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8. Treatment strategy for insomnia disorder: Japanese expert consensus

Author

Takaesu, Yoshikazu, primary, Sakurai, Hitoshi, additional, Aoki, Yumi, additional, Takeshima, Masahiro, additional, Ie, Kenya, additional, Matsui, Kentaro, additional, Utsumi, Tomohiro, additional, Shimura, Akiyoshi, additional, Okajima, Isa, additional, Kotorii, Nozomu, additional, Yamashita, Hidehisa, additional, Suzuki, Masahiro, additional, Kuriyama, Kenichi, additional, Shimizu, Eiji, additional, Mishima, Kazuo, additional, Watanabe, Koichiro, additional, and Inada, Ken, additional

Published
2023
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9. Treatment strategy for insomnia disorder: Japanese expert consensus

Author

Takaesu, Yoshikazu, Sakurai, Hitoshi, Aoki, Yumi, Takeshima, Masahiro, Ie, Kenya, Matsui, Kentaro, Utsumi, Tomohiro, Shimura, Akiyoshi, Okajima, Isa, Kotorii, Nozomu, Yamashita, Hidehisa, Suzuki, Masahiro, Kuriyama, Kenichi, Shimizu, Eiji, Mishima, Kazuo, Watanabe, Koichiro, Inada, Ken, Takaesu, Yoshikazu, Sakurai, Hitoshi, Aoki, Yumi, Takeshima, Masahiro, Ie, Kenya, Matsui, Kentaro, Utsumi, Tomohiro, Shimura, Akiyoshi, Okajima, Isa, Kotorii, Nozomu, Yamashita, Hidehisa, Suzuki, Masahiro, Kuriyama, Kenichi, Shimizu, Eiji, Mishima, Kazuo, Watanabe, Koichiro, and Inada, Ken

Abstract

Purpose: There is a lack of evidence regarding answers for clinical questions about treating insomnia disorder. This study aimed to answer the following clinical questions: (1) how to use each hypnotic and non-pharmacological treatment differently depending on clinical situations and (2) how to reduce or stop benzodiazepine hypnotics using alternative pharmacological and nonpharmacological treatments. Methods: Experts were asked to evaluate treatment choices based on 10 clinical questions about insomnia disorder using a nine-point Likert scale (1 = “disagree” to 9 = “agree”). The responses of 196 experts were collected, and the answers were categorized into first-, second-, and third-line recommendations. Results: The primary pharmacological treatment, lemborexant (7.3 2.0), was categorized as a first-line recommendation for sleep initiation insomnia, and lemborexant (7.3 1.8) and suvorexant (6.8 1.8) were categorized as the first-line recommendations for sleep maintenance insomnia. Regarding nonpharmacological treatments for primary treatment, sleep hygiene education was categorized as the first-line recommendation for both sleep initiation (8.4 1.1) and maintenance insomnia (8.1 1.5), while multicomponent cognitive behavioral therapy for insomnia was categorized as the second-line treatment for both sleep initiation (5.6 2.3) and maintenance insomnia (5.7 2.4). When reducing or discontinuing benzodiazepine hypnotics by switching to other medications, lemborexant (7.5 1.8) and suvorexant (6.9 1.9) were categorized as first-line recommendations. Conclusion: Expert consensus indicates that orexin receptor antagonists and sleep hygiene education are recommended as first-line treatments in most clinical situations to treat insomnia disorder.

Published
2023

11. Development and acceptability of a decision aid for chronic insomnia considering discontinuation of benzodiazepine hypnotics

Author

Aoki, Yumi, Takaesu, Yoshikazu, Suzuki, Masahiro, Okajima, Isa, Takeshima, Masahiro, Shimura, Akiyoshi, Utsumi, Tomohiro, Kotorii, Nozomu, Yamashita, Hidehisa, Kuriyama, Kenichi, Watanabe, Norio, and Mishima, Kazuo

Subjects
decision aid, hypnotics, shared decision-making, benzodiazepines, chronic insomnia
Abstract

Aim: To describe the development and acceptability of a decision aid (DA) for chronic insomnia considering discontinuation of benzodiazepine (BZD) and benzodiazepine receptor agonist (BZRA) hypnotics, and if discontinuing, tapering with or without cognitive behavioral therapy for insomnia (CBT-I). Methods: We reviewed relevant literature describing chronic insomnia to identify options. We used the results of the systematic review and meta-analysis conducted previously to determine the related outcomes of two options: discontinuation of BZD/BZRA hypnotics by gradual tapering alone and discontinuation of BZD/BZRA hypnotics by gradual tapering with CBT-I. We then developed a prototype of DA following the International Patient Decision Aid Standards. A mixed methods survey was conducted to assess the acceptability among patients and healthcare providers. Results: The prototype consisted of a description of insomnia, options of continuing or discontinuing BZD/BRZA hypnotics (if discontinuing, the options of tapering hypnotics with or without CBT-I), pros and cons of each option, and a value clarification

Published
2021

18. Hyperarousal Scale--Japanese Version

Author

Ayabe, Naoko, primary, Nakajima, Shun, additional, Okajima, Isa, additional, Inada, Ken, additional, Yamadera, Wataru, additional, Yamashita, Hidehisa, additional, Tachimori, Hisateru, additional, Kamei, Yuichi, additional, Takeshima, Masahiro, additional, Inoue, Yuichi, additional, and Mishima, Kazuo, additional

Published
2022
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20. Understanding the process for developing sleep disorders among Japanese workers: a qualitative study

Author

Toyoshima, Ayako, Moriyama, Michiko, Yamashita, Hidehisa, Rahman, Md Moshiur, Huq, KATM Ehsanul, Jahan, Yasmin, Kazawa, Kana, Toyoshima, Ayako, Moriyama, Michiko, Yamashita, Hidehisa, Rahman, Md Moshiur, Huq, KATM Ehsanul, Jahan, Yasmin, and Kazawa, Kana

Abstract

type:text, Background: Sleep disorders have an enormous impact on occupational health and are counterproductive from an economic perspective. However, the processes of causing sleep disorders from psychosocial aspects have not yet been known. The purpose of this study was to describe how sleep disorders develop among workers with respect to different psychosocial conditions. Methods: A conventional qualitative content analysis was conducted with a semi-structured interview among twenty-seven workers (14 males and 13 females) who were diagnosed with sleep disorders or had a self-reported history of sleep difficulties. Study participants were recruited from a specialized clinic and communities using snowball sampling. This paper adhered to the Standards for Reporting Qualitative Research (SRQR) checklist. Results: The results showed that there were four steps involved in the sleep disorders development process. Firstly, participants with sleep disorders developed ‘early warning signs’ with 11 categories of triggers; secondly, ‘aggravating factors’ on top of these early warning signs; thirdly, workers tried to ‘cope with’ their sleep disorders in the ways they thought would be effective. Finally, when coping failed to improve the quality of sleep, it led to the onset of sleep disorders. Conclusion: The development of sleep disorders and triggers of psychosocial factors were revealed. An occupational health nurse can bring these findings in practice for preventing worker’s sleep disorders., This study is carried out with funding of the Grants-in-Aid for Scientific Research Program (KAKENHI), Japan (No.15H05078).

Published
2021

21. Current state of hypnotic use disorders: Results of a survey using the Japanese version of Benzodiazepine Dependence Self-Report Questionnaire

Author

Yamamoto, Mai, Inada, Ken, Enomoto, Minori, Habukawa, Mitsunari, Hirose, Takahisa, Inoue, Yuichi, Ishigooka, Jun, Kamei, Yuichi, Kitajima, Tsuyoshi, Miyamoto, Masayuki, Shinno, Hideto, Nishimura, Katsuji, Ozone, Motohiro, Takeshima, Masahiro, Suzuki, Mayumi, Yamashita, Hidehisa, Mishima, Kazuo, Yamamoto, Mai, Inada, Ken, Enomoto, Minori, Habukawa, Mitsunari, Hirose, Takahisa, Inoue, Yuichi, Ishigooka, Jun, Kamei, Yuichi, Kitajima, Tsuyoshi, Miyamoto, Masayuki, Shinno, Hideto, Nishimura, Katsuji, Ozone, Motohiro, Takeshima, Masahiro, Suzuki, Mayumi, Yamashita, Hidehisa, and Mishima, Kazuo

Abstract

Aims Benzodiazepine receptor agonists (BZ-RAs) are frequently prescribed to treat insomnia; however, their long-term use is not recommended. To introduce an appropriate pharmaco-therapy, the current state and background factors of BZ-RAs' dependence must be elucidated. In this study, we developed a Japanese version of the Benzodiazepine Dependence Self-Report Questionnaire (Bendep-SRQ-J) and conducted a study of BZ-RAs' use disorder. Methods The Bendep-SRQ-J was created with permission from the original developer. Subjects were inpatients and outpatients receiving BZ-RAs between 2012 and 2013. Clinical data collected were Bendep-SRQ-J scores, sleep disorders for which BZ-RAs were prescribed, physical comorbidities, psychotropic drugs, and lifestyle factors. Logistic analysis was performed to extract factors associated with severe symptoms. Results Of the 707 patients prescribed BZ-RAs, 324 had voluntarily tapered or discontinued their drugs. Logistic analysis showed that the total number of drugs administered in the last 6 months correlated with both worsening of symptoms or conditions. This was more notable among younger patients, and the proportion of patients with severe symptoms or conditions increased with the increasing number of drugs. Conclusion Using the Bendep-SRQ-J, we elucidated the current state of BZ-RA dependence. Nearly half of the patients were non-compliant. The proportion of patients with severe symptoms or disease conditions increased with the increase in the number of drugs administered. These findings highlight the need for clinicians to be aware of the likelihood of benzodiazepine dependence, especially in young patients and patients prescribed multiple hypnotics.

Published
2021

24. Abstracts for the 6th Congress of Asian Sleep Research Society

Author

Kim, Seog Ju, Lyoo, In Kyoon, Lee, Yu-Jin, Jeong, Do-Un, Kanai, Hirohiko, Ookubo, Masanori, Yoshimura, Atsushi, Okawa, Masako, Yamada, Noto, Munezawa, Takeshi, Kaneita, Yoshitaka, Osaki, Yoneatsu, Kanda, Hideyuki, Ohtsu, Tadahiro, Minowa, Masumi, Suzuki, Kenji, Hijuchi, Susumu, Suzuki, Hiroyuki, Ohida, Takashi, Abe, Takashi, Komada, Yoko, Asaoka, Shoichi, Inoue, Yuichi, Lee, Jin-Seong, Cho, Sang-Yong, Kumar, Deependra, Mallick, Hruda N., Kumar, Velayudhan M., Kaushik, Mahesh K., Karashima, Akihiro, Katayama, Noiihiro, Nakao, Mitsuyuki, Nagendra, Ravindra P., Sulekha, Sathiamma, Narasappa, Sathyaprabha T., Nityanadan, Pradhan, Kutty, Bindu M., Nirmala, M., Ravindra, P. N., Tubaki, Basavaraj Ramappa, Sathyaprabha, T. N., Sudhakar, D., Lavekar, G. S., Chandrashekar, C. R., Kitaoka, Kazuyoshi, Shimizu, Mika, Chikahisa, Sachiko, Yoshizaki, Kazuo, Sei, Hiroyoshi, Kim, Jong-Won, Takegami, Misa, Yamazaki, Shin, Hayashino, Yasuaki, Ono, Rei, Otani, Koji, Sekiguchi, Miho, Konno, Shinichi, Fukuhara, Shunichi, Jakobson, Antonia J., Fitzgerald, Paul, Conduit, Russell, Li, Xin Shirley, Lam, Siu Ping Joyce, Yu, Wai Man Mandy, Wing, Yun Kwok, Okamoto-Mizuno, Kazue, Mizuno, Koh, Yamamoto, Mituaki, Shirakawa, Shuichiro, Doi, Hirokazu, Kato, Mikako, Shinohara, Kazuyuki, Tamaki, Masako, Matsuda, Shiori, Yamazaki, Katsuo, Hori, Tadao, Ogawa, Keiko, Takahashi, Kazumi, Kitahama, Kunio, Yamazaki, Katuo, Koyama, Yoshimasa, Shioda, Kohei, Ueda, Yugo, Nakamura, Yukiko, Inoue, Clara, Goto, Kazushige, Uchida, Sunao, Morita, Yuko, Honda, Yoshiko, Kodama, Tohru, Hagihara, Mari, Nakajima, Toru, Saito, Masato, Koga, Yoshihiko, Tanaka, Shinichiro, Yamadera, Hiroshi, Takahara, Madoka, Suwa, Sachiko, Onozuka, Minoru, Sato, Sadao, Togo, Fumiharu, Komatsu, Taiki, Mitani, Takeshi, Choi, Jongbae, Zhang, Bin, Sasai, Taeko, Mitsubayashi, Hiromi, Ohtsu, Mitsuhiro, Hasegawa, Isao, Ishii, Tatsuya, Komori, Akira, Suzuki, Asami, Nakahara, Yue, Hiroki, Mitsuyasu, Nakauma, Mariko, Someya, Nobuo, Ochiai, Tomomasa, Komori, Shouhei, Chiang, Rayleigh Ping-Ying, Yeh, Zai-Ting, Kim, Seong T., Yoon, Seung H., Kwon, Jeong S., Choi, Jong H., Ahn, Hyung J., Kim, Youngsoo, Yunren, Bolortuya, Chen, Lichao, Basheer, Radhika, Mccarley, Robert W., Strecker, Robert E., Honda, Makoto, Arai, Tetsuaki, Fukazawa, Miyuki, Honda, Yutaka, Tsuchiya, Kuniaki, Akiyama, Haruhiko, Mignot, Emmanuel, Jung, Ki-Young, Ko, Deokwon, Koo, Yong-Seo, Zhang, Jihui, Ping Lam, Siu, Hong, Seung Chul, Chung, Kyoo In, Lee, Sung Pil, Lee, Chung Tai, Seo, Ho Jun, Jeong, Jong Hyeon, Lim, Hyeon Kuk, Shin, Yoon Kyung, You, Ji Hee, Suzuki, Jun-Ichi, Ogawa, Masahito, Liu, Xianchen, Ye, Wenyu, Watson, Peter, Dube, Sanjay, Wohlreich, Madelaine, Kwan, Benjamin C. H., Joseph, Francoise, Mckenzie, David M., Lee, Bonne, Lee, Sang-Ahm, Lee, Eun-Mi, Kim, Cheon-Sik, Nishijima, Tsuguo, Sakurai, Shigeru, Tokunaga, Jun, Takahashi, Susumu, Kanbayashi, Takashi, Hitomi, Jirou, Shimizu, Tetsuo, Murashima, Koji, Ozaki, Masayuki, Hang, Liang-Wen, Lin, Chen-Liang, Huang, Cheng-Ning, Huang, Wen-Yen, Choi, Ji Ho, Kim, Eun Joong, Kim, Tae Hoon, Lee, Sang Hag, Shin, Chol, Lee, Seung Hoon, Chen, Chia Chi, Lo, Men-Tzung, Lin, Chen, Lee, Min-Ying, Lin, Chia-Mo, Tsuiki, Satoru, Kobayashi, Mina, Takashima, Akiyo, Maeda, Keiko, Matsuura, Masato, Furukawa, Tomokazu, Nakano, Hiroshi, Hirayama, Kenji, Tanahashi, Tokusei, Yoshihara, Kazufumi, Kubo, Chiharu, Sudo, Nobuyuki, Kim, Eui-Joong, Ahn, Young Min, Shin, Hong-Beom, Kim, Jong Won, Matsuo, Akira, Nakai, Takayuki, Tsuiki, Storu, Chiba, Higoshige, Sawada, Koki, Chiba, Shintaro, Endo, Makoto, Moriwaki, Hiroto, Uchida, Ryo, Kim, Sung Wan, Chung, Dae Han, Shin, Seung Youp, Lee, Kun Hee, Cho, Joong Saeng, Tazoe, Mari, Ayuse, Takao, Yamamura, Satoshi, Kirkness, Jason P., Oi, Kumiko, Ishida, Katsunori, Kato, Masahiko, Kato, Yosuke, Yanagihara, Kiyotaka, Kinugasa, Yoshiharu, Sugihara, Shinobu, Hirai, Masayuki, Hamada, Toshihiro, Igawa, Osamu, Hisatome, Ichiro, Shigemasa, Chiaki, Shimizu, Noriyuki, Oura, Masahiro, Usui, Akira, Okajima, Isa, Matsuura, Noriko, Hiroki, Ikeda, Mitsuo, Hayashi, Choi, Jiae, Yoon, Inyoung, Furutani, Maki, Takase, M., Nakayama, K., Kita, Y., Sakohara, T., Yoshimura, H., Satoki, Y., Sakai, Y., Murakami, A., Kouno, K., Ikeda, R., Tanaka, H., Tanaka, Hideki, Yamano, Emi, Fukuda, Sanae, Joudoi, Takako, Mizuno, Kei, Tanaka, Masaaki, Kawatani, Junko, Takano, Miyuki, Tomoda, Akemi, Imai-Matsumura, Kyoko, Miike, Teruhisa, Watanabe, Yasuyoshi, Furihata, Ryuji, Uchiyama, Makoto, Takahashi, Sakae, Suzuki, Masahiro, Konno, Chisato, Ohsaki, Kouichi, Chiang, Hsin Ju, Tsai, Ling Ling, Weng, Chia Ying, Kawauchi, Tomomi, Tanaka, Yuu, Ohira, Hideki, Na, Hae-Ran, Kang, Eun-Ho, Sim, Hyun-Bo, Woo, Jong-Min, Yu, Bum-Hee, Ahmed, Wael, Kitanaka, Takahiro, Nishimura, Yoichi, Ando, Kayoko, Kurahashi, Hiroki, Abe, Akiko, Yamamoto, Ryuichiro, Matsuda, Michikazu, Ogawa, Toru, Ito, Toshimi, Suzuki, Tasuku, Sasaki, Keiichi, Shinno, Hideto, Otsuki, Manabu, Tsuchiya, Satoshi, Oka, Yasunori, Kawada, Seiichi, Innami, Toshihiko, Horikoshi, Tatsuru, Sasaki, Akira, Hineno, Takashi, Sakamoto, Tetsuro, Inami, Yasushi, Yamashita, Hidehisa, Mizuno, Soichi, Nakamura, Yu, Horiguchi, Jun, Iwanaga, Koichi, Kanemura, Takashi, Ohno, Mikako, Kato, Yuichi, Miyazaki, Soichiro, Maritani, Shinji, Ito, Yukihiko, Shen, Manzhen, Takahashi, Satomi, Kajiwara, Nobuko, Satoh, Makoto, Kinouchi, Kaori, Tokuyama, Kana, Akai, Yukiko, Fukuyama, Tomoko, Takahashi, Hiroe, Tanbara, Tadashi, Nishihara, Kyoko, Ozawa, Nobuyuki, Shin, Duk, Sakai, Hiroyuki, Uchiyama, Yuji, Wakita, Toshihiro, Sugi, Takenao, Yoshiyama, Hiroaki, Matsuoka, Genya, Sakai, Kazuhiro, Nakamura, Masatoshi, Cho, Yong Won, Lee, Joo Hwa, Jung, Sang Hun, Cho, Hwa Ra, Yi, Sang Doe, Kobayashi, Masato, Moromugi, Shunji, Sakamoto, Taichi, Ishimatsu, Takakazu, Lee, Jeong Su, Chung, Gih Sung, Park, Kwang Suk, Shin, Won Chul, Yoon, Jung Eun, Jang, Eun Joo, Sung, Min Jee, Cha, Hyun Keuk, Taguchi, T., Nakamori, M., Taneike, R., Hayashi, A., Sugimori, S., Kamiyama, J., Hamada, T., Itoi, H., Koyama, Emi, Kubo, Tomohide, Takahashi, Masaya, Sato, Tomoaki, Sasaki, Takeshi, Oka, Tatsuo, Iwasaki, Kenji, Son, Mia, Yeom, Myeonggul, Harma, Mikko, Wakamura, Tomoko, Tojo, Chiaki, Horita, Sachiko, Takahashi, Ken-Ichi, Sumi, Kensuke, Nakayama-Ashida, Yukiyo, Nakamura, Takaya, Minami, Itunari, Oka, Yasunari, Chin, Kazuo, Kadotani, Hiroshi, Hayashi, Etsuko, Kato, Rumiko, Tanaka, Yu, Yamamoto, Takuro, Yamashita, Shiko, Matsumoto, Masahiro, Nakashima, Yusaku, Soma, Haruhiko, Yasuda, Akio, Kuriki, Ayano, Hayashi, Mituo, MurakI, Takeya, Yamashiro, Keitaro, Aritomi, Ryoji, Sakurai, Shihomi, Kishi, Akifumi, Natelson, Benjamin H., Struzik, Zbigniew R., Yamamoto, Yoshiharu, Terashima, Ryuta, Nakade, Miyo, Murata, Chiyoe, Hirai, Hiroshi, Kondo, Katsunori, Tsutsui, Hideyo, Tsuboi, Hirohito, Ojima, Toshiyuki, Fu, Ying-Hui, He, Ying, Jones, Christopher, Fujiki, Nobuhiro, Nishino, Seiji, Ito, Asao, Fredholm, Bertil B., Hillman, David R., Hayashi, Mitsuo, Kennaway, David J., Mallick, H. N., Hui, David S., Chee, Michael W. L., Takahashi, Toshiharu, Sasaki, Mitsuo, Gedal, Lalaine, Honma, Sato, Yoshikawa, Tomoko, Hashimoto, Satoko, Honma, Ken-Ichi, Lee, Li-Ang, Li, Hsueh-Yu, Tsai, Ling-Ling, Hsieh, Shulan, Zucconi, Marco, Yang, Chien-Ming, Lo, Hsiao-Sui, Wu, Chia-Suo, Huang, Yen-Ling, Tsai, Ming-Chieh, Han, Fang, Yoshida, Kazuya, Mcardle, Nigel, Jung, Chul Ho, Choi, Ji Hye, Soon, Park Chan, Sarte, Michael Alexius A., Wai, Talen, Sasao, Yasuhiro, Liu, Lianqi, Owens, Judith, Shrivastava, Deepak, Kanabayashi, Takashi, Hishikawa, Yasuo, Naughton, Matthew T., Miyamoto, Masayuki, Lam, Jamie C., Dworak, Markus, Kalinchuk, Anna, Kim, Tae, Brown, Ritchie, Strecker, Robert, Huang, Yu-Shu, Tsou, Meng-Chen, Hsu, Shih-Pin, Vachiramon, Amornpong, Nakata, Seiichi, Luppi, Pierre-Herve, Chen, Ning-Hung, Mallick, Birendra N., Hong, Seung Bong, Ho, Crover K., Goh, Yau Hong, Mark, Ignatius, Opp, Mark R., Sullivan, Colin E., Kim, Kwang-Jin, Preutthipan, Aroonwan, Strohl, Kingman P., Fuller, Patrick, Wang, Yang, Bhatia, Manvir, Lee, Chul Hee, and Bassetti, Claudio L.

Published
2009
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29. Dysfunction in early auditory processing in major depressive disorder revealed by combined MEG and EEG

Author

Kahkonen, Seppo, Yamashita, Hidehisa, Rytsala, Heikki, Suominen, Kirsi, Ahveninen, Jyrki, and Isometsa, Erkki

Subjects
Major depressive disorder -- Physiological aspects, Auditory perception -- Evaluation, Magnetoencephalography -- Usage, Electroencephalography -- Usage, Cognition disorders -- Physiological aspects
Abstract

Background: Patients with major depressive disorder (MDD) show impairments in cognitive functions. However, neural mechanisms underlying these disturbances are poorly understood. We investigated whether MDD affects neural mechanisms of involuntary [...]

Published
2007

32. Current state of hypnotic use disorders: Results of a survey using the Japanese version of Benzodiazepine Dependence Self‐Report Questionnaire

Author

Yamamoto, Mai, primary, Inada, Ken, additional, Enomoto, Minori, additional, Habukawa, Mitsunari, additional, Hirose, Takahisa, additional, Inoue, Yuichi, additional, Ishigooka, Jun, additional, Kamei, Yuichi, additional, Kitajima, Tsuyoshi, additional, Miyamoto, Masayuki, additional, Shinno, Hideto, additional, Nishimura, Katsuji, additional, Ozone, Motohiro, additional, Takeshima, Masahiro, additional, Suzuki, Mayumi, additional, Yamashita, Hidehisa, additional, and Mishima, Kazuo, additional

Published
2020
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33. Development and acceptability of a decision aid for chronic insomnia considering discontinuation of benzodiazepine hypnotics.

Author

Aoki, Yumi, Takaesu, Yoshikazu, Suzuki, Masahiro, Okajima, Isa, Takeshima, Masahiro, Shimura, Akiyoshi, Utsumi, Tomohiro, Kotorii, Nozomu, Yamashita, Hidehisa, Kuriyama, Kenichi, Watanabe, Norio, and Mishima, Kazuo

Subjects
COGNITIVE therapy, HYPNOTICS, MEDICAL personnel, BENZODIAZEPINE receptors, INSOMNIA, BENZODIAZEPINES, TRAZODONE
Abstract

Aim: To describe the development and acceptability of a decision aid (DA) for chronic insomnia considering discontinuation of benzodiazepine (BZD) and benzodiazepine receptor agonist (BZRA) hypnotics, and if discontinuing, tapering with or without cognitive behavioral therapy for insomnia (CBT‐I). Methods: We reviewed relevant literature describing chronic insomnia to identify options. We used the results of the systematic review and meta‐analysis conducted previously to determine the related outcomes of two options: discontinuation of BZD/BZRA hypnotics by gradual tapering alone and discontinuation of BZD/BZRA hypnotics by gradual tapering with CBT‐I. We then developed a prototype of DA following the International Patient Decision Aid Standards. A mixed methods survey was conducted to assess the acceptability among patients and healthcare providers. Results: The prototype consisted of a description of insomnia, options of continuing or discontinuing BZD/BRZA hypnotics (if discontinuing, the options of tapering hypnotics with or without CBT‐I), pros and cons of each option, and a value clarification exercise. Patients (n = 24) reported that the DA had acceptable language (79%), adequate information (71%), and well‐balanced presentation (91%). Healthcare providers (n = 20) also provided favorable feedback. Conclusion: We developed a DA for chronic insomnia considering discontinuation of BZD/BRZA hypnotics, which was acceptable for stakeholders. The developed DA was designed to support patients and healthcare providers to make a decision about whether to discontinue BZD/BRZA hypnotics. [ABSTRACT FROM AUTHOR]

Published
2022
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36. The right hemisphere is important for driving-related cognitive function after stroke

Author

Shimonaga, Koji, primary, Hama, Seiji, additional, Tsuji, Toshio, additional, Yoshimura, Kazumasa, additional, Nishino, Shinya, additional, Yanagawa, Akiko, additional, Soh, Zu, additional, Matsushige, Toshinori, additional, Mizoue, Tatsuya, additional, Onoda, Keiichi, additional, Yamashita, Hidehisa, additional, Yamawaki, Shigeto, additional, and Kurisu, Kaoru, additional

Published
2020
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46. The Neurocognitive Effects of Aripiprazole Compared with Risperidone in the Treatment of Schizophrenia

Author

Sato, Goro, Yoshimura, Shinpei, Yamashita, Hidehisa, Okamoto, Yasumasa, and Yamawaki, Shigeto

Subjects
Randomized crossover trial, Neurocognitive functioning, Aripiprazole, Schizophrenia
Abstract

Aripiprazole is a D2 and D3 receptor partial agonist that is unlike other second generation antipsychotics. The effectiveness of aripiprazole with regard to neurocognitive function and its adverse effects is unclear. The present study evaluates the comparative efficacy, effects on neurocognitive function, and adverse effects of aripiprazole and risperidone in the treatment of hospitalized patients with schizophrenia. This double-blind, cross-over study included 23 patients with schizophrenia who were randomly assigned to be treated first with either aripiprazole or risperidone. After eight weeks on one medication, the patients were switched to the other medication for eight weeks. The patient assessment included the Positive and Negative Syndrome Scale (PANSS), neurocognitive assessments, and adverse events including extrapyramidal symptoms, vital signs, electrocardiogram, and clinical laboratory tests. The study findings indicated that psychopathology assessed with the PANSS, extrapyramidal symptoms and other adverse effects did not differ between aripiprazole and risperidone for the subjects remaining in treatment. In the neurocognitive assessments, the score for disinhibition with aripiprazole was significantly lower than with risperidone (p

Published
2012

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