Search

Your search keyword '"Yan, Hede"' showing total 309 results
Start Over Author "Yan, Hede"
309 results on '"Yan, Hede"'

20. Chiral MoS2@BC fibrous membranes selectively promote peripheral nerve regeneration.

Author

Li, Mengru, Li, Xiao, Lv, Yaowei, Yan, Hede, Wang, Xiang-Yang, He, Jin, Zhou, Chao, and Ouyang, Yuanming

Subjects
NERVOUS system regeneration, NEURAL stem cells, SCIATIC nerve, PERIPHERAL nervous system, MYELIN sheath, MOLYBDENUM disulfide, SCHWANN cells, CYTOTOXINS
Abstract

Background: Molybdenum disulfide (MoS2) has excellent physical and chemical properties. Further, chiral MoS2 (CMS) exhibits excellent chiroptical and enantioselective effects, and the enantioselective properties of CMS have been studied for the treatment of neurodegenerative diseases. Intriguingly, left- and right-handed materials have different effects on promoting the differentiation of neural stem cells into neurons. However, the effect of the enantioselectivity of chiral materials on peripheral nerve regeneration remains unclear. Methods: In this study, CMS@bacterial cellulose (BC) scaffolds were fabricated using a hydrothermal approach. The CMS@BC films synthesized with L-2-amino-3-phenyl-1-propanol was defined as L-CMS. The CMS@BC films synthesized with D-2-amino-3-phenyl-1-propanol was defined as D-CMS. The biocompatibility of CMS@BC scaffolds and their effect on Schwann cells (SCs) were validated by cellular experiments. In addition, these scaffolds were implanted in rat sciatic nerve defect sites for three months. Results: These chiral scaffolds displayed high hydrophilicity, good mechanical properties, and low cytotoxicity. Further, we found that the L-CMS scaffolds were superior to the D-CMS scaffolds in promoting SCs proliferation. After three months, the scaffolds showed good biocompatibility in vivo, and the nerve conducting velocities of the L-CMS and D-CMS scaffolds were 51.2 m/s and 26.8 m/s, respectively. The L-CMS scaffolds showed a better regenerative effect than the D-CMS scaffolds. Similarly, the sciatic nerve function index and effects on the motor and electrophysiological functions were higher for the L-CMS scaffolds than the D-CMS scaffolds. Finally, the axon diameter and myelin sheath thickness of the regenerated nerves were improved in the L-CMS group. Conclusion: We found that the CMS@BC can promote peripheral nerve regeneration, and in general, the L-CMS group exhibited superior repair performance. Overall, the findings of this study reveal that CMS@BC can be used as a chiral nanomaterial nerve scaffold for peripheral nerve repair. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

48. Trans-Cinnamaldehyde Increases Random Pattern Flap Survival Through Activation of the Nitric Oxide Pathway

Author

Luo,Xiaobin, Zhao,Bin, Chen,Baoxia, Chen,Hongyu, Han,Tao, Bsoul,Najeeb Bassam Najeeb, Yan,Hede, Luo,Xiaobin, Zhao,Bin, Chen,Baoxia, Chen,Hongyu, Han,Tao, Bsoul,Najeeb Bassam Najeeb, and Yan,Hede

Abstract

Xiaobin Luo,1 Bin Zhao,2 Baoxia Chen,2 Hongyu Chen,1 Tao Han,1 Najeeb Bassam Najeeb Bsoul,1 Hede Yan1 1Department of Orthopedics (Division of Hand Surgery), The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Key Laboratory of Orthopedics of Zhejiang Province, The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People’s Republic of China; 2Department of Post Anaesthesia Care Unit, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, The Second School of Medicine, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People’s Republic of ChinaCorrespondence: Hede YanDepartment of Orthopaedics (Division of Hand Surgery), The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, West Xueyuan Road 109#, Wenzhou, 325027, Zhejiang Province, People’s Republic of ChinaEmail yanhede@hotmail.comBackground: The application of random pattern skin flaps is limited in plastic surgery reconstruction due to necrosis. Trans-cinnamaldehyde has antibacterial, anticancer, and antioxidant properties. In this study, we aimed to investigate the effect of trans-cinnamaldehyde on skin flap survival and its possible mechanism regarding nitric oxide.Materials and Methods: One hundred forty male Sprague-Dawley rats were randomly divided into seven groups (n = 20 each group). After the dorsal flap was raised, different doses of trans-cinnamaldehyde (10, 20, and 30 mg/kg) were immediately given by oral gavage in the three different groups. To assess the possible involvement of the nitric oxide system, NG-nitro-L-arginine methyl ester (L-NAME, a nonselective nitric oxide synthase inhibitor) was used in this study. All flap samples were incised on postoperative day 7.Results: Our results showed that flap survival was increased significantly in the 20 mg/kg (P < 0.001) trans-cinnamald

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results