666 results on '"Yamazoe, Yasushi"'
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2. Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms
3. Construction of a fused grid-based CYP2C18-Template system and its application to drug metabolism
4. Construction of a fused grid-based CYP2C19-Template system and the application
5. Construction of a fused grid-based template system of CYP2C9 and its application
6. Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system
7. Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 1. Focusing on polycyclic arenes and the related chemicals
8. Construction of a fused grid-based CYP2C8-Template system and the application
9. Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether
10. A category approach to predicting the repeated-dose hepatotoxicity of allyl esters
11. Novel Cell-based Reporter Assay System Using Epitope-tagged Protein for the Identification of Agonistic Ligands of Constitutive Androstane Receptor (CAR)
12. Enterobacteria-mediated deconjugation of taurocholic acid enhances ileal farnesoid X receptor signaling
13. Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes
14. Polycyclic Aromatic Hydrocarbons Activate CYP3A4 Gene Transcription through Human Pregnane X Receptor
15. Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase
16. Combined Risk Assessment of Food-derived Coumarin with in Silico Approaches
17. Application of CYP1A2-Template System to Understand Metabolic Processes in the Safety Assessment
18. List of Contributors
19. Assessment of Nongenotoxic Mechanisms in Carcinogenicity Test of Chemicals; Quinone, Quinone Imine, and Quinone Methide as Examples
20. Clioquinol is sulfated by human jejunum cytosol and SULT1A3, a human-specific dopamine sulfotransferase
21. Development of Two-dimensional Template System for the Prediction of CYP2B6-mediated Reaction Sites
22. Predicting Oxidation Sites with Order of Occurrence among Multiple Sites for CYP4A-mediated Reactions
23. Drug Conjugation: Diversity and Biological Significance
24. Refined CYP2E1∗ Template∗∗ system to decipher the ligand-interactions
25. Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians
26. Sulfotransferase- and Acetyltransferase-Mediated Activation of Carcinogenic N-Hydroxyarylamines in Mammals and Bacteria, and Their Modulation by Thiols
27. Authorsʼ response to Letter to the Editor by Jeff Kelsey et al. “Response to ‘Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether.’” 2015
28. Construction of a System that Simultaneously Evaluates CYP1A1 and CYP1A2 Induction in a Stable Human-derived Cell Line using a Dual Reporter Plasmid
29. Possible protective role of pregnenolone-16α-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis
30. Enzymic Aspects on the Metabolic Activation of Aromatic and Heterocyclic Amine Mutagens in Mammalian and Bacterial Cells
31. Simultaneous Expression of Plural Forms of Human Cytochrome P450 at Desired Ratios in HepG2 Cells: Adenovirus-mediated Tool for Cytochrome P450 Reconstitution
32. Cytochrome b 5 Potentiation of Cytochrome P-450 Catalytic Activity Demonstrated by a Vaccinia Virus-Mediated in situ Reconstitution System
33. Characterization and Expression of Hepatic Sulfotransferase Involved in the Metabolism of N-Substituted Aryl Compounds
34. Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template
35. Deciphering Key Interactions of Ligands with CYP3A4-Template* system
36. Subject fields in Food Safety during 10 years
37. Protein-Protein Interactions between Rat Hepatic Cytochromes P450 (P450s) and UDP-Glucuronosyltransferases (UGTs): Evidence for the Functionally Active UGT in P450-UGT Complex
38. Role of Human Hepatocyte Nuclear Factor 4α in the Expression of Drug-Metabolizing Enzymes and Transporters in Human Hepatocytes Assessed by Use of Small Interfering RNA
39. Broad but Distinct Role of Pregnane X Receptor on the Expression of Individual Cytochrome P450s in Human Hepatocytes
40. ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output
41. Applications of a grid-based CYP3A4 Template system to understand the interacting mechanisms of large-size ligands; part 4 of CYP3A4 Template study
42. Ileal apical sodium-dependent bile acid transporter protein levels are down-regulated through ubiquitin-dependent protein degradation induced by bile acids
43. Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator
44. Inhibition of CYP3A4 by 6′,7′-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells
45. Chenodeoxycholic Acid-mediated Activation of the Farnesoid X Receptor Negatively Regulates Hydroxysteroid Sulfotransferase
46. Construction of Several Human-derived Stable Cell Lines Displaying Distinct Profiles of CYP3A4 Induction
47. Antiepileptic Drug–Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator–Activated Receptorαand Peroxisome Proliferator–Activated ReceptorγCoactivator 1α–Dependent Gene Expression to Increase Blood Triglyceride Levels
48. Versatile applicability of a grid-based CYP3A4 Template to understand the interacting mechanisms with the small-size ligands; part 3 of CYP3A4 Template study
49. Prediction of regioselectivity and preferred order of CYP1A1-mediated metabolism: Solving the interaction of human and rat CYP1A1 forms with ligands on the template system
50. UDP‐Glucuronosyltransferase (UGT)‐mediated attenuations of cytochrome P450 3A4 activity: UGT isoform‐dependent mechanism of suppression
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