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3,341 results on '"Yamoah A"'

1. Atomistic mechanisms of the regulation of small-conductance Ca2+-activated K+ channel (SK2) by PIP2

Author

Woltz, Ryan L, Zheng, Yang, Choi, Woori, Ngo, Khoa, Trinh, Pauline, Ren, Lu, Thai, Phung N, Harris, Brandon J, Han, Yanxiao, Rouen, Kyle C, Mateos, Diego Lopez, Jian, Zhong, Chen-Izu, Ye, Dickson, Eamonn J, Yamoah, Ebenezer N, Yarov-Yarovoy, Vladimir, Vorobyov, Igor, Zhang, Xiao-Dong, and Chiamvimonvat, Nipavan

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Cardiovascular, 1.1 Normal biological development and functioning, 5.1 Pharmaceuticals, Phosphatidylinositol 4, 5-Diphosphate, Small-Conductance Calcium-Activated Potassium Channels, Molecular Dynamics Simulation, Animals, Calmodulin, Humans, Ion Channel Gating, Calcium, Protein Binding, Myocytes, Cardiac, atrial arrhythmias, calmodulin, optogenetics, phosphatidylinositol 4, 5-bisphosphate, small conductance Ca2+-activated K+ channel
Abstract

Small-conductance Ca2+-activated K+ channels (SK, KCa2) are gated solely by intracellular microdomain Ca2+. The channel has emerged as a therapeutic target for cardiac arrhythmias. Calmodulin (CaM) interacts with the CaM binding domain (CaMBD) of the SK channels, serving as the obligatory Ca2+ sensor to gate the channels. In heterologous expression systems, phosphatidylinositol 4,5-bisphosphate (PIP2) coordinates with CaM in regulating SK channels. However, the roles and mechanisms of PIP2 in regulating SK channels in cardiomyocytes remain unknown. Here, optogenetics, magnetic nanoparticles, combined with Rosetta structural modeling, and molecular dynamics (MD) simulations revealed the atomistic mechanisms of how PIP2 works in concert with Ca2+-CaM in the SK channel activation. Our computational study affords evidence for the critical role of the amino acid residue R395 in the S6 transmembrane segment, which is localized in propinquity to the intracellular hydrophobic gate. This residue forms a salt bridge with residue E398 in the S6 transmembrane segment from the adjacent subunit. Both R395 and E398 are conserved in all known isoforms of SK channels. Our findings suggest that the binding of PIP2 to R395 residue disrupts the R395:E398 salt bridge, increasing the flexibility of the transmembrane segment S6 and the activation of the channel. Importantly, our findings serve as a platform for testing of structural-based drug designs for therapeutic inhibitors and activators of the SK channel family. The study is timely since inhibitors of SK channels are currently in clinical trials to treat atrial arrhythmias.

Published
2024

8. The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell

Author

Lee, Jeong Han, Perez-Flores, Maria C, Park, Seojin, Kim, Hyo Jeong, Chen, Yingying, Kang, Mincheol, Kersigo, Jennifer, Choi, Jinsil, Thai, Phung N, Woltz, Ryan L, Perez-Flores, Dolores Columba, Perkins, Guy, Sihn, Choong-Ryoul, Trinh, Pauline, Zhang, Xiao-Dong, Sirish, Padmini, Dong, Yao, Feng, Wayne Wei, Pessah, Isaac N, Dixon, Rose E, Sokolowski, Bernd, Fritzsch, Bernd, Chiamvimonvat, Nipavan, and Yamoah, Ebenezer N

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Ear, Animals, Mice, Hair Cells, Auditory, Inner, Hair Cells, Auditory, Stereocilia, Ear, Inner, Hearing, Mechanotransduction, Cellular, Mammals, Ion Channels
Abstract

The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the sound-balance-brain interface, but the channel-complex composition is not entirely known. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as MET-complex components. The Pz channels, expressed in HC stereocilia, and cell lines are co-localized and co-assembled with MET complex partners. Mice expressing non-functional Pz1 and Pz2 at the ROSA26 locus have impaired auditory and vestibular traits that can only be explained if the Pzs are integral to the MET complex. We suggest that Pz subunits constitute part of the MET complex and that interactions with other MET complex components yield functional MET units to generate HC MET currents.

Published
2024

10. Agroforestry as an old approach to a new challenge of combating climate change: a critical analysis of the cocoa sector

Author

James S. Kaba, Ernest K. Agyei, Mohan Krishna Chowdry Avilineni, Fred A. Yamoah, Ibrahim Issahaku, Priscilla Ntiamoah, Emmanuel Acquah, and Mustapha Mas-Ud

Subjects
Climate change, Adaptation, Mitigation, Agroforestry, Pro-environmental, Cocoa production, Agriculture (General), S1-972, Environmental sciences, GE1-350
Abstract

Abstract Climate change is the greatest challenge to developing countries, especially where rain-fed agriculture is the main source of livelihood and revenue. Agroforestry provides an opportunity for farmers to adapt and reduce the carbon footprint. We conducted an exploratory review on the role of cocoa agroforestry for climate change mitigation and adaptation of smallholders by applying combinations of keywords that include climate change, agroforestry, stakeholders, Paris agreement, INDCs/NDCs, mitigation and adaptation. The paper combined data sources covering reports on past and on-going cocoa sustainability projects and policy interventions in Ghana as well as the output of exploratory review that utilized relevant key words to identify appropriate literature for investigation and analysis. We established that, there is low adoption of pro-environmental interventions introduced by both Government and NGOs in the cocoa sector. In addition, there is a shift in cocoa farming from expansion into forest areas to adoption of intensive cocoa monoculture. Despite the importance of shaded trees in cocoa production such as the benefits gained from agroforestry system, cocoa farmers have low appreciation of their environmental, soil, nutrients and other ecological benefits. We recommend that cocoa farmers should be involved in the formulation and implementation of pro-environmental interventions that affect their cocoa production practices. This will make farmers take ownership of the innovation instead of it being introduced to them. In addition, since our review of the literature established that the surge in yield is the impetus for cocoa monoculture adoption, there is the need to introduce cocoa varieties with higher yields under agroforestry system. Finally, there should be monetary valuation of shade trees used in cocoa agroforestry systems for payment to farmers to help improve agroforestry adoption. We argue that cocoa agroforestry though considered an old practice, remains one of the most appropriate land-use systems that is climate-smart with great potential to contribute to sustainable cocoa production.

Published
2024
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11. Adaptation of the socioecological model to address disparities in engagement of Black men in prostate cancer genetic testing

Author

Amy E. Leader, Timothy R. Rebbeck, William K. Oh, Alpa V. Patel, Eric P. Winer, LeeAnn O. Bailey, Leonard G. Gomella, Crystal Y. Lumpkins, Isla P. Garraway, Lisa B. Aiello, Monica L. Baskin, Heather H. Cheng, Kathleen A. Cooney, Amanda Ganzak, Daniel J. George, Susan Halabi, Feighanne Hathaway, Claire Healy, Joseph W. Kim, Michael S. Leapman, Stacy Loeb, Kara N. Maxwell, Christopher McNair, Todd M. Morgan, Breanne Prindeville, Howard R. Soule, Whitney L. Steward, Sakinah C. Suttiratana, Mary-Ellen Taplin, Kosj Yamoah, Thierry Fortune, Kris Bennett, Joshua Blanding-Godbolt, Laura Gross, and Veda N. Giri

Subjects
Prostate cancer, Genetic testing, Disparities, Health equity, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Black men consistently have higher rates of prostate cancer (PCA)- related mortality. Advances in PCA treatment, screening, and hereditary cancer assessment center around germline testing (GT). Of concern is the significant under-engagement of Black males in PCA GT, limiting the benefit of precision therapy and tailored cancer screening despite longstanding awareness of these disparities. To address these critical disparities, the Socioecological Model (SEM) was employed to develop comprehensive recommendations to overcome barriers and implement equitable strategies to engage Black males in PCA GT. Methods Clinical/research experts, national organization leaders, and community stakeholders spanning multiple regions in US and Africa participated in developing a framework for equity in PCA GT grounded in the SEM. A novel mixed-methods approach was employed to generate key areas to be addressed and informed statements for consensus consideration utilizing the modified Delphi model. Statements achieving strong consensus (> =75% agreement) were included in final equity frameworks addressing clinical/community engagement and research engagement. Results All societal levels of the SEM (interpersonal, institutional, community, and policy/advocacy) must deliver information about PCA GT to Black males that address benefits/limitations, clinical impact, hereditary cancer implications, with acknowledgment of mistrust (mean scores [MS] 4.57-5.00). Interpersonal strategies for information delivery included engagement of family/friends/peers/Black role models to improve education/awareness and overcome mistrust (MS 4.65-5.00). Institutional strategies included diversifying clinical, research, and educational programs and integrating community liaisons into healthcare institutions (MS 4.57-5.00). Community strategies included partnerships with healthcare institutions and visibility of healthcare providers/researchers at community events (MS 4.65–4.91). Policy/advocacy included improving partnerships between advocacy and healthcare/community organizations while protecting patient benefits (MS 4.57-5.00). Media strategies were endorsed for the first time at every level (MS 4.56-5.00). Conclusion The SEM-based equity frameworks proposed provide the first multidisciplinary strategies dedicated to increase engagement of Black males in PCA GT, which are critical to reduce disparities in PCA-mortality through informing tailored screening, targeted therapy, and cascade testing in families.

Published
2024
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12. Spatially fractionated GRID radiation potentiates immune-mediated tumor control

Author

Rebecca A. Bekker, Nina Obertopp, Gage Redler, José Penagaricano, Jimmy J. Caudell, Kosj Yamoah, Shari Pilon-Thomas, Eduardo G. Moros, and Heiko Enderling

Subjects
Tumor immune interactions, Spatially fractionated radiotherapy, Mathematical model, Personalized oncology, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Tumor-immune interactions shape a developing tumor and its tumor immune microenvironment (TIME) resulting in either well-infiltrated, immunologically inflamed tumor beds, or immune deserts with low levels of infiltration. The pre-treatment immune make-up of the TIME is associated with treatment outcome; immunologically inflamed tumors generally exhibit better responses to radio- and immunotherapy than non-inflamed tumors. However, radiotherapy is known to induce opposing immunological consequences, resulting in both immunostimulatory and inhibitory responses. In fact, it is thought that the radiation-induced tumoricidal immune response is curtailed by subsequent applications of radiation. It is thus conceivable that spatially fractionated radiotherapy (SFRT), administered through GRID blocks (SFRT-GRID) or lattice radiotherapy to create areas of low or high dose exposure, may create protective reservoirs of the tumor immune microenvironment, thereby preserving anti-tumor immune responses that are pivotal for radiation success. Methods We have developed an agent-based model (ABM) of tumor-immune interactions to investigate the immunological consequences and clinical outcomes after $$2\,\text{Gy} \times 35$$ 2 Gy × 35 whole tumor radiation therapy (WTRT) and SFRT-GRID. The ABM is conceptually calibrated such that untreated tumors escape immune surveillance and grow to clinical detection. Individual ABM simulations are initialized from four distinct multiplex immunohistochemistry (mIHC) slides, and immune related parameter rates are generated using Latin Hypercube Sampling. Results In silico simulations suggest that radiation-induced cancer cell death alone is insufficient to clear a tumor with WTRT. However, explicit consideration of radiation-induced anti-tumor immunity synergizes with radiation cytotoxicity to eradicate tumors. Similarly, SFRT-GRID is successful with radiation-induced anti-tumor immunity, and, for some pre-treatment TIME compositions and modeling parameters, SFRT-GRID might be superior to WTRT in providing tumor control. Conclusion This study demonstrates the pivotal role of the radiation-induced anti-tumor immunity. Prolonged fractionated treatment schedules may counteract early immune recruitment, which may be protected by SFRT-facilitated immune reservoirs. Different biological responses and treatment outcomes are observed based on pre-treatment TIME composition and model parameters. A rigorous analysis and model calibration for different tumor types and immune infiltration states is required before any conclusions can be drawn for clinical translation.

Published
2024
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15. Adaptation of the socioecological model to address disparities in engagement of Black men in prostate cancer genetic testing

Author

Leader, Amy E., Rebbeck, Timothy R., Oh, William K., Patel, Alpa V., Winer, Eric P., Bailey, LeeAnn O., Gomella, Leonard G., Lumpkins, Crystal Y., Garraway, Isla P., Aiello, Lisa B., Baskin, Monica L., Cheng, Heather H., Cooney, Kathleen A., Ganzak, Amanda, George, Daniel J., Halabi, Susan, Hathaway, Feighanne, Healy, Claire, Kim, Joseph W., Leapman, Michael S., Loeb, Stacy, Maxwell, Kara N., McNair, Christopher, Morgan, Todd M., Prindeville, Breanne, Soule, Howard R., Steward, Whitney L., Suttiratana, Sakinah C., Taplin, Mary-Ellen, Yamoah, Kosj, Fortune, Thierry, Bennett, Kris, Blanding-Godbolt, Joshua, Gross, Laura, and Giri, Veda N.

Published
2024
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20. Sand mining deteriorates soil fertility and farming livelihoods around Accra, Ghana

Author

Katharina Salomea Hemmler, Kofi Yeboah Asare, Emmanuel Yamoah Tenkorang, and Andreas Buerkert

Subjects
Medicine, Science
Abstract

Abstract Urbanization in Sub-Saharan Africa requires vast quantities of sand to meet infrastructural demands. In Accra, Ghana, sand mining occurs predominantly on farmlands at the city’s periphery. We selected three study communities to assess the effects of sand mining on agriculture using interviews with local farmers and soil analyses of mined and unmined fields. The results underscore the profound repercussions of sand mining on farmers, characterized by substantial agricultural land loss, the destruction of food crops, and the absence of compensation payments or land reclamation. The study further reveals a significant decline in soil fertility of mined fields compared to unmined fields as evidenced by reduced levels of carbon (C, by 6.3 g kg-1) and macronutrients (nitrogen (N, by 0.6 g kg-1), phosphorus (P, 12.7 mg kg-1), potassium (K, 77 mg kg-1) and magnesium (Mg, 88 mg kg-1)), and an increase in soil compaction (bulk density by 0.13 g cm-3 and penetration resistance by 0.11 MPa). Soil texture and pH were altered and sodium (Na, by 16 mg kg-1) and soil moisture (by 4%) increased. On a communal level, sand mining adversely affected water availability, road infrastructure, and the health of residents. The study fills research gaps on the effects of sand mining on agricultural productivity, soil fertility and livelihoods, emphasizing the urgent need for effective regulation, law enforcement and collaboration as well as compensation and land reclamation mechanisms to limit the adverse impacts of sand mining on ecosystem services. Further, the use of more sustainable building materials should be fostered to reduce the demand for sand in Ghana.

Published
2024
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21. Glacial changes in sea level modulated millennial-scale variability of Southeast Asian autumn monsoon rainfall

Author

Patterson, Elizabeth W, Johnson, Kathleen R, Griffiths, Michael L, Kinsley, Christopher W, McGee, David, Du, Xiaojing, Pico, Tamara, Wolf, Annabel, Ersek, Vasile, Mortlock, Richard A, Yamoah, Kweku A, Bùi, Thành N, Trần, Mùi X, Đỗ-Trọng, Quốc, Võ, Trí V, and Đinh, Trí H

Subjects
Earth Sciences, Physical Geography and Environmental Geoscience, Climate Change Science, Geology, Climate Action, Vietnam, paleoclimate, autumnmonsoon, speleothem, sealevel, autumn monsoon, sea level
Abstract

Most paleoclimate studies of Mainland Southeast Asia hydroclimate focus on the summer monsoon, with few studies investigating rainfall in other seasons. Here, we present a multiproxy stalagmite record (45,000 to 4,000 years) from central Vietnam, a region that receives most of its annual rainfall in autumn (September-November). We find evidence of a prolonged dry period spanning the last glacial maximum that is punctuated by an abrupt shift to wetter conditions during the deglaciation at ~14 ka. Paired with climate model simulations, we show that sea-level change drives autumn monsoon rainfall variability on glacial-orbital timescales. Consistent with the dry signal in the stalagmite record, climate model simulations reveal that lower glacial sea level exposes land in the Gulf of Tonkin and along the South China Shelf, reducing convection and moisture delivery to central Vietnam. When sea level rises and these landmasses flood at ~14 ka, moisture delivery to central Vietnam increases, causing an abrupt shift from dry to wet conditions. On millennial timescales, we find signatures of well-known Heinrich Stadials (HS) (dry conditions) and Dansgaard-Oeschger Events (wet conditions). Model simulations show that during the dry HS, changes in sea surface temperature related to meltwater forcing cause the formation of an anomalous anticyclone in the Western Pacific, which advects dry air across central Vietnam, decreasing autumn rainfall. Notably, sea level modulates the magnitude of millennial-scale dry and wet phases by muting dry events and enhancing wet events during periods of low sea level, highlighting the importance of this mechanism to autumn monsoon variability.

Published
2023

22. Actionable Genomic Alterations in Prostate Cancer Among Black and White United States Veterans.

Author

Valle, Luca F, Nickols, Nicholas G, Hausler, Ryan, Alba, Patrick R, Anglin-Foote, Tori, Perez, Cristina, Yamoah, Kosj, Rose, Brent S, Kelley, Michael J, DuVall, Scott L, Garraway, Isla P, Maxwell, Kara N, and Lynch, Julie A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Aging, Clinical Research, Human Genome, Clinical Trials and Supportive Activities, Prostate Cancer, Genetics, Urologic Diseases, Cancer, Good Health and Well Being, Male, Humans, United States, Retrospective Studies, Black or African American, Veterans, Precision Medicine, Prostatic Neoplasms, Genomics, White, metastatic prostate cancer, actionable alterations, next-generation sequencing, disparities, race, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Black Veterans have higher a incidence of localized and metastatic prostate cancer compared to White Veterans yet are underrepresented in reports of frequencies of somatic and germline alterations. This retrospective analysis of somatic and putative germline alterations was conducted in a large cohort of Veterans with prostate cancer (N = 835 Black, 1613 White) who underwent next generation sequencing through the VA Precision Oncology Program, which facilitates molecular testing for Veterans with metastatic cancer. No differences were observed in gene alterations for FDA approved targetable therapies (13.5% in Black Veterans vs. 15.5% in White Veterans, P = .21), nor in any potentially actionable alterations (25.5% vs. 28.7%, P =.1). Black Veterans had higher rates of BRAF (5.5% vs. 2.6%, P < .001) alterations, White Veterans TMPRSS2 fusions (27.2% vs. 11.7%, P < .0001). Putative germline alteration rates were higher in White Veterans (12.0% vs. 6.1%, P < .0001). Racial disparities in outcome are unlikely attributable to acquired somatic alterations in actionable pathways.

Published
2023

24. Structures, processes and outcomes between first referral and referral hospitals in low-income and middle-income countries: a secondary preplanned analysis of the FALCON and ChEETAh randomised trials

Author

Rajeev Sharma, Neha Mishra, Simon Cousens, Sanjay Gupta, Thomas Pinkney, Neil Smart, Jonathan Cook, David Jayne, Hemanth Kumar, Peter Brocklehurst, Mohammed Bashir, Dmitri Nepogodiev, Adesoji O Ademuyiwa, Philip Alexander, Laura Magill, Mark Monahan, Rachel Moore, Stephen Tabiri, Joseph Yorke, Dion Morton, Aneel Bhangu, Bryar Kadir, Naveen Sharma, Punam Mistry, Joshua Arthur, Muneer A Malik, Tracy Roberts, Elisee Rwagahirima, Christian Urimubabo, Ewen Harrison, Vijay Kumar, Julia Brown, Pollyanna Hardy, Amit Mahajan, Pratik Solanki, James Glasbey, Himani Gupta, Omar Omar, Joana Simoes, Sivesh K Kamarajah, Adesoji Ademuyiwa, Felix Alakaloko, Olumide Elebute, Omolara Faboya, Justina Seyi-Olajide, Anita Thomas, David Lissauer, Zainab Imam, George Ihediwa, Zainab O Imam, Felix M Alakaloko, Pradeep Zechariah, Suraj Surendran, Olatunji O Lawal, Mohammed Adnan, Savleen Kaur, Faustin Ntirenganya, JC Allen Ingabire, Lawani Ismaïl, Emmy Runigamugabo, Djifid Morel Seto, Paul Wondoh, Charles Dally, Kwabena Agbedinu, Florence Dedey, Enoch Tackie, Frank Enoch Gyamfi, Anthony Davor, Akinlabi Ajao, Omobolaji Ayandipo, Olalekan Ajai, Mobolaji Oludara, Muhammad Daniyan, Danjuma Sale, Lawal Abdullahi, Olabisi Osagie, Adedeji Fatuga, Muzzammil Abdullahi, Manish Pathak, Prashant Singh, Rita Jain, Kwaku Boakye-Yiadom, Kazeem Atobatele, Ayokunle Ogunyemi, Olabode Oshodi, Christopher Bode, Omobolaji O Ayandipo, Akinlabi E Ajao, Godwin Akaba, Gabriella Hyman, Deepak Singh, Olukemi Akande, Sivesh Kathir Kamarajah, Naseem Akhtar, José A Flores, Donna Smith, Olatunji Lawal, Hadijat Olaide Raji, Zafar Khan, Matthew Francis, Emmanuel Williams, Pardeep Kumar, Oliver Samuel, María Paz Muñoz, Arun Chaturvedi, Sameer Gupta, Puneet Prakash, John Raphael, Funmilola Wuraola, Olalekan Olasehinde, Murlidhar V Pai, Deepak Jain, Anwar Sadat Seidu, Victor Ifeanyichukwu Modekwe, Jideofor Okechukwu Ugwu, Lukmon Amosu, Akan Inyang, Michael Amoah, Boateng Nimako, Dhruva Ghosh, Neil Winkles, Olabisi O Osagie, Karolin Kroese, Olubunmi Ogein, Mustapha Yakubu, Vasanth Mark Samuel, Cecil Thomas, Enono Yhoshu, Vishal Michael, William Bhatti, Swati Daniel, Jyoti Dhiman, Atul Suroy, Christopher O Bode, George C Ihediwa, Adaiah Soibi-Harry, Benedetto Osunwusi, Elizabeth Li, Sonia Mathai, Deepak Singla, Farhanul Huda, Aisha Mustapha, Anisah Yahya, Samuel Mensah, Puneet Pareek, Bernard Ofori, Souliath Lawani, Oluwafunmilayo Adeniyi, Opeyemi Rebecca Akinajo, Richard Ofosu-Akromah, Olumide Adeniyi, Adewale O. Adisa, Natacha Boumas, Fareeda Galley, Frank Enoch Gyamfi Parvez D Haque, Antonio Ramos de la Medina, Chukwuma Okereke, Ronald Tubasime, Felicity Brant, Sohini Chakrabortee, Parvez D Haque, Emily Heritage, Carmela Lapitan, Rachel Lillywhite, Pierre Sodonougbo, Pamphile Assouto, Michel Fiogbe, Houenoukpo Koco, Serge Metchinhoungbe, Hodonou Sogbo, Hulrich Behanzin, Yannick Tandje, Sosthène Kangni, Cyrile Kpangon, Marcelin Akpla, Hugues Herve Chobli, Blaise Kovohouande, Gérard Agboton, Rene Ahossi, Raoul Baderha Ngabo, Nathan Bisimwa, Covalic Melic Bokossa Kandokponou, Mireille Dokponou, Francis Moïse Dossou, Corinne Dzemta, Antoine Gaou, Roland Goudou, Emmanuel Hedefoun, Sunday Houtoukpe, Felix Kamga, Eric Kiki- Migan, Ismaïl Lawani, René Loko, Afissatou Moutaïrou, Pencome Ogouyemi, Fouad Soumanou, Pia Tamadaho, Mack-Arthur Zounon, Luke Aniakwo Adagrah, Bin Baaba Alhaji Alhassan, Mabel Pokuah Amoako-Boateng, Anthony Baffour Appiah, Alvin Asante-Asamani, Benedict Boakye, Samuel A Debrah, Donald Enti, Rahman Adebisi Ganiyu, Patience Koggoh, Richard Kpankpari, Isabella Naa M. Opandoh, Meshach Agyemang Manu, Maison Patrick Opoku Manu, Martin Tangnaa Morna, John Nkrumah, Michael Nortey, Emmanuel Owusu Ofori, Elizaberth Mercy Quartson, Esther Adjei-Acquah, Eric Agyemang Vera Agyekum, Rebecca Adjeibah Akesseh, Forster Amponsah-Manu, Ato Oppong Acquah, Leslie Issa Adam-Zakariah, Esther Asabre, Ruby Acheampong Boateng, Barbara Koomson, Ataa Kusiwaa, Emmanuel Yaw Twerefour, James Ankomah, Frank Assah-Adjei, Anthony Appiah Boakye, Godfred Fosu, Godwin Serbeh, Kofi Yeboah Gyan, Isaac Omane Nyarko, Zelda Robertson, Ralph Armah, Christopher Asare, Delali Akosua Gakpetor, Victoria Sena Gawu, Ambe Obbeng, Doris Ofosuhene, Dorcas Osei-Poku, Diana Puozaa, Arkorful Ebenezer Temitope, Regina Acquah, James Amoako, Akosua Dwamena Appiah, Mark Aseti, Charles Banka, Samuel Dadzie, Derick Essien, Romeo Hussey, Jemima Kwarteng, Naa Anyekaa Sowah, Grace Yeboah, Cynthia Yeboah, Kwame Gyambibi Addo, Enoch Appiah Akosa, Percy Boakye, Christian Larbi Coompson, Brian Gyamfi, Bismark Effah Kontor, Christian Kyeremeh, Ruth Manu, Elijah Mensah, Friko Ibrahim Solae, Gideon Kwasi Toffah, Dorcas Otuo Acheampong, Jane Acquaye, Michael Adinku, Anita Eseenam Agbeko, Emmanuel Gyimah Amankwa, George Amoah, Juliana Appiah, Alex Ayim, Emmanuel Kafui Ayodeji, Jonathan Boakye-Yiadom, Edward Amoah Boateng, Christian Kofi Gyasi-Sarpong, Naabo Nuhu Noel Hamidu, Iddrisu Haruna, Naa Kwarley, Agbenya Kobla Lovi, Bertina Beauty Nyadu, Dominic Opoku, Anita Osabutey, Robert Sagoe, Samuel Tuffour, Yaa Tufour, Francis Akwaw Yamoah, Abiboye Cheduko Yefieye, Nii Armah Adu-Aryee, Faisal Adjei, Erica Akoto, Elikem Ametefe, Joachim Kwaku Amoako, Godsway Solomon Attepor, George Darko Brown, Benjamin Fenu, Philemon Kwame Kumassah, David Olatayo Olayiwola, Theodore Wordui, Nelson Agboadoh, Fatao Abubakari, Cletus Ballu, Charles Gyamfi Barimah, Guy Casskey Boateng, Prosper Tonwisi Luri, Abraham Titigah, Frank Owusu, Raphael Adu-Brobbey, Abdul-Hamid Labaran, Junior Atta Owusu, Vivian Adobea, Amos Bennin, Fred Dankwah, Stanley Doe, Ruth Sarfo Kantanka, Ephraim Kobby, Kennedy Kofi Korankye Hanson Larnyor, Edwin Osei, Prince Yeboah Owusu, Clement Ayum Sie-Broni, Marshall Zume, Francis Atindaana Abantanga, Darling Ramatu Abdulai, Daniel Kwesi Acquah, Emmanuel Ayingayure, Imoro Osman, Sheba Kunfah, Gbana Limann, Shamudeen Alhassan Mohammed, Sheriff Mohammed, Yakubu Musah, Emmanuel Abem Owusu, Abdul-Hafiz Saba, Edwin Mwintiereh Ta-ang Yenli, Arun Gautham, Alice Hepzibah, Grace Mary, Dimple Bhatti, Karan Bir, Tapasya Dhar, Sunita Goyal, Goyal Ankush, Monika Hans, Parvez Haque, Samuel Konda, Anil Luther, Shalini Makkar, Kavita Mandrelle, Partho Mukherjee, Reuben Rajappa, Ravinder Thind, Alen Thomas, Arti Tuli, Sreejith Veetil, Esther Daniel Mark Jesudason, K Priyadarshini, Latha Madankumar, Rohin Mittal, Ida Nagomy, Rajesh Selvakumar, Bharat Shankar, Moonish Sivakumar, Rajeevan Sridhar, Devabalan Titus, Manisha Aggarwal, Parth Dhamija, Vinoth Kanna, Ashwani Kumar, Gurtaj Singh, Josy Thomas, Amos Dasari, Priya Jacob, Elizabeth Kurien, Arpit Mathew, Danita Prakash, Anju Susan, Rose Varghese, Rahul Alpheus, Ashish Choudhrie, Nitin Peters, Subrat Raul, Rakesh Vakil, Wenceslao Ángeles Bueno, Francisco Barbosa Camacho, Aldo Bernal Hernández, Ana Bogurin Arellano, Edgar Cortes Torres, Clotilde Fuentes Orozco, Erick González García de Rojas, Alejandro González Ojeda, Bertha Guzmán Ramírez, Michel Hernández Valadez, Diego Luna Acevedo, Rubén Morán Galaviz, Oscar Olvera Flores, José Pérez Navarro, Kevin Pintor Belmontes, Fernando Ramirez Marbello, Luis Ramírez-González, Laura Reyes Aguirre, Ramona Rojas García, Eduardo Valtierra Robles, Reyes Cervantes Ortiz, Gonzalo Hernandez Gonzalez, Rosa Hernandez Krauss, Luis Hernández Miguelena, Marco Hurtado Romero, Isaac Baltazar Gomez, Celina Cuellar Aguirre, Alejandro Cuevas Avendaño, Luis Dominguez Sansores, Hector Ortiz Mejia, Laura Urdapilleta Gomez del Campo, Claudia Caballero Cerdan, David Dominguez Solano, Rafael Toriz Garcia, Mariana Barreto Gallo, Ana Cortes Flores, Alejandro Gonzalez Ojeda, Monica Jimenez Velasco, Rozana Reyes Gamez, Roque Lincona Menindez, Alberto Navarrete Peón, Irani Durán Sánchez, Diana Gonzalez Vazquez, Maria Martínez Lara, Laura Martinez Perez Maldonado, Alejandra Nayen Sainz de la Fuente, Antonio Ramos De la Medina, Khadija Ado, Mohammed Aliyu, Lofty-John Anyanwu, Mahmoud Magashi, Abubakar Muhammad, Saminu Muhammad, Bello Muideen, Idris Takai, Onyekachi Ukata, Opeoluwa Adesanya, David Awonuga, Olushola Fasiku, Chidiebere Ogo, Moruf Abdulsalam, Abimbola Adeniran, Grace Eke, Esther Momson, Francisca Nwaenyi, Olufunmilade Omisanjo, Yusuf Oshodi, Yemisi Oyewole, Omotade Salami, Omolara Williams, Victoria Adeleye, Opeyemi Akinajo, David Akinboyewa, Iyabo Alasi, Oluwole Atoyebi, Olanrewaju Balogun, Orimisan Belie, Andrew Ekwesianya, Francis Ezenwankwo, Adesola Jimoh, Jubril Kuku, Oluwaseun Ladipo- Ajayi, Ayomide Makanjuola, Olayanju Mokwenyei, Samuel Nwokocha, Rufus Ojewola, Abraham Oladimeji, Thomas Olajide, Oluwaseun Oluseye, Aloy Ugwu, Ochomma Egwuonwu, Okechukwu Ekwunife, Victor Modekwe, Chukwuemeka Okoro, Chisom Uche, Kenneth Ugwuanyi, Chuka Ugwunne, Akeem Adeleke, Wilson Adenikinju, Akinfolarin Adepiti, Adewale Aderounmu, Abdulhafiz Adesunkanmi, Adewale Adisa, Samuel Ajekwu, Olusegun Ajenjfuja, Jerrie Akindojutimi, Akinbolaji Akinkuolie, Olusegun Alatise, Olubukola Allen, Micheal Archibong, Olukayode Arowolo, Deborah Ayantona, Ademola Ayinde, Olusegun Badejoko, Tajudeen Badmus, Amarachukwu Etonyeaku, Emeka Igbodike, Omotade Ijarotimi, Adedayo Lawal, Fayowole Nana, Tunde Oduanafolabi, Olaniyi Olayemi, Stephen Omitinde, Owolabi Oni, Chigozie Onyeze, Ernest Orji, Adewale Rotimi, Abdulkadir Salako, Olufemi Solaja, Oluwaseun Sowemimo, Ademola Talabi, Mohammed Tajudeen, Francis Adebayo, Oseremen Aisuodionoe- Shadrach, Lazarus Ameh, Ndubuisi Mbajiekwe, Felix Ogbo, Samson Olori, Samuel Sani Abu Sadiq, Nancy Tabuanu, Martins Uanikhoba, Godwin Chiejina, Ekpo Edet, Mary Isa, Faith Iseh, Adams Marwa, Sunday Ogbeche, Edima Olory, Gabriel Udie, Joseph Udosen, Usang Usang, Olukayode Abayomi, Rukiyat Abdus-Salam, Sikiru Adebayo, Olanrewaju Amusat, Kelvin Egbuchulem, Hyginus Ekwuazi, Peter Elemile, Taiwo Lawal, Solomon Olagunju, Peter Osuala, Bamidele Suleman, Augustine Takure, Lukman Abdur-Rahman, Nurudeen Adeleke, Muideen Adesola, Rafiat Afolabi, Sulaiman Agodirin, Isiaka Aremu, Jibril Bello, Saheed Lawal, Abdulwahab Lawal, Hadijat Raji, Olayinka Sayomi, Asimiyu Shittu, Jude Ede, Sebastian Ekenze, Vincent Enemuo, Matthew Eze, Uchechukwu Ezomike, Emmanuel Izuka, Okezie Mbadiwe, Ngozi Mbah, Uba Ezinne, Iweha Ikechukwu, Okoi Nnyonno, Philemon Okoro, Igwe Patrick, Oriji Vaduneme, Abhulimen Victor, Salathiel Kanyarukiko, Francine Mukaneza, Deborah Mukantibaziyaremye, Aphrodis Munyaneza, Gibert Ndegamiye, Ronald Tubasiime, Moses Dusabe, Emelyne Izabiriza, Hope Lydia Maniraguha, Christophe Mpirimbanyi, Josiane Mutuyimana, Olivier Mwenedata, Francine Uwizeyimana, Job Zirikana, Aime Dieudonne Hirwa, Elysee Kabanda, Salomee Mbonimpaye, Christine Mukakomite, Piolette Muroruhirwe, Georges Bucyibaruta, Gisele Juru Bunogerane, Sosthene Habumuremyi, Jean de Dieu Haragirimana, Alphonsine Imanishimwe, Violette Mukanyange, Emmanuel Munyaneza, Emmanuel Mutabazi, Isaie Ncogoza, Jeannette Nyirahabimana, Mary Augusta Adams, Richard Crawford, Chikwendu Jeffrey Ede, Maria Fourtounas, Morapedi Kwati, Mpho Nosipho Mathe, Ncamsile Anthea Nhlabathi, Hlengiwe Samkelisiwe Nxumalo, Paddy Pattinson, Nnosa Sentholang, Mmule Evelyn Sethoana, Maria Elizabeth Stassen, Laura Thornley, Cheryl Birtles, Mathete Ivy, Cynthia Mbavhalelo, Zain Ally, Abdus-sami Adewunmi, Maria Picciochi, Michael Bahrami-Hessari, Didier Ahogni Benin, Aristide Ahounou, K. Alassan Boukari, Oswald Gbehade, Thierry K Hessou, Sinama Nindopa, M.J. Bienvenue Nontonwanou, Nafissatou Orou Guessou, Arouna Sambo, Sorekou Victoire Tchati, Affisatou Tchogo, Semevo Romaric Tobome, Parfait Yanto, Isidore Gandaho, Armel Hadonou, Simplice Hinvo, Montcho Adrien Hodonou, Sambo Bio Tamou, Marie-Claire Kouroumta, Enrif Malade, Anne stredy Mkoh Dikao, Joel Nzuwa Nsilu, Nathan Bisimwa Mitima, Cyrille Kpangon, Stephane Laurent Loupeda, Mamonde Victorin Agbangla, Sena Emmanuel Hedefoun, Thierry Mavoha, Juvenal Ngaguene, Janvier Rugendabanga, Rish Romaric Soton, Martin Totin, Mouhamed Agbadebo, Irene Akpo, Hubert Dewamon, Martin Djeto, Aissatou Hada, Monsede Hollo, Albert Houndji, Anasthasie Houndote, Sylvestre Hounsa, Expedit Kpatchassou, Hugues Yome, Mohamed Moussa Alidou, Bonheur Dossou Yovo, Robert Guinnou, Souleymane Hamadou, Nabil Moussa, Boniface Cakpo, Lolyta Etchisse, Emery Hatangimana, Moise Muhindo, Katia Sanni, Agossou Barthelemy Yevide, Hermann Agossou, Fiston Basirwa Musengo, Bill Armstrong Alia, Arnaud Alitonou, Lucien Agbanda, Julien Attinon, Marcel Gbassi, Nounagnon Rene Hounsou, Derick Esssien, Yakubu Mustapha, Kojo Nunoo-Ghartey, Luke A Aniakwo, Margarey N M Adjei, Yvonne Adofo-Asamoah, Meshach M Agyapong, Thomas Agyen, Baba A B Alhassan, Mabel P Amoako-Boateng, Josephine Ashong, Joseph K Awindaogo, Benjamin B Brimpong, Makafui S C J K Dayie, Wendy W Ghansah, Jude E Gyamfi, Vincent Kudoh, Philip Mensah, Isabella N Morkor Opandoh, Martin T Morna, Emelia Odame, Emmanuel O Ofori, Sandra Quaicoo, Elizabert M Quartson, Cynthia Teye-Topey, Makafui Yigah, Safia Yussif, Vera O Agyekum-Gyimah, Eric Agyemang, Arko Akoto- Ampaw, Temitope E Arkorful, Moses A Dokurugu, Nanabanyin Essel, Aja Ijeoma, Emmanuel L Obiri, Karen N D Quarchey, Leslie Adam-Zakariah, Aaron B Andoh, Ruby A Boateng, Atta Kusiwaa, Adeline Naah, Ato Oppon-Acquah, Benjamin A Oppong, Emma A Agbowada, Ameley Akosua, O Lawrence Dorcas Acheampong, Frank E Gyamfi, Bertina B Nyadu, Samira Abdulai, Nii A Adu-Aryee, Joachim K Amoako, Nicholas T Aperkor, Wilfred K Asman, Godsway S Attepor, Antoinette A Bediako-Bowan, George D Brown, Victor K Etwire, Benjamin S Fenu, Philemon K Kumassah, Linda A Larbi-Siaw, Josephine Nsaful, David O Olatola, Sandra E Tsatsu, Iddrisu I A Abdul-Aziz, Johnson Akunyam, Gilbert A G Anasara, Charles G Barimah, Guy C Boateng, Ponala W Kwabena, Seidu M Kwarteng, Prosper T Luri, Kennedy Ngaaso, David K D Ogudi, Collins Kyeremeh, Clement Sie-Broni, Saba Abdul-Hafiz, Daniel K Acquah, Shamsudeen M Adams, Mohammed S Alhassan, Munira Amadu, Samuel A Asirifi, Martin Awe, Millicent Azanlerigu, Mathias K Dery, Yenli Edwin, Abantanga Atindaana Francis, Aloysius Maalekuu, Hawa Malechi, Ibrahim Mohammed, Kareem Mumuni, Bernard A Ofori, Jonathan I K Quansah, Napoleon Bellua Sam, Anwar S Seidu, Shekira Yahaya, Emmanuel Kojo Acquah, Jaabir Alhassan, Christian L Coompson, Addo K Gyambibi, Ametepe Jeffery-Felix, Bismark E Kontor, Gifty Naah, Carmen Noufuentes, Abraham Sakyi, Ramkaran Chaudhary, Sanjeev Misra, Dharma R Poonia, Kirti K Rathod, Mahaveer S Rodha, Nivedita Sharma, Subhash C Soni, Vaibhav K Varsheney, Jeevan R Vishnoi, Deepak K Garnaik, Manoj J Lokavarapu, Rohit Ranjan, Rajkumar K Seenivasagam, Shanky Singh, Raunak Verma, Suzan John, Jeffery A Kalyanapu, Ananta Kutma, Sanish Philips, Arun K Gautham, Deepak S Singh, Eunice S Abraham, Chetana Chetana, Prashant Dummala, Chinta S Gold, Jurgen Jacob, Jeremiah N Joseph, Elizabeth N Kurien, Priya Mary, Arpit J Mathew, Amy E Mathew, Danita D Prakash, Ashwin Sukumar, Niyah Syam, Alisha Bhatt, Dhruva N Ghosh, Ankush Goyal, Monika A Hans, Jyoti Jyoti, Karan Kumar, Vivin Daniel Sam, Ravinder Singh Thind, Sreejith K Veetil, Rahul Williams, D Sreekar, Esther R Daniel, Smitha E Jacob, Mark R Jesudason, Pushplatha Kumari, Soosan Prasad, Srujan Sharma, Moonish V Sivakumar, Paul Trinity, Sudheer Kanchodu, K Leshiini, Sundeep S Saluja, Ashok K Attri, Ishan Bansal, Monika Gureh, Simran Kapoor, Harmanjot Kaur, Simrandeep Singh, Viju John, Nivesh Agrawal, Uttkarsh Kumar, S Abhishek, Vikram Sehrawat, Gaurav Thami, Stanley Mathew, P S Prabhu, P T Sundeep, Shiv Rajan, Mohit Singh, Abhilasha Tripathi, Philip V Alexander, A Vijay, Moloti Kichu* Ismavel, Carolin V Solomi, Rahul A Alpheus, Ashish Victor Choudhrie, Rashmi Jacob Gunny, Susan Joseph, Nitin J Peters, Neha Pundir, Ram Samujh, Hafsa I Ahmed, Gowhar Aziz, Nisar A Chowdri, Rayees A Dar, Robindera Kour, Imtiyaz Mantoo, Asif Mehraj, Fazl Q Parray, Najmus Saqib, Zamir A Shah, Rauf A Wani, Komal Rautela, Nishu Singh, Priyanka Chowdhury, Sona Chowdhury, Pragyanmai Nayak, Bipradas Roy, Andrea S Alvarez Villaseñor, Kriscia V Ascencio Díaz, Victor J Avalos Herrera, Francisco J Barbosa, Elyoenai Bonilla Ahumada, Irma V Brancaccio, Miguel A Calderón, Guadalupe Castillo Cardiel, Guillermo A Cervantes, Gabino Cervantes Guevara, Enrique Cervantes Perez, Maria Chávez, Jonathan M Chejfec, Luis R Cifuentes, Ana O Cortés, Edgar J Cortes, Tania A Cueto, Andrea E Cueto, Esteban Cueva Martinez, Paulina Domínguez Barradas, Isaac Esparza Estrada, Paola Flores Becerril, Luis A García, Benjamín García Reyna, Eduardo Gómez Sánchez, Jaime L González, Eduardo González Espinoza, Fanny Y González, Cristhian S Guerrero, José A Guzmán, Bertha G Guzmán, Mario J Guzmán, DanielA Hérnandez Alva, SilviaA Ibarra Camargo, JuanC Ibarrola Peña, Martin Islas Torres, Jorge Jiménez Tornero, ZayraM Lara Pérez, Roberto Mares País, MelP Mellado Tellez, RobertoC Miranda Ackerman, Damián Mora Santana, Gilberto Morgan Villela, Rodrigo Nájar Hinojosa, Cesar Nuño Escobar, Itzel Ochoa Rodríguez, Angelica Ortega Barreiro, Jacqueline Osuna Rubio, Luis RPacheco Vallejo, VíctorH Pérez Bocanegra, JoseV Pérez Navarro, Francisco JPlascencia Posada, MaríaA Quirarte Hernández, LuisR Ramirez Gonzalez, Emilio AReyes Elizalde, EveliaV Romo Ascencio, Cornelio Ruelas Bravo, CarlosB Ruiz Velasco, JoséA Sánchez Martínez, Guillermo Sanchez Villaseñor, JoséI Sandoval Pulido, AlejandroG Serrano García, LuisO Suárez Carreón, JuanJ Tijerina Ávila, JesusO Vega Gastelum, MelissaL Vicencio Ramirez, MariaF Zarate Casas, CarlosJ Zuloaga, Fernández del Valle, JesusAntonion Aguilar Mata, MiguelAntonio Calderon Vanegas, RocioGuadalupe Cano Arias, Carlos Colunga Tinajero, Fernanda Diaz Samano, Fernando Duque Zepeda, BrendaVanessa Enriquez Barajas, Gerardo Gallardo Banuelos, MarijoseDe CristoGonzalez Calvillo, Francisco Ibanez Ortiz, Maryzela Lazo Ramirez, Gerardo Lopez Arroyo, LauraOlivia Montano Angeles, DavidGiovannyI Morales Iriarte, AngeloFernando Mortola Lomeli, Jose EstebanOrozco Navarro, Jaime Orozco Perez, Damaris Orozco Ramirez, LauraGabriela Pena Baolboa, Jesus Pizarro Lozano, Guillermo Yanowsky Reyes, Monica N Castillo, Ana CamilleG Dominguez, Dorihela H Mellado, Jesus FlavioM Morales, Luzdel CarmenM Namur, Jose AlbertoA Pesquera, LauraMartinez Perez Maldonado, Antonio RamosDe laMedina, Katya Bozada-Gutierrez, AnaFlorencia Casado-Zarate, Roberto Delano-Alonso, Jose Herrera-Esquivel, Mucio Moreno-Portillo, Mario Trejo-Avila, Roland Kevin CethorthFonseca, Edgard Efren LozadaHernandez, Bruno Crocco Quiros, JairoArturo Rodriguez Ramirez, Gabriela Ambriz-González, MitziR Becerra Moscoso, Ishtar Cabrera-Lozano, AnaB Calderón-Alvarado, FranciscoJ León-Frutos, ErickE Villanueva-Martínez, Aisha Abdullahi, Maimuna Abubakar, MohammedS Aliyu, Mudi Awaisu, Fadimatu Bakari, Abigail Olajumoke Balogun, Ahmad Bello, Kehinde Michael Duromola, Stephen G Gana, Mukoro Duke George, Justina Gimba, Isaac Gundu, Lambert Onahi Iji, Aminat O Jimoh, Afolabi K Koledade, Ahmad T Lawal, Bilkisu K Lawal, Stanley Emeka Nwabuoku, Oluseyi O Ogunsua, Ifeanyi Fidelis Okafor, Ethos Ike Okorie, Nasir Oyelowo, Ibrahim A Saidu, Tunde T Sholadoye, Ibrahim Sufyan, Musliu Adetola Tolani, Aliyu Muhammad Tukur, Ahmad Shehu Umar, Aminatu M Umar, Hajara Umaru-Sule, Mohammed Usman, Alfa Yakubu, Salisu Abeku Yusuf, Abdulhafiz A Abdulkarim, Lawal Barau Abdullahi, Khadija A Ado, Nura U Aliyu, Lofty-John Chukwuemeka Anyanwu, Sulaiman M Daneji, Mahmoud Kawu Magashi, Mohammad A Mohammad, Abubakar Bala Muhammad, Saminu S Muhammad, Bello Abodunde Muideen, Calistus U Nwachukwu, Suleiman B Sallau, Abdulrahman A Sheshe, Abdulmajeed Soladoye, Idris Usman Takai, Garzali I Umar, Abubakar Yahaya, Lubabatu Abdulrasheed, Joel A Adze, Lydia R Airede, Bashiru Aminu, Stephen B Bature, Firdaws Bello-Tukur, Damai Chinyio, SharonA N Duniya, Moses C Galadima, Babatunde K Hamza, Samaila Joshua, Stephen A Kache, Williams Y Kagomi, Ifeanyi A Kene, Jamila Lawal, Jerry G Makama, Caleb Mohammed, Amina A Mohammed-Durosinlorun, Deborah Nuwam, Abdulrasheed Sani, Salome Tabara, Mathew C Taingson, Emmanuel Usam, Josiah Yakubu, Folasade Adegoke, Oluwasuyi Ige, Tunde A Odunafolabi, Chukwuma E Okereke, Oluwafemi O Oladele, Oluwaseun H Olaleye, Oyetunde O Olubayo, Olukayode P Abiola, Henry O Abiyere, Idowu O Adebara, GbadeboT C Adeleye, Adebayo A Adeniyi, Olumide E Adewara, Olabisi T Adeyemo, Ademola A Adeyeye, Abimbola L Ariyibi, Babatunde S Awoyinka, Olumide M Ayankunle, Olakunle F Babalola, Adewumi Bakare, TajudeenI B Bakare, Oluseyi O Banjo, Peter A Egharevba, Oluwafemi S Fatudimu, John A Obateru, Oluremi J Odesanya, Owolabi D Ojo, Abiodun I Okunlola, Cecilia K Okunlola, Adewale T Olajide, Tesleem O Orewole, Adedayo I Salawu, Moruf A Abdulsalam, Aderinsola T Adelaja, Olalekan T Ajai, Noble Anyanwu, Kazeem M Atobatele, Oludayo Oluwaseyi Bakare, Omolara M Faboya, Francisca C Nwaenyi, Ayokunle A Ogunyemi, Mobolaji A Oludara, Olufunmilade A Omisanjo, Chinonso U Onyeka, Olabode A Oshodi, Yusuf A Oshodi, Omotade S Salami, Omolara M Williams, Esther Abunimye, Adebunmi Adeoluwa, Adedotun Adesiyakan, Victoria Ibukunoluwa Adeyeye, Moses Vincent Agbulu, David O Akinboyewa, Iyabo O Alasi, Michael Amao, Christiana Ashley-Osuzoka, Oluwole A Atoyebi, Olanrewaju S Balogun, Maryam Oluwatobi Busari, Nnamdi Jonathan Duru, Glory Bassey Edet, Olumide A Elebute, Francis Chinonso Ezenwankwo, Adedeji L Fatuga, Christianah Gbenga-Oke, Emmanuel Sylvester Inyang, Adesola I Jimoh, Jubril Oladayo Kuku, OluwaseunA Ladipo-Ajayi, Abdulrazzaq O Lawal, Christian Chigoze Makwe, Chinelo Victoria Mgbemena, Samuel U Nwokocha, Moses Adebisi Ogunjimi, Ephraim Okwudiri Ohazurike, Rufus W Ojewola, Moyosoluwa Eunice Badedale, Chike J Okeke, Adeyemi A Okunowo, Abraham T Oladimeji, Thomas O Olajide, Olabisi Olanrewaju, Olawunmi Olayioye, Oluwaseun O Oluseye, Stephen Olutola, Kenneth Onyekachi, Adeola Ayoola Orowale, Emili Osariemen, Adedapo Olumide Osinowo, Emmanuel Owie, Christianah Bidemi Oyegbola, Justina OSeyi-Olajide, AdaiahP Soibi-Harry, Manuella Talla Timo, Aloy Okechukwu Ugwu, Emmanuel Ojo Williams, Innocent O Duruewuru, Ochonma A Egwuonwu, Okechukwu Hyginus Ekwunife, James J Emeka, Chimdiebele Daisy Nwosu, Sylvester O Obiechina, Ahuizechukwu E Obiesie, Celestine I Okafor, Theophilus O Okonoboh, Odili A Okoye, Onyekachi A Onu, Chukwudubem C Onyejiaka, Chisom Faith Uche, JosephO Ugboajah, Akeem A Adeleke, Akinfolarin C Adepiti, Adewale A Aderounmu, Abdulhafiz O Adesunkanmi, Adewale O Adisa, Samuel C Ajekwu, Olusegun K Ajenifuja, Olusegun I Alatise, Tajudeen A Badmus, Tajudeen O Mohammed, Abdulkadir A Salako, Oludayo A Sowande, Ademola O Talabi, Funmilola O Wuraola, Paul Aderemi Adegoke, Abidemi Akinloye, Ayodeji Akinniyi, Joseph Ejimogu, Ideyonbe Samuel Eseile, Olakayode Olaolu Ogundoyin, Amos Okedare, Dare Isaac Olulana, Omolara Omotola, Francis Sanwo, Collins C Adumah, Adewale O Ajagbe, Olugbenga P Akintunde, Opeyemi Q Asafa, Kehinde Awodele, Amogu K Eziyi, Adeniyi O Fasanu, Olufemi O Ojewuyi, Abiodun R Ojewuyi, Abisola E Oyedele, Oluwaseun A Taiwo, Habiba I Abdullahi, Nathaniel D Adewole, Teddy E Agida, Eunice E Ailunia, Oseremen Aisuodionoe-Shadrach, Godwin O Akaba, Janet Alfred, Terkaa Atim, Kehinde G Bawa, John Y Chinda, Esther B Daluk, Sefiu B Eniola, Augusta O Ezenwa, Stephen E Garba, Philip M Mshelbwala, Ngozi O Ndukwe, Idoko P Ogolekwu, Alexander A Ohemu, Samuel A Sani, Salisu Suleiman, Helen Sunday, Nancy O Tabuanu, Aminu M Umar, Peter I Agbonrofo, Alexander I Arekhandia, Morrison E Edena, Raymond A Eghonghon, Joel E Enaholo, Genesis Ida, Stanley N Ideh, Oseihie I Iribhogbe, Omorodion O Irowa, Maradona E Isikhuemen, Oluwatomi R Odutola, Kester O Okoduwa, Scott O Omorogbe, David Oruade, Osasumwen T Osagie, Osarenkhoe Osemwegie, RukiyatA Abdus-Salam, Sikiru Adekola Adebayo, Oluwasanmi A Ajagbe, Gboyega Ajibola, Kelvin I Egbuchulem, Hyginus O Ekwuazi, Adegbolahan Fakoya, Oluwasegun C Idowu, David O Irabor, Taiwo A Lawal, Olakayode O Ogundoyin, Oluwabukade Ojediran, Naomi Olagunju, Akinsola T Sanusi, Augustine O Takure, Lukman Olajide Abdur-Rahman, Mary Oluwadamilola Adebisi, Nurudeen Abiola Adeleke, Rafiat Tinuola Afolabi, Isiaka Ishola Aremu, Jibril Oyekunle Bello, Robiat Bello, Saheed Abolade Lawal, Adeolu Ojajuni, Sabur Oyewale, Victor Abhulimen, Patrick O Igwe, Ikechukwu Enyinnaya Iweha, Raphael E John, Nnyonno Okoi, Philemon E Okoro, Vaduneme Kingsley Oriji, Ibiene T Oweredaba, Japhet Mizero, Immaculee Mutimamwiza, Francoise Nirere, Irenee Niyongombwa, Jean Paul Majyabere, Anastase Byaruhanga, Rongin Dukuzimana, Jean Aimable Habiyakare, Marie Gloriose Nabada, Marcel Uwizeye, Mathias Ruhosha, Joselyne Igiraneza, Faustine Ingabire, Aloys Karekezi, Jean pierre Masengesho, Lydia Mukamazera, Clemence Mukangabo, Jean Paul Niyomuremyi, Gabriel Ntwari, Celestin Seneza, Divine Umuhoza, Pierrine Nyirangeri, Jean Claude Uwimana, Isaie Sibomana, Desire Rubanguka, Josine Umuhoza, Roda Uwayezu, Leoncie Uzikwambara, Herbert Butana, Moise Dusabeyezu, Athanasie Mukasine, Jean N Utumatwishima, Mediatrice Batangana, Jeande Dieu Haragirimana, AllenJ C Ingabire, Espoir Mwungura, Dancilla Nyirasebura, Christian Jean Urimubabo, Anaclet Dusabimana, Sam Kanyesigye, Robert Munyaneza, Jean Yves Shyirakera, Aimee Domingo, Philip Munda, Chido Nyatsambo, Victor Ojo, Rudo Pswarayi, and Soeren Laurberg

Subjects
Medicine (General), R5-920, Infectious and parasitic diseases, RC109-216
Published
2024
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25. Assessment Design And Practices Toward Holistic Learning Of Higher Education Students: Empirical Evidence Via Path Analysis Modelling Approach

Author

Ebenezer Afrifa-Yamoah, Esther Adama, Amanda Graf, and Kwadwo Adusei-Asante

Subjects
non-invigilated assessments, student wellbeing, student success, invigilated exams, SEM, Theory and practice of education, LB5-3640
Abstract

COVID-19 has revolutionised assessment design and practices in higher education; however, there has not been a shift in the overall objective of enhancing that the association between assessments and learning promotes the holistic development of students. In this study, we provide an empirical evaluation of the perceived effects of assessment practices (invigilated examination and alternative assessments) on students’ mental wellbeing, learning processes and academic misconduct. A cross-sectional study design was employed for this study in which a self-reported survey instrument was administered to 380 social science and nursing undergraduate and postgraduate students in a public university in Australia. We explored the correlations within defined networks by path analysis via partial least square structural equation modelling (PLS-SEM) framework of SmartPLS 3. Model assessment indexes indicated acceptable convergent, divergent and construct validity scores for the instrument used. Compared to invigilated exams, students perceived alternative assessments to have significant positive direct effects on stress levels, research skills, learning process and time management (). In relation to academic misconduct, students generally perceived invigilated exams to restrain such practices; however, the perceived effect was not statistically significant when compared with alternative assessments (. Although, the popularity of alternative assessment practices may have been driven by COVID-19, the pilot findings from this study suggest these assessment designs and practices have greater potential to promote overall student success and productivity and must be encouraged and utilised in the post-COVID-19 era.

Published
2024

27. Using machine learning algorithms to predict COVID-19 vaccine uptake: A year after the introduction of COVID-19 vaccines in Ghana

Author

Cornelius C. Dodoo, Ebo Hanson-Yamoah, David Adedia, Irene Erzuah, Peter Yamoah, Fareeda Brobbey, Constance Cobbold, and Josephine Mensah

Subjects
Vaccine hesitancy, COVID-19 vaccine, Machine learning, Immunologic diseases. Allergy, RC581-607
Abstract

The impact of vaccine hesitancy on global health is one that carries dire consequences. This was evident during the outbreak of the COVID-19 pandemic, where numerous theories and rumours emerged. To facilitate targeted actions aimed at increasing vaccine acceptance, it is essential to identify and understand the barriers that hinder vaccine uptake, particularly regarding the COVID-19 vaccine in Ghana, one year after its introduction in the country.We conducted a cross-sectional study utilizing self-administered questionnaires to determine factors, including barriers, that predict COVID-19 vaccine uptake among clients visiting a tertiary and quaternary hospital using some machine learning algorithms. Among the findings, machine learning models were developed and compared, with the best model employed to predict and guide interventions tailored to specific populations and contexts. A random forest model was utilized for prediction, revealing that the type of facility respondents visited and the presence of underlying medical conditions were significant factors in determining an individual's likelihood of receiving the COVID-19 vaccine. The results showed that machine learning algorithms can be of great use in determining COVID-19 vaccine uptake.

Published
2024
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28. Leveraging Supervised Machine Learning for Determining the Link between Suboptimal Health Status and the Prognosis of Chronic Diseases

Author

Adua, Eric, Afrifa-Yamoah, Ebenezer, Kolog, Emmanuel Awuni, Golubnitschaja, Olga, Series Editor, Baban, Babak, Editorial Board Member, Bubnov, Rostylav, Editorial Board Member, Costigliola, Vincenzo, Editorial Board Member, Grech, Godfrey, Editorial Board Member, Mozaffari, Mahmood, Editorial Board Member, Parini, Paolo, Editorial Board Member, Paul, Friedermann, Editorial Board Member, Yoo, Byong Chul, Editorial Board Member, Zhan, Xianquan, Editorial Board Member, Andrews, Russell J., Editorial Board Member, Fröhlich, Holger, Editorial Board Member, Kokubo, Yoshihiro, Editorial Board Member, Krapfenbauer, Kurt, Editorial Board Member, Podbielska, Halina, Editorial Board Member, Tasker, R. Andrew, Editorial Board Member, Nardini, Christine, Editorial Board Member, Chaari, Lotfi, Editorial Board Member, Polivka Jr., Jiri, Editorial Board Member, Mandel, Silvia, Editorial Board Member, Erb, Carl, Editorial Board Member, and Wang, Wei, Editorial Board Member

Published
2024
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29. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Author

Wang, Anqi, Shen, Jiayi, Rodriguez, Alex A., Saunders, Edward J., Chen, Fei, Janivara, Rohini, Darst, Burcu F., Sheng, Xin, Xu, Yili, Chou, Alisha J., Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N., Plym, Anna, Sahimi, Ali, Hoffman, Thomas J., Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Laisk, Triin, Figuerêdo, Jéssica, Muir, Kenneth, Ito, Shuji, Liu, Xiaoxi, Uchio, Yuji, Kubo, Michiaki, Kamatani, Yoichiro, Lophatananon, Artitaya, Wan, Peggy, Andrews, Caroline, Lori, Adriana, Choudhury, Parichoy P., Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Cybulski, Cezary, Wokolorczyk, Dominika, Lubinski, Jan, Rentsch, Christopher T., Cho, Kelly, Mcmahon, Benjamin H., Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nordestgaard, Borge G., Nielsen, Sune F., Weischer, Maren, Bojesen, Stig E., Røder, Andreas, Stroomberg, Hein V., Batra, Jyotsna, Chambers, Suzanne, Horvath, Lisa, Clements, Judith A., Tilly, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordstrom, Tobias, Pashayan, Nora, Dunning, Alison M., Ghoussaini, Maya, Travis, Ruth C., Key, Tim J., Riboli, Elio, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie, Cook, Michael B., Mucci, Lorelei A., Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J., Penney, Kathryn L., Turman, Constance, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr., Ian M., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L., Ostrander, Elaine A., Koutros, Stella, Beane Freeman, Laura E., Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L., Hoover, Robert N., Machiela, Mitchell J., Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J., Zheng, Wei, Yeboah, Edward D., Mensah, James E., Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., West, Catharine M. L., Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Geraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M., Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A., Stern, Mariana C., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Teixeira, Manuel R., Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T., Butler, Ebonee N., Mohler, James L., Taylor, Jack A., Kogevinas, Manolis, Dierssen-Sotos, Trinidad, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C., Huff, Chad D., Pilie, Patrick, Yu, Yao, Bohlender, Ryan J., Gu, Jian, Strom, Sara S., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J., Brenner, Hermann, Chen, Xuechen, Holleczek, Bernd, Schöttker, Ben, Klein, Eric A., Hsing, Ann W., Kittles, Rick A., Murphy, Adam B., Logothetis, Christopher J., Kim, Jeri, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, Isaacs, William B., Nemesure, Barbara, Hennis, Anselm J. M., Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Lin, Daniel W., Fowke, Jay H., Neslund-Dudas, Christine M., Rybicki, Benjamin A., Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Abraham, Aswin, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer, Petrovics, Gyorgy, Casey, Graham, Wang, Ying, Tettey, Yao, Lachance, Joseph, Tang, Wei, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Yamoah, Kosj, Govindasami, Koveela, Chokkalingam, Anand P., Keaton, Jacob M., Hellwege, Jacklyn N., Clark, Peter E., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Ogunbiyi, Olufemi, Shittu, Olayiwola, Amodu, Olukemi, Adebiyi, Akindele O., Aisuodionoe-Shadrach, Oseremen I., Ajibola, Hafees O., Jamda, Mustapha A., Oluwole, Olabode P., Nwegbu, Maxwell, Adusei, Ben, Mante, Sunny, Darkwa-Abrahams, Afua, Diop, Halimatou, Gundell, Susan M., Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Hu, Jennifer J., Sanderson, Maureen, Kachuri, Linda, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Preuss, Michael H., Loos, Ruth J. F., Zawistowski, Matthew, Zöllner, Sebastian, Lu, Zeyun, Van Den Eeden, Stephen K., Easton, Douglas F., Ambs, Stefan, Edwards, Todd L., Mägi, Reedik, Rebbeck, Timothy R., Fritsche, Lars, Chanock, Stephen J., Berndt, Sonja I., Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S., Gaziano, J. Michael, Justice, Amy C., Mancuso, Nick, Terao, Chikashi, Eeles, Rosalind A., Kote-Jarai, Zsofia, Madduri, Ravi K., Conti, David V., and Haiman, Christopher A.

Published
2023
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31. Enhancing Workplace Productivity: The Nexus of Organizational Culture and Policies in Public Institutions

Author

Emmanuel Erastus YAMOAH, Felicity OFFEI-GYEKYI, and Joseph Ato FORSON

Subjects
productivity, organizational culture, policies, public institution, ghana, Social sciences (General), H1-99
Abstract

Aim – This study aims to explore the intricate interplay between organizational culture, policies, and productivity within a major public institution in Ghana. The primary purpose is to investigate the relationships between organizational policies, characteristics of organizational culture, and non-financial indicators of organizational productivity. Design/methodology/approach – This study utilizes a descriptive survey design, using a sample of 119 respondents randomly selected from a population of 1489 employees. Advanced statistical techniques, including Pearson Correlation and Multiple Linear Regression, are employed to identify relationships and test hypotheses. Findings – The results indicate positive and statistically significant relationships between organizational policies, cultural characteristics, and productivity. Multiple linear regression analysis supported the hypothesis, demonstrating a substantial influence of these factors on productivity. Notably, a moderate to strong positive correlation was found, highlighting the critical role of organizational culture in fostering improved performance. Limitations – Reliance on self-reported data raises concerns about social desirability bias. Additionally, the descriptive survey design allows for the identification of correlations, but causal relationships between variables cannot be established. Practical implications – This research highlights the importance of strategic policies and a supportive culture for public sector productivity. Clear policy implementation, leadership fostering a positive work environment, and engagement in policymaking likely enhance performance, particularly within diverse workforces. However, future research should explore causal relationships between these factors and productivity for deeper understanding and continuous optimization. Originality/value – This study investigates the combined effects of organizational culture, policy clarity, and employee participation on productivity in a Ghanaian public institution. It contributes to the literature by confirming the positive influence of a supportive culture and well-defined policies, while emphasizing the importance of employee involvement in policy development. These findings offer practical insights for leaders seeking to enhance productivity in similar contexts.

Published
2024
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32. Assessing the impact of telephone call intervention on medication adherence in individuals with mental health disorders: A longitudinal study in a tertiary facility in Volta Region

Author

Thelma Alalbila Aku, Ebenezer Wiafe, Samira Mina Alhassan, Peter Yamoah, Eugene Dordoye, Joseph K.N. Nyoagbe, Araba Hutton-Nyameaye, Israel Sefah, Justice Jones, Harrison Awuttey, John K.A. Korbuvi, and Varsha Bangalee

Subjects
Medication adherence, Mental health disorders, Patient counselling, Pharmacy practice, Telephone call interventions, Science
Abstract

Medication adherence strategies that are successful, suitable and economical are vital to the treatment outcome of persons living with mental illness. Mobile-phone-based intervention is one such strategy and is particularly critical to reducing medication non-adherence, especially in mental health disorders. This study aimed to assess the impact of telephone adherence counselling on medication adherence in persons with mental health disorders. A longitudinal study was conducted on study participants who were randomly assigned to control and intervention groups over three months. Both groups received standard medication adherence counselling for the first month and then baseline adherence levels were determined using the medication adherence rating scale (MARS). The control group received standard medication adherence counselling at the psychiatric clinic whilst the intervention group received additional telephone calls made to each member of the intervention group once a week for a total of 8 times over 2 months. Of the patients who were screened for potential participation, 149 participants passed and 87 participants participated making a response rate of 58.40 %. The t-test conducted on the participants after the first (Month 2) and second (Month 3) on those with Telephone Call Intervention inferred significant statistical differences (p < 0.001). MARS Scores appreciated in the intervention group compared to the control group in Month 2 (1.64) and Month 3 (1.79). A positive impact of Telephone Call Interventions on medication adherence was achieved. This intervention can be a medication adherence strategy to supplement the standard medication adherence counselling which could improve treatment outcomes.

Published
2024
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33. Assessing the effectiveness of social accountability interventions in selected district assemblies in Ghana

Author

Patrick Osei-Kufuor, Emmanuel Yamoah Tenkorang, Frederick Koomson, and Richard Oppong Ntiri

Subjects
Capacity building, citizen-state engagement, effectiveness, Ghana, participation, social accountability, Social Sciences
Abstract

Social accountability interventions have been implemented in low-and middle-income countries as a strategy to improve state-citizen engagement. However, there has been a minimal systematic attempt to document the effectiveness of social accountability initiatives, especially their ability to stimulate accountability actions by citizens. Subsequently, this paper assesses the effectiveness of a social accountability project in Ghana to build the capacity of citizens to participate in state-society engagements and how such engagements resulted in citizens’ actions. Participants were selected from eight Metropolitan, Municipal and District Assemblies (MMDAs) in Ghana using a mixed-method approach and a multi-stage sampling procedure involving simple random and purposive sampling techniques. Key informant interviews and Focus Group Discussions were used to collect data from representatives of traditional authorities, media houses and public officers from MMDAs. Structured interviews were used to collect data from 240 participants of the social accountability project to complement the qualitative data. The project was relevant in addressing national efforts to increase citizens’ participation in local governance. Furthermore, the project raised awareness and increased knowledge about participatory principles and platforms for participation among citizens. Overall, the social accountability interventions improve state-citizen engagement. The frequency of citizen-state engagements increased with the project’s inception but did not enhance the responsiveness of the MMDAs to citizens’ demands due to resource constraints and the overreliance on intermediaries to follow up on community issues at the MMDA, thereby failing to translate into agency for collective action. As a result, the paper recommends that social accountability interventions should improve cooperation between public officials and community members around the delivery of specific public services to build trust between them. Furthermore, such interventions should orient public officials to be receptive and responsive to the concerns of community members.

Published
2024
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34. Sustainability of alternative livelihood strategies in selected sand mining communities in the Ga South Municipality and Gomoa East District of Ghana

Author

Kofi Yeboah Asare, John Victor Mensah, Joseph Boateng Agyenim, and Emmanuel Yamoah Tenkorang

Subjects
Alternative livelihood strategies, farmlands, local government authorities, sand mining, sustainable livelihoods, survival-induced factors, Social Sciences
Abstract

AbstractIn Ghana, terrestrial sand mining in rural and peri-urban areas negatively affects the livelihoods of the majority of the residents employed in land-based livelihoods. We examine the sustainability of the alternative livelihood strategies the residents in these areas adopt as they lose their original livelihoods to sand mining. Both quantitative and qualitative data were collected from 278 household heads and 23 key informants. Descriptive statistics and the chi-square test of independence were employed to analyse the quantitative data, while the qualitative data were analysed thematically. The study revealed that while more than half of the respondents had adopted alternative livelihood strategies as a survival strategy, the remaining household heads were unable to secure alternative livelihoods because of a lack of startup capital, inadequate skills, and the unattractiveness of the alternative livelihood options. Though the adoption of alternative strategies had contributed to improvements in food consumption, employment for some farmers displaced by sand mining, and the resilience of some household heads to handle shocks from sand mining, the strategies were largely unsustainable compared to the residents’ original livelihoods (farming). We recommend that the local government authorities develop policies in consultation with landowners to preserve and restore the original land-based livelihoods of the residents.

Published
2024
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36. Epigenome‐wide association study of prostate cancer in African American men identified differentially methylated genes

Author

Anders Berglund, Kosj Yamoah, Steven A. Eschrich, Rana Falahat, James J. Mulé, Sungjune Kim, Jaime Matta, Julie Dutil, Gilberto Ruiz‐Deya, Carmen Ortiz Sanchez, Liang Wang, Hyun Park, Hirendra N. Banerjee, Tamara Lotan, Kathryn Hughes Barry, Ryan M. Putney, Seung Joon Kim, Clement Gwede, Jacob K. Kresovich, Youngchul Kim, Hui‐Yi Lin, Jasreman Dhillon, Ratna Chakrabarti, and Jong Y. Park

Subjects
epidemiology, epigenetics, methylation, prostate cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Introduction Men with African ancestry have the highest incidence and mortality rates of prostate cancer (PCa) worldwide. Methods This study aimed to identify differentially methylated genes between tumor vs. adjacent normal and aggressive vs. indolent PCa in 121 African American patients. Epigenome‐wide DNA methylation patterns in tumor DNA were assessed using the human Illumina Methylation EPIC V1 array. Results Around 5,139 differentially methylated CpG‐sites (q 0.2) were identified when comparing normal vs. tumor, with an overall trend of hypermethylation in prostate tumors. Multiple representative differentially methylated regions (DMRs), including immune‐related genes, such as CD40, Galectin3, OX40L, and STING, were detected in prostate tumors when compared to adjacent normal tissues. Based on an epigenetic clock model, we observed that tumors’ total number of stem cell divisions and the stem cell division rate were significantly higher than adjacent normal tissues. Regarding PCa aggressiveness, 2,061 differentially methylated CpG‐sites (q .05) were identified when the grade group (GG)1 was compared with GG4/5. Among these 2,061 CpG sites, 155 probes were consistently significant in more than one comparison. Among these genes, several immune system genes, such as COL18A1, S100A2, ITGA4, HLA‐C, and ADCYAP1, have previously been linked to tumor progression in PCa. Conclusion Several differentially methylated genes involved in immune‐oncologic pathways associated with disease risk or aggressiveness were identified. In addition, 261 African American‐specific differentially methylated genes related to the risk of PCa were identified. These results can shedlight on potential mechanisms contributing to PCa disparities in the African American Population.

Published
2024
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37. Clinical Outcomes of Prostate SBRT Using Non-adaptive MR-Guided Radiotherapy

Author

Maria L. Sandoval MD, MS, Anupam Rishi MD, Kujtim Latifi PhD, G. Daniel Grass MD, PhD, Javier Torres-Roca MD, Stephen A. Rosenberg MD, MS, Kosj Yamoah MD, PhD, and Peter A. S. Johnstone MD

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Objectives Stereotactic body radiotherapy (SBRT) is widely used for localized prostate cancer and implementation of MR-guided radiotherapy has the advantage of tighter margins and improved sparing of organs at risk. Here we evaluate outcomes and time required to treat using non-adaptive MR-guided SBRT (MRgSBRT) for localized prostate cancer at our institution. Methods From 9/2019 to 11/2021 we conducted a retrospective review of 80 consecutive patients who were treated with MRgSBRT to the prostate. Patients included low (LR) (5%), favorable intermediate (FIR) (40%), unfavorable intermediate (UIR) (49%), and high risk (HR) (6%). Short-term androgen deprivation therapy was used in 32% of patients. Target volumes included prostate gland and proximal seminal vesicles with an isotropic 3 mm margin. Treatment was prescribed to 36.25 Gy in 5 fractions every other day with urethral sparing. Hydrogel spacer was used in 18% of patients. Time on the linac was recorded as beam on time (BOT) plus total treatment time (TTT) including gating. Analyzed outcomes included PSA response and patient reported outcomes scored by the American Urological Association (AUA) questionnaire and toxicity per CTCAE v5. General linear regression model was used to analyze factors affecting PSA and AUA in longitudinal follow up, and chi-square test was used to assess factors affecting toxicity. Results Median follow up was 19.3 months (3.8 – 36.6). Median BOT was 4.6 min (2.6 – 7.2) with a median TTT of 11 min (7.6 – 15.8). Pre-treatment vs post-RT median PSA was 6.36 (2.20 – 19.6) vs 0.85 (0.19 – 3.6), respectively ( P < 0.001). PSA decrease differed significantly when patients were stratified by risk category, favoring LR/FIR vs UIF/HR group ( P = 0.019). Four (5%) patients experienced a biochemical failure (BCF), with a median time to BCF of 20.4 months (7.9 – 34.5). Median biochemical failure free survival (BCFFS) was not reached, with 2-yr and 4-yr BCFFS of 97.1% and 72.1%, respectively. Patients with LR/FIR disease had 100% 2-yr and 4-yr BCFFS, whereas patients with UIF/HR had 95% and 41% 2-yr and 4-yr BCFFS ( P = 0.05). Mean pre-treatment AUA was 7.3 (1 - 25) vs 11.3 (1 - 26) at first follow-up; however, AUA normalized to baseline over time. Urethral Dmax ≥35 Gy trended to lower AUA score at all follow-ups ( P = 0.07). Forty-one (51%) patients reported grade 1-2 genitourinary toxicities at the 1 month follow up. Grade 3 toxicity (proctitis) was noted in 1 patient. There was no decrease in any grade rectal toxicity with use of hydrogel spacer (3 vs 6, P = 0.2). No grade ≥4 toxicities was observed. Conclusions MRgSBRT has the potential for treatment adaptation but this comes at the cost of increased resource utilization. Our experience with non-adaptive MRgSBRT of the prostate highlights its short treatment times as well as efficacy with good PSA control and low toxicity profile.

Published
2024
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38. Understanding and Addressing Prostate Cancer Disparities in Diagnosis, Treatment, and Outcomes Among Black Men

Author

Anastasia Murphy DrPH, MS, Cherell C. Cottrell-Daniels PhD, MPH, Shivanshu Awasthi PharmD, MPH, Esther Katende BS, Jong Y. Park PhD, Justin Denis BS, B. Lee Green PhD, and Kosj Yamoah MD, PhD

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Despite advances in screening, diagnosis, and treatment for prostate cancer (PCa), Black men tend to be diagnosed at younger ages, have higher mortality rates, and are at increased risk of recurrence or metastasis compared to their White counterparts. PCa disparities among Black men are caused by a complex interaction of social, behavioral, and biological factors across the public policy, community, organizational, interpersonal, and individual levels. Key contributing factors include mistrust in the health care system, poor communication between patients and providers, low awareness of screening guidelines, and high medical costs. These disparities are further exacerbated by the low representation of Black men in clinical trials, which limits access to high-quality cancer care and generalizability for PCa treatments. In this narrative review of the existing literature, we examined the epidemiology and identified contributing factors, and propose multi-level strategies to address and mitigate disparities among Black men with PCa.

Published
2024
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39. A comprehensive exploration of schistosomiasis: Global impact, molecular characterization, drug discovery, artificial intelligence and future prospects

Author

William Ekloh, Andy Asafu-Adjaye, Christopher Nii Laryea Tawiah-Mensah, Selina Mawunyo Ayivi-Tosuh, Naa Kwarley-Aba Quartey, Albert Fynn Aiduenu, Blessing Kwabena Gayi, Juliet Ama Mawusi Koudonu, Laud Anthony Basing, Jennifer Afua Afrifa Yamoah, Aboagye Kwarteng Dofuor, and Joseph Harold Nyarko Osei

Subjects
Schistosomiasis, Schistosoma, Anti-schistosomal, Praziquantel, Cercariae, Miracidia, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Schistosomiasis, one of the neglected tropical diseases which affects both humans and animals, is caused by trematode worms of the genus Schistosoma. The disease is caused by several species of Schistosoma which affect several organs such as urethra, liver, bladder, intestines, skin and bile ducts. The life cycle of the disease involves an intermediate host (snail) and a mammalian host. It affects people who are in close proximity to water bodies where the intermediate host is abundant. Common clinical manifestations of the disease at various stages include fever, chills, headache, cough, dysuria, hyperplasia and hydronephrosis. To date, most of the control strategies are dependent on effective diagnosis, chemotherapy and public health education on the biology of the vectors and parasites. Microscopy (Kato-Katz) is considered the golden standard for the detection of the parasite, while praziquantel is the drug of choice for the mass treatment of the disease since no vaccines have yet been developed. Most of the previous reviews on schistosomiasis have concentrated on epidemiology, life cycle, diagnosis, control and treatment. Thus, a comprehensive review that is in tune with modern developments is needed. Here, we extend this domain to cover historical perspectives, global impact, symptoms and detection, biochemical and molecular characterization, gene therapy, current drugs and vaccine status. We also discuss the prospects of using plants as potential and alternative sources of novel anti-schistosomal agents. Furthermore, we highlight advanced molecular techniques, imaging and artificial intelligence that may be useful in the future detection and treatment of the disease. Overall, the proper detection of schistosomiasis using state-of-the-art tools and techniques, as well as development of vaccines or new anti-schistosomal drugs may aid in the elimination of the disease.

Published
2024
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40. Multinational, Multicenter Evaluation of Prostate Cancer Tissue in Sub-Saharan Africa: Challenges and Opportunities

Author

Abraham C. van Wyk, Priti Lal, J. Olufemi Ogunbiyi, Lynnette Kyokunda, Fred Hobenu, Cherif Dial, Mohamed Jalloh, Richard Gyasi, Olabode P. Oluwole, Afua D. Abrahams, Adam R. Botha, Nompumelelo Zamokuhle Mtshali, Caroline Andrews, Sunny Mante, Ben Adusei, Serigne M. Gueye, James E. Mensah, Andrew Anthony Adjei, Yao Tettey, Akin Adebiyi, Oseremen Aisuodionoe-Shadrach, Sefiu Bolarinwa Eniola, Amparo Serna, Kosj Yamoah, Wenlong Carl Chen, Pedro Fernandez, Brian D. Robinson, Juan Miguel Mosquera, Ann W. Hsing, Ilir Agalliu, and Timothy R. Rebbeck

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

PURPOSEProstate cancer disproportionately affects men of African descent, yet their representation in tissue-based studies is limited. This multinational, multicenter pilot study aims to establish the groundwork for collaborative research on prostate cancer in sub-Saharan Africa.METHODSThe Men of African Descent and Carcinoma of the Prostate network formed a pathologist working group representing eight institutions in five African countries. Formalin-fixed paraffin-embedded prostate tissue specimens were collected from Senegal, Nigeria, and Ghana. Histology slides were produced and digitally scanned. A central genitourinary pathologist (P.L.) and eight African general pathologists reviewed anonymized digital whole-slide images for International Society of Urological Pathology grade groups and other pathologic parameters. Discrepancies were re-evaluated, and consensus grading was assigned. A virtual training seminar on prostate cancer grading was followed by a second assessment on a subcohort of the same tissue set.RESULTSOf 134 tissue blocks, 133 had evaluable tissue; 13 lacked cancer evidence, and four were of insufficient quality. Post-training, interobserver agreement for grade groups improved to 56%, with a median Cohen's quadratic weighted kappa of 0.83 (mean, 0.74), compared with an initial 46% agreement and a quadratic weighted kappa of 0.77. Interobserver agreement between African pathologist groups was 40%, with a quadratic weighted kappa of 0.66 (95% CI, 0.51 to 0.76). African pathologists tended to overgrade (36%) more frequently than undergrade (18%) compared with the reference genitourinary pathologist. Interobserver variability tended to worsen with a decrease in tissue quality.CONCLUSIONTissue-based studies on prostate cancer in men of African descent are essential for a better understanding of this common disease. Standardized tissue handling protocols are crucial to ensure good tissue quality and data. The use of digital slide imaging can enhance collaboration among pathologists in multinational, multicenter studies.

Published
2024
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41. Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains

Author

Ren, Lu, Thai, Phung N, Gopireddy, Raghavender Reddy, Timofeyev, Valeriy, Ledford, Hannah A, Woltz, Ryan L, Park, Seojin, Puglisi, Jose L, Moreno, Claudia M, Santana, Luis Fernando, Conti, Alana C, Kotlikoff, Michael I, Xiang, Yang Kevin, Yarov-Yarovoy, Vladimir, Zaccolo, Manuela, Zhang, Xiao-Dong, Yamoah, Ebenezer N, Navedo, Manuel F, and Chiamvimonvat, Nipavan

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Heart Disease, Cardiovascular, 1.1 Normal biological development and functioning, Aetiology, 2.1 Biological and endogenous factors, Underpinning research, Animals, Mice, Sinoatrial Node, Adenylyl Cyclases, Calcium, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Protein Isoforms, Arrhythmias, Calcium signaling, Cardiology, Cardiovascular disease, Biomedical and clinical sciences, Health sciences
Abstract

Sinoatrial node (SAN) cells are the heart's primary pacemaker. Their activity is tightly regulated by β-adrenergic receptor (β-AR) signaling. Adenylyl cyclase (AC) is a key enzyme in the β-AR pathway that catalyzes the production of cAMP. There are current gaps in our knowledge regarding the dominant AC isoforms and the specific roles of Ca2+-activated ACs in the SAN. The current study tests the hypothesis that distinct AC isoforms are preferentially expressed in the SAN and compartmentalize within microdomains to orchestrate heart rate regulation during β-AR signaling. In contrast to atrial and ventricular myocytes, SAN cells express a diverse repertoire of ACs, with ACI as the predominant Ca2+-activated isoform. Although ACI-KO (ACI-/-) mice exhibit normal cardiac systolic or diastolic function, they experience SAN dysfunction. Similarly, SAN-specific CRISPR/Cas9-mediated gene silencing of ACI results in sinus node dysfunction. Mechanistically, hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) channels form functional microdomains almost exclusively with ACI, while ryanodine receptor and L-type Ca2+ channels likely compartmentalize with ACI and other AC isoforms. In contrast, there were no significant differences in T-type Ca2+ and Na+ currents at baseline or after β-AR stimulation between WT and ACI-/- SAN cells. Due to its central characteristic feature as a Ca2+-activated isoform, ACI plays a unique role in sustaining the rise of local cAMP and heart rates during β-AR stimulation. The findings provide insights into the critical roles of the Ca2+-activated isoform of AC in sustaining SAN automaticity that is distinct from contractile cardiomyocytes.

Published
2022

42. Disruption of mitochondria–sarcoplasmic reticulum microdomain connectomics contributes to sinus node dysfunction in heart failure

Author

Ren, Lu, Gopireddy, Raghavender R, Perkins, Guy, Zhang, Hao, Timofeyev, Valeriy, Lyu, Yankun, Diloretto, Daphne A, Trinh, Pauline, Sirish, Padmini, Overton, James L, Xu, Wilson, Grainger, Nathan, Xiang, Yang K, Dedkova, Elena N, Zhang, Xiao-Dong, Yamoah, Ebenezer N, Navedo, Manuel F, Thai, Phung N, and Chiamvimonvat, Nipavan

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Cardiovascular, Heart Disease, 2.1 Biological and endogenous factors, Aetiology, Animals, Connectome, Heart Failure, Mice, Mitochondria, Heart, Myocytes, Cardiac, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Sick Sinus Syndrome, Sinoatrial Node, sinoatrial node, mitochondria, heart failure, bradycardia, sinoatrial node dysfunction
Abstract

The sinoatrial node (SAN), the leading pacemaker region, generates electrical impulses that propagate throughout the heart. SAN dysfunction with bradyarrhythmia is well documented in heart failure (HF). However, the underlying mechanisms are not completely understood. Mitochondria are critical to cellular processes that determine the life or death of the cell. The release of Ca2+ from the ryanodine receptors 2 (RyR2) on the sarcoplasmic reticulum (SR) at mitochondria-SR microdomains serves as the critical communication to match energy production to meet metabolic demands. Therefore, we tested the hypothesis that alterations in the mitochondria-SR connectomics contribute to SAN dysfunction in HF. We took advantage of a mouse model of chronic pressure overload-induced HF by transverse aortic constriction (TAC) and a SAN-specific CRISPR-Cas9-mediated knockdown of mitofusin-2 (Mfn2), the mitochondria-SR tethering GTPase protein. TAC mice exhibited impaired cardiac function with HF, cardiac fibrosis, and profound SAN dysfunction. Ultrastructural imaging using electron microscope (EM) tomography revealed abnormal mitochondrial structure with increased mitochondria-SR distance. The expression of Mfn2 was significantly down-regulated and showed reduced colocalization with RyR2 in HF SAN cells. Indeed, SAN-specific Mfn2 knockdown led to alterations in the mitochondria-SR microdomains and SAN dysfunction. Finally, disruptions in the mitochondria-SR microdomains resulted in abnormal mitochondrial Ca2+ handling, alterations in localized protein kinase A (PKA) activity, and impaired mitochondrial function in HF SAN cells. The current study provides insights into the role of mitochondria-SR microdomains in SAN automaticity and possible therapeutic targets for SAN dysfunction in HF patients.

Published
2022

46. Microbiology testing capacity and antimicrobial drug resistance in surgical-site infections: a post-hoc, prospective, secondary analysis of the FALCON randomised trial in seven low-income and middle-income countries

Author

Aboderin, Aaron Oladipo, Amfoabegyi, Solomon, Awopeju, Abimbola Temitayo, Bahrami-Hessari, Michael, Garchie, Emmanuel Isaac Acquah, Gill, Martin, Karikari, Akosua, Kirby, Andrew, Makanjuola, Olufunmilola, Mutiu, Bamidele, Offiong, Anthony Bassey, Oshun, Philip Olayiwola, Osumanu, Hisham Alhassan, Owusu-Ofori, Alex, Varghese, Shereen Rachel, Adam-Zakariah, Leslie Issa, Adebanjo, Ademola Tolulope, Aguirre, Celina Cuellar, Akoto, Erica, Aminu, Aliyu, Armah, Ralph, Aruldas, Neerav David, Choudhrie, Ashish V, Coompson, Christian Larbi, Ekwunife, Okechukwu Hyginus, Fourtounas, Maria, Lawani, Souliath, Mathew, Arpit Jacob, Patel, Akhil, Ademuyiwa, Adesoji O, Hardy, Pollyanna, Runigamugabo, Emmy, Sodonougbo, Pierre, Behanzin, Hulrich, Kangni, Sosthène, Agboton, Gérard, Adagrah, Luke Aniakwo, Adjei-Acquah, Esther, Acquah, Ato Oppong, Ankomah, James, Acquah, Regina, Addo, Kwame Gyambibi, Acheampong, Dorcas Otuo, Adu-Aryee, Nii Armah, Abubakari, Fatao, Titigah, Abraham, Owusu, Frank, Adu-Brobbey, Raphael, Adobea, Vivian, Abantanga, Francis Atindaana, Gautham, Arun, Bhatti, Dimple, Jesudason, Esther Daniel Mark, Aggarwal, Manisha, Alexander, Philip, Dasari, Amos, Alpheus, Rahul, Kumar, Hemanth, Raul, Subrat, Bueno, Wenceslao Ángeles, Ortiz, Reyes Cervantes, Gomez, Isaac Baltazar, Cerdan, Claudia Caballero, Gallo, Mariana Barreto, Gamez, Rozana Reyes, Sánchez, Irani Durán, Abdullahi, Lawal, Adesanya, Opeoluwa, Abdulsalam, Moruf, Adeleye, Victoria, Egwuonwu, Ochomma, Adeleke, Akeem, Adebayo, Francis, Chiejina, Godwin, Abayomi, Olukayode, Abdur-Rahman, Lukman, Ede, Jude, Ezinne, Uba, Kanyarukiko, Salathiel, Dusabe, Moses, Hirwa, Aime Dieudonne, Bucyibaruta, Georges, Adams, Mary Augusta, Birtles, Cheryl, Ally, Zain, Adewunmi, Abdus-sami, Cook, Jonathan, Brown, Julia, Adisa, Adewale O, Ismail, Lawani, Bhangu, Aneel, Omar, Omar, Simoes, Joana FF, Li, Elizabeth, Chaudhry, Daoud, Saeed, Samerah, Spurring, Eleanor Margaret, Verjee, Azmina, Assouto, Pamphile, Seto, Djifid Morel, Kpangon, Cyrile, Ahossi, Rene, Alhassan, Bin Baaba Alhaji, Agyekum, Vera, Assah-Adjei, Frank, Asare, Christopher, Amoako, James, Akosa, Enoch Appiah, Acquaye, Jane, Adjei, Faisal, Ballu, Cletus, Bennin, Amos, Abdulai, Darling Ramatu, Hepzibah, Alice, Bhatti, William, Paul, Priyadarshini K, Dhamija, Parth, Thomas, Josy, Jacob, Priya, Choudhrie, Ashish, Peters, Nitin, Sharma, Rajeev, Camacho, Francisco Barbosa, Gonzalez, Gonzalo Hernandez, Solano, David Dominguez, Flores, Ana Cortes, Menindez, Roque Lincona, Vazquez, Diana Gonzalez, Ado, Khadija, Awonuga, David, Adeniran, Abimbola, Ademuyiwa, Adesoji, Ekwunife, Okechukwu, Adenikinju, Wilson, Aisuodionoe-Shadrach, Oseremen, Edet, Ekpo, Abdus-Salam, Rukiyat, Adeleke, Nurudeen, Ekenze, Sebastian, Francis, Matthew, Mukaneza, Francine, Izabiriza, Emelyne, Kabanda, Elysee, Bunogerane, Gisele Juru, Crawford, Richard, Ivy, Mathete, Jayne, David, Cousens, Simon, Chakrabortee, Sohini, Ghosh, Dhruva, Gyamfi, Frank Enoch, Brant, Felicity, Fiogbe, Michel, Tandje, Yannick, Akpla, Marcelin, Ngabo, Raoul Baderha, Amoako-Boateng, Mabel Pokuah, Agyemang, Eric, Asabre, Esther, Boakye, Anthony Appiah, Gakpetor, Delali Akosua, Appiah, Akosua Dwamena, Boakye, Percy, Adinku, Michael, Barimah, Charles Gyamfi, Labaran, Abdul-Hamid, Dankwah, Fred, Acquah, Daniel Kwesi, Mary, Grace, Bir, Karan, Madankumar, Latha, Gupta, Himani, Zechariah, Pradeep, Kurien, Elizabeth, Vakil, Rakesh, Hernández, Aldo Bernal, Krauss, Rosa Hernandez, Avendaño, Alejandro Cuevas, Garcia, Rafael Toriz, Ojeda, Alejandro Gonzalez, Peón, Alberto Navarrete, Lara, Maria Martínez, Aliyu, Mohammed, Fasiku, Olushola, Ajai, Olalekan, Adeniyi, Oluwafunmilayo, Modekwe, Victor, Adeniyi, Olumide, Akaba, Godwin, Inyang, Akan, Adebayo, Sikiru, Adesola, Muideen, Enemuo, Vincent, Ikechukwu, Iweha, Mukantibaziyaremye, Deborah, Maniraguha, Hope Lydia, Mbonimpaye, Salomee, Habumuremyi, Sosthene, Ede, Chikwendu Jeffrey, Mbavhalelo, Cynthia, Laurberg, Soren, Smart, Neil, de la Medina, Antonio Ramos, Brocklehurst, Peter, Koco, Houenoukpo, Chobli, Hugues Herve, Bisimwa, Nathan, Appiah, Anthony Baffour, Akesseh, Rebecca Adjeibah, Boateng, Ruby Acheampong, Fosu, Godfred, Gawu, Victoria Sena, Aseti, Mark, Agbedinu, Kwabena, Ametefe, Elikem, Boateng, Guy Casskey, Owusu, Junior Atta, Doe, Stanley, Ayingayure, Emmanuel, Singh, Deepak, Daniel, Swati, Mittal, Rohin, Kanna, Vinoth, Mathew, Arpit, Arellano, Ana Bogurin, Miguelena, Luis Hernández, Sansores, Luis Dominguez, Velasco, Monica Jimenez, Muñoz, Maria Paz, Perez-Maldonado, Laura Martinez, Anyanwu, Lofty-John, Ogo, Chidiebere, Akande, Olukemi, Akinajo, Opeyemi, Okoro, Chukwuemeka, Adepiti, Akinfolarin, Ameh, Lazarus, Isa, Mary, Ajao, Akinlabi, Afolabi, Rafiat, Eze, Matthew, Nnyonno, Okoi, Munyaneza, Aphrodis, Mpirimbanyi, Christophe, Mukakomite, Christine, Haragirimana, Jean de Dieu, Moore, Rachel, Metchinhoungbe, Serge, Kovohouande, Blaise, Kandokponou, Covalic Melic Bokossa, Asante-Asamani, Alvin, Amponsah-Manu, Forster, Koomson, Barbara, Serbeh, Godwin, Obbeng, Ambe, Banka, Charles, Gyamfi, Brian, Agbeko, Anita Eseenam, Amoako, Joachim Kwaku, Luri, Prosper Tonwisi, Kantanka, Ruth Sarfo, Osman, Imoro, Dhar, Tapasya, Nagomy, Ida, Kumar, Ashwani, Prakash, Danita, Torres, Edgar Cortes, Romero, Marco Hurtado, Mejia, Hector Ortiz, de la Fuente, Alejandra Nayen Sainz, Magashi, Mahmoud, Atobatele, Kazeem, Akinboyewa, David, Uche, Chisom, Aderounmu, Adewale, Mbajiekwe, Ndubuisi, Iseh, Faith, Amusat, Olanrewaju, Agodirin, Sulaiman, Ezomike, Uchechukwu, Okoro, Philemon, Ndegamiye, Gibert, Mutuyimana, Josiane, Muroruhirwe, Piolette, Imanishimwe, Alphonsine, Hyman, Gabriella, Ntirenganya, Faustin, Sogbo, Hodonou, Dokponou, Mireille, Boakye, Benedict, Ofosu-Akromah, Richard, Kusiwaa, Ataa, Gyan, Kofi Yeboah, Ofosuhene, Doris, Dadzie, Samuel, Kontor, Bismark Effah, Amankwa, Emmanuel Gyimah, Attepor, Godsway Solomon, Kobby, Ephraim, Kunfah, Sheba, Dhiman, Jyoti, Selvakumar, Rajesh, Singh, Gurtaj, Susan, Anju, Orozco, Clotilde Fuentes, del Campo, Laura Urdapilleta Gomez, de la Medina, Antonio Ramos De, Muhammad, Abubakar, Eke, Grace, Alasi, Iyabo, Ugwuanyi, Kenneth, Adesunkanmi, Abdulhafiz, Ogbo, Felix, Marwa, Adams, Ayandipo, Omobolaji, Aremu, Isiaka, Izuka, Emmanuel, Patrick, Igwe, Tubasiime, Ronald, Mwenedata, Olivier, Ingabire, JC Allen, Khan, Zafar, Harrison, Ewen, Tabiri, Stephen, Glasbey, James, Dossou, Francis Moïse, Debrah, Samuel A, Enti, Donald, Twerefour, Emmanuel Yaw, Nyarko, Isaac Omane, Osei-Poku, Dorcas, Essien, Derick, Kyeremeh, Christian, Amoah, Michael, Brown, George Darko, Larnyor, Kennedy Kofi Korankye-Hanson, Limann, Gbana, Shankar, Bharat, Varghese, Rose, de Rojas, Erick González García, Muhammad, Saminu, Faboya, Omolara, Alakaloko, Felix, Ugwunne, Chuka, Adisa, Adewale, Olori, Samson, Ogbeche, Sunday, Egbuchulem, Kelvin, Bello, Jibril, Mbadiwe, Okezie, Raphael, John, Rwagahirima, Elisee, Mukanyange, Violette, Kwati, Morapedi, Dzemta, Corinne, Ganiyu, Rahman Adebisi, Robertson, Zelda, Puozaa, Diana, Manu, Ruth, Amoah, George, Fenu, Benjamin, Osei, Edwin, Mohammed, Shamudeen Alhassan, Goyal, Sunita, Sivakumar, Moonish, Muideen, Bello, Imam, Zainab, Atoyebi, Oluwole, Ajekwu, Samuel, Osagie, Olabisi, Olory, Edima, Ekwuazi, Hyginus, Lawal, Saheed, Mbah, Ngozi, Vaduneme, Oriji, Uwizeyimana, Francine, Munyaneza, Emmanuel, Mathe, Mpho Nosipho, Haque, Parvez D, Gaou, Antoine, Koggoh, Patience, Tackie, Enoch, Hussey, Romeo, Mensah, Elijah, Appiah, Juliana, Kumassah, Philemon Kwame, Owusu, Prince Yeboah, Mohammed, Sheriff, Goyal, Ankush, Sridhar, Rajeevan, Ramírez, Bertha Guzmán, Takai, Idris, Momson, Esther, Balogun, Olanrewaju, Ajenjfuja, Olusegun, Sadiq, Abu, Udie, Gabriel, Elemile, Peter, Lawal, Abdulwahab, Victor, Abhulimen, Zirikana, Job, Mutabazi, Emmanuel, Heritage, Emily, Goudou, Roland, Kpankpari, Richard, Temitope, Arkorful Ebenezer, Kwarteng, Jemima, Solae, Friko Ibrahim, Arthur, Joshua, Olayiwola, David Olatayo, Sie-Broni, Clement Ayum, Musah, Yakubu, Thomas, Cecil, Valadez, Michel Hernández Valadez, Ukata, Onyekachi, Nwaenyi, Francisca, Belie, Orimisan, Akindojutimi, Jerrie, Sani, Samuel, Udosen, Joseph, Lawal, Taiwo, Raji, Hadijat, Ncogoza, Isaie, Nhlabathi, Ncamsile Anthea, Hedefoun, Emmanuel, Opandoh, Isabella Naa M., Sowah, Naa Anyekaa, Toffah, Gideon Kwasi, Ayim, Alex, Wordui, Theodore, Zume, Marshall, Ofori, Bernard, Hans, Monika, Titus, Devabalan, Acevedo, Diego Luna, Ogunyemi, Ayokunle, Bode, Christopher, Akinkuolie, Akinbolaji, Tabuanu, Nancy, Usang, Usang, Lawal, Olatunji, Sayomi, Olayinka, Nxumalo, Hlengiwe Samkelisiwe, Kroese, Karolin, Houtoukpe, Sunday, Manu, Meshach Agyemang, Yeboah, Grace, Ayodeji, Emmanuel Kafui, Agboadoh, Nelson, Owusu, Emmanuel Abem, Haque, Parvez, Galaviz, Rubén Morán, Oludara, Mobolaji, Ekwesianya, Andrew, Alatise, Olusegun, Uanikhoba, Martins, Olagunju, Solomon, Shittu, Asimiyu, Nyirahabimana, Jeannette, Pattinson, Paddy, Lillywhite, Rachel, Lapitan, Carmela, Kamga, Felix, Manu, Maison Patrick Opoku, Yeboah, Cynthia, Boakye-Yiadom, Jonathan, Saba, Abdul-Hafiz, Konda, Samuel, Flores, Oscar Olvera, Omisanjo, Olufunmilade, Elebute, Olumide, Allen, Olubukola, Osuala, Peter, Urimubabo, Christian, Sentholang, Nnosa, Kiki-Migan, Eric, Mensah, Samuel, Boateng, Edward Amoah, Seidu, Anwar Sadat, Luther, Anil, Navarro, José Pérez, Oshodi, Olabode, Ezenwankwo, Francis, Amosu, Lukmon, Suleman, Bamidele, Sethoana, Mmule Evelyn, Lissauer, David, Morna, Martin Tangnaa, Dally, Charles, Mahajan, Amit, Belmontes, Kevin Pintor, Oshodi, Yusuf, Fatuga, Adedeji, Archibong, Micheal, Takure, Augustine, Stassen, Maria Elizabeth, Magill, Laura, Lawani, Ismaïl, Nkrumah, John, Davor, Anthony, Yakubu, Mustapha, Makkar, Shalini, Marbello, Fernando Ramirez, Oyewole, Yemisi, Ihediwa, George, Arowolo, Olukayode, Thornley, Laura, Morton, Dion, Loko, René, Nortey, Michael, Gyasi-Sarpong, Christian Kofi, Yenli, Edwin Mwintiereh Ta-ang, Mandrelle, Kavita, Ramírez-González, Luis, Salami, Omotade, Jimoh, Adesola, Ayantona, Deborah, Wondoh, Paul, Nepogodiev, Dmitri, Mistry, Punam, Moutaïrou, Afissatou, Ofori, Emmanuel Owusu, Hamidu, Naabo Nuhu Noel, Michael, Vishal, Aguirre, Laura Reyes, Williams, Omolara, Kuku, Jubril, Ayinde, Ademola, Monahan, Mark, Ogouyemi, Pencome, Quartson, Elizaberth Mercy Quartson, Haruna, Iddrisu, Mukherjee, Partho, García, Ramona Rojas, Ladipo-Ajayi, Oluwaseun, Badejoko, Olusegun, Soumanou, Fouad, Kwarley, Naa, Rajappa, Reuben, Robles, Eduardo Valtierra, Makanjuola, Ayomide, Badmus, Tajudeen, Smith, Donna, Tamadaho, Pia, Lovi, Agbenya Kobla, Singh, Prashant, Mokwenyei, Olayanju, Etonyeaku, Amarachukwu, Zounon, Mack-Arthur, Nimako, Boateng, Suroy, Atul, Nwokocha, Samuel, Igbodike, Emeka, Nyadu, Bertina Beauty, Thind, Ravinder, Ogein, Olubunmi, Ijarotimi, Omotade, Opoku, Dominic, Thomas, Alen, Ojewola, Rufus, Lawal, Adedayo, Pinkney, Thomas, Osabutey, Anita, Tuli, Arti, Oladimeji, Abraham, Nana, Fayowole, Roberts, Tracy, Sagoe, Robert, Veetil, Sreejith, Olajide, Thomas, Oduanafolabi, Tunde, Tuffour, Samuel, Oluseye, Oluwaseun, Olasehinde, Olalekan, Tufour, Yaa, Seyi-Olajide, Justina, Olayemi, Olaniyi, Winkles, Neil, Yamoah, Francis Akwaw, Soibi-Harry, Adaiah, Omitinde, Stephen, Yefieye, Abiboye Cheduko, Ugwu, Aloy, Oni, Owolabi, Yorke, Joseph, Williams, Emmanuel, Onyeze, Chigozie, Orji, Ernest, Rotimi, Adewale, Salako, Abdulkadir, Solaja, Olufemi, Sowemimo, Oluwaseun, Talabi, Ademola, Tajudeen, Mohammed, and Wuraola, Funmilola

Published
2024
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48. Revaccination outcomes among adolescents and adults with suspected hypersensitivity reactions following COVID-19 vaccination: A Canadian immunization research network study

Author

Fitzpatrick, Tiffany, Yamoah, Peter, Lacuesta, Gina, Sadarangani, Manish, Cook, Victoria, Pourshahnazari, Persia, Kalicinsky, Chrystyna, Upton, Julia E.M., Cameron, Scott B., Zaborniak, Karver, Kanani, Amin, Lam, Godfrey, Burton, Catherine, Constantinescu, Cora, Pernica, Jeffrey M., Abdurrahman, Zainab, Betschel, Stephen, Drolet, Jean-Philippe, De Serres, Gaston, Quach, Caroline, Des Roches, Anne, Chapdelaine, Hugo, Salvadori, Marina I., Carignan, Alex, McConnell, Athena, Pham-Huy, Anne, Buchan, C. Arianne, Cowan, Juthaporn, Hildebrand, Kyla, and Top, Karina A.

Published
2024
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