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7. Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell–mediated inflammation in the skin

Author

Takahashi, H., primary, Nomura, H., additional, Iriki, H., additional, Kubo, A., additional, Isami, K., additional, Mikami, Y., additional, Mukai, M., additional, Sasaki, T., additional, Yamagami, J., additional, Kudoh, J., additional, Ito, H., additional, Kamata, A., additional, Kurebayashi, Y., additional, Yoshida, H., additional, Yoshimura, A., additional, Sun, H. W., additional, Suematsu, M., additional, O’Shea, J. J., additional, Kanno, Y., additional, and Amagai, M., additional

Published
2021
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10. Analysis of clinical characteristics, prognosis and antibody pathogenicity of pemphigus patients positive for anti‐desmoglein IgG autoantibodies in remission: a retrospective cohort study.

Author

Zhao, W.L., Ishii, K., Egami, S., Xu, Z., Funakoshi, T., Takahashi, H., Tanikawa, A., Ishiko, A., Amagai, M., and Yamagami, J.

Subjects
PEMPHIGUS, AUTOANTIBODIES, IMMUNOGLOBULIN G, ANTIBODY titer, COHORT analysis, IMMUNOGLOBULINS
Abstract

Background: The detection of serum anti‐desmoglein (Dsg) IgG autoantibodies has been reported to be useful for assessment of disease activity in pemphigus. However, previous studies have reported that anti‐Dsg autoantibodies remain detectable in some patients without active pemphigus lesions. Objectives: To investigate the clinical characteristics and antibody pathogenicity of pemphigus patients positive for anti‐Dsg IgG autoantibodies in remission. Methods: We retrospectively investigated pemphigus patients with a history of clinical remission who visited the Department of Dermatology of Keio University during 2019 and 2020. The antibody pathogenicity was assessed by bead aggregation assay. Results: When patients were recognized as having entered remission (PDAI = 0 and PSL ≦ 10 mg/day for 2 months), serum autoantibodies against Dsg were detected in 72 of 132 patients (54.5%, positive group; PG), but were not detected in 60 patients (45.5%, negative group; NG). Anti‐Dsg antibody titres in remission declined from the active phase in 33 patients in the PG for whom data were available. There were no differences in the chance of reducing PSL to 5 mg/day (P = 0.885) and rate of relapse (P = 0.279) between PG and NG, but fewer patients in PG discontinued corticosteroids (P = 0.004). The ability of patients' sera to block aggregation of Dsg/desmocollin beads was significantly reduced in remission compared to the active phase. However, our results revealed that whole sera in remission still had pathogenic activity in seven of nine patients, and the approximately equal amounts of anti‐Dsg antibodies in active phase and remission showed similar pathogenicity. Conclusions: This study will provide guidance in cases where autoantibodies are found to be positive in pemphigus patients during remission or steroid reduction. [ABSTRACT FROM AUTHOR]

Published
2022
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20. Inter‐rater reliability of the BIOCHIP indirect immunofluorescence dermatology mosaic in bullous pemphigoid and pemphigus patients

Author

Yang, A., primary, Xuan, R.R., additional, Melbourne, W., additional, Hashimoto, T., additional, Uzun, S., additional, Daneshpazhooh, M., additional, Yamagami, J., additional, Di Zenzo, G., additional, Mascaro, J.M., additional, Mahmoudi, H., additional, Patsatsi, A., additional, Drenovska, K., additional, Vassileva, S., additional, and Murrell, D.F., additional

Published
2019
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25. Basement membrane zone IgE deposition is associated with bullous pemphigoid disease severity and treatment results.

Author

Kamata, A., Kurihara, Y., Funakoshi, T., Takahashi, H., Kuroda, K., Hachiya, T., Amagai, M., and Yamagami, J.

Subjects
BULLOUS pemphigoid, BASAL lamina, THERAPEUTICS, ENZYME-linked immunosorbent assay, PATHOLOGY, SERUM
Abstract

Summary: Background: A subset of patients with bullous pemphigoid (BP) show deposition of IgE in the basement membrane zone (BMZ), yet the relationship between BMZ IgE and the clinical presentation of BP remains unclear. Objectives: To investigate the relationship between IgE deposition, IgE levels in serum, and disease severity in patients with BP. Methods: We investigated IgE autoantibodies in 53 patients with BP by direct immunofluorescence (DIF), indirect immunofluorescence and enzyme‐linked immunosorbent assay. Results: Of 53 patients with BP, 23 (43%) had IgE deposition, 10 (19%) of whom were IgE+ and 13 (25%) IgE± according to DIF analyses. Erosion/blister (E/B) Bullous Pemphigoid Disease Area Index (BPDAI) scores were significantly higher in IgE+ patients than in IgE− patients (n = 15), while no significant differences were found for urticaria/erythema BPDAI scores. IgE+ and IgE± patients took longer to reduce their E/B BPDAI score by 75% after systemic corticosteroid treatment. BP180‐IgE levels were significantly higher among IgE+ patients than IgE± or IgE− patients (n = 10). Total IgE levels in the serum and blood eosinophil counts did not differ between IgE+, IgE± and IgE− patients. A significant correlation was detected between BP180‐IgG and BP180‐IgE, but not between BPDAI scores and any of BP180‐IgG, BP180‐IgE or blood eosinophil count. Conclusions: IgE deposition in the BMZ is associated with higher E/B BPDAI scores and longer treatment periods. We conclude that IgE binding in the BMZ may contribute to BP pathogenesis by promoting blister formation. What's already known about this topic? BP180‐IgE autoantibodies have an important role in the pathogenesis of bullous pemphigoid (BP).A subset of patients with BP display deposition of IgE within the basement membrane zone (BMZ) of skin tissue. What does this study add? Patients with in vivo IgE deposition in the BMZ displayed higher erosion/blister Bullous Pemphigoid Disease Area Index (BPDAI) scores, while urticaria/erythema BPDAI scores were not significantly different.Patients with in vivo IgE deposition in the BMZ took longer to reduce their erosion/blister BPDAI score by 75% after systemic corticosteroid treatment.BP180‐specific IgE levels in serum were higher among patients with linear IgE deposition in the BMZ than in those with granular or no IgE deposition. Respond to this article Plain language summary available online [ABSTRACT FROM AUTHOR]

Published
2020
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27. Azathioprine-induced alopecia and leukopenia associated with NUDT15 polymorphisms

Author

Nomura, H., primary, Kurihara, Y., additional, Saito, M., additional, Fukushima, A., additional, Shintani, Y., additional, Shiiyama, R., additional, Toshima, S., additional, Kamata, A., additional, Yamagami, J., additional, Funakoshi, T., additional, Kameyama, K., additional, Amagai, M., additional, Kubo, A., additional, and Umegaki-Arao, N., additional

Published
2018
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31. Unique clinical and serological features of bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitors

Author

Horikawa, H., primary, Kurihara, Y., additional, Funakoshi, T., additional, Umegaki-Arao, N., additional, Takahashi, H., additional, Kubo, A., additional, Tanikawa, A., additional, Kodani, N., additional, Minami, Y., additional, Meguro, S., additional, Itoh, H., additional, Izumi, K., additional, Nishie, W., additional, Shimizu, H., additional, Amagai, M., additional, and Yamagami, J., additional

Published
2018
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32. 053 Autoantibodies in vancomycin-induced linear IgA bullous dermatosis target type VII collagen in the presence of vancomycin

Author

Yamagami, J., primary, Nakamura, Y., additional, Nagao, K., additional, Funakoshi, T., additional, Takahashi, H., additional, Tanikawa, A., additional, Hachiya, T., additional, Yamamoto, T., additional, Ishida-Yamamoto, A., additional, Tanaka, T., additional, Nishigori, C., additional, Ishii, N., additional, Hashimoto, T., additional, and Amagai, M., additional

Published
2017
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41. Changes in ocular surface caused by antiglaucomatous eyedrops: prospective, randomised study for the comparison of 0.5% timolol v 0.12% unoprostone

Author

Shimazaki, J., Hanada, K., Ishioka, M., Shimmura, S., Tsubota, K., and Yamagami, J.

Abstract

AimTo study changes induced in ocular surface epithelia and the tear film by antiglaucomatous eyedrops. A β blocker (0.5% timolol) and a novel prostaglandin F2α metabolite related drug (0.12% unoprostone) were examined in a prospective, randomised fashion.Methods40 patients were randomly assigned to use either 0.5% timolol (timolol group) or 0.12% unoprostone eyedrops (unoprostone group) twice a day for 24 weeks. In addition to routine ocular examinations, corneal epithelial integrity (vital staining tests, tear film break up time (BUT), anterior fluorometry, specular microscopy) and tear function (Schirmer's test, cotton thread test, tear clearance test (TCT)) were examined before and after the treatment.ResultsBoth eyedrops caused significant reduction in intraocular pressure from the baseline levels. No significant changes were noted in corneal integrity in both groups, except a decrease in BUT at 20 weeks in the timolol group. The timolol group demonstrated significant decreases in Schirmer's test, tear clearance test, and tear function index (Schirmer's test value multiplied by clearance test); however, no such changes were noted in the unoprostone group.ConclusionWhile unoprostone eyedrops caused no adverse effects on the corneal epithelial integrity and tear function, timolol caused significant impairments in tear production and turnover.

Published
2000

42. Trabeculectomy with mitomycin C for post-keratoplasty glaucoma

Author

Ishioka, M., Shimazaki, J., Fujishima, H., Shimmura, S., Tsubota, K., and Yamagami, J.

Abstract

AimTo investigate the effect of trabeculectomy with and without mitomycin C in post-keratoplasty glaucoma.MethodsA retrospective study was performed on patients who underwent trabeculectomy for glaucoma after penetrating keratoplasty. 34 eyes of 32 patients were included in this study. 26 eyes received trabeculectomy with mitomycin C and eight eyes without mitomycin C. The procedure was deemed successful if the intraocular pressure was maintained below 21 mm Hg with or without use of additional antiglaucoma medication (mean follow up time 22.3 (SD 10.3) months).ResultsAt the last examination trabeculectomy was successful in 19 of 26 eyes (73.0%) with mitomycin C (+) and two of eight (25.0%) without (p=0.0219). When the prognosis was analysed by Kaplan-Meier curve, the mitomycin C (+) group showed a better prognosis (p=0.0182). Mean intraocular pressure and average number of glaucoma medications improved in the group with mitomycin C without severe side effects on the graft. Graft rejection after trabeculectomy was seen in two eyes in the mitomycin C group. Final graft clarity rate was 69.2% (18/26) in the mitomycin C (+) group and 37.5% (3/8) in the mitomycin C (-) group. Complications such as persistent epithelial defect, cystoid macular oedema, choroidal detachment, leakage from bleb were seen in four eyes in the mitomycin C (+) group and in one eye in the mitomycin C (-) group.ConclusionsTrabeculectomy with mitomycin C showed better results for glaucoma following keratoplasty.

Published
2000

43. [Combined posterior chamber intraocular lens implantation and trabeculectomy--a life-table analysis of postoperative clinical course]

Author

Yamagami S, Araie M, Shimizu K, Miyuki Nagahara, Shirato S, Yamagami J, Koseki N, Takenaka Y, and Kohda F

Subjects
Lenses, Intraocular, Male, Survival Rate, Humans, Female, Life Tables, Trabeculectomy, Fluorouracil, Prognosis, Intraocular Pressure, Vision, Ocular, Aged, Retrospective Studies
Abstract

Postoperative courses of 68 eyes of 58 glaucoma patients who underwent posterior chamber intraocular lens implantation combined with trabeculectomy were studied retrospectively. The visual acuity was 0.5 or better in 66% of the eyes at 3 months postoperatively. The average intraocular pressure (IOP) was below 15 mmHg till 16 months postoperatively. An analysis of the postoperative course using the life-table method of Kaplan-Meier revealed that the probability of successful IOP control with medication was 83% at 18 months and 47% without medication. The subjects aged 75 years or older showed significantly higher success probability than those younger than 75 years, while types of glaucoma, the preoperative IOP control, location of conjunctival or sclerocorneal incision, postoperative 5-fluorouracil (5-FU) injections or surgical intervention on the iris had no significant effects on the probability of successful IOP control. The probability of subsistence of functional filtering bleb was 24% at 18-month follow-up, on which postoperative administration of 5-FU of 35 mg or more had a favorable effect.

44. EFFECTS OF I.P.P.B. THERAPY ON SILICOTIC PATIENTS

Author

ONISHI, S., primary, ABE, A., additional, OKAMOTO, T., additional, SASAKI, T., additional, TANIMORI, H., additional, TOYOFUKU, Y., additional, MATSUSHIMA, T., additional, YAMAGAMI, J., additional, and YAMAMOTO, H., additional

Published
1959
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47. Quantitative assessment of tumour extraction from dermoscopy images and evaluation of computer-based extraction methods for an automatic melanoma diagnostic system

Author

Seiichiro Kobayashi, Ayako Miyake, Hitoshi Iyatomi, H. Peter Soyer, Giuseppe Argenziano, Masayuki Kimoto, Hiroshi Oka, Akiko Tanikawa, Jun Yamagami, Koichi Ogawa, Masaru Tanaka, Masafumi Hagiwara, Masataka Saito, Iyatomi, H, Oka, H, Saito, M, Miyake, A, Kimoto, M, Yamagami, J, Kobayashi, S, Tanikawa, A, Hagiwara, M, Ogawa, K, Argenziano, Giuseppe, Soyer, Hp, and Tanaka, M.

Subjects
Cancer Research, medicine.medical_specialty, Skin Neoplasms, Diagnostic accuracy, Dermatology, Diagnostic system, Sensitivity and Specificity, Image Processing, Computer-Assisted, medicine, Quantitative assessment, Humans, skin and connective tissue diseases, Melanoma, Receiver operating characteristic, business.industry, Computer based, Reproducibility of Results, Pattern recognition, Thresholding, Surgery, ROC Curve, Oncology, Area Under Curve, Extraction methods, Artificial intelligence, Precision and recall, business, Algorithms
Abstract

The aims of this study were to provide a quantitative assessment of the tumour area extracted by dermatologists and to evaluate computer-based methods from dermoscopy images for refining a computer-based melanoma diagnostic system. Dermoscopic images of 188 Clark naevi, 56 Reed naevi and 75 melanomas were examined. Five dermatologists manually drew the border of each lesion with a tablet computer. The inter-observer variability was evaluated and the standard tumour area (STA) for each dermoscopy image was defined. Manual extractions by 10 non-medical individuals and by two computer-based methods were evaluated with STA-based assessment criteria: precision and recall. Our new computer-based method introduced the region-growing approach in order to yield results close to those obtained by dermatologists. The effectiveness of our extraction method with regard to diagnostic accuracy was evaluated. Two linear classifiers were built using the results of conventional and new computer-based tumour area extraction methods. The final diagnostic accuracy was evaluated by drawing the receiver operating curve (ROC) of each classifier, and the area under each ROC was evaluated. The standard deviations of the tumour area extracted by five dermatologists and 10 non-medical individuals were 8.9% and 10.7%, respectively. After assessment of the extraction results by dermatologists, the STA was defined as the area that was selected by more than two dermatologists. Dermatologists selected the melanoma area with statistically smaller divergence than that of Clark naevus or Reed naevus (P = 0.05). By contrast, non-medical individuals did not show this difference. Our new computer-based extraction algorithm showed superior performance (precision, 94.1%; recall, 95.3%) to the conventional thresholding method (precision, 99.5%; recall, 87.6%). These results indicate that our new algorithm extracted a tumour area close to that obtained by dermatologists and, in particular, the border part of the tumour was adequately extracted. With this refinement, the area under the ROC increased from 0.795 to 0.875 and the diagnostic accuracy showed an increase of approximately 20% in specificity when the sensitivity was 80%. It can be concluded that our computer-based tumour extraction algorithm extracted almost the same area as that obtained by dermatologists and provided improved computer-based diagnostic accuracy.

Published
2006

50. A case of IgA pemphigus with acantholysis in oral mucosal lesions.

Author

Yamanishi A, Ono N, Tsunoda A, Asahina Y, Fusumae T, Yamagami J, Sakai N, Ishii N, Amagai M, and Takahashi H

Abstract

IgA pemphigus is an autoimmune bullous disease caused by anti-keratinocyte cell surface IgA autoantibodies. Mucous membrane involvement is rare in IgA pemphigus. We report a case of IgA pemphigus with oral mucosal lesions, in which acantholysis was pathologically confirmed. A 31-year-old woman presented with skin erythema with small pustules and oral mucosal erosions. Histopathological examination of the erosions on her oral mucosa and papules on her back revealed acantholysis and intraepidermal infiltration of neutrophils. Direct immunofluorescence tests showed intercellular deposition of IgA, but not IgG, mainly in the lower, but not entire, layer of the epidermis. C3 was linearly present in the basement membrane zone (BMZ), but not in the intercellular space. Enzyme-linked immunosorbent assay revealed that both anti-desmoglein (Dsg) 3 IgA and IgG were positive. Neither IgA nor IgG against desmocollin 1-3 were detected. This case was clinically and histologically compatible with IgA pemphigus, but immunologically anti-BMZ autoimmunity was additionally observed. IgA pemphigus is classified into two major types: subcorneal pustular dermatosis type and intraepidermal neutrophilic dermatosis type. This case was not typical in terms of rarely observed oral lesions and predominant deposition of IgA in the lower layer of the epidermis. Instead, this case could be considered a rare subtype of IgA pemphigus, IgA-pemphigus vulgaris. Oral lesions in IgA pemphigus may be clinical clue of having anti-Dsg3 IgA that cannot be routinely examined., Competing Interests: The authors declare no conflicts of interest., (© 2024 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.)

Published
2024
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