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18 results on '"Yan, Bohua"'

3. Microstructure Formation and Characterization of Long-Acting Injectable Microspheres: The Gateway to Fully Controlled Drug Release Pattern

Author

Wang,Mengdi, Wang,Shan, Zhang,Changhao, Ma,Ming, Yan,Bohua, Hu,Xinming, Shao,Tianjiao, Piao,Yan, Jin,Lili, Gao,Jing, Wang,Mengdi, Wang,Shan, Zhang,Changhao, Ma,Ming, Yan,Bohua, Hu,Xinming, Shao,Tianjiao, Piao,Yan, Jin,Lili, and Gao,Jing

Abstract

Mengdi Wang,1,* Shan Wang,1,* Changhao Zhang,2,* Ming Ma,1 Bohua Yan,1 Xinming Hu,2 Tianjiao Shao,2 Yan Piao,2 Lili Jin,2 Jing Gao1 1State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, People’s Republic of China; 2College of Pharmacy, Key Laboratory of Natural Medicines of the Changbai Mountain of Ministry of Education, Yanbian University, Yanji, Jilin, 133002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Gao; Lili Jin, Email gjsmmu@126.com; jinlili@ybu.edu.cnAbstract: Long-acting injectable microspheres have been on the market for more than three decades, but if calculated on the brand name, only 12 products have been approved by the FDA due to numerous challenges in achieving a fully controllable drug release pattern. Recently, more and more researches on the critical factors that determine the release kinetics of microspheres shifted from evaluating the typical physicochemical properties to exploring the microstructure. The microstructure of microspheres mainly includes the spatial distribution and the dispersed state of drug, PLGA and pores, which has been considered as one of the most important characteristics of microspheres, especially when comparative characterization of the microstructure (Q3) has been recommended by the FDA for the bioequivalence assessment. This review extracted the main variables affecting the microstructure formation from microsphere formulation compositions and preparation processes and highlighted the latest advances in microstructure characterization techniques. The further understanding of the microsphere microstructure has significant reference value for the development of long-acting injectable microspheres, particularly for the development of the generic microspheres. Keywords: long-acting injectable microsphere, microstructure, PLGA, controlled drug release

Published
2024

11. PRMT5 regulates RNA m6A demethylation for doxorubicin sensitivity in breast cancer

Author

Wu, Ying, primary, Wang, Zhe, additional, Han, Lu, additional, Guo, Zhihao, additional, Yan, Bohua, additional, Guo, Lili, additional, Zhao, Huadong, additional, Wei, Mengying, additional, Hou, Niuniu, additional, Ye, Jing, additional, Shi, Changhong, additional, Liu, Suling, additional, Chen, Ceshi, additional, Chen, Suning, additional, Wang, Ting, additional, Yi, Jun, additional, Zhou, JianPing, additional, Yao, Libo, additional, Zhou, Wenxia, additional, Ling, Rui, additional, and Zhang, Jian, additional

Published
2022
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12. Effects and safety of herbal medicines among community-dwelling residents during COVID-19 pandemic: A large prospective, randomized controlled trial (RCT)

Author

Yan, Bohua, primary, Jiang, Zhiwei, additional, Yuan, Jing, additional, Li, Minghui, additional, Zeng, Jieping, additional, Tang, Jianyuan, additional, Lu, Z. Kevin, additional, Ding, Hong, additional, Xia, Jielai, additional, Wang, Qiaoling, additional, Wang, Jundong, additional, Xie, Hongyan, additional, Li, Wenyuan, additional, Zhang, Na, additional, Li, Haiyan, additional, Sang, Xiaoya, additional, Wu, Lina, additional, Xiong, Xiaomo, additional, Tang, Shiyun, additional, Li, Yan, additional, Tao, Mengyao, additional, Xie, Chunguang, additional, and Yu, Shuguang, additional

Published
2021
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