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29. Chondromodulin-1 directly suppresses growth of human cancer cells

Author

Kondo Naoki, Yamagiwa Hiroshi, Kitahara Hiroshi, Hayami Tadashi, Ali Md, Ishibashi Osamu, Yoshizawa Tatsuya, Kawashima Hiroyuki, Mera Hisashi, Ogose Akira, and Endo Naoto

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Chondromodulin-1 (ChM1), an endogenous anti-angiogenic factor expressed in cartilage, has been suggested to inhibit invasion of endothelial cells into cartilage. In addition, the ectopic administration of ChM1 has been reported to suppress tumorigenesis in vivo. However, it is unclear whether the anti-tumor effect is due to not only the anti-vascularization effect of ChM1, but also its direct action against oncocytes. In the present study, we sought to determine whether ChM1 has a direct action on tumor cells. Methods BrdU incorporation assay was performed on human umbilical vein endothelial cells (HUVECs), normal human dermal fibroblasts (NHDFs), HepG2 cells and HeLa cells in the presence or absence of recombinant human ChM1 (rhChM1). An adenovirus that expresses ChM1, Ad-ChM1, was established and applied to the tumor xenografted in vivo, and to in vitro tumor cells cultured on plates or in soft agar. Cell cycle-related proteins and the phosphorylation of Erk, Akt, and GSK3β, the downstream molecules of the extracellular matrix-integrin signaling pathways, in HepG2 cells treated with or without Ad-ChM1 were detected by western blot analysis. Luciferase reporter assays of STAT, GAS, and ISRE, which participate in another cytokine signaling pathway, ware performed in HepG2, HeLa, and HUVEC cells. Results ChM1 suppressed BrdU incorporation in HUVECs and in HepG2 cells dose-dependently, but did not suppress BrdU incorporation in NHDFs and HeLa cells cultured on plates. In soft agar, however, ChM1 suppressed the growth of HeLa cells, as well as HepG2 cells. Western blot analyses demonstrated that ChM1 decreased the levels of cyclin D1, cyclin D3, and cdk6 and increased those of p21cip1 without affecting the phosphorylation levels of Erk, Akt, and GSK3β in HepG2 cells. The luciferase reporter assay demonstrated that ChM1 suppressed the transcriptional activities of STAT and GAS but not of ISRE. Conclusion ChM1 directly suppressed the proliferation of tumor cells in an anchorage-independent manner. However, ChM1 did not alter the phosphorylation of downstream molecules, at which the signaling pathways through growth factor and cytokine receptors converge with the anchorage-dependent pathway. Our results show that ChM1 has a direct anti-tumor effect; moreover, this effect occurs by inhibiting the STAT signaling pathway.

Published
2009
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30. Correlation between posterior tibial slope and sagittal alignment under weight-bearing conditions in osteoarthritic knees

Author

Mochizuki, Tomoharu, primary, Tanifuji, Osamu, additional, Koga, Yoshio, additional, Sato, Takashi, additional, Kobayashi, Koichi, additional, Watanabe, Satoshi, additional, Fujii, Toshihide, additional, Yamagiwa, Hiroshi, additional, Katsumi, Ryota, additional, Koga, Hiroshi, additional, Omori, Go, additional, and Endo, Naoto, additional

Published
2018
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31. Pycnodysostosis with a Cathepsin K Mutation : A Case Report

Author

YAMAGIWA, Hiroshi, ASAOKA, Mayumi, KATO, Hisayoshi, SHIBATA, Minoru, and ENDO, Naoto

Subjects
nonunion, Pycnodysostosis, mutation, cathepsin K, histomorphometric analysis
Abstract

Pycnodysostosis (PKND) is a type of osteosclerosing bone disease. Recent studies have demonstrated that several cathepsin K mutations can be identified in PKND families. A fifty-three-year-old Japanese woman diagnosed with PKND with typical features suffered from the nonunion of the right tibial shaft. We did open reduction and performed a vascularized fibular graft using an external fixator. A low-intensity pulsed ultrasound device was used three months after surgery. Union of the tibia was completed about one year after surgery. Histomorphometric analysis of the iliac bone revealed that the patient had low turnover bone with increased bone volume. Analysis of the cathepsin K coding region from the genomic DNA of the patient and her family (consanguineous parents and three sisters who were all of normal stature) revealed that the patient had a deletion of genomic DNA nucleotide 426 T in exon 5. Her parents and two sisters had a heterozygous mutation, while one sister had a normal sequence. In summary, a mutation in the cathepsin K gene was identified, providing further evidence that a deficiency in the activity of this enzyme causes PKND.

Published
2001

32. 胃転移を来した悪性神経鞘腫の1例

Author

Shigemori, Chika, Ikeda, Tetsuya, Yamagiwa, Hiroshi, and Suzuki, Hiroshi

Subjects
malignant schwannoma, gastric metastasis
Abstract

左上肢原発の悪性神経鞘腫が胃に転移した症例を報告する.症例は54歳の女性で,主訴は貧血である.10年前,左前腕背側の腫瘤に始まる悪性神経鞘腫で, 左上肢を切断されるも,再発,転移を来していた.昨年,Hb4.5g/dlと貧血を認め,精査にて胃の巨大粘膜下腫瘤を認めた.粘膜生検標本は腺管構造を欠くも,低分化な腫瘍細胞からなっていた.上肢悪性神経鞘腫患者に発症した胃癌と診断し手術を施行した.摘出標本は胃体下部から幽門部の潰瘍を伴う巨大な粘膜下腫瘍で,組織所見は,悪性神経鞘腫の所見を呈し,S-100蛋白陰性も,NSE陽性,デスミン,ビメンチン,アクチン,ミオシン抗体は陰性であった.この結果は上肢の原発巣と一致し,悪性神経鞘腫の胃転移と診断した.悪性神経鞘腫は軟部組織腫瘍の10%を占めるが,胃に転移した症例の報告はなく, 極めてまれな症例であると思われた., We present a very rare case of malignant schwannoma with gastric metastasis. A 54-year-old woman was admitted to the Department of Orthopedics due to local recurrence of malignant schwannoma in the left upper arm associated with lung metastasis. She underwent amputation of the left upper arm at 44 years of age. Examination of the severe anemia (Hb 4.5g/ml), as well as upper gastrointestinal fiberscopy (GIF) and upper gastrointestinal tract series (UGIS) were performed in our department. The findings showed a large tumor with ulceration in the stomach, but pathological findings from the biopsy specimen suspected poorly differentiated adenocarcinoma. Surgery was performed with a pre-operative diagnosis of gastric cancer and malignant schwannoma in the left upper arm. The tumor arose from the submucosal layer of the stomach, and occupied the antrum. Microscopic findings confirmed the diagnosis of malignant schwanoma in the left upper arm. The results of immunohistochemical staining of the specimens from the left upper arm and the stomach were also the same:S-100 protein (-), NSE (+). The final diagnosis was malignant schwannoma with gastric metastasis.

Published
1999

33. Sex differences in femoral deformity determined using three-dimensional assessment for osteoarthritic knees

Author

Mochizuki, Tomoharu, primary, Tanifuji, Osamu, additional, Koga, Yoshio, additional, Sato, Takashi, additional, Kobayashi, Koichi, additional, Nishino, Katsutoshi, additional, Watanabe, Satoshi, additional, Ariumi, Akihiro, additional, Fujii, Toshihide, additional, Yamagiwa, Hiroshi, additional, Omori, Go, additional, and Endo, Naoto, additional

Published
2016
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35. Abstracts of selected papers presented at the 28th Annual Meeting of the Japanese Society of Gastroenterology Kanazawa, Japan, October 1–3, 1986

Author

Ogura, Yoshifumi, Yamagiwa, Hiroshi, Tsuzuki, Toshiharu, Ogata, Yoshiro, Konishi, Ichiro, Nagakawa, Takukazu, Miyazaki, Itsuo, Todoroki, Takeshi, Iwasaki, Yoji, Tanaka, Junichi, Koyama, Kenji, Nakamura, Hiroshi, Nagamori, Seishi, Homma, Sadamu, Kameda, Haruo, Karasawa, E., Saotome, N., Sugiura, N., Miki, M., Kuniyasu, Y., Suyama, Masafumi, Ariyama, Joe, Koga, Michiaki, Yano, Michitami, Tanaka, N., Watanabe, Toshiaki, Ichida, Fumihiro, Yamada, Gotaro, Gibo, Yukio, Saito, Shinobu, Hisamitsu, Toju, Tameda, Yukihiko, Kikkawa, N., Yagyuu, T., Kikkawa, Nobuteru, Sakata, Yuh, Munakata, Akihiro, Fujita, Masahide, Taguchi, Tetsuo, Takahashi, Yutaka, Mai, Masayoshi, Yamaguchi, Toshiharu, Takahashi, Toshio, Noguchi, T., Hamano, K., Eguchi, Hideo, Sugahara, Katsuhiko, Kimura, Kouzaburo, Sarashina, Hiromi, Todoroki, Takeshi, Tanaka, Sachiko, Kitamura, Tsugio, Saito, Akiko, Obata, Hiroshi, Yoshida, Takanobu, Yoshino, Masahiro, Matsui, Osamu, Takashima, Tsutomu, Tokuyama, Katsuyuki, Jinno, Kenji, Kondo, Fukuo, Ebara, Masaaki, Sugihara, Shigetaka, Kojiro, Masamichi, Shoji, Masamitsu, Kobori, Ohichiro, Haruma, Ken, Tokutomi, Tadashi, Saito, T., Kobayashi, M., Shirohzu, Genzan, Kakegawa, Teruo, Yamaki, Goro, Maruyama, Toshihide, Sugihara, Takashi, Mitomi, Toshio, Yamada, Akiyoshi, Itoh, Tadahiko, Yoshida, Tomoharu, Udagawa, Harushi, Tsurumaru, Masahiko, Yasui, Akihiro, Nimura, Yuji, Ri, Sigen, Nabeya, Kin-Ichi, Fujita, Hideharu, Noto, Hirofumi, Sano, Fumio, Uchino, Junichi, Kawaura, Yukimitsu, Mori, Yoshihiro, Kano, Tomoyuki, Ito, Yoshiaki, Hishikawa, Yoshio, Miura, Takashi, Karaki, Yoshiaki, Fujimaki, Masao, Kashiwagi, Toni, Koizumi, Takeo, Hata, Yoshinobu, Itoh, Kazuo, Sato, Shizou, Mimura, Hisashi, Kuniyasu, Yoshio, Takada, Tadanori, Nakajima, Michiko, Itoh, Susumu, Bando, Tsuyoshi, Tanaka, Michio, Aibe, Tsuyoshi, Fujimura, Hiroshi, Hayashi, Yoshiki, Kimoto, Eizo, Ohishi, Hajime, Morita, Tomofumi, Sugano, Shigeo, Abei, Tohru, Ikari, T., Ariyama, J., Ibuki, Yoshikazu, Kuronuma, Yukio, Kodama, Takahiro, Numa, Yoshinori, Saito, K., Kasukawa, R., Kagawa, Hiroyuki, Nishioka, Mikio, Imai, Haruhiko, Kiyosawa, Kendo, Abe, Hirohiko, Tanikawa, Kyuichi, Furusawa, Akihiko, Takase, Kojiro, Kosaka, Yoshitane, Higuchi, Kiyohiro, Matsui, Shinjiro, Watanabe, Satoshi, Ichida, Fumihiro, Kato, Yasuhiro, Shimizu, Masanori, Yuh, Kouichi, Yagisawa, Hitoshi, Komatsu, Masafumi, Maeda, Takashi, Miyazaki, Masako, Ishii, Hideo, Usui, Kou, Oda, M., Komatsu, H., Mizoguchi, Yasuhiro, Kuroki, Tetsuo, Mori, Yoshio, Ogawa, Makoto, Mori, Teruo, Ueda, Shiro, Yoshida, Hiromichi, Wakashin, Yoko, Wakashin, Masafumi, Okuda, Kunio, Watanabe, Yasuyuki, Kawakami, Hiroiku, Nonomura, Akitaka, Ohta, Goroku, Suzuki, Hiroshi, Takino, Tatsuro, Kawaguchi, Hideki, Ichida, Fumihiro, Hinoue, Yoshinobu, Unoura, Masashi, Mizoguchi, Yasuhiro, Kagawa, Hiroyuki, Nishioka, Mikio, Arakawa, Yasuyuki, Amaki, Schuichi, Ikeda, Kenji, Kumada, Hiromitsu, Ikeda, Toshio, Tarao, Kazuo, Nakano, Masami, Saito, Shozo, Takahashi, Akira, Shimamura, Yoshiyuki, Matsuda, Yoshiro, Yasuhara, Minoru, Matsuo, Yutaka, Miyake, Takeo, Matsuo, Y., Watanabe, Akiharu, Nei, Jinichi, Matsuda, Yoshiro, Iwasaki, Ariyoshi, Sugimura, Fumiaki, Yamagata, Susumu, Arakawa, Tetsuo, Kobayashi, Kenzo, Miyamoto, Shintaro, Yukawa, Eiyo, Kitajima, Masaki, Seki, Manabu, Murakami, M., Kobayashi, Y., Mizuno, M., Yoo, J. K., Saita, H., Inoue, R., Inada, M., Miyake, T., Hirai, Nobuyuki, Tanaka, Nobuyoshi, Miyake, Takeo, Ando, Keijiro, Sanuki, Kazutoshi, Inui, Kazuo, Nakazawa, Saburo, Tanaka, Ryoji, Ukida, Minoru, Miyashita, Tadashi, Tobe, Takayoshi, Kosen, Kenzo, Takahashi, Hiroshi, Kadota, Toshio, Tamakuma, Shouetsu, Kitano, Seigo, Sugimachi, Keizo, Nakao, Akimasa, Takagi, Hiroshi, Sawai, Kiyoshi, Takahashi, Toshio, Kusano, Toshiomi, Furukawa, Masato, Yamane, Tetsuro, Takahashi, Toshio, and Iida, Shuhei

Published
1987
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39. Proceedings of the 27th Annual Meeting Matsuyama, Japan, November 7–9, 1985

Author

Rogler, C. E., Muto, Yoshihiro, Uchimura, Masayuki, Kijima, Hiroshi, Watanabe, Hidenobu, Kakita, A., Kambayashi, M., Takahashi, T., Saji, Y., Tsuburaya, T., Uchino, J., Ogura, Yoshifumi, Yamagiwa, Hiroshi, Takehara, Y., Yamashita, K., Shimaguchi, Seikoh, Ariyama, Joe, Tomatsu, Sei, Oi, Itaru, Fuji, Tadasu, Noguchi, Takayoshi, Yamao, Kenji, Nakazawa, Saburo, Suzuki, H., Mizumoto, R., Kumon, Masamitu, Ogata, Takuro, Yamamoto, Kenichi, Sasaki, Kenichi, Kida, Hideo, Nimura, Yuji, Hayakawa, Naokazu, Kamiya, Junichi, Shionoya, Shigehiko, Hata, Yoshinobu, Uchino, Jun-Ichi, Yamane, Takaaki, Mori, Katsutaka, Kinoshita, Hiroaki, Inoue, Tadashi, Takayasu, Kenichi, Moriyama, Noriyuki, Makuuchi, Masatoshi, Takasaki, Ken, Tanaka, Seiichi, Shirakawa, K., Misaki, F., Shibue, Tadashi, Tanaka, Keizo, Asaka, Masahiro, Saito, Masao, Yamagata, Susumu, Utiyama, Yasuo, Kobayashi, K., Arakawa, T., Matsueda, Kei, Muraoka, Akira, Umeda, Noritsugu, Mizumachi, Shyuzi, Okita, Kiwamu, Sakaue, Hiroshi, Akamatsu, Kouichi, Aoki, Teruaki, Nagao, Fusahiro, Watanabe, Yozo, Kidokoro, Tsutomu, Nakano, Satoshi, Kumada, Takashi, Kondo, Takaharu, Hayakawa, Tetsuo, Ogawa, Michio, Matsuda, Yasuki, Mori, Takesada, Yasuda, Hideki, Atomi, Yutaka, Ohnishi, Norihito, Kuroda, Akira, Morioka, Yasuhiko, Satake, Katsusuke, Tsuchiya, Ryoichi, Isaji, Shuji, Mizumoto, Ryuji, Yamamoto, Masahiro, Saitoh, Yoichi, Takeda, Kazunori, Taguchi, Susumu, Funatomi, Hitoshi, Hatta, Yoshio, Ono, Mikiko, Itoshima, Tatsuya, Tanaka, Ryoji, Sato, Shunichi, Sugaya, Hitoshi, Futagawa, Shunji, Kobayashi, Kenichi, Kawasaki, Hironaka, Akamatsu, Kouichi, Ohkubo, Hirotada, Kawarada, Yoshifumi, Mizumoto, Ryuji, Hirasawa, Hiroyuki, Odaka, Michio, Isono, Kaichi, Miura, Soichiro, Hamada, Yoshiki, Bamba, Tadao, Chikamochi, Nobuo, Nezu, R., Okada, A., Okuno, Masahiro, Umeyama, Kaoru, Hiwatashi, Nobuo, Nakajima, Kazuyuki, Fuchigami, Tadahiko, Yao, Tsuneyoshi, Matsueda, Kei, Takazoe, Masakazu, Shoda, Ryosuke, Umeda, Noritsugu, Fukushima, T., Kawamoto, M., Mizutani, Kenji, Nakai, Katsuhiko, Aoki, Katsunori, Morioka, Satoru, Baba, Shozo, Sakamoto, Akio, Usui, Sadahito, Fukuda, Yoshihiro, Tamura, Kazutami, Watanabe, Hikaru, Ueno, Takato, Tanikawa, Kyuichi, Oda, Masaya, Morizane, Toshio, Hashimoto, Hiroyuki, Akamatsu, Kouichi, Shimizu, Ichiro, Shima, Kenji, Sasaki, Kohsuke, Okita, Kiwamu, Suzuki, Toshimitsu, Seto, Yoshifumi, Nakashima, Toshiaki, Kiyosawa, Kendo, Imai, Haruhiko, Shimizu, Yukihiro, Sasaki, Hiroshi, Mori, Teruo, Mori, Yoshio, Ogawa, Makoto, Wakashin, Masafumi, Okuda, Kunio, Kawamoto, Chiaki, Ido, Kenichi, Fujise, Kiyotaka, Nagamori, Seishi, Fujikura, Shinichiro, Shimada, Kazuhiko, Yamaguchi, Kazuhito, Fujimura, Yoshinori, Kihara, Tsuyoshi, Kitamura, Hironobu, Fujiyama, Yoshihide, Asakura, Hitoshi, Kobayashi, Kensuke, Nagura, Hiroshi, Koshikawa, Takashi, Murata, Yuji, Kuroe, Kiyoo, Kawanishi, H., Koyama, K., Senda, S., Kiely, J., Harima, Kazuo, Fuji, Tadasu, Furukawa, Masato, Nakata, Toshinori, Kawahara, Hiroyuki, Komi, Nobuhiko, Ishihara, Yukio, Kondo, Satoshi, Nimura, Yuji, Suda, Koichi, Miyano, Takeshi, Inui, Kazuo, Ohnuma, Toshikazu, Hata, Yoshinobu, Uchino, Jun-Ichi, Yamamichi, Noboru, Konishi, Fumio, Morita, Nobuto, Tanikawa, Yutaka, Kitani, Eiichi, Tamura, Toshikazu, Komi, Nobuhiko, Ohta, Tetsuo, Konishi, Kohji, Utsumi, Makoto, Ueda, Noriyuki, Sasaki, Hideto, Ogura, Yoshifumi, Kawamoto, Toshio, Horiuchi, Itaru, Tada, Kouji, Akamatsu, Kouichi, Nakai, Teiko, Yamashita, Katsuko, Ninomiya, Fuyuhiko, Tanikawa, Kyuichi, Naito, Yasuo, Morita, Keiichi, Hachiya, Hitoshi, Takeuchi, Toshihiko, Onuki, Keizo, Ozaki, Toshihiko, Tsuchiya, Y., Nakamura, H., Nagashima, Hideyuki, Matsushiro, Takashi, Nakai, Masahiro, Isaji, Shuji, Takeuchi, K., Watanabe, G., Ito, T., Idezuki, Y., Isogai, Masatoshi, and Hachisuka, Kitao

Published
1986
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41. Proceedings of the 72nd general meeting Niigata, Japan, March 27–29, 1986

Author

Uchida, Katsuyuki, Watanabe, Hidenobu, Inui, K., Nakazawa, S., Suyama, Masafumi, Ariyama, Joe, Kakita, Akira, Kambayashi, Masaaki, Takahashi, Tsuyoshi, Saji, Yutaka, Takahashi, Masatoshi, Tsuburaya, Toshihiko, Uchino, Junichi, Ogura, Yoshifumi, Yamagiwa, Hiroshi, Wada, Yoshiyuki, Nagai, Hideo, Kuroda, Akira, Morioka, Yasuhiko, Yoshikawa, Tatsuya, Hanyu, Fujio, Tsunoda, Tsukasa, Tsuchiya, Ryoichi, Ouchi, Kiyoaki, Sato, Toshio, Kawaguchi, Hidehiro, Yoshida, Keisuke, Ishihara, Yukio, Sugiyama, Masanori, Kimura, Toshinari, Ibayashi, Hiroshi, Isaji, Shuji, Mizumoto, Ryuji, Ogawa, Michio, Mori, Takesada, Koizumi, Masaru, Fukao, Akira, Oguchi, Hisao, Kawa, Shigeyuki, Takemori, Yasuhiro, Sawabu, Norio, Ichihara, Toru, Nakao, Akimasa, Ishii, Hiromasa, Shigeta, Yohsuke, Matsuda, Yoshiro, Yasuhara, Minoru, Omata, Masao, Ito, Yoshimi, Takahashi, Toru, Himori, Masakado, Kamimura, Tomoteru, Ichida, Fumihiro, Koyama, Wataru, Hasumura, Yasushi, Inagaki, Takao, Sawaki, Shunji, Ichinohe, Akira, Itoh, Susumu, Komatsu, Masafumi, Tobori, Fumio, Inoue, Kyoichi, Aoyama, Keiichi, Abe, Hirohiko, Yamauchi, Kazuaki, Ohishi, Saburo, and Saibara, Toshiji

Published
1986
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43. Association between anteroposterior laxity in mid-range flexion and subjective healing of instability after total knee arthroplasty.

Author

Mochizuki, Tomoharu, Tanifuji, Osamu, Sato, Takashi, Hijikata, Hiroki, Koga, Hiroshi, Watanabe, Satoshi, Higano, Yukimasa, Ariumi, Akihiro, Murayama, Takayuki, Yamagiwa, Hiroshi, and Endo, Naoto

Subjects
JOINT hypermobility, TOTAL knee replacement reoperation, ARTIFICIAL knees, TOTAL knee replacement, HEALING, RANGE of motion of joints, KNEE surgery, KNEE, KNEE diseases, OSTEOARTHRITIS, WOUND healing, DIAGNOSIS
Abstract

Purpose: Flexion instability following total knee arthroplasty (TKA) is a common indication of early revision. The association between the objective anteroposterior (AP) laxity direction in mid-range flexion and the subjective healing of instability remains unclear; thus, this study aimed to clarify this association.Methods: In this study, 110 knees (74 females, 92 knees; 16 males, 18 knees) with medial pivot implants were examined with a median age of 79 (range 60-92) years for a median follow-up duration of 22 (range 6-125) months. AP laxity was measured using a KT-1000 arthrometer. Self-reported knee instability score was used for the subjective healing of instability.Results: Eighty-seven knees did not feel unstable (Group 0), whereas 23 knees felt unstable (Group 1). There was a significant difference in AP displacement [Group 0: median 6 mm; range 2-15 mm and Group 1: median 8 mm; range 4-14; p < 0.0001]. The threshold value of 7 mm was determined using the area under receiver operating characteristic curve of 0.79 [95% confidence interval (CI) 0.69-0.88, p < 0.0001]. In multivariate analysis, AP displacement of ≥7 mm was an independent risk factor for feelings of instability (odds ratio 7.695; 95% CI 2.306-25.674; p = 0.001).Conclusions: AP laxity of ≥7 mm represents a known cause of feelings of instability. By controlling AP laxity in TKAs, without stiffness in the knee, it is possible to prevent feelings of instability. The clinical relevance is that AP laxity of <7 mm is one of the target areas in TKA.Level Of Evidence: IV. [ABSTRACT FROM AUTHOR]

Published
2017
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45. 1 関節鏡視下手術の現況と今後(各科における鏡視下手術の現状と今後 (2009年),第651回新潟医学会)

Author

山際, 浩史, Yamagiwa, Hiroshi, 山際, 浩史, and Yamagiwa, Hiroshi

Abstract

関節鏡視下手術は, 関節切開下の手術に比べて低侵襲であり, 術後の回復が早く疼痛が少ない, 術野や組織が拡大されるため正確で精密な処置が可能, と行った利点があり, 人体のほぼすべての関節の疾患に対して広く行われるようになっている. 特に膝関節・足関節を中心とするスポーツに関連した外傷/障害の治療に対して, 関節鏡なくしては手術治療が成立しない. 今後の課題として, 特に若手医師のトレーニンングをどのようにしてすすめるか, 術中ナビゲーションの応用, 生物学的治癒の促進をはかる方法の開発, などがあり, これらの進歩をふまえてさらに適応が拡大されて行く可能性を秘めている.

Published
2012

46. Kinematics of the knee after unicompartmental arthroplasty is not the same as normal and is similar to the kinematics of the knee with osteoarthritis

Author

Mochizuki, Tomoharu, primary, Sato, Takashi, additional, Blaha, John David, additional, Tanifuji, Osamu, additional, Kobayashi, Koichi, additional, Yamagiwa, Hiroshi, additional, Watanabe, Satoshi, additional, Matsueda, Munenori, additional, Koga, Yoshio, additional, Omori, Go, additional, and Endo, Naoto, additional

Published
2013
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48. Chondromodulin-1 directly suppresses growth of human cancer cells

Author

Mera, Hisashi, primary, Kawashima, Hiroyuki, additional, Yoshizawa, Tatsuya, additional, Ishibashi, Osamu, additional, Ali, Md Moksed, additional, Hayami, Tadashi, additional, Kitahara, Hiroshi, additional, Yamagiwa, Hiroshi, additional, Kondo, Naoki, additional, Ogose, Akira, additional, and Endo, Naoto, additional

Published
2009
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