Shen, Zhe Chen, Yue-Ting Chen, Xiao-Yu Li, and Qian-Zhou Lv
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Linezolid ,Population pharmacokinetics ,External evaluation ,NONMEM ,Microbiology ,QR1-502 - Abstract
ABSTRACT: Objectives: Several linezolid population pharmacokinetic (popPK) models have been established to facilitate optimal therapy; however, their extrapolated predictive performance to other clinical sites is unknown. This study aimed to externally evaluate the predictive performance of published pharmacokinetic models of linezolid in adult patients. Methods: For the evaluation dataset, 150 samples were collected from 70 adult patients (72.9% of which were critically ill) treated with linezolid at our center. Twenty-five published popPK models were identified from PubMed and Embase. Model predictability was evaluated using prediction-based, simulation-based, and Bayesian forecasting-based approaches to assess model predictability. Results: Prediction-based diagnostics found that the prediction error within ±30% (F30) was less than 40% in all models, indicating unsatisfactory predictability. The simulation-based prediction- and variability-corrected visual predictive check and normalized prediction distribution error test indicated large discrepancies between the observations and simulations in most of the models. Bayesian forecasting with one or two prior observations significantly improved the models’ predictive performance. Conclusion: The published linezolid popPK models showed insufficient predictive ability. Therefore, their sole use is not recommended, and incorporating therapeutic drug monitoring of linezolid in clinical applications is necessary.
- Published
- 2023
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45. Distribution-Aware Graph Representation Learning for Transient Stability Assessment of Power System
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Chen, Kaixuan, Liu, Shunyu, Yu, Na, Yan, Rong, Zhang, Quan, Song, Jie, Feng, Zunlei, and Song, Mingli
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Electrical Engineering and Systems Science - Systems and Control ,Computer Science - Artificial Intelligence - Abstract
The real-time transient stability assessment (TSA) plays a critical role in the secure operation of the power system. Although the classic numerical integration method, \textit{i.e.} time-domain simulation (TDS), has been widely used in industry practice, it is inevitably trapped in a high computational complexity due to the high latitude sophistication of the power system. In this work, a data-driven power system estimation method is proposed to quickly predict the stability of the power system before TDS reaches the end of simulating time windows, which can reduce the average simulation time of stability assessment without loss of accuracy. As the topology of the power system is in the form of graph structure, graph neural network based representation learning is naturally suitable for learning the status of the power system. Motivated by observing the distribution information of crucial active power and reactive power on the power system's bus nodes, we thus propose a distribution-aware learning~(DAL) module to explore an informative graph representation vector for describing the status of a power system. Then, TSA is re-defined as a binary classification task, and the stability of the system is determined directly from the resulting graph representation without numerical integration. Finally, we apply our method to the online TSA task. The case studies on the IEEE 39-bus system and Polish 2383-bus system demonstrate the effectiveness of our proposed method., Comment: 8 pages, 6 figures, 4 tables
- Published
- 2022
46. The 'Hand as foot' teaching method in mitral valve and tricuspid valve
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Yan Rong Feng, Xiao Yu Liu, Tian Hao, and Rui Dong
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The mitral valve and tricuspid valve ,Mitral stenosis ,Mitral insufficiency ,Hand as foot ,Medical education ,Surgery ,RD1-811 - Published
- 2024
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47. Design and evaluation of piperidine carboxamide derivatives as potent ALK inhibitors through 3D-QSAR modeling, artificial neural network and computational analysis
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Ya-Kun Zhang, Jian-Bo Tong, Mu-Xuan Luo, Xiao-Yu Xing, Yu-Lu Yang, Zhi-Peng Qing, Ze-Lei Chang, and Yan-Rong Zeng
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Tumor ,QSAR ,Artificial neural network ,Piperidine carboxamide derivatives ,ALK inhibitors ,Chemistry ,QD1-999 - Abstract
Tumor stands as one of the principal contributors to global mortality. As research into tumor treatments advances, tumor inhibitors emerge as pivotal milestones in tumor therapy. Among these inhibitors, Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase, is critical owing to its close association with tumor cell proliferation and growth, which renders it a critical therapeutic target. This work systematically explores the relationship between the chemical structures of 36 piperidine carboxamide derivatives and their efficacy in inhibiting Karpas-299 tumor cell activity by employing a rigorous 3D-QSAR modeling approach. A robust Topomer CoMFA model was generated and was meticulously validated through ANN neural network analysis (q2 = 0.597, r2 = 0.939, F = 84.401, N = 4, SEE = 0.268). Based on the model, 60 new compounds with desirable inhibitory activities were successfully designed. Combined with Lipinski’s rule and ADMET criteria alongside molecular docking and dynamics simulations, a lead compound with high inhibitory activity and good drug-likeness was selected. Further computational analyses, encompassing free energy landscape and binding free energy calculations, provided compelling evidence of the stable binding conformation of the lead compound and the superior affinity with the target protein at the active site, underscoring its potential therapeutic utility. In summary, this investigation offers valuable insights and methodological guidance for advancing tumor therapy and underscores the promise of piperidine carboxamide derivatives as prospective ALK inhibitors.
- Published
- 2024
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48. A Chinese telemedicine-dialogue dataset annotated for named entities
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Wang, Shanshan, Yan, Yajing, Yan, Rong, Li, Ting, Ma, Kaijie, and Yan, Yani
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- 2023
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49. Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression
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Yan, Rong-Ge, He, Zhen, Wang, Fei-Chen, Li, Shuang, Shang, Qin-Bang, and Yang, Qi-En
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- 2023
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50. The cardiovascular and renal effects of glucagon-like peptide 1 receptor agonists in patients with advanced diabetic kidney disease
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Lin, Yuan, Wang, Te-Hsiung, Tsai, Ming-Lung, Wu, Victor Chien-Chia, Tseng, Chin-Ju, Lin, Ming-Shyan, Li, Yan-Rong, Chang, Chih-Hsiang, Chou, Tien-Shin, Tsai, Tzu-Hsien, Yang, Ning-I, Hung, Ming-Jui, and Chen, Tien-Hsing
- Published
- 2023
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