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10 results on '"Yamadi, Maryam"'

1. Gα13 restricts nutrient driven proliferation in mucosal germinal centers

Author

Nguyen, Hang T., Li, Moyi, Vadakath, Rahul, Henke, Keirstin A., Tran, Tam C., Li, Huifang, Yamadi, Maryam, Darbha, Sriranjani, Yang, Yandan, Kabat, Juraj, Albright, Anne R., Centeno, Enoc Granados, Phelan, James D., Roulland, Sandrine, Huang, Da Wei, Kelly, Michael C., Young, Ryan M., Pittaluga, Stefania, Difilippantonio, Simone, and Muppidi, Jagan R.

Published
2024
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6. Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma

Author

Razzaghi, Raud, primary, Agarwal, Shreya, additional, Kotlov, Nikita, additional, Plotnikova, Olga, additional, Nomie, Krystle, additional, Huang, Da Wei, additional, Wright, George W., additional, Smith, Grace A., additional, Li, Moyi, additional, Takata, Katsuyoshi, additional, Yamadi, Maryam, additional, Yao, Chen, additional, O’Shea, John J., additional, Phelan, James D., additional, Pittaluga, Stefania, additional, Scott, David W., additional, and Muppidi, Jagan R., additional

Published
2020
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7. Regional sequence expansion or collapse in heterozygous genome assemblies

Author

Asalone, Kathryn C., primary, Ryan, Kara M., additional, Yamadi, Maryam, additional, Cohen, Annastelle L., additional, Farmer, William G., additional, George, Deborah J., additional, Joppert, Claudia, additional, Kim, Kaitlyn, additional, Mughal, Madeeha Froze, additional, Said, Rana, additional, Toksoz-Exley, Metin, additional, Bisk, Evgeny, additional, and Bracht, John R., additional

Published
2020
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8. Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma

Author

Razzaghi, Raud, Agarwal, Shreya, Kotlov, Nikita, Plotnikova, Olga, Nomie, Krystle, Huang, Da Wei, Wright, George W., Smith, Grace A., Li, Moyi, Takata, Katsuyoshi, Yamadi, Maryam, Yao, Chen, O’Shea, John J., Phelan, James D., Pittaluga, Stefania, Scott, David W., and Muppidi, Jagan R.

Abstract

Fas is highly expressed on germinal center (GC) B cells, and mutations of FAS have been reported in diffuse large B cell lymphoma (DLBCL). Although GC-derived DLBCL has better overall outcomes than other DLBCL types, some cases are refractory, and the molecular basis for this is often unknown. We show that Fas is a strong cell-intrinsic regulator of GC B cells that promotes cell death in the light zone, likely via T follicular helper (Tfh) cell–derived Fas ligand. In the absence of Fas, GCs were more clonally diverse due to an accumulation of cells that did not demonstrably bind antigen. FAS alterations occurred most commonly in GC-derived DLBCL, were associated with inferior outcomes and an enrichment of Tfh cells, and co-occurred with deficiency in HVEM and PD-L1 that regulate the Tfh–B cell interaction. This work shows that Fas is critically required for GC homeostasis and suggests that loss of Tfh-mediated counterselection in the GC contributes to lethality in GC-derived lymphoma.

Published
2021
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9. GAGA zinc finger transcription factor searches chromatin by 1D-3D facilitated diffusion.

Author

Feng XA, Yamadi M, Fu Y, Ness KM, Liu C, Ahmed I, Bowman GD, Johnson ME, Ha T, and Wu C

Abstract

To elucidate how eukaryotic sequence-specific transcription factors (TFs) search for gene targets on chromatin, we used multi-color smFRET and single-particle imaging to track the diffusion of purified GAGA-Associated Factor (GAF) on DNA and nucleosomes. Monomeric GAF DNA-binding domain (DBD) bearing one zinc finger finds its cognate site by 1D or 3D diffusion on bare DNA and rapidly slides back-and-forth between naturally clustered motifs for seconds before escape. Multimeric, full-length GAF also finds clustered motifs on DNA by 1D-3D diffusion, but remains locked on target for longer periods. Nucleosome architecture effectively blocks GAF-DBD 1D-sliding into the histone core but favors retention of GAF-DBD when targeting solvent-exposed sites by 3D-diffusion. Despite the occlusive power of nucleosomes, 1D-3D facilitated diffusion enables GAF to effectively search for clustered cognate motifs in chromatin, providing a mechanism for navigation to nucleosome and nucleosome-free sites by a member of the largest TF family.

Published
2024
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10. Dynamic 1D Search and Processive Nucleosome Translocations by RSC and ISW2 Chromatin Remodelers.

Author

Kim JM, Carcamo CC, Jazani S, Xie Z, Feng XA, Yamadi M, Poyton M, Holland KL, Grimm JB, Lavis LD, Ha T, and Wu C

Abstract

Eukaryotic gene expression is linked to chromatin structure and nucleosome positioning by ATP-dependent chromatin remodelers that establish and maintain nucleosome-depleted regions (NDRs) near transcription start-sites. Conserved yeast RSC and ISW2 remodelers exert antagonistic effects on nucleosomes flanking NDRs, but the temporal dynamics of remodeler search, engagement and directional nucleosome mobilization for promoter accessibility are unknown. Using optical tweezers and 2-color single-particle imaging, we investigated the Brownian diffusion of RSC and ISW2 on free DNA and sparse nucleosome arrays. RSC and ISW2 rapidly scan DNA by one-dimensional hopping and sliding respectively, with dynamic collisions between remodelers followed by recoil or apparent co-diffusion. Static nucleosomes block remodeler diffusion resulting in remodeler recoil or sequestration. Remarkably, both RSC and ISW2 use ATP hydrolysis to translocate mono-nucleosomes processively at ~30 bp/sec on extended linear DNA under tension. Processivity and opposing push-pull directionalities of nucleosome translocation shown by RSC and ISW2 shape the distinctive landscape of promoter chromatin., Competing Interests: Declaration of Interests The authors declare the following competing financial interest: Patents and patent applications describing deuterium-containing fluorophores (with inventors J.B.G. and L.D.L.) are assigned to HHMI.

Published
2024
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