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2. Cardiac Adrenergic Imaging

Author

Fujimoto, Shinichiro, Yamashina, Shohei, Yamazaki, Junichi, Movahed, Assad, editor, Gnanasegaran, Gopinath, editor, Buscombe, John, editor, and Hall, Margaret, editor

Published
2009
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4. Transcriptome-Based Systematic Identification of Extracellular Matrix Proteins

Author

Manabe, Ri-ichiroh, Tsutsui, Ko, Yamada, Tomiko, Kimura, Mina, Nakano, Itsuko, Shimono, Chisei, Sanzen, Noriko, Furutani, Yutaka, Fukuda, Tomohiko, Oguri, Yasuko, Shimamoto, Keiko, Kiyozumi, Daiji, Sato, Yuya, Sado, Yoshikazu, Senoo, Haruki, Yamashina, Shohei, Fukuda, Shiro, Kawai, Jun, Sugiura, Nobuo, Kimata, Koji, Hayashizaki, Yoshihide, and Sekiguchi, Kiyotoshi

Published
2008
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19. Role for laminin-[alpha]5 chain LG4 module in epithelial branching morphogenesis

Author

Kadoya, Yuichi, Mochizuki, Mayumi, Nomizu, Motoyoshi, Sorokin, Lydia, and Yamashina, Shohei

Subjects
Laminin -- Physiological aspects, Laminin -- Research, Membrane, Basement -- Research, Morphogenesis -- Research, Biological sciences
Abstract

Laminin-[alpha]5 chain was localized in all epithelial basement membranes (BMs) of mouse submandibular gland (SMG) from the onset of branching morphogenesis and became restricted to BMs of epithelial ducts in the adult. To investigate whether the laminin-[alpha]5 chain plays a role in branching morphogenesis, a set of cell-adhesive peptides from the C-terminal globular domains (LG1-5) was tested for their effects in SMG organ cultures. One peptide, LVLFLNHGH (A5G77f), which represents a sequence located in the connecting loop between strands E and F of LG4, perturbed branching morphogenesis and resulted in irregularities in the contours of epithelial structures, with formation of deep clefts. The data suggest a role for the laminin-[alpha]5 LG4 module in the development of the duct system, rather than in the bifurcation of epithelial clusters. The epithelial BM of A5G77f-peptide-treated explants was continuous, which was in contrast to our previous finding of impaired epithelial BM assembly in explants treated with the laminin-[alpha]1 LG4 module peptide, or with a monoclonal antibody against this domain. A5G77f also perturbed in vitro development of lung and kidney. These results suggest a crucial role for the LG4 module of laminin-[alpha]5 in epithelial morphogenesis that is distinct from that of the laminin-[alpha]1 LG4. Keywords: Basement membrane; Branching morphogenesis; Immunohistochemistry; Laminin-[alpha] chain; Laminin-[alpha]5; Organ culture; Peptide; Submandibular gland

Published
2003

25. Good Ultrastructural Preservation of Human Tissues and Cultured Cells by Glutaraldehyde Fixation, Sandwich Freezing, and Freeze-Substitution

Author

Yamaguchi, Masashi, primary, Wakabayashi, Seiichiro, additional, Nakamura, Yuumi, additional, Matsue, Hiroyuki, additional, Hirao, Takuya, additional, Aoki, Shigeki, additional, Yamashina, Shohei, additional, Yamada, Hiroyuki, additional, Mamizu, Nobuya, additional, Furukawa, Hiromitsu, additional, and Chibana, Hiroji, additional

Published
2020
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36. Current abstracts of the articles published in the Japanese journal of nuclear medicine

Author

Fujita, Seigo, Nagamachi, Shigeki, Nishii, Ryuichi, Futami, Shigemi, Nakada, Hiroshi, Kuroki, Masaomi, Ono, Seiji, Tamura, Shozo, Matsuzaki, Yasunori, Onizuka, Toshio, Asada, Yujiro, Kataoka, Hiroaki, Hisatake, Shinji, Yamashina, Shohei, Yamazaki, Junichi, Watabe, Hiroshi, Iida, Hidehiro, Matsumoto, Keiichi, Sakamoto, Setsu, Senda, Michio, Watanabe, Masayoshi, Ishikawa, Naofumi, Ito, Kunihiko, and Ito, Koichi

Published
2004
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45. Guidelines for clinical use of cardiac nuclear medicine (JCS 2010) : digest version

Author

Tamaki, Nagara, Kumita, Shinichiro, Kusakabe, Kiyoko, Matsuzaki, Masunori, Nishimura, Tsunehiko, Senda, Shoichi, Shimamoto, Kazuaki, Yamashita, Akira, Yamazaki, Junichi, Chikamori, Taishiro, Ishida, Yoshio, Iwado, Yasuyoshi, Kiriyama, Tomonari, Kiso, Keisuke, Kondo, Chisato, Matsumoto, Naoya, Nakajima, Kenichi, Nakata, Tomoaki, Yamashina, Shohei, Yoshinaga, Keiichiro, Doi, Yoshinori, Fujita, Masatoshi, Nishimura, Shigeyuki, Ohsuzu, Fumitaka, and Takeishi, Yasuchika

Published
2012

49. Cyclo-oxygenase-2 enhances basic fibroblast growth factor-induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants

Author

Majima, Masataka, Hayashi, Izumi, Muramatsu, Michiko, Katada, Jun, Yamashina, Shohei, and Katori, Makoto

Subjects
Male, Vascular Endothelial Growth Factor A, Lymphokines, Granuloma, Cyclooxygenase 2 Inhibitors, Neovascularization, Pathologic, Reverse Transcriptase Polymerase Chain Reaction, Vascular Endothelial Growth Factors, Foreign-Body Reaction, Endothelial Growth Factors, Immunohistochemistry, Rats, Isoenzymes, Rats, Sprague-Dawley, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, Papers, Prostaglandins, Animals, Cyclooxygenase Inhibitors, Fibroblast Growth Factor 2
Abstract

Angiogenesis is reportedly enhanced by prostaglandins (PGs). In the present study, we investigated whether or not cyclo-oxygenase (COX)-2 mediated angiogenesis in chronic and proliferate granuloma. In rat sponge implants, angiogenesis was gradually developed over a 14-day experimental period as granuloma formed. This angiogenesis was enhanced by topical injections of human recombinant basic fibroblast growth factor (bFGF). In sponge granuloma, mRNA of COX-1 was constitutively expressed, whereas that of COX-2 was increased with neovascularization in parallel with that of vascular endothelial growth factor (VEGF). Topical injections of bFGF increased the expression of COX-2 mRNA. bFGF-stimulated angiogenesis was inhibited by indomethacin or selective COX-2 inhibitors, NS-398, nimesulide, and JTE-522. The levels of PGE(2) and 6-keto-PGF(1alpha) in the sponge granuloma were increased with bFGF 13 fold and 9 fold, respectively, and these levels were markedly reduced by NS-398. The expression of VEGF mRNA in the granuloma was also enhanced by bFGF, and was reduced by NS-398. Topical injections of PGE(2) and beraprost sodium, a PGI(2) analogue, increased the expression of VEGF mRNA, with angiogenesis enhancement. The enhanced angiogenesis by bFGF was significantly inhibited by topical injections of VEGF anti-sense oligonucleotide. These results suggested that COX-2 may enhance bFGF-induced neovascularization in sponge granuloma by PG-mediated expression of VEGF, and that a COX-2 inhibitor would facilitate the management of conditions involving angiogenesis.

Published
2000

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