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3. Prenatal risk factors of indoor environment and incidence of childhood eczema in the Japan Environment and Children's Study

Author

Ait Bamai, Yu, Miyashita, Chihiro, Ikeda, Atsuko, Yamazaki, Keiko, Kobayashi, Sumitaka, Itoh, Sachiko, Saijo, Yasuaki, Ito, Yoshiya, Yoshioka, Eiji, Sato, Yukihiro, Kishi, Reiko, Kamijima, Michihiro, Yamazaki, Shin, Ohya, Yukihiro, Yaegashi, Nobuo, Hashimoto, Koichi, Mori, Chisato, Ito, Shuichi, Yamagata, Zentaro, Inadera, Hidekuni, Nakayama, Takeo, Sobue, Tomotaka, Shima, Masayuki, Nakamura, Hiroshige, Suganuma, Narufumi, Kusuhara, Koichi, and Katoh, Takahiko

Published
2024
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4. Effects of Persistent Organic Pollutants (POPs) in the Ecosystem and Human Health: Focusing on Chlorinated Chemicals

Author

Araki, Ikeda-Atsuko, Miyashita, Chihiro, Kobayashi, Sumitaka, Yamazaki, Keiko, Kishi, Reiko, Barceló, Damià, Series Editor, de Boer, Jacob, Editorial Board Member, Kostianoy, Andrey G., Series Editor, Garrigues, Philippe, Editorial Board Member, Hutzinger, Otto, Founding Editor, Gu, Ji-Dong, Editorial Board Member, Jones, Kevin C., Editorial Board Member, Knepper, Thomas P., Editorial Board Member, Negm, Abdelazim M., Editorial Board Member, Newton, Alice, Editorial Board Member, Nghiem, Duc Long, Editorial Board Member, Garcia-Segura, Sergi, Editorial Board Member, Tanaka, Shunitz, editor, Kurasaki, Masaaki, editor, Morikawa, Masaaki, editor, and Kamiya, Yuichi, editor

Published
2023
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5. The association between prenatal per-and polyfluoroalkyl substance levels and Kawasaki disease among children of up to 4 years of age: A prospective birth cohort of the Japan Environment and Children’s study

Author

Iwata, Hiroyoshi, Kobayashi, Sumitaka, Itoh, Mariko, Itoh, Sachiko, Mesfin Ketema, Rahel, Tamura, Naomi, Miyashita, Chihiro, Yamaguchi, Takeshi, Yamazaki, Keiko, Masuda, Hideyuki, Ait Bamai, Yu, Saijo, Yasuaki, Ito, Yoshiya, Nakayama, Shoji F, Kamijima, Michihiro, and Kishi, Reiko

Published
2024
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6. Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations.

Author

Degenhardt, Frauke, Mayr, Gabriele, Wendorff, Mareike, Boucher, Gabrielle, Ellinghaus, Eva, Ellinghaus, David, ElAbd, Hesham, Rosati, Elisa, Hübenthal, Matthias, Juzenas, Simonas, Abedian, Shifteh, Vahedi, Homayon, Thelma, B, Yang, Suk-Kyun, Ye, Byong, Cheon, Jae, Datta, Lisa, Daryani, Naser, Ellul, Pierre, Esaki, Motohiro, Fuyuno, Yuta, McGovern, Dermot, Haritunians, Talin, Hong, Myhunghee, Juyal, Garima, Jung, Eun, Kubo, Michiaki, Kugathasan, Subra, Lenz, Tobias, Leslie, Stephen, Malekzadeh, Reza, Midha, Vandana, Motyer, Allan, Ng, Siew, Okou, David, Raychaudhuri, Soumya, Schembri, John, Schreiber, Stefan, Song, Kyuyoung, Sood, Ajit, Takahashi, Atsushi, Torres, Esther, Umeno, Junji, Alizadeh, Behrooz, Weersma, Rinse, Wong, Sunny, Yamazaki, Keiko, Karlsen, Tom, Rioux, John, Brant, Steven, and Franke, Andre

Subjects
Alleles, Cohort Studies, Colitis, Ulcerative, Ethnicity, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, HLA Antigens, HLA-DQ Antigens, HLA-DRB1 Chains, Haplotypes, Humans, Linkage Disequilibrium, Peptides, Polymorphism, Single Nucleotide, Protein Binding
Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the highly variable human leukocyte antigen (HLA) region as the strongest susceptibility locus for IBD and specifically DRB1*01:03 as a determining factor for ulcerative colitis (UC). However, for most of the association signal such as delineation could not be made because of tight structures of linkage disequilibrium within the HLA. The aim of this study was therefore to further characterize the HLA signal using a transethnic approach. We performed a comprehensive fine mapping of single HLA alleles in UC in a cohort of 9272 individuals with African American, East Asian, Puerto Rican, Indian and Iranian descent and 40 691 previously analyzed Caucasians, additionally analyzing whole HLA haplotypes. We computationally characterized the binding of associated HLA alleles to human self-peptides and analyzed the physicochemical properties of the HLA proteins and predicted self-peptidomes. Highlighting alleles of the HLA-DRB1*15 group and their correlated HLA-DQ-DR haplotypes, we not only identified consistent associations (regarding effects directions/magnitudes) across different ethnicities but also identified population-specific signals (regarding differences in allele frequencies). We observed that DRB1*01:03 is mostly present in individuals of Western European descent and hardly present in non-Caucasian individuals. We found peptides predicted to bind to risk HLA alleles to be rich in positively charged amino acids. We conclude that the HLA plays an important role for UC susceptibility across different ethnicities. This research further implicates specific features of peptides that are predicted to bind risk and protective HLA proteins.

Published
2021

7. HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis

Author

Akar, Alaa, Flemming, Cornelius, Felix, Flomm, Flosbach, Markus, Jäger, Julia, Jeromin, Niklas, Jung, Johannes, Ohms, Mareike, Reinshagen, Konrad, Rische, Johann, Sagebiel, Adrian, Sandfort, Deborah, Steinert, Fenja, Tomuschat, Christian, Wesche, Jasmin, Shifteh Abedian, Abraham, Clara, Achkar, Jean-Paul, Ahmad, Tariq, Alberts, Rudi, Alizadeh, Behrooz, Amininejad, Leila, Ananthakrishnan, Ashwin N., Andersen, Vibeke, Anderson, Carl A., Andrews, Jane M., Annese, Vito, Aumais, Guy, Baidoo, Leonard, Baldassano, Robert N., Bampton, Peter A., Barclay, Murray, Barrett, Jeffrey C., Bethge, Johannes, Bewshea, Claire, Bis, Joshua C., Bitton, Alain, BK, Thelma, Boucher, Gabrielle, Brain, Oliver, Brand, Stephan, Brant, Steven R., Cheon, Jae Hee, Chew, Angela, Cho, Judy H., Cleynen, Isabelle, Cohain, Ariella, Cooney, Rachel, Croft, Anthony, Daly, Mark J., D'Amato, Mauro, Danese, Silvio, Daryani, Naser Ebrahim, Datta, Lisa Wu, Degenhardt, Frauke, Denapiene, Goda, Denson, Lee A., Devaney, Kathy L., Dewit, Olivier, D'Inca, Renata, Drummond, Hazel E., Dubinsky, Marla, Duerr, Richard H., Edwards, Cathryn, Ellinghaus, David, Ellul, Pierre, Esaki, Motohiro, Essers, Jonah, Ferguson, Lynnette R., Festen, Eleonora A., Fleshner, Philip, Florin, Tim, Franchimont, Denis, Franke, Andre, Fuyuno, Yuta, Gearry, Richard, Georges, Michel, Gieger, Christian, Glas, Jürgen, Goyette, Philippe, Green, Todd, Griffiths, Anne M., Guthery, Stephen L., Hakonarson, Hakon, Halfvarson, Jonas, Hanigan, Katherine, Haritunians, Talin, Hart, Ailsa, Hawkey, Chris, Hayward, Nicholas K., Hedl, Matija, Henderson, Paul, Hold, Georgina L., Hong, Myhunghee, Hu, Xinli, Huang, Hailiang, Hugot, Jean-Pierre, Hui, Ken Y., Imielinski, Marcin, Jazayeri, Omid, Jonaitis, Laimas, Jostins, Luke, Juyal, Garima, Chandra Juyal, Ramesh, Kalla, Rahul, Karlsen, Tom H., Kennedy, Nicholas A., Khan, Mohammed Azam, Kim, Won Ho, Kitazono, Takanari, Kiudelis, Gediminas, Kubo, Michiaki, Kugathasan, Subra, Kupcinskas, Limas, Lamb, Christopher A., de Lange, Katrina M., Latiano, Anna, Laukens, Debby, Lawrance, Ian C., Lee, James C., Lees, Charlie W., Leja, Marcis, Lewis, Nina, Van Limbergen, Johan, Lionetti, Paolo, Liu, Jimmy Z., Louis, Edouard, Luo, Yang, Mahy, Gillian, Malekzadeh, Masoud Mohammad, Malekzadeh, Reza, Mansfield, John, Marriott, Suzie, Massey, Dunecan, Mathew, Christopher G., Matsui, Toshiyuki, McGovern, Dermot P.B., van der Meulen, Andrea, Midha, Vandana, Milgrom, Raquel, Mirzaei, Samaneh, Mitrovic, Mitja, Montgomery, Grant W., Mowat, Craig, Müller, Christoph, Newman, William G., Ng, Aylwin, Ng, Siew C., Evelyn Ng, Sok Meng, Nikolaus, Susanna, Ning, Kaida, Nöthen, Markus, Oikonomou, Ioannis, Okou, David, Orchard, Timothy R., Palmieri, Orazio, Parkes, Miles, Phillips, Anne, Ponsioen, Cyriel Y., Potocnik, Urõs, Poustchi, Hossein, Prescott, Natalie J., Proctor, Deborah D., Radford-Smith, Graham, Rahier, Jean- Francois, Regueiro, Miguel, Reinisch, Walter, Rieder, Florian, Rioux, John D., Roberts, Rebecca, Rogler, Gerhard, Russell, Richard K., Sanderson, Jeremy D., Sans, Miquel, Satsangi, Jack, Schadt, Eric E., Scharl, Michael, Schembri, John, Schreiber, Stefan, Schumm, L. Philip, Scott, Regan, Seielstad, Mark, Shah, Tejas, Sharma, Yashoda, Silverberg, Mark S., Simmons, Alison, Simms, Lisa A., Singh, Abhey, Skieceviciene, Jurgita, van Sommeren, Suzanne, Song, Kyuyoung, Sood, Ajit, Spain, Sarah L., Steinhart, A. Hillary, Stempak, Joanne M., Stronati, Laura, Sung, Joseph J.Y., Targan, Stephan R., Taylor, Kirstin M., Theatre, Emilie, Torkvist, Leif, Torres, Esther A., Tremelling, Mark, Uhlig, Holm H., Umeno, Junji, Vahedi, Homayon, Vasiliauskas, Eric, Velde, Anje ter, Ventham, Nicholas T., Vermeire, Severine, Verspaget, Hein W., De Vos, Martine, Walters, Thomas, Wang, Kai, Wang, Ming-Hsi, Weersma, Rinse K., Wei, Zhi, Whiteman, David, Wijmenga, Cisca, Wilson, David C., Winkelmann, Juliane, Wong, Sunny H., Xavier, Ramnik J., Yamazaki, Keiko, Yang, Suk-Kyun, Ye, Byong Duk, Zeissig, Sebastian, Zhang, Bin, Zhang, Clarence K., Zhang, Hu, Zhang, Wei, Zhao, Hongyu, Zhao, Zhen Z., Baumdick, Martin E., Niehrs, Annika, Schwerk, Maria, Hinrichs, Ole, Jordan-Paiz, Ana, Padoan, Benedetta, Wegner, Lucy H.M., Schloer, Sebastian, Zecher, Britta F., Malsy, Jakob, Joshi, Vinita R., Illig, Christin, Schröder-Schwarz, Jennifer, Möller, Kimberly J., Martin, Maureen P., Yuki, Yuko, Ozawa, Mikki, Sauter, Jürgen, Schmidt, Alexander H., Perez, Daniel, Giannou, Anastasios D., Carrington, Mary, Davis, Randall S., Schumacher, Udo, Sauter, Guido, Huber, Samuel, Puelles, Victor G., Melling, Nathaniel, Altfeld, Marcus, and Bunders, Madeleine J.

Published
2023
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9. Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children’s study using the ASQ-3 questionnaire: A prospective birth cohort

Author

Kobayashi, Sumitaka, Itoh, Sachiko, Miyashita, Chihiro, Ait Bamai, Yu, Yamaguchi, Takeshi, Masuda, Hideyuki, Itoh, Mariko, Yamazaki, Keiko, Tamura, Naomi, Hanley, Sharon J.B., Ikeda-Araki, Atsuko, Saijo, Yasuaki, Ito, Yoshiya, Iwai-Shimada, Miyuki, Yamazaki, Shin, Kamijima, Michihiro, and Kishi, Reiko

Published
2022
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11. Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method

Author

Sakaue, Saori, Hosomichi, Kazuyoshi, Hirata, Jun, Nakaoka, Hirofumi, Yamazaki, Keiko, Yawata, Makoto, Yawata, Nobuyo, Naito, Tatsuhiko, Umeno, Junji, Kawaguchi, Takaaki, Matsui, Toshiyuki, Motoya, Satoshi, Suzuki, Yasuo, Inoko, Hidetoshi, Tajima, Atsushi, Morisaki, Takayuki, Matsuda, Koichi, Kamatani, Yoichiro, Yamamoto, Kazuhiko, Inoue, Ituro, and Okada, Yukinori

Published
2022
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12. The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study

Author

Itoh, Sachiko, Yamazaki, Keiko, Suyama, Satoshi, Ikeda-Araki, Atsuko, Miyashita, Chihiro, Ait Bamai, Yu, Kobayashi, Sumitaka, Masuda, Hideyuki, Yamaguchi, Takeshi, Goudarzi, Houman, Okada, Emiko, Kashino, Ikuko, Saito, Takuya, and Kishi, Reiko

Published
2022
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20. The association between flooring materials and childhood asthma: A prospective birth cohort in the Japan Environment and Children's Study.

Author

Iwata, Hiroyoshi, Ikeda, Atsuko, Itoh, Mariko, Itoh, Sachiko, Ketema, Rahel Mesfin, Tamura, Naomi, Miyashita, Chihiro, Yamaguchi, Takeshi, Yamazaki, Keiko, Yamamoto, Rieko, Tojo, Maki, Saijo, Yasuaki, Ito, Yoshiya, and Kishi, Reiko

Subjects
FLOORING, ASTHMA in children, COHORT analysis, AIR conditioning, LOGISTIC regression analysis
Abstract

Background: Childhood asthma is known to be affected by a range of factors, including conditions in the indoor environment. While flooring material influences indoor air conditions, the potential association between flooring materials and childhood asthma remains poorly understood in Japan. Objective: The present study aims to assess the association between childhood asthma incidence and the primary flooring material with the ongoing prospective nationwide birth cohort data of the Japan Environment and Children's Study (JECS). Methods: The JECS gathered data on mothers and children through 15 Regional Centres across Japan. The present study assessed flooring materials used in the home and asthma incidence at age four among children born between 2011 and 2014. We implemented logistic regressions, setting asthma incidence among the children as the outcome and home floor type as the exposure. Additional analyses were conducted, stratifying the home's age as a proxy for tatami age, to assess whether the potential effect of tatami flooring on asthma risk is influenced by its age. Results: The present study included total of 75,629 infants. For tatami flooring, the main multivariable regression and additional sub-group regression for homes over ten years old produced odds ratios of 1.09; 95% Confidence Interval (CI) [1.01–1.17] and 1.10; 95% CI [1.00–1.21] compared with flooring, respectively. Conclusion: These results imply that exposure to tatami flooring, particularly in older homes, may be associated with childhood asthma incidence. Moreover, our study highlights the importance of evaluating the relationship between regional and cultural differences between asthma and flooring materials. [ABSTRACT FROM AUTHOR]

Published
2024
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24. The association between prenatal per-and polyfluoroalkyl substance levels and Kawasaki disease among children of up to 4 years of age: A prospective birth cohort of the Japan Environment and Children’s Study

Author

Iwata, Hiroyoshi, primary, Kobayashi, Sumitaka, additional, Itoh, Mariko, additional, Itoh, Sachiko, additional, Mesfin Ketema, Rahel, additional, Tamura, Naomi, additional, Miyashita, Chihiro, additional, Yamaguchi, Takeshi, additional, Yamazaki, Keiko, additional, Masuda, Hideyuki, additional, Ait Bamai, Yu, additional, Saijo, Yasuaki, additional, Ito, Yoshiya, additional, Nakayama, Shoji F, additional, Kamijima, Michihiro, additional, and Kishi, Reiko, additional

Published
2023
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28. Null Association Between Isolated Orofacial Clefts and Sleep Duration: A Cohort Study From the Japan Environment and Children's Study.

Author

Sato, Yukihiro, Yoshioka, Eiji, Saijo, Yasuaki, Kato, Yasuhito, Nagaya, Ken, Takahashi, Satoru, Ito, Yoshiya, Kobayashi, Sumitaka, Ait Bamai, Yu, Yamazaki, Keiko, Itoh, Sachiko, Miyashita, Chihiro, Ikeda-Araki, Atsuko, and Kishi, Reiko

Subjects
CONFIDENCE intervals, CLEFT palate, REGRESSION analysis, CLEFT lip, SLEEP duration, RISK assessment, RESEARCH funding, LONGITUDINAL method, DISEASE complications, CHILDREN
Abstract

Objectives: Although children with orofacial clefts have an increased risk for sleep-disordered breathing, no studies have examined the association of sleep duration. Thus, this study aimed to examine associations between orofacial clefts and sleep duration at 1 month, 6 months, 1 year, and 3 years of age in Japan. Design: A cohort study from the Japan Environment and Children's Study. Setting and Patients: This study consisted of 91 497 children, including ones with isolated cleft lip and palate (n = 69), isolated cleft lip only (n = 48), and isolated cleft palate only (n = 37), for which recruitment was undertaken during 2011 to 2014. Main Outcome Measures: Seep durations (hours per day) at 1 month, 6 months, 1 year, and 3 years of age, as reported by their mothers. Results: In the control group, mean sleep durations and standard deviations at 1 month, 6 months, 1 year, and 3 years of age were 15.2 (2.5), 13.6 (1.9), 12.9 (1.6), and 11.6 (1.2) h, respectively. Compared to the control group, linear regression models reported effect sizes and 95% confidence intervals shorter than 1 h for sleep duration of each type of isolated orofacial cleft at each time point. Conclusions: This study suggested null associations between isolated orofacial clefts and sleep duration at 1 month, 6 months, 1 year, and 3 years of age. Children with isolated orofacial clefts had sufficient mean sleep duration. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Change of radiofrequency electromagnetic exposure of children from 2020 to 2021: A report from Hokkaido Study

Author

Yamazaki, Keiko, primary, Tamura, Naomi, additional, Miyashita, Chihiro, additional, Yoshikawa, Toshio, additional, Ikeda-Araki, Atsuko, additional, Hikage, Takashi, additional, Omiya, Manabu, additional, Mizuta, Masahiro, additional, Ikuyo, Miwa, additional, Tobita, Kazuhiro, additional, Onishi, Teruo, additional, Taki, Masao, additional, Watanabe, Soichi, additional, and Kishi, Reiko, additional

Published
2023
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36. 扇生産自動化研究

Author

DIAGO, Luis, primary, SHINODA, Junichi, additional, YAMAZAKI, Keiko, additional, ADACHI, Yuko, additional, and HAGIWARA, Ichiro, additional

Published
2023
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38. Germline variants of IGHV3-53 / V3-66 are determinants of antibody responses to the BNT162b2 mRNA COVID-19 vaccine

Author

Mashimo, Yoichi, primary, Yamazaki, Keiko, additional, Kageyama, Takahiro, additional, Tanaka, Shigeru, additional, Taniguchi, Toshibumi, additional, Matsushita, Kazuyuki, additional, Igari, Hidetoshi, additional, Hanaoka, Hideki, additional, Yokote, Koutaro, additional, Nakajima, Hiroshi, additional, and Onouchi, Yoshihiro, additional

Published
2022
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41. A Genome-Wide Association Study Identifies 2 Susceptibility Loci for Crohn's Disease in a Japanese Population

Author

Yamazaki, Keiko, Umeno, Junji, Takahashi, Atsushi, Hirano, Atsushi, Johnson, Todd Andrew, Kumasaka, Natsuhiko, Morizono, Takashi, Hosono, Naoya, Kawaguchi, Takaaki, Takazoe, Masakazu, Yamada, Tetsuhiro, Suzuki, Yasuo, Tanaka, Hiroki, Motoya, Satoshi, Hosokawa, Masayo, Arimura, Yoshiaki, Shinomura, Yasuhisa, Matsui, Toshiyuki, Matsumoto, Takayuki, Iida, Mitsuo, Tsunoda, Tatsuhiko, Nakamura, Yusuke, Kamatani, Naoyuki, and Kubo, Michiaki

Published
2013
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42. Genome‐wide Association Studies Categorized by Class of Antihypertensive Drugs Reveal Complex Pathogenesis of Hypertension with Drug Resistance.

Author

Yamazaki, Keiko, Terao, Chikashi, Takahashi, Atsushi, Kamatani, Yoichiro, Matsuda, Koichi, Asai, Satoshi, and Takahashi, Yasuo

Subjects
GENOME-wide association studies, ANTIHYPERTENSIVE agents, ANGIOTENSIN-receptor blockers, BLOOD pressure, DRUG resistance, CALCIUM antagonists, HYPERTENSION
Abstract

Resistant hypertension is defined as uncontrolled blood pressure (BP) despite the use of three or more antihypertensive drugs of different classes. Although genetic factors may greatly contribute to hypertension with resistance to multiple drug classes, more than for general hypertension, its pathogenesis remains unknown. To reveal the genetic background of resistant hypertension, we categorized 32,239 patients whose data were obtained from the BioBank Japan Project, by prescription of 7 classes of antihypertensive drugs and performed genome‐wide association studies (GWAS). Our GWAS identified four loci with significant association (P < 5 × 10−8): rs6445583 in CACNA1D and rs12308051 in the intergenic region on chromosome 12 for angiotensin II receptor blockers, rs35497065 in FOXA3 for calcium channel blockers, and rs11066280 in HECTD4 for αβ‐blockers. Because these loci are known to be susceptibility loci for hypertension and/or BP, our results indicate that resistant hypertension is caused by a combination of excessive BP and drug resistance to each antihypertensive pharmacological class. Furthermore, to investigate the genetic difference between BP traits and the treatment effectiveness of antihypertensive drugs, we performed gene‐set analysis and calculated the genetic correlation continuously. Most of the genetic factors were in common between BP traits and antihypertensive effectiveness, but it seems that the genetic architecture of the drug response to antihypertensive treatment is more complicated than BP traits. This corresponds to the well‐known mosaic theory of hypertension. Our findings reveal the complex pathogenesis of hypertension with resistance to multiple classes of antihypertensive drugs. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

Author

Liu, Jimmy Z, van Sommeren, Suzanne, Huang, Hailiang, Ng, Siew C, Alberts, Rudi, Takahashi, Atsushi, Ripke, Stephan, Lee, James C, Jostins, Luke, Shah, Tejas, Abedian, Shifteh, Cheon, Jae Hee, Cho, Judy, Daryani, Naser E, Franke, Lude, Fuyuno, Yuta, Hart, Ailsa, Juyal, Ramesh C, Juyal, Garima, Kim, Won Ho, Morris, Andrew P, Poustchi, Hossein, Newman, William G, Midha, Vandana, Orchard, Timothy R, Vahedi, Homayon, Sood, Ajit, Sung, Joseph J Y, Malekzadeh, Reza, Westra, Harm-Jan, Yamazaki, Keiko, Yang, Suk-Kyun, Barrett, Jeffrey C, Franke, Andre, Alizadeh, Behrooz Z, Parkes, Miles, B K, Thelma, Daly, Mark J, Kubo, Michiaki, Anderson, Carl A, and Weersma, Rinse K

Published
2015
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44. Disease susceptibility genes shared by primary biliary cirrhosis and Crohn’s disease in the Japanese population

Author

Aiba, Yoshihiro, Yamazaki, Keiko, Nishida, Nao, Kawashima, Minae, Hitomi, Yuki, Nakamura, Hitomi, Komori, Atsumasa, Fuyuno, Yuta, Takahashi, Atsushi, Kawaguchi, Takaaki, Takazoe, Masakazu, Suzuki, Yasuo, Motoya, Satoshi, Matsui, Toshiyuki, Esaki, Motohiro, Matsumoto, Takayuki, Kubo, Michiaki, Tokunaga, Katsushi, and Nakamura, Minoru

Published
2015
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45. Association between maternal caffeine intake during pregnancy and child development at 6 and 12 months: The Japan Environment and Children's Study

Author

Nishihara, Shinkichi, primary, Kobayashi, Sumitaka, additional, Ikeda-Araki, Atsuko, additional, Miyashita, Chihiro, additional, Itoh, Sachiko, additional, Yamazaki, Keiko, additional, Bamai, Yu Ait, additional, Tamura, Naomi, additional, Masuda, Hideyuki, additional, Itoh, Mariko, additional, Saijo, Yasuaki, additional, Ito, Yoshiya, additional, and Kishi, Reiko, additional

Published
2022
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46. Risk factors for motor coordination problems in preschool-age children

Author

Suyama, Satoshi, Yagyu, Kazuyori, Araki, Atsuko, Miyashita, Chihiro, Itoh, Sachiko, Minatoya, Machiko, Yamazaki, Keiko, Tamura, Naomi, Nakai, Akio, Saito, Takuya, and Kishi, Reiko

Subjects
Japan, cohort study, maternal smoking, motor coordination problem, preschool-age
Abstract

Background Motor coordination problems (MCP) in children can sometimes be diagnosed as developmental coordination disorder. Early intervention for developmental coordination disorder is necessary because it often continues into adolescence, causing mental and physical complications. Few studies have investigated the prevalence of childhood MCP in the Japanese population, examining the risk factors for MCP. We therefore investigated the prenatal factors associated with MCP in preschool-age children. Methods This study was based on a prospective cohort study, the Hokkaido Study on Environment and Children's Health. Mothers of 4,851 children who reached the age of 5 years within the study-period received questionnaires, including the Japanese version of the Developmental Coordination Disorder Questionnaire (DCDQ-J). We examined the risk factors associated with MCP using logistic regression analysis. Results Of 3,402 returned DCDQ-J questionnaires, 3,369 were answered completely. From the 3,369 children, we categorized having MCP by using two cut-off scores: that of the DCDQ'07 and the cut-off at the 5th percentile of a total DCDQ-J score. Comparing children with and without MCP, we found significant differences in the education level of the mothers, annual household income during pregnancy, maternal alcohol consumption and smoking during pregnancy, and sex and age of the children at the time of completing the DCDQ-J by both categorizations. Adjusted logistic regression analysis revealed that maternal smoking during the first trimester of pregnancy and male sex were significantly associated with MCP. Conclusions Our results suggest that maternal smoking during pregnancy is the main factor associated with MCP in preschool-age children.

Published
2020

47. The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study

Author

1000090580936, Itoh, Sachiko, 1000060732120, Yamazaki, Keiko, Suyama, Satoshi, 1000000619885, Ikeda-Araki, Atsuko, 1000070632389, Miyashita, Chihiro, 1000090752907, Bamai, Yu Ait, 1000010733371, Kobayashi, Sumitaka, 1000020869119, Masuda, Hideyuki, 1000080894972, Yamaguchi, Takeshi, 1000040713607, Goudarzi, Houman, 1000000766537, Okada, Emiko, 1000020515936, Kashino, Ikuko, 1000020246961, Saito, Takuya, 1000080112449, Kishi, Reiko, 1000090580936, Itoh, Sachiko, 1000060732120, Yamazaki, Keiko, Suyama, Satoshi, 1000000619885, Ikeda-Araki, Atsuko, 1000070632389, Miyashita, Chihiro, 1000090752907, Bamai, Yu Ait, 1000010733371, Kobayashi, Sumitaka, 1000020869119, Masuda, Hideyuki, 1000080894972, Yamaguchi, Takeshi, 1000040713607, Goudarzi, Houman, 1000000766537, Okada, Emiko, 1000020515936, Kashino, Ikuko, 1000020246961, Saito, Takuya, 1000080112449, and Kishi, Reiko

Abstract

Background: Disruption of thyroid hormone (TH) levels during pregnancy contributes to attention deficit hyperactivity disorder (ADHD). Exposure to perfluoroalkyl substances (PFAS) during gestation may affect levels of maternal and neonatal TH; however, little is known about the effect of PFAS on ADHD mediated by TH. Objectives: We investigated the impact of maternal PFAS exposure on children's ADHD symptoms with the mediating effect of TH. Methods: In a prospective birth cohort (the Hokkaido study), we included 770 mother-child pairs recruited between 2002 and 2005 for whom both prenatal maternal and cord blood samples were available. Eleven PFAS were measured in maternal serum obtained at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. TH and thyroid antibody, including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured in maternal blood during early pregnancy (median 11 gestational weeks) and in cord blood at birth. ADHD symptoms in the children at 8 years of age were rated by their parents using the ADHD-Rating Scale (ADHD-RS). The cut-off value was set at the 80th percentile for each sex. Results: Significant inverse associations were found between some PFAS in maternal serum and ADHD symptoms among first-born children. Assuming causality, we found only one significant association: maternal FT4 mediated 17.6% of the estimated effect of perfluoroundecanoic acid exposure on hyperactivity-impulsivity among firstborn children. Discussion: Higher PFAS levels in maternal serum during pregnancy were associated with lower risks of ADHD symptoms at 8 years of age. The association was stronger among first-born children in relation to hyperactivity-impulsivity than with regard to inattention. There was little mediating role of TH during pregnancy in the association between mat

Published
2022

48. Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire : A prospective birth cohort

Author

1000010733371, Kobayashi, Sumitaka, 1000090580936, Itoh, Sachiko, 1000070632389, Miyashita, Chihiro, 1000090752907, Bamai, Yu Ait, 1000080894972, Yamaguchi, Takeshi, Masuda, Hideyuki, Itoh, Mariko, 1000060732120, Yamazaki, Keiko, 1000080836164, Tamura, Naomi, Hanley, Sharon J. B., 1000000619885, Ikeda-Araki, Atsuko, Saijo, Yasuaki, Ito, Yoshiya, Iwai-Shimada, Miyuki, Yamazaki, Shin, Kamijima, Michihiro, 1000080112449, Kishi, Reiko, 1000010733371, Kobayashi, Sumitaka, 1000090580936, Itoh, Sachiko, 1000070632389, Miyashita, Chihiro, 1000090752907, Bamai, Yu Ait, 1000080894972, Yamaguchi, Takeshi, Masuda, Hideyuki, Itoh, Mariko, 1000060732120, Yamazaki, Keiko, 1000080836164, Tamura, Naomi, Hanley, Sharon J. B., 1000000619885, Ikeda-Araki, Atsuko, Saijo, Yasuaki, Ito, Yoshiya, Iwai-Shimada, Miyuki, Yamazaki, Shin, Kamijima, Michihiro, 1000080112449, and Kishi, Reiko

Abstract

Neurodevelopmental delay is associated with neurodevelopmental disorders. Prenatal metal exposure can potentially cause neurodevelopmental delays in children. This study examines whether prenatal exposure to mercury (Hg) and selenium (Se) is associated with the risk of neurodevelopmental delays in children up to 4 years of age. Children enrolled in a prospective birth cohort of the Japan Environment and Children's Study were examined. Hg and Se levels in maternal (n(child )= 48,731) and cord (n(child )= 3,083) blood were analyzed by inductively coupled plasma-mass spectrometry. Neurodevelopmental delays were assessed in children between the ages of 0.5 to 4 years using the Ages and Stages Questionnaires, Third Edition. The association between exposure and outcomes was examined using the generalized estimation equation models. In maternal blood, compared to participants with Se levels in the first quartile (83.0 to < 156 ng/g), the odds ratio (95 % confidence intervals) for problem-solving ability in children of mothers in the third (168 to < 181 ng/g) and fourth quartiles (181 to 976 ng/g) were 1.08 (1.01 to 1.14) and 1.10 (1.04 to 1.17), respectively. Furthermore, communication, gross and fine motor skills, and problem-solving delays were also observed. However, prenatal Hg levels in maternal and cord blood and Se levels in the latter were not associated with neurodevelopmental delays in children. Thus, the findings of this study suggest an association between Se levels in maternal blood and slightly increased risks of neurodevelopmental delays in children up to the age of 4 years.

Published
2022

49. Association of prenatal exposure to dioxin-like compounds, polychlorinated biphenyl, and methylmercury with event-related brain potentials in school-aged children：The Hokkaido study

Author

1000060732120, Yamazaki, Keiko, 1000090580936, Itoh, Sachiko, 1000000619885, Ikeda-Araki, Atsuko, 1000070632389, Miyashita, Chihiro, Hori, Tsuguhide, Hachiya, Noriyuki, 1000080112449, Kishi, Reiko, 1000060732120, Yamazaki, Keiko, 1000090580936, Itoh, Sachiko, 1000000619885, Ikeda-Araki, Atsuko, 1000070632389, Miyashita, Chihiro, Hori, Tsuguhide, Hachiya, Noriyuki, 1000080112449, and Kishi, Reiko

Abstract

Previous studies have indicated that prenatal exposure to dioxin-like compounds (DLC) or polychlorinated biphenyl (PCB) has a negative association with neurodevelopment in school-aged children. Event-related brain potentials (ERP) can reveal subtle and specific differences in the modulation of cognitive processes that are assumed when they are associated with lower levels of prenatal exposure to DLC or PCBs. This prospective birth cohort study was conducted to examine the association between prenatal exposure to relatively low levels of DLC, PCB or methylmercury (MeHg), and ERP. A total of 55 children who were 13 years old participated in a 3stimulus oddball task to detect P3a and P3b waves. The task required participants to respond to a target among random stimuli at two difficulty levels. The P3a amplitude reflects an automated attention capture process, and P3b reflects a voluntary attention allocation process. We analyzed DLC congeners in blood samples from four groups, including 7 polychlorinated dibenzo-p-dioxins (PCDD), 10 polychlorinated dibenzofuranes (PCDF), 4 non-ortho PCBs, and 8 mono-ortho PCBs. PCB-153 was chosen as an indicator because of its high correlation with the sum of 58 NDL (non-dioxin-like)-PCBs. MeHg exposure level was assessed by the mercury concentration in hair samples (HHg) taken during the perinatal period. The reaction time to the target stimulus during the oddball task shortened with the increasing MeHg exposure level. Furthermore, P3b latency, which reflect response decision and correlates with reaction time, was also shortened with increasing MeHg level in the difficult condition. These results are counterintuitive because shorter reaction times or rapid decision making reflected by P3 latency are generally favorable. This might be due to nutritional factors such as fatty acids, which have beneficial effects on brain development. The P3a amplitude decreased with non- and mono-ortho PCB and HHg levels, regardless of the difficulty le

Published
2022

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