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Your search keyword '"Yamaoto, M."' showing total 6 results
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6 results on '"Yamaoto, M."'

3. Test of cesium telluride photocathode as a feasibility study on polarized RF-gun.

Author

Furuta, F., Sugiyama, H., Nakanishi, T., Okumi, S., Togowa, K., Suzuki, C., Wada, K., Yamaoto, M., Nishitani, T., Watanabe, J., Kurahashi, S., Miyamoto, M., Kuwahara, M., Mizuno, R., Hirose, T., Kimura, K., Kobayakawa, H., Takashima, Y., Yoshioka, M., and Matsumoto, H.

Subjects
LINEAR accelerators, POLARIZATION (Nuclear physics), ELECTRON-positron interactions
Abstract

Our collaboration group have continued to develop the polarized DC-gun system for future electron-positron linear colliders. In parallel, the feasibility study to develop the polarized RF-gun is planned. As the first step, the test of Cs[sub 2]Te photocathode was performed. [ABSTRACT FROM AUTHOR]

Published
2001

4. Transcriptional targeting of adenoviral vector through the CXCR4 tumor-specific promoter.

Author

Zhu, Z. B., Makhija, S. K., Lu, B., Wang, M., Kaliberova, L., Liu, B., Rivera, A. A., Nettelbeck, D. M., Mahasreshti, P. J., Leath, C. A., Yamaoto, M., Alvarez, R. D., and Curiel, D. T.

Subjects
GENETIC vectors
Abstract

A correction to the article "Transcriptional Targeting of Adenoviral Vector Through the CXCR4 Tumor-Specific Promoter" that was previously published in the journal is presented.

Published
2006
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5. Transcriptional targeting of tumors with a novel tumor-specific survivin promoter.

Author

Zhu ZB, Makhija SK, Lu B, Wang M, Kaliberova L, Liu B, Rivera AA, Nettelbeck DM, Mahasreshti PJ, Leath CA, Barker S, Yamaoto M, Li F, Alvarez RD, and Curiel DT

Subjects
Adenoviridae genetics, Animals, Cell Line, Tumor, Cyclooxygenase 2, Gene Expression, Gene Expression Regulation, Neoplastic, Gene Transfer Techniques, Genes, Reporter genetics, Genetic Vectors genetics, Humans, Inhibitor of Apoptosis Proteins, Isoenzymes genetics, Luciferases analysis, Luciferases genetics, Membrane Proteins, Mice, Mice, Inbred C57BL, Microtubule-Associated Proteins metabolism, Neoplasm Proteins, Neoplasms therapy, Prostaglandin-Endoperoxide Synthases genetics, RNA, Messenger analysis, Survivin, Genetic Therapy methods, Microtubule-Associated Proteins genetics, Neoplasms metabolism, Promoter Regions, Genetic genetics, Transcription, Genetic genetics
Abstract

It has been demonstrated that survivin, a novel member of the inhibitor of apoptosis (IAP) protein family, is expressed in human cancers but is undetectable in normal differentiated tissues. We employed a recombinant adenoviral vector (reAdGL3BSurvivin) in which a tumor-specific survivin promoter and a luciferase reporter gene were inserted into the E1-deleted region of adenovirus vector. Luciferase activity was measured in both multiple tumor cell lines and two primary melanoma cells infected with reAdGL3BSurvivin. Human fibroblast and mammary epithelial cell lines were used as negative controls. A reAdGL3CMV, containing the CMV promoter and luciferase gene, was used as a positive control to normalize the luciferase activity generated by the survivin promoter. Our data revealed that the survivin promoter showed high activity in both established tumor cell lines and the primary melanoma cells. In contrast, the in vivo studies indicated that the activities of survivin promoter were extremely low in the major mouse organs. The survivin promoter appears to be a promising tumor-specific promoter exhibiting a "tumor on" and "liver off" profile, and therefore, it may prove to be a good candidate for transcriptional targeting of cancer gene therapy in a wide variety of tumors.

Published
2004
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6. [Sero-epidemiological studies of rubella in Japan. 3. Neutralizing antibody level to rubella virus among inhabitants of Otsu City and its suburbs].

Author

Otawara M, Sato H, Shishido A, Yamaoto M, and Tokuchi M

Subjects
Adolescent, Adult, Age Factors, Child, Child, Preschool, Eye Diseases complications, Female, Humans, Infant, Infant, Newborn, Japan, Male, Maternal-Fetal Exchange, Measles immunology, Neutralization Tests, Pregnancy, Rubella complications, Rubella immunology, Antibodies analysis, Rubella epidemiology, Rubella virus immunology
Published
1968

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