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3. The Combination of Hyperuricemia and Elevated High-Sensitivity C-Reactive Protein Increased the Risk of Cardiac Conduction Block

Author

Li, Na, primary, Cui, Liufu, additional, Tse, Gary, additional, Korantzopoulos, Panagiotis, additional, Letsas, Konstantinos, additional, Bazoukis, George, additional, Chen, Shuohua, additional, Zhang, Nan, additional, Yang, Xuemei, additional, Liu, Peipei, additional, Wu, Lili, additional, Yan, Gan-Xin, additional, Lip, Gregory, additional, Wu, Shouling, additional, and Liu, Tong, additional

Published
2024
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6. Pacemaker-Mediated Arrhythmias

Author

Zhang, Yubin, Liu, Tong, Liu, Xing-Bin, Yan, Gan-Xin, Toth, Peter P., Series Editor, Yan, Gan-Xin, editor, Kowey, Peter R., editor, and Antzelevitch, Charles, editor

Published
2020
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10. The Combination of Hyperuricemia and Elevated High-Sensitivity C-Reactive Protein Increased the Risk of Cardiac Conduction Block

Author

Li,Na, Cui,Liufu, Tse,Gary, Korantzopoulos,Panagiotis, Letsas,Konstantinos, Bazoukis,George, Chen,Shuohua, Zhang,Nan, Yang,Xuemei, Liu,Peipei, Wu,Lili, Yan,Gan-Xin, Lip,Gregory, Wu,Shouling, Liu,Tong, Li,Na, Cui,Liufu, Tse,Gary, Korantzopoulos,Panagiotis, Letsas,Konstantinos, Bazoukis,George, Chen,Shuohua, Zhang,Nan, Yang,Xuemei, Liu,Peipei, Wu,Lili, Yan,Gan-Xin, Lip,Gregory, Wu,Shouling, and Liu,Tong

Abstract

Na Li,1 Liufu Cui,1 Gary Tse,2,3 Panagiotis Korantzopoulos,4 Konstantinos P Letsas,5 George Bazoukis,6,7 Shuohua Chen,8 Nan Zhang,2 Xuemei Yang,9 Peipei Liu,10 Lili Wu,11 Gan-Xin Yan,12,13 Gregory Yoke Hong Lip,14,15 Shouling Wu,8 Tong Liu2 1Department of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, Hebei Province, People’s Republic of China; 2Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, People’s Republic of China; 3School of Nursing and Health Studies, Hong Kong Metropolitan University, Hong Kong, People’s Republic of China; 4First Department of Cardiology, University of Ioannina Medical School, Ioannina, Greece; 5Arrhythmia Unit, Laboratory of Cardiac Pacing and Electrophysiology, Onassis Cardiac Surgery Center, Athens, Greece; 6Department of Cardiology, Larnaca General Hospital, Larnaca, Cyprus; 7European University Cyprus, Medical School, Nicosia, Cyprus; 8Department of Cardiology, Kailuan General Hospital, Tangshan, Hebei Province, People’s Republic of China; 9School of Clinical Medicine, North China University of Science and Technology, Tangshan, Hebei Province, People’s Republic of China; 10School of Public Health, North China University of Science and Technology, Tangshan, Hebei Province, People’s Republic of China; 11Department of Cardiology, Shanghai Songjiang District Central Hospital, Shanghai, People’s Republic of China; 12Lankenau Medical Center and Lankenau Institute for Medical Research, Wynnewood, PA, USA; 13Department of Cardiology, Fuwai Huazhong Hospital, Zhengzhou, Henan Province, People’s Republic of China; 14Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK; 15Danish Center for Clinical Health Services Research, Department of Clinical Medicine, Aalborg Un

Published
2024

13. Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome

Author

Milman, Anat, Andorin, Antoine, Postema, Pieter G., Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Juang, Jimmy J.M., Leshem, Eran, Michowitz, Yoav, Fogelman, Rami, Hochstadt, Aviram, Mizusawa, Yuka, Giustetto, Carla, Arbelo, Elena, Huang, Zhengrong, Corrado, Domenico, Delise, Pietro, Allocca, Giuseppe, Takagi, Masahiko, Wijeyeratne, Yanushi D., Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Jespersen, Camilla H., Tfelt-Hansen, Jacob, Veltmann, Christian, Priori, Silvia G., Behr, Elijah R., Yan, Gan-Xin, Brugada, Josep, Gaita, Fiorenzo, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Published
2019
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14. Characterization and Management of Arrhythmic Events in Young Patients With Brugada Syndrome

Author

Michowitz, Yoav, Milman, Anat, Andorin, Antoine, Sarquella-Brugada, Georgia, Gonzalez Corcia, M. Cecilia, Gourraud, Jean-Baptiste, Conte, Giulio, Sacher, Frederic, Juang, Jimmy J.M., Kim, Sung-Hwan, Leshem, Eran, Mabo, Philippe, Postema, Pieter G., Hochstadt, Aviram, Wijeyeratne, Yanushi D., Denjoy, Isabelle, Giustetto, Carla, Mizusawa, Yuka, Huang, Zhengrong, Jespersen, Camilla H., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Arbelo, Elena, Mazzanti, Andrea, Allocca, Giuseppe, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Priori, Silvia G., Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Brugada, Josep, Kusano, Kengo F., Hirao, Kenzo, Calo, Leonardo, Takagi, Masahiko, Tfelt-Hansen, Jacob, Yan, Gan-Xin, Gaita, Fiorenzo, Leenhardt, Antoine, Behr, Elijah R., Wilde, Arthur A.M., Nam, Gi-Byoung, Brugada, Pedro, Probst, Vincent, and Belhassen, Bernard

Published
2019
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16. Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays.

Author

Brown, Alan P., Friedrichs, Gregory S., Tang, Hai-Ming, Traebert, Martin, Weber, Valerie, Yao, Nancy, and Yan, Gan-Xin

Subjects
ION channels, ARRHYTHMIA, DRUG discovery, PERIPHERAL vascular diseases, ELECTROPHYSIOLOGY, SMALL molecules
Abstract

During drug discovery, small molecules are typically assayed in vitro for secondary pharmacology effects, which include ion channels relevant to cardiac electrophysiology. Compound A was an irreversible inhibitor of myeloperoxidase investigated for the treatment of peripheral artery disease. Oral doses in dogs at ≥5 mg/kg resulted in cardiac arrhythmias in a dose-dependent manner (at Cmax, free ≥1.53 μM) that progressed in severity with time. Nevertheless, a panel of 13 different cardiac ion channel (K, Na, and Ca) assays, including hERG, failed to identify pharmacologic risks of the molecule. Compound A and a related Compound B were evaluated for electrophysiological effects in the isolated rabbit ventricular wedge assay. Compounds A and B prolonged QT and Tp-e intervals at ≥1 and ≥.3 μM, respectively, and both prolonged QRS at ≥5 μM. Compound A produced early after depolarizations and premature ventricular complexes at ≥5 μM. These data indicate both compounds may be modulating hERG (Ikr) and Nav1.5 ion channels. In human IPSC cardiomyocytes, Compounds A and B prolonged field potential duration at ≥3 μM and induced cellular dysrhythmia at ≥10 and ≥3 μM, respectively. In a rat toxicology study, heart tissue: plasma concentration ratios for Compound A were ≥19X at 24 hours post-dose, indicating significant tissue distribution. In conclusion, in vitro ion channel assays may not always identify cardiovascular electrophysiological risks observed in vivo, which can be affected by tissue drug distribution. Risk for arrhythmia may increase with a "trappable" ion channel inhibitor, particularly if cardiac tissue drug levels achieve a critical threshold for pharmacologic effects. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Association between cumulative uric acid exposure and the risk of incident cardiac conduction block.

Author

Li, Na, Cui, Liufu, Korantzopoulos, Panagiotis, Zhang, Nan, Shu, Rong, Song, Haicheng, Wang, Jierui, Chen, Shuohua, Lip, Gregory Y H, Tse, Gary, Letsas, Konstantinos P, Bazoukis, George, Yan, Gan-Xin, Yang, Xuemei, Wu, Shouling, and Liu, Tong

Subjects
BUNDLE-branch block, CARDIAC hypertrophy, TYPE 2 diabetes, GLOMERULAR filtration rate, BODY mass index, HEART block, HEART failure
Published
2024
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38. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS.

Author

Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frédéric, Mabo, Philippe, Kim, SungHwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi YD, Mazzanti, Andrea, Brugada, Ramon, Casado Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah Raphael, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo KF, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frédéric, Mabo, Philippe, Kim, SungHwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi YD, Mazzanti, Andrea, Brugada, Ramon, Casado Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah Raphael, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo KF, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

39. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram:Sub-Analysis From the SABRUS

Author

Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Published
2023

42. J Wave Syndromes

Author

Lian, Jianfang, Kowey, Peter R., Yan, Gan-Xin, Yan, Gan-Xin, editor, and Kowey, Peter R., editor

Published
2011
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46. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS

Author

Milman, Anat, primary, Sabbag, Avi, additional, Conte, Giulio, additional, Postema, Pieter G., additional, Andorin, Antoine, additional, Gourraud, Jean-Baptiste, additional, Sacher, Frederic, additional, Mabo, Philippe, additional, Kim, Sung-Hwan, additional, Maeda, Shingo, additional, Takahashi, Yoshihide, additional, Kamakura, Tsukasa, additional, Aiba, Takeshi, additional, Juang, Jimmy JM, additional, Michowitz, Yoav, additional, Leshem, Eran, additional, Mizusawa, Yuka, additional, Arbelo, Elena, additional, Huang, Zhengrong, additional, Denjoy, Isabelle, additional, Giustetto, Carla, additional, Wijeyeratne, Yanushi D., additional, Mazzanti, Andrea, additional, Brugada, Ramon, additional, Casado-Arroyo, Ruben, additional, Champagne, Jean, additional, Calo, Leonardo, additional, Sarquella-Brugada, Georgia, additional, Tfelt-Hansen, Jacob, additional, Priori, Silvia G., additional, Takagi, Masahiko, additional, Veltmann, Christian, additional, Delise, Pietro, additional, Corrado, Domenico, additional, Behr, Elijah R., additional, Gaita, Fiorenzo, additional, Yan, Gan-Xin, additional, Brugada, Josep, additional, Leenhardt, Antoine, additional, Wilde, Arthur A.M., additional, Brugada, Pedro, additional, Kusano, Kengo F., additional, Hirao, Kenzo, additional, Nam, Gi-Byoung, additional, Probst, Vincent, additional, and Belhassen, Bernard, additional

Published
2023
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