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1. Spectroscopy of deeply bound orbitals in neutron-rich Ca isotopes

Author

Li, P. J., Lee, J., Doornenbal, P., Chen, S., Wang, S., Obertelli, A., Chazono, Y., Holt, J. D., Hu, B. S., Ogata, K., Utsuno, Y., Yoshida, K., Achouri, N. L., Baba, H., Browne, F., Calvet, D., Château, F., Chiga, N., Corsi, A., Cortés, M. L., Delbart, A., Gheller, J-M., Giganon, A., Gillibert, A., Hilaire, C., Isobe, T., Kobayashi, T., Kubota, Y., Lapoux, V., Liu, H. N., Motobayashi, T., Murray, I., Otsu, H., Panin, V., Paul, N., Rodriguez, W., Sakurai, H., Sasano, M., Steppenbeck, D., Stuhl, L., Sun, Y. L., Togano, Y., Uesaka, T., Wimmer, K., Yoneda, K., Aktas, O., Aumann, T., Boretzky, K., Caesar, C., Chung, L. X., Flavigny, F., Franchoo, S., Gasparic, I., Gerst, R. -B., Gibelin, J., Hahn, K. I., Kahlbow, J., Kim, D., Koiwai, T., Kondo, Y., Körper, D., Koseoglou, P., Lehr, C., Linh, B. D., Lokotko, T., MacCormick, M., Miki, K., Moschner, K., Nakamura, T., Park, S. Y., Rossi, D., Sahin, E., Schindler, F., Simon, H., Söderström, P-A., Sohler, D., Takeuchi, S., Toernqvist, H., Tscheuschner, J., Vaquero, V., Wagner, V., Werner, V., Xu, X., Yamada, H., Yan, D., Yang, Z., Yasuda, M., and Zanetti, L.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The calcium isotopes are an ideal system to investigate the evolution of shell structure and magic numbers. Although the properties of surface nucleons in calcium have been well studied, probing the structure of deeply bound nucleons remains a challenge. Here, we report on the first measurement of unbound states in $^{53}$Ca and $^{55}$Ca, populated from \ts{54,56}Ca($p,pn$) reactions at a beam energy of around 216 MeV/nucleon at the RIKEN Radioactive Isotopes Beam Factory. The resonance properties, partial cross sections, and momentum distributions of these unbound states were analyzed. Orbital angular momentum $l$ assignments were extracted from momentum distributions based on calculations using the distorted wave impulse approximation (DWIA) reaction model. The resonances at excitation energies of 5516(41)\,keV in $^{53}$Ca and 6000(250)\,keV in $^{55}$Ca indicate a significant $l$\, =\,3 component, providing the first experimental evidence for the $\nu 0f_{7/2}$ single-particle strength of unbound hole states in the neutron-rich Ca isotopes. The observed excitation energies and cross-sections point towards extremely localized and well separated strength distributions, with some fragmentation for the $\nu 0f_{7/2}$ orbital in $^{55}$Ca. These results are in good agreement with predictions from shell-model calculations using the effective GXPF1Bs interaction and \textit{ab initio} calculations and diverge markedly from the experimental distributions in the nickel isotones at $Z=28$., Comment: 13 pages, 7 figures

Published
2024
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3. Validation of the $^{10}\mathrm{Be}$ Ground-State Molecular Structure Using $^{10}\mathrm{Be}(p,p\alpha)^{6}\mathrm{He}$ Triple Differential Reaction Cross-Section Measurements

Author

Li, P. J., Beaumel, D., Lee, J., Assié, M., Chen, S., Franchoo, S., Gibelin, J., Hammache, F., Harada, T., Kanada-En'yo, Y., Kubota, Y., Leblond, S., Liang, P. F., Lokotko, T., Lyu, M., Marqués, F. M., Matsuda, Y., Ogata, K., Otsu, H., Rindel, E., Stuhl, L., Suzuki, D., Togano, Y., Tomai, T., Xu, X. X., Yoshida, K., Zenihiro, J., Achouri, N. L., Aumann, T., Baba, H., Cardella, G., Ceruti, S., Stefanescu, A. I., Corsi, A., Frotscher, A., Gao, J., Gillibert, A., Inaba, K., Isobe, T., Kawabata, T., Kitamura, N., Kobayashi, T., Kondo, Y., Kurihara, A., Liu, H. N., Miki, H., Nakamura, T., Obertelli, A., Orr, N. A., Panin, V., Sasano, M., Shimada, T., Sun, Y. L., Tanaka, J., Trache, L., Tudor, D., Uesaka, T., Wang, H., Yamada, H., Yang, Z. H., and Yasuda, M.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The cluster structure of the neutron-rich isotope $^{10}$Be has been probed via the $(p,p\alpha)$ reaction at 150 MeV/nucleon in inverse kinematics and in quasifree conditions. The populated states of $^{6}$He residues were investigated through missing mass spectroscopy. The triple differential cross-section for the ground-state transition was extracted for quasifree angle pairs ($\theta_{p}$, $\theta_{\alpha}$) and compared to distorted-wave impulse approximation reaction calculations performed in a microscopic framework using successively the Tohsaki-Horiuchi-Schuck-R\"opke product wave-function and the wave-function deduced from Antisymmetrized Molecular Dynamics calculations. The remarkable agreement between calculated and measured cross-sections in both shape and magnitude validates the molecular structure description of the $^{10}$Be ground-state, configured as an $\alpha$-$\alpha$ core with two valence neutrons occupying $\pi$-type molecular orbitals., Comment: 7 pages, 3 figures, 1 tables

Published
2023
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4. Level Structures of $^{56,58}$Ca Cast Doubt on a doubly magic $^{60}$Ca

Author

Chen, S., Browne, F., Doornenbal, P., Lee, J., Obertelli, A., Tsunoda, Y., Otsuka, T., Chazono, Y., Hagen, G., Holt, J. D., Jansen, G. R., Ogata, K., Shimizu, N., Utsuno, Y., Yoshida, K., Achouri, N. L., Baba, H., Calvet, D., Château, F., Chiga, N., Corsi, A., Cortés, M. L., Delbart, A., Gheller, J. -M., Giganon, A., Gillibert, A., Hilaire, C., Isobe, T., Kobayashi, T., Kubota, Y., Lapoux, V., Liu, H. N., Motobayashi, T., Murray, I., Otsu, H., Panin, V., Paul, N., Rodriguez, W., Sakurai, H., Sasano, M., Steppenbeck, D., Stuhl, L., Sun, Y. L., Togano, Y., Uesaka, T., Wimmer, K., Yoneda, K., Aktas, O., Aumann, T., Chung, L. X., Flavigny, F., Franchoo, S., Gasparic, I., Gerst, R. -B., Gibelin, J., Hahn, K. I., Kim, D., Koiwai, T., Kondo, Y., Koseoglou, P., Lehr, C., Linh, B. D., Lokotko, T., MacCormick, M., Moschner, K., Nakamura, T., Park, S. Y., Rossi, D., Sahin, E., Söderström, P. -A., Sohler, D., Takeuchi, S., Törnqvist, H., Vaquero, V., Wagner, V., Wang, S., Werner, V., Xu, X., Yamada, H., Yan, D., Yang, Z., Yasuda, M., and Zanetti, L.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Gamma decays were observed in $^{56}$Ca and $^{58}$Ca following quasi-free one-proton knockout reactions from $^{57,59}$Sc beams at $\approx 200$ MeV/nucleon. For $^{56}$Ca, a $\gamma$ ray transition was measured to be 1456(12) keV, while for $^{58}$Ca an indication for a transition was observed at 1115(34) keV. Both transitions were tentatively assigned as the $2^+_1 \rightarrow 0^+_{gs}$ decays, and were compared to results from ab initio and conventional shell-model approaches. A shell-model calculation in a wide model space with a marginally modified effective nucleon-nucleon interaction depicts excellent agreement with experiment for $2^+_1$ level energies, two-neutron separation energies, and reaction cross sections, corroborating the formation of a new nuclear shell above the $N$ = 34 shell. Its constituents, the $0f_{5/2}$ and $0g_{9/2}$ orbitals, are almost degenerate. This degeneracy precludes the possibility for a doubly magic $^{60}$Ca and potentially drives the dripline of Ca isotopes to $^{70}$Ca or even beyond., Comment: 8 pages, 3 figures

Published
2023
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7. Antiproton-nucleus annihilation cross section at low energy

Author

Aghai–Khozani H., Bianconi A., Corradini M., Hayano R., Hori M., Leali M., Lodi–Rizzini E., Mascagna V., Murakami Y., Prest M., Vallazza E., Venturelli L., and Yamada H.

Subjects
Physics, QC1-999
Abstract

The antinucleon-nuclei annihilation cross sections at low energies were systematically measured at CERN in the 80’s and 90’s with the LEAR facility and later with the Antiproton Decelerator. Unfortunately only few data exist for very low energy antiprotons (p

Published
2018
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8. Experimental technique for antiproton-nucleus annihilation cross section measurements at low energy

Author

Aghai-Khozani H., Corradini M., Hayano R., Hori M., Leali M., Lodi-Rizzini E., Mascagna V., Murakami Y., Prest M., Solazzi L., Vallazza E., Venturelli L., and Yamada H.

Subjects
Physics, QC1-999
Abstract

The interaction of very low energy antiprotons (ps) and antineutrons (ns) with nuclei is interesting for its influence on both fundamental cosmology and nuclear physics. Measuring the annihilation cross section of antimatter on matter can help in solving the universe matter-antimatter puzzle and could give relevant hints in the definition of strong interaction model parameters as well. The ASACUSA collaboration recently measured the antiproton-carbon annihilation cross section at 5.3 MeV of kinetic energy of the incoming antiproton. The experimental apparatus consisted in a vacuum chamber containing thin foils (~0.7-1 μm) of carbon crossed by a bunched beam of antiprotons from the CERN Antiproton Decelerator (AD). The fraction of antiprotons annihilating on the target nucleons gives origin to charged pions which can be detected and counted by segmented scintillators placed outside the chamber. This work describes the experimental details of the apparatus and the technique to perform the cross section measurements.

Published
2018
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9. A First Glimpse at the Shell Structure beyond $^{54}$Ca: Spectroscopy of $^{55}$K, $^{55}$Ca, and $^{57}$Ca

Author

Koiwai, T., Wimmer, K., Doornenbal, P., Obertelli, A., Barbieri, C., Duguet, T., Holt, J. D., Miyagi, T., Navrátil, P., Ogata, K., Shimizu, N., Somà, V., Utsuno, Y., Yoshida, K., Achouri, N. L., Baba, H., Browne, F., f, D. Calvet, Château, F., Chen, S., Chiga, N., Corsi, A., Cortés, M. L., Delbart, A., Gheller, J. -M., Giganon, A., Gillibert, A., Hilaire, C., Isobe, T., Kobayashi, T., Kubota, Y., Lapoux, V., Liu, H. N., Motobayashi, T., Murray, I., Otsu, H., Panin, V., Paul, N., Rodriguez, W., Sakurai, H., Sasano, M., Steppenbeck, D., Stuhl, L., Sun, Y. L., Togano, Y., Uesaka, T., Yoneda, K., Aktas, O., Aumann, T., Chung, L. X., Flavigny, F., Franchoo v, S., Gasparic, I., Gerst, R. -B., Gibelin, J., Hahn, K. I., Kim, D., Kondo, Y., Koseoglou, P., Lee, J., Lehr, C., Linh, B. D., Lokotko, T., MacCormick, M., Moschner, K., Nakamura, T., Park, S. Y., Rossi, D., Sahin, E., Söderström, P-A., Sohler, D., Takeuchi, S., Toernqvist, H., Vaquero, V., Wagner, V., Wang, S., Werner, V., Xu, X., Yamada, H., Yan, D., Yang, Z., Yasuda, M., and Zanetti, L.

Subjects
Nuclear Experiment
Abstract

States in the $N=35$ and 37 isotopes $^{55,57}$Ca have been populated by direct proton-induced nucleon removal reactions from $^{56,58}$Sc and $^{56}$Ca beams at the RIBF. In addition, the $(p,2p)$ quasi-free single-proton removal reaction from $^{56}$Ca was studied. Excited states in $^{55}$K, $^{55}$Ca, and $^{57}$Ca were established for the first time via in-beam $\gamma$-ray spectroscopy. Results for the proton and neutron removal reactions from $^{56}$Ca to states in $^{55}$K and $^{55}$Ca for the level energies, excited state lifetimes, and exclusive cross sections agree well with state-of-the-art theoretical calculations using different approaches. The observation of a short-lived state in $^{57}$Ca suggests a transition in the calcium isotopic chain from single-particle dominated states at $N=35$ to collective excitations at $N=37$., Comment: accepted Phys. Lett. B

Published
2022
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10. New results of the antiproton-carbon annihilation cross section measurement at low energies

Author

Aghai–Khozani H., Corradini M., Hayano R., Hori M., Leali M., Lodi–Rizzini E., Mascagna V., Murakami Y., Prest M., Solazzi L., Vallazza E., Venturelli L., and Yamada H.

Subjects
Physics, QC1-999
Abstract

The antinucleon-nuclei annihilation cross section at very low energy has been measured at the LEAR facility (CERN) during the 80’s and 90’s and recently at the Antiproton Decelerator. The results have raised some interesting questions that still need answers. The ASACUSA collaboration performed an experiment to measure the σann of 100 MeV/c antiprotons on carbon target and the preliminary results are presented here.

Published
2016
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12. Long-pulse Plasma Discharges by Upgraded ECH System in the LHD

Author

Yoshimura Y., Kasahara H., Nagasaki K., Tokitani M., Ashikawa N., Ueda Y., Ito S., Kubo S., Shimozuma T., Igami H., Takahashi H., Nishiura M., Kobayashi S., Mizuno Y., Okada K., Ogasawara S., Makino R., Yamada I., Tokuzawa T., Tanaka K., Mutoh T., and Yamada H.

Subjects
Physics, QC1-999
Abstract

Until 2009, three high-power, over 1MW each, 77GHz gyrotrons have been installed and applied to the LHD experiment. In addition, a 154GHz gyrotron of 1MW was installed in 2012. The 77GHz gyrotrons suffer gradual increases of internal pressure during long-pulse operation delivering power to LHD. To mitigate the problem, quasi-steady operation by combination of on-off operations of the 77GHz gyrotrons was performed. Applying two 77GHz gyrotrons alternately with intervals of two minutes and an 84GHz gyrotron continuously, a 30 min. long-pulse discharge with the line average electron density ne_ave of 0.7×1019m−3 and the central electron temperature Te0 of 1.7keV was achieved by the time average injection power Pinj of 260kW in 2012, showing significant progress in sustained density from the former 65 min. discharge with ne_ave of 0.15×1019m−3 and Te0 of 1.7keV by Pinj of 110kW of 84GHz wave. In 2013, one of the 77GHz gyrotron was improved to furnish a sub-window to remove stray radiation inside the tube. And the new 154GHz gyrotron was applied to the long-pulse discharge experiment. Using three gyrotrons: 154, the improved and an existing 77GHz with Pinj of 340kW in total, higher temperature plasma having steep temperature gradient typical for internal transport barrier, with ne_ave of 1.1×1019m−3 and Te0 of 3.5keV was quite stably sustained for 325s.

Published
2015
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13. Near-infrared laser spectroscopy of antiprotonic helium atoms

Author

Kobayashi T., Barna D., Hayano R. S., Murakami Y., Todoroki K., Yamada H., Dax A., Venturelli L., Zurlo N., Horváth D., Aghai-Khozani H., Sótér A., and Hori M.

Subjects
Physics, QC1-999
Abstract

The ASACUSA (Atomic Spectroscopy and Collisions Using Slow Antiprotons) collaboration is currently attempting to observe a laser-induced resonant transition of antiprotonic helium atoms at wavelength of 1154.9 nm. Motivations to observe this transition and a nanosecond near-infrared laser prepared for this work are presented.

Published
2014
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14. $\boldsymbol{N=32}$ shell closure below calcium: Low-lying structure of $^{50}$Ar

Author

Cortés, M. L., Rodriguez, W., Doornenbal, P., Obertelli, A., Holt, J. D., Menéndez, J., Ogata, K., Schwenk, A., Shimizu, N., Simonis, J., Utsuno, Y., Yoshida, K., Achouri, L., Baba, H., Browne, F., Calvet, D., Château, F., Chen, S., Chiga, N., Corsi, A., Delbart, A., Gheller, J-M., Giganon, A., Gillibert, A., Hilaire, C., Isobe, T., Kobayashi, T., Kubota, Y., Lapoux, V., Liu, H. N., Motobayashi, T., Murray, I., Otsu, H., Panin, V., Paul, N., Sakurai, H., Sasano, M., Steppenbeck, D., Stuhl, L., Sun, Y. L., Togano, Y., Uesaka, T., Wimmer, K., Yoneda, K., Aktas, O., Aumann, T., Chung, L. X., Flavigny, F., Franchoo, S., Gašparić, I., Gerst, R. -B., Gibelin, J., Hahn, K. I., Kim, D., Koiwai, T., Kondo, Y., Koseoglou, P., Lee, J., Lehr, C., Linh, B. D., Lokotko, T., MacCormick, M., Moschner, K., Nakamura, T., Park, S. Y., Rossi, D., Sahin, E., Söderström, P. -A., Sohler, D., Takeuchi, S., Toernqvist, H., Vaquero, V., Wagner, V., Wang, S., Werner, V., Xu, X., Yamada, H., Yan, D., Yang, Z., Yasuda, M., and Zanetti, L.

Subjects
Nuclear Experiment
Abstract

Low-lying excited states in the $N=32$ isotope $^{50}$Ar were investigated by in-beam $\gamma$-ray spectroscopy following proton- and neutron-knockout, multi-nucleon removal, and proton inelastic scattering at the RIKEN Radioactive Isotope Beam Factory. The energies of the two previously reported transitions have been confirmed, and five additional states are presented for the first time, including a candidate for a 3$^-$ state. The level scheme built using $\gamma\gamma$ coincidences was compared to shell-model calculations in the $sd-pf$ model space, and to ab initio predictions based on chiral two- and three-nucleon interactions. Theoretical proton- and neutron-knockout cross sections suggest that two of the new transitions correspond to $2^+$ states, while the previously proposed $4^+$ state could also correspond to a $2^+$ state., Comment: Accepted for Phys. Rev. C

Published
2020
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15. Nonmagnetic-magnetic transition and magnetically ordered structure in SmS

Author

Yoshida, S., Koyama, T., Yamada, H., Nakai, Y., Ueda, K., Mito, T., Kitagawa, K., and Haga, Y.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract

SmS, a prototypical intermediate valence compound, has been studied by performing high-pressure nuclear magnetic resonance measurements on a $^{33}$S-enriched sample. The observation of an additional signal below 15-20 K above a nonmagnetic-magnetic transition pressure $P_{\rm c2} \approx 2$ GPa gives evidence of a magnetic transition. The absence of a Curie-term in the Knight shift near $P_{\rm c2}$ indicates that the localized character of $4f$ electrons is entirely screened and the mechanism of the magnetic ordering is not described within a simple localized model. Simultaneously, the line shape in the magnetically ordered state is incompatible with a spin density wave order. These suggest that the magnetic order in SmS may require an understanding beyond the conventional framework for heavy fermions. The fact that hyperfine fields from the ordered moments cancel out at the S site leads us to a conclusion that the ordered phase has a type II antiferromagnetic structure.

Published
2020
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16. Shell evolution of $N=40$ isotones towards $^{60}$Ca: First spectroscopy of $^{62}$Ti

Author

Cortés, M. L., Rodriguez, W., Doornenbal, P., Obertelli, A., Holt, J. D., Lenzi, S. M., Menéndez, J., Nowacki, F., Ogata, K., Poves, A., Rodríguez, T. R., Schwenk, A., Simonis, J., Stroberg, S. R., Yoshida, K., Achouri, L., Baba, H., Browne, F., Calvet, D., Château, F., Chen, S., Chiga, N., Corsi, A., Delbart, A., Gheller, J-M., Giganon, A., Gillibert, A., Hilaire, C., Isobe, T., Kobayashi, T., Kubota, Y., Lapoux, V., Liu, H. N., Motobayashi, T., Murray, I., Otsu, H., Panin, V., Paul, N., Sakurai, H., Sasano, M., Steppenbeck, D., Stuhl, L., Sun, Y. L., Togano, Y., Uesaka, T., Wimmer, K., Yoneda, K., Aktas, O., Aumann, T., Chung, L. X., Flavigny, F., Franchoo, S., Gašparić, I., Gerst, R. -B., Gibelin, J., Hahn, K. I., Kim, D., Koiwai, T., Kondo, Y., Koseoglou, P., Lee, J., Lehr, C., Linh, B. D., Lokotko, T., MacCormick, M., Moschner, K., Nakamura, T., Park, S. Y., Rossi, D., Sahin, E., Sohler, D., Söderström, P. -A., Takeuchi, S., Toernqvist, H., Vaquero, V., Wagner, V., Wang, S., Werner, V., Xu, X., Yamada, H., Yan, D., Yang, Z., Yasuda, M., and Zanetti, L.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Excited states in the $N=40$ isotone $^{62}$Ti were populated via the $^{63}$V$(p,2p)$$^{62}$Ti reaction at $\sim$200~MeV/u at the Radioactive Isotope Beam Factory and studied using $\gamma$-ray spectroscopy. The energies of the $2^+_1 \rightarrow 0^{+}_{\mathrm{gs}}$ and $4^+_1 \rightarrow 2^+_1$ transitions, observed here for the first time, indicate a deformed $^{62}$Ti ground state. These energies are increased compared to the neighboring $^{64}$Cr and $^{66}$Fe isotones, suggesting a small decrease of quadrupole collectivity. The present measurement is well reproduced by large-scale shell-model calculations based on effective interactions, while ab initio and beyond mean-field calculations do not yet reproduce our findings. The shell-model calculations for $^{62}$Ti show a dominant configuration with four neutrons excited across the $N=40$ gap. Likewise, they indicate that the $N=40$ island of inversion extends down to $Z=20$, disfavoring a possible doubly magic character of the elusive $^{60}$Ca.

Published
2019
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17. Effect of high strain rate on micro-indentation test in pure aluminum

Author

Kobayashi H., Horikawa H., Shimizu Y., Ogasawara N., and Yamada H.

Subjects
Physics, QC1-999
Abstract

The indentation properties of pure aluminum (99.9%, 3N aluminum) and high purity aluminum (99.999%, 5N aluminum) with respect to the strain rate dependence of strength are experimentally investigated in order to clarify the effect of strain rate on the micro-indentation test. A micro-indentation test using a Berkovich indenter was performed at loading rates of 0.7, 7, and 70 mN/s. In all of the specimens, the indenter was loaded to a maximum value of 1200 mN, and then was maintained for 30 s. In the 3N specimen, the dependence of the loading rate on the load was slight at loading rates of 0.7 and 7 mN/s, whereas the load at the loading rate of 70 mN/s was higher than the loads at loading rates of 0.7 and 7 mN/s. On the other hand, the load for the 5N specimen increased with the increasing loading rate. Thus, the effect of the loading rate on the load-displacement curve for the 3N and 5N specimens was similar to the strain rate dependence of strength for theses metals. In addition, the micro-indentation test was demonstrated to be strongly affected by high strain rate at a loading rate of 70 mN/s.

Published
2012
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18. Teneligliptin, a DPP-4 Inhibitor, Improves Vascular Endothelial Function via Divergent Actions Including Changes in Circulating Endothelial Progenitor Cells

Author

Akashi N, Umemoto T, Yamada H, Fujiwara T, Yamamoto K, Taniguchi Y, Sakakura K, Wada H, Momomura SI, and Fujita H

Subjects
endothelial progenitor cell, teneligliptin, dpp-4 inhibitor, flow-mediated dilation, type 2 diabetes mellitus., Specialties of internal medicine, RC581-951
Abstract

Naoyuki Akashi,1 Tomio Umemoto,1 Hodaka Yamada,2 Takayuki Fujiwara,3 Kei Yamamoto,1 Yousuke Taniguchi,1 Kenichi Sakakura,1 Hiroshi Wada,1 Shin-ichi Momomura,1 Hideo Fujita1 1Division of Cardiovascular Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan; 2Division of Endocrinology and Metabolism, Jichi Medical University Saitama Medical Center, Saitama, Japan; 3Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, JapanCorrespondence: Tomio Umemoto, Division of Cardiovascular Medicine, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama, 330-8503, Japan, Tel +81-48-647-2111, Fax +81-48-648-5188, Email to-ume@omiya.jichi.ac.jpPurpose: Dipeptidyl peptidase-4 (DPP-4) inhibitors increase endothelial progenitor cells (EPCs) in peripheral blood circulation. However, the underlying mechanisms and effects on vascular endothelial function remain unclear. We evaluated whether the DPP-4 inhibitor teneligliptin increases circulating EPCs by inhibiting stromal-derived factor-1α (SDF-1α) and improves flow-mediated vascular dilatation (FMD) in type 2 diabetes mellitus patients with acute coronary syndrome (ACS) or its risk factors.Patients and Methods: This single-center, open-label, prospective, randomized controlled trial evaluated 17 patients (hemoglobin A1c ≤ 7.5% and peak creatinine phosphokinase < 2000 IU/mL) with ACS or a history of ACS or multiple cardiovascular risk factors. Metabolic variables of glucose and lipids, circulating EPCs, plasma DPP-4 activity, and SDF-1α levels, and FMD were evaluated at baseline and 28 ± 4 weeks after enrollment. Patients were randomly assigned to either the teneligliptin (n = 8) or control (n = 9) groups.Results: The DPP-4 activity (∆− 509.5 ± 105.7 vs ∆32.8 ± 53.4 μU/mL) and SDF-1α levels (∆− 695.6 ± 443.2 vs ∆11.1 ± 193.7 pg/mL) were significantly decreased after 28 weeks in the teneligliptin group than those in the control group. The number of EPCs showed an increasing trend in the teneligliptin treated group; albeit this did not reach statistical significance. Glucose and lipid levels were not significantly different between the groups before and after 28 weeks. However, FMD was significantly improved in the teneligliptin group when compared to the control group (∆3.8% ± 2.1% vs ∆− 0.3% ± 2.9%, P=0.006).Conclusion: Teneligliptin improved FMD through a mechanism other than increasing the number of circulating EPCs.Keywords: endothelial progenitor cell, teneligliptin, DPP-4 inhibitor, flow-mediated dilation, type 2 diabetes mellitus

Published
2023

19. Study of multi-neutron systems with SAMURAI spectrometer

Author

Yang, Z. H., Marqués, F. M., Achouri, N. L., Ahn, D. S., Aumann, T., Baba, H., Beaumel, D., Böhmer, M., Boretzky, K., Caamaño, M., Chen, S., Chiga, N., Cortés, M. L., Cortina, D., Doornenbal, P., Douma, C. A., Dufter, F., Feng, J., Fernández-Domínguez, B., Elekes, Z., Forsberg, U., Fujino, T., Fukuda, N., Gašparić, I., Ge, Z., Gernhäuser, R., Gheller, J. M., Gibelin, J., Gillibert, A., Godoy, B. M., Halász, Z., Harada, T., Harakeh, M. N., Hirayama, A., Huang, S. W., Inabe, N., Isobe, T., Kahlbow, J., Kalantar-Nayestanaki, N., Kim, D., Kim, S., Knösel, M. A., Kobayashi, T., Kondo, Y., Koseoglou, P., Kubota, Y., Kuti, I., Lehr, C., Li, P. J., Liu, Y., Maeda, Y., Masuoka, S., Matsumoto, M., Mayer, J., Miki, H., Miwa, M., Murray, I., Nakamura, T., Obertelli, A., Orr, N., Otsu, H., Panin, V., Park, S., Parlog, M., Paschalis, S., Potlog, M., Reichert, S., Revel, A., Rossi, D., Saito, A., Sasano, M., Sato, H., Scheit, H., Schindler, F., Shimada, T., Shimizu, Y., Shimoura, S., Stefan, I., Storck, S., Stuhl, L., Suzuki, H., Symochko, D., Takeda, H., Takeuchi, S., Tanaka, J., Togano, Y., Tomai, T., Tscheuschner, H. T. Törnqvsit. J., Uesaka, T., Wagner, V., Wimmer, K., Yamada, H., Yang, B., Yang, L., Yasuda, Y., Yoneda, K., Zanetti, L., and Zenihiro, J.

Subjects
Nuclear Experiment
Abstract

The tetraneutron has been drawing the attention of the nuclear physics community for decades, but a firm conclusion on its existence and properties is still far from being reached despite many experimental and theoretical efforts. New measurements have recently been performed at RIBF with the SAMURAI spectrometer by applying complementary reaction probes, which will help to pin down the properties of this four-neutron system., Comment: 5 pages, 2 figures, conference proceedings of XXII International Conference on Few-Body Problems in Physics (FB22), Caen, France, July 2018

Published
2019

23. Infective endocarditis in adult patients with congenital heart disease

Author

Habib, Gilbert, Lancellotti, Patrizio, Cosyns, Bernard, Donal, Erwan, Erba, Paola, Iung, Bernard, Maggioni, Aldo P., Popescu, Bogdan A., Prendergast, Bernard, Tornos, Pilar, Tatar-Chentir, Nora Nabila Ali, Al-Mallah, Mouaz, Aneq, Meriam Astrom, Athanassopoulos, George, Badano, Luigi Paolo, Benyoussef, Soraya, Aranda, Erick Calderon, Cardim, Nuno Miguel, Chan, Kwan-Leung, Cruz, Ines, Edvardsen, Thor, Goliasch, Georg, Hagendorff, Andreas, Hristova, Krasimira, Kamp, Otto, Kang, Duk-Hyun, Kong, William, Matskeplishvili, Simon, Meshaal, Marwa, Mirocevic, Maja, Neskovic, Aleksandar N., Pazdernik, Michal, Plonska-Gosciniak, Edyta, Raissouni, Maha, Ronderos, Ricardo, Sade, Leyla Elif, Sadeghpour, Anita, Sambola, Antonia, Sengupta, Shantanu, Separovic-Hanzevacki, Jadranka, Takeuchi, Masaaki, Tucay, Edwin, Rodrigues, Ana Clara Tude, Varga, Albert, Vaskelyte, Jolanta, Yamagata, Kentaro, Yiangou, Kyriakos, Zaky, Hosam, Ronderos, R., Avegliano, G., Oses, P. Fernandez, Filipini, E., Granada, I., Iribarren, A., Mahia, M., Nacinovich, F., Ressi, S., Obregon, R., Bangher, M., Dho, J., Cartasegna, L., Plastino, M.L., Novas, V., Shigel, C., Reyes, G., De Santos, M., Gastaldello, N., Fernandez, M. Granillo, Potito, M., Streitenberger, G., Velazco, P., Casabé, J.H., Cortes, C., Guevara, E., Salmo, F., Seijo, M., Weidinger, F., Heger, M., Brooks, R., Stöllberger, C., Ho, C.-Y., Perschy, L., Puskas, L., Goliasch, G., Binder, C., Rosenhek, R., Schneider, M., Winter, M.-P., Hoffer, E., Melissopoulou, M., Lecoq, E., Legrand, D., Jacquet, S., Massoz, M., Lancellotti, P., Pierard, L., Dulgheru, R., Marchetta, S., D'Emal, C., Oury, C., Cosyns, B., Droogmans, S., Kerkhove, D., Motoc, A., Plein, D., Roosens, B., Soens, L., Weytjens, C., Lemoine, I., Rodrigus, I., Paelinck, B., Amsel, B., Unger, P., Konopnicki, D., Beauloye, C., Pasquet, A., Pierard, S., Vancraeynest, D., Vanoverschelde, J.L., Sinnaeve, F., Andrade, J.L., Rodrigues, A.C. Tude, Staszko, K., Monteiro, R. Dos Santos, Miglioranza, M.H., Shuha, D.L., Alcantara, M., Cravo, V., Fazzio, L., Felix, A., Iso, M., Musa, C., Siciliano, A.P., Filho, F. Villaca, Braga, J., Rodrigues, A., Silva, R., Vilela, F., Rodrigues, D., Silva, L., Morhy, S., Fischer, C., Vieira, M., Afonso, T., Abreu, J., Falcao, S.N., Moises, V., Gouvea, A., João, G., Mancuso, F., Silva, C., Souza, A.C., Abboud, C.S., de Mattos Barretto, R. Bellio, Ramos, A., Arnoni, R., Assef, J.E., Togna, D.J. Della, Le Bihan, D., Miglioli, L., Oliveira, A.P. Romero, Kroll, R. Tadeu Magro, Cortez, D., Gelape, C.L., Nunes, M.d.C. Peirira, Ferrari, T.C. De Abreu, Chan, K.-L., Hay, K., Le, V., Page, M., Poulin, F., Sauve, C., Serri, K., Mercure, C., Beaudoin, J., Pibarot, P., Sebag, I., Rudski, L., Ricafort, G., Barsic, B., Krajinovic, V., Vargovic, M., Separovic-Hanzevacki, J., Lovric, D., Reskovic-Luksic, V., Vincelj, J., Jurinjak, S. Jaksic, Yiannikourides, V., Ioannides, M., Kyriakou, C., Pofaides, C., Masoura, V., Yiangou, K., Pudich, J., Linhart, A., Siranec, M., Marek, J., Blechova, K., Kamenik, M., Pazdernik, M., Pelouch, R., Coufal, Z., Mikulica, M., Griva, M., Jancova, E., Mikulcova, M., Taborsky, M., Precek, J., Jecmenova, M., Latal, J., Widimsky, J., Butta, T., Machacek, S., Vancata, R., Spinar, J., Holicka, M., Long, F. Pow Chon, Anzules, N., Carpio, A. Bajana, Largacha, G., Penaherrera, E., Moreira, D., Mahfouz, E., Elsafty, E., Soliman, A., Zayed, Y., Aboulenein, J., Abdel-Hay, M., Almaghraby, A., Abdelnaby, M., Ahmed, M., Hammad, B., Saleh, Y., Zahran, H., Elgebaly, O., Saad, A., Ali, M., Zeid, A., El Sharkawy, R., Meshaal, M., Al Kholy, A., Doss, R., Osama, D., Rizk, H., Elmogy, A., Mishriky, M., Assayag, P., El Hatimi, S., Botelho-Nevers, E., Campisi, S., Fuzellier, J.-F., Gagneux-Brunon, A., Pierrard, R., Tulane, C., Detoc, M., Mehalla, T., Boutoille, D., Al Habash, O., Asseray-Madani, N., Biron, C., Brochard, J., Caillon, J., Cueff, C., Le Tourneau, T., Lecompte, A.S., Lecomte, R., Lefebvre, M., Michel, M.M. Magali, Pattier, S., Delarue, S., Le Bras, M., Orain, J., Faucher, J.-F., Aboyans, V., Beeharry, A., Durox, H., Lacoste, M., Magne, J., Mohty, D., David, A., Pradel, V., Sierra, V., Neykova, A., Bettayeb, B., Elkentaoui, S., Tzvetkov, B., Landry, G., Strady, C., Ainine, K., Baumard, S., Brasselet, C., Tassigny, C., Valente-Pires, V., Lefranc, M., Hoen, B., Lefevre, B., Curlier, E., Callier, C., Fourcade, N., Jobic, Y., Ansard, S., Le Berre, R., Le Roux, P., Le Ven, F., Pouliquen, M.-C., Prat, G., Bouchart, F., Savoure, A., Alarcon, C., Chapuzet, C., Gueit, I., Tribouilloy, C., Bohbot, Y., Peugnet, F., Gun, M., Iung, B., Duval, X., Lescure, X., Ilic-Habensus, E., Sadoul, N., Selton-Suty, C., Alla, F., Chevalier, E., Goehringer, F., Huttin, O., Garcia, R., Le Marcis, V., Tattevin, P., Donal, E., Flecher, E., Revest, M., Habib, G., Hubert, S., Casalta, J.-P., Gouriet, F., Arregle, F., Cammilleri, S., Tessonnier, L., Riberi, A., Chirouze, C., Bouiller, K., Brunel, A.-S., Fournier, D., Hustache-Mathieu, L., Klopfenstein, T., Moreau, J., Lim, P., Oliver, L., Ternacle, J., Moussafeur, A., Chavanet, P., Piroth, L., Buisson, M., Mahy, S., Martins, C., Salmon-Rousseau, A., Gohier, S., Piper, C., Börgermann, J., Guckel, D., Horstkotte, D., Brockmeier, B., Winkelmann, E., Hagendorff, A., Grey, D., Nickenig, G., Schueler, R., Öztürk, C., Stöhr, E., Hamm, C., Walther, T., Brandt, R., Frühauf, A.-C., Hartung, C.T., Hellner, C., Wild, C., Becker, M., Hamada, S., Kaestner, W., Stangl, K., Knebel, F., Baldenhofer, G., Brecht, A., Dreger, H., Isner, C., Pfafflin, F., Stegemann, M., Zahn, R., Fraiture, B., Kilkowski, C., Karcher, A.-K., Klinger, S., Tolksdorf, H., Tousoulis, D., Aggeli, C., Sarri, G., Sideris, S., Venieri, E., Athanassopoulos, G., Tsiapras, D., Armenis, I., Koutsiari, A., Floros, G., Grassos, C., Dragasis, S., Rallidis, L., Varlamos, C., Michalis, L., Naka, K., Bechlioulis, A., Kotsia, A., Lakkas, L., Pappas, K., Papadopoulos, C., Kiokas, S., Lioni, A., Misailidou, S., Barbetseas, J., Bonou, M., Kapelios, C., Tomprou, I., Zerva, K., Manolis, A., Hamodraka, E., Athanasiou, D., Haralambidis, G., Poulimenos, L., Samaras, H., Nagy, A., Bartykowszki, A., Gara, E., Sengupta, S., Mungulmare, K., Kasliwal, R., Bansal, M., Bhan, A., Ranjan, S., Kyavar, M., Maleki, M., Bezanjani, F. Noohi, Sadeghpour, A., Alizadehasl, A., Boudagh, S., Ghavidel, A., Moradnejad, P., Pasha, H.R., Ghadrdoost, B., Gilon, D., Strahilevitz, J., Israel, S., Wanounou, M., d'Agostino, C., Colonna, P., De Michele, L., Fumarola, F., Stante, M., Marchionni, N., Scheggi, V., Alterini, B., Del Pace, S., Stefano, P., Sparano, C., Badano, L.P., Muraru, D., Ruozi, N., Tenaglia, R., Limbruno, U., Cresti, A., Baratta, P., Solari, M., Giannattasio, C., Moreo, A., De Chiara, B., Montero, B. Lopez, Musca, F., Orcese, C.A., Panzeri, F., Russo, C.F., Spano, F., Alfieri, O., De Bonis, M., Agricola, E., Busnardo, E., Carletti, S., Castiglioni, B., Chiappetta, S., Del Forno, B., Ferrara, D., Guffanti, M., Iaci, G., Lapenna, E., Nisi, T., Oltolini, C., Pajoro, U., Pasciuta, R., Ripa, M., Scarpellini, P., Din, C. Tassan, Meneghin, R., Schiavi, D., Piscione, F., Citro, R., Benvenga, R.M., Greco, L., Prota, C., Radano, I., Soriente, L., Bellino, M., Di Vece, D., Santini, F., Salsano, A., Olivieri, G.M., Turrini, F., Messora, R., Tondi, S., Olaru, A., Agnoletto, V., Grassi, L., Leonardi, C., Sansoni, S., Del Ponte, S., Dato, G.M. Actis, De Martino, A., Ohte, N., Kikuchi, S., Wakami, K., Aonuma, K., Seo, Y., Ishizu, T., Machino-Ohtsuka, T., Yamamoto, M., Iida, N., Nakajima, H., Nakagawa, Y., Izumi, C., Amano, M., Miyake, M., Takahashi, K., Shiojima, I., Miyasaka, Y., Maeba, H., Suwa, Y., Taniguchi, N., Tsujimoto, S., Kitai, T., Ota, M., Yuda, S., Sasaki, S., Hagiwara, N., Yamazaki, K., Ashihara, K., Arai, K., Saitou, C., Saitou, S., Suzuki, G., Shibata, Y., Watanabe, N., Nishino, S., Ashikaga, K., Kuriyama, N., Mahara, K., Abe, K., Fujimaki, H., Okubo, T., Shitan, H., Takanashi, S., Terada, M., Yamamoto, H., Sata, M., Yamada, H., Kusunose, K., Saijo, Y., Seno, H., Yuichiro, O., Sakata, Y., Mizuno, H., Nakatani, S., Onishi, T., Sengoku, K., Sera, F., Park, S.W., Kyoung, K. Eun, Yeon, L. Ga, Hwang, J.-W., Jin-Oh, C., Park, S.-J., Sang-Chol, L., Sung-A, C., Jang, S.Y., Kang, D.-H., Heo, R., Lee, S., Song, J.-M., Jung, E., Plisiene, J., Dambrauskaite, A., Gruodyte, G., Jonkaitiene, R., Vaskelyte, J., Mizariene, V., Atkocaityte, J., Zvirblyte, R., Sow, R., Codreanu, A., De la Vega, E.C.L., Michaux, C., Staub, T., Jacobs-Orazi, L., Azzopardi, C. Mallia, Xuereb, R.G., Piscopo, T., Borg, D., Casha, R., Farrugia, J., Fenech, M., Pllaha, E., Vella, C., Yamagata, K., Grib, L., Raevschi, E., Grejdieru, A., Balan, G., Cardaniuc, I., Cardaniuc, L., Corcea, V., Feodorovici, A., Gaina, V., Girbu, L., Jimbei, P., Kravcenco, D., Panfile, E., Prisacari, E., Samohvalov, E., Samohvalov, S., Sceglova, N., Benesco, I., Marian, V., Sumarga, N., Mirocevic, M., Bozovic, B., Bulatovic, N., Lakovic, P., Music, L., Roos-Hesselink, J., Budde, R., Gamela, T., Wahadat, A., Kamp, O., Meijers, T., Van Melle, J.P., Deursen, V.M., Crijns, H., Bekkers, S., Cheriex, E., Gilbers, M., Kietselaer, B., Knackstedt, C., Lorusso, R., Schalla, S., Streukens, S., Chamuleau, S., Cramer, M.-J., Teske, A., Van der Spoel, T., Wind, A., Liesbek, O., Lokhorst, J., Van Heusden, H., Tanis, W., Van der Bilt, I., Vriend, J., Bruggen, H. De Lange-van, Karijodikoro, E., Riezebos, R., van Dongen, E., Schoep, J., Stolk, V., Axler, O., Baumann, F., Lebras, S., Edvardsen, T., Offstad, J.T., Beitnes, J.O., Helle-Valle, T., Skulstad, H., Skardal, R., Qamar, N., Furnaz, S., Ahmed, B., Butt, M.H., Khanzada, M.F., Saghir, T., Wahid, A., Hryniewiecki, T., Szymanski, P., Marzec, K., Misztal-Ogonowska, M., Kosmala, W., Przewlocka-Kosmala, M., Rojek, A., Woznicka, K., Zachwyc, J., Lisowska, A., Kaminska, M., Kasprzak, J., Kowalczyk, E., Strzecka, D.F., Wejner-Mik, P., Trabulo, M., Freitas, P., Ranchordas, S., Rodrigues, G., Pinto, P., Queiros, C., Azevedo, J., Marques, L., Seabra, D., Branco, L., Cruz, M., Galrinho, A., Moreira, R., Rio, P., Timoteo, A.T., Selas, M., Cardim, N.M., Carmelo, V., Neves, B. Duque, Pereira, H., Cruz, I., Guerra, A., Marques, A., Pintassilgo, I., Tomescu, M.C., Trofenciuc, N.-M., Andor, M., Bordejevic, A., Branea, H.S., Caruntu, F., Cirin, L., Citu, I.M., Cotoraci, C.A., Darabantiu, D., Farcas, R., Marincu, I., Mavrea, A., Onel, M.F., Parvanescu, T., Pop, D., Pop-Moldovan, A.L., Puticiu, M.I., Velcean, L.A., Ionac, A., Cozma, D., Mornos, C., Goanta, F., Popescu, I., Beyer, R., Mada, R., Rancea, R., Rosianu, H., Tomoaia, R., Stanescu, C., Kobalava, Z., Karaulova, J., Kotova, E., Milto, A., Pisaryuk, A., Povalyaev, N., Sorokina, M., Alrahimi, J., Elshiekh, A., Jamiel, A., Ahmed, A., Al-Mallah, M., Attia, N., Putnikovic, B., Neskovic, A., Dimic, A., Ivanovic, B., Matic, S., Trifunovic, D., Petrovic, J., Kosevic, D., Dabic, P., Milojevic, P., Petrovic, I., Stojanovic, I., Srdanovic, I., Kovacevic, M., Redzek, A., Stefanovic, M., Susak, S., Velicki, L., Vulin, A., Yeo, T.C., Kong, W.K.F., Poh, K.K., Vilacosta, I., El-Nasser, M. Abd, Ferrera, C., Olmos, C., Iglesias, F. Calvo, Blanco-Gonzalez, E., Amaro, M. Bravo, Germinas, A.N., Lopez-Rodriguez, E., Adan, J. Lugo, Pazos-Lopez, P., Loureiro, M. Pereira, Perez, M.T., Raposeiras-Roubin, S., Yas, S. Rasheed, Suarez-Varela, M.-M., Vidal, F. Vasallo, Garcia-Dorado, D., Sambola, A., Fernandez-Hidalgo, N., Gonzalez-Alujas, T., Lozano, J., Maisterra, O., Pizzi, N., Rios, R., Tornos, P., Bayes-Genis, A., Botet, L. Pedro, Vallejo, N., Berastegui, E., Llibre, C., Mateu, L., Nunez, R., Quesada, D., Portell, D. Bosch, Vinas, J. Aboal, Bertran, X. Albert, Tarradellas, R. Brugada, Ricon, P. Loma-Osorio, de Llano, C. Tiron, Arnau, M.A., Bel, A., Blanes, M., Osa, A., Anguita, M., Carrasco, F., Castillo, J., Zamorano, J.L., Mur, J.L. Moya, Alvaro, M., Fernandez-Golfin, C., Monteagudo, J.M., Elorza, E. Navas, Alvarez, M.C. Farinas, Balbin, J. Aguero, Arminanzas, C., de las Revillas, F. Arnaiz, Garcia, A. Arnaiz, Belaustegui, M. Cobo, Sampedro, M. Fernandez, Cuadra, M. Gutierrez, Gutierrez-Diez, J.F., Zarauza, J., Cuello, L. Garcia, Rico, C. Gonzalez, Rodriguez-Alvarez, R., Goikoetxea, J., Montejo, M., Miro, J., Almela, M., Ambrosioni, J., Falces, C., Fuster, D., Garcia-de-la-Maria, C., Hernandez-Meneses, M., Llopis, J., Marco, F., Moreno, A., Quintana, E., Sandoval, E., Tellez, A., Tolosana, J.M., Vidal, B., Ruiz-Zamora, I., Ruiz, A. Bardaji, Girgas, E. Sanz, Garcia-Pardo, G., Marzo, M. Guillen, Oviedo, A. Rodriguez, Jimenez, A. Villares, Abid, L., Hammami, R., Kammoun, S., Mourali, M.S., Zghal, F. Mghaieth, Hlima, M. Ben, Boudiche, S., Ouali, S., Zakhama, L., Antit, S., Slama, I., Gulel, O., Sahin, M., Sade, L.E., Karacaglar, E., Kucukoglu, S., Cetinarslan, O., Yasar, U.S., Canpolat, U., Mutlu, B., Atas, H., Dervishova, R., Ileri, C., Zaky, H., Alhashmi, J., Baslib, F., Tahir, J., Zarger, P., Woldman, S., Menezes, L., Primus, C., Uppal, R., Bvekerwa, I., Chandrasekaran, B., Kopanska, A., Prendergast, B., Cannata, S., Chambers, J., Hancock, J., Klein, J., Rajani, R., Ursi, M.P., Dworakowski, R., Fife, A., Breeze, J., Browne-Morgan, M., Gunning, M., Streather, S., Asch, F., Zemedkun, M., Alyavi, B., Uzokov, J., van Melle, Joost P., Roos-Hesselink, Jolien W., Bansal, Manish, Pudich, Jiri, Luksic, Vlatka Reskovic, Rodriguez-Alvarez, Regino, Hanzevacki, Jadranka Separovic, Sow, Rouguiatou, Timóteo, Ana Teresa, Morgado, Marisa Trabulo, De Bonis, Michele, Laroche, Cecile, and Boersma, Eric

Published
2023
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24. Turbulence Transition in Magnetically Confined Hydrogen and Deuterium Plasmas

Author

Kinoshita, T., primary, Tanaka, K., additional, Ishizawa, A., additional, Sakai, H., additional, Nunami, M., additional, Ohtani, Y., additional, Yamada, H., additional, Sato, M., additional, Nakata, M., additional, Tokuzawa, T., additional, Yasuhara, R., additional, Takemura, Y., additional, Yamada, I., additional, Funaba, H., additional, Ida, K., additional, Yoshinuma, M., additional, Tsujimura, T., additional, Seki, R., additional, Ichiguchi, K., additional, and Michael, C. A., additional

Published
2024
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25. OP0041 COMPARISON OF b/tsDMARDs ABOUT NON-INFLAMMATORY PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS–ANSWER LONGITUDINAL COHORT STUDY

Author

Yamashita, M., primary, Okano, T., additional, Shirasugi, I., additional, Yamada, H., additional, Nishimura, K., additional, Sendo, S., additional, Ueda, Y., additional, Maeda, T., additional, Hayashi, S., additional, Yamamoto, W., additional, Onishi, A., additional, Murakami, K., additional, Shiba, H., additional, Hata, K., additional, Tsujimoto, K., additional, Ebina, K., additional, Son, Y., additional, Yoshida, N., additional, Hara, R., additional, Watanabe, R., additional, Hashimoto, M., additional, Kuroda, R., additional, and Saegusa, J., additional

Published
2024
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26. POS0737 HIGHER HEALTH-RELATED QUALITY OF LIFE MEASURED BY LUPUS PATIENT-REPORTED OUTCOME WAS ASSOCIATED WITH LOWER INCREASE IN DAMAGE ACCRUAL IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A LONGITUDINAL STUDY USING THE JAPANESE MULTICENTER REGISTRY

Author

Nose, Y., primary, Onishi, A., additional, Nishimura, K., additional, Yamamoto, Y., additional, Yamada, H., additional, Sendo, S., additional, Ueda, Y., additional, Sada, K. E., additional, Ichinose, K., additional, Yoshimi, R., additional, Ohno, S., additional, Yajima, N., additional, Kajiyama, H., additional, Sato, S., additional, Shimojima, Y., additional, Fujiwara, M., additional, Kida, T., additional, Miyawaki, Y., additional, Matsuo, Y., additional, Tsuji, H., additional, Morinobu, A., additional, and Saegusa, J., additional

Published
2024
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27. Observation of a correlated free four-neutron system

Author

Duer, M., Aumann, T., Gernhäuser, R., Panin, V., Paschalis, S., Rossi, D. M., Achouri, N. L., Ahn, D., Baba, H., Bertulani, C. A., Böhmer, M., Boretzky, K., Caesar, C., Chiga, N., Corsi, A., Cortina-Gil, D., Douma, C. A., Dufter, F., Elekes, Z., Feng, J., Fernández-Domínguez, B., Forsberg, U., Fukuda, N., Gasparic, I., Ge, Z., Gheller, J. M., Gibelin, J., Gillibert, A., Hahn, K. I., Halász, Z., Harakeh, M. N., Hirayama, A., Holl, M., Inabe, N., Isobe, T., Kahlbow, J., Kalantar-Nayestanaki, N., Kim, D., Kim, S., Kobayashi, T., Kondo, Y., Körper, D., Koseoglou, P., Kubota, Y., Kuti, I., Li, P. J., Lehr, C., Lindberg, S., Liu, Y., Marqués, F. M., Masuoka, S., Matsumoto, M., Mayer, J., Miki, K., Monteagudo, B., Nakamura, T., Nilsson, T., Obertelli, A., Orr, N. A., Otsu, H., Park, S. Y., Parlog, M., Potlog, P. M., Reichert, S., Revel, A., Saito, A. T., Sasano, M., Scheit, H., Schindler, F., Shimoura, S., Simon, H., Stuhl, L., Suzuki, H., Symochko, D., Takeda, H., Tanaka, J., Togano, Y., Tomai, T., Törnqvist, H. T., Tscheuschner, J., Uesaka, T., Wagner, V., Yamada, H., Yang, B., Yang, L., Yang, Z. H., Yasuda, M., Yoneda, K., Zanetti, L., Zenihiro, J., and Zhukov, M. V.

Published
2022
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28. How Robust is the N = 34 Subshell Closure? First Spectroscopy of $^{52}$Ar

Author

Liu, H. N., Obertelli, A., Doornenbal, P., Bertulani, C. A., Hagen, G., Holt, J. D., Jansen, G. R., Morris, T. D., Schwenk, A., Stroberg, R., Achouri, N., Baba, H., Browne, F., Calvet, D., Château, F., Chen, S., Chiga, N., Corsi, A., Cortés, M. L., Delbart, A., Gheller, J. -M., Giganon, A., Gillibert, A., Hilaire, C., Isobe, T., Kobayashi, T., Kubota, Y., Lapoux, V., Motobayashi, T., Murray, I., Otsu, H., Panin, V., Paul, N., Rodriguez, W., Sakurai, H., Sasano, M., Steppenbeck, D., Stuhl, L., Sun, Y. L., Togano, Y., Uesaka, T., Wimmer, K., Yoneda, K., Aktas, O., Aumann, T., Chung, L. X., Flavigny, F., Franchoo, S., Gašparić, I., Gerst, R. -B., Gibelin, J., Hahn, K. I., Kim, D., Koiwai, T., Kondo, Y., Koseoglou, P., Lee, J., Lehr, C., Linh, B. D., Lokotko, T., MacCormick, M., Moschner, K., Nakamura, T., Park, S. Y., Rossi, D., Sahin, E., Sohler, D., Söderström, P. -A., Takeuchi, S., Törnqvist, H., Vaquero, V., Wagner, V., Wang, S., Werner, V., Xu, X., Yamada, H., Yan, D., Yang, Z., Yasuda, M., and Zanetti, L.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The first $\gamma$-ray spectroscopy of $^{52}$Ar, with the neutron number N = 34, was measured using the $^{53}$K(p,2p) one-proton removal reaction at $\sim$210 MeV/u at the RIBF facility. The 2$^{+}_{1}$ excitation energy is found at 1656(18) keV, the highest among the Ar isotopes with N $>$ 20. This result is the first experimental signature of the persistence of the N = 34 subshell closure beyond $^{54}$Ca, i.e., below the magic proton number Z = 20. Shell-model calculations with phenomenological and chiral-effective-field-theory interactions both reproduce the measured 2$^{+}_{1}$ systematics of neutron-rich Ar isotopes, and support a N = 34 subshell closure in $^{52}$Ar.

Published
2018
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30. Depth profiling charge accumulation from a ferroelectric into a doped Mott insulator

Author

Marinova, M., Rault, J. E., Gloter, A., Nemsak, S., Palsson, G. K., Rueff, J. -P., Fadley, C. S., Carretero, C., Yamada, H., March, K., Garcia, V., Fusil, S., Barthelemy, A., Stephan, O., Colliex, C., and Bibes, M.

Subjects
Condensed Matter - Materials Science
Abstract

The electric field control of functional properties is a crucial goal in oxide-based electronics. Non-volatile switching between different resistivity or magnetic states in an oxide channel can be achieved through charge accumulation or depletion from an adjacent ferroelectric. However, the way in which charge distributes near the interface between the ferroelectric and the oxide remains poorly known, which limits our understanding of such switching effects. Here we use a first-of-a-kind combination of scanning transmission electron microscopy with electron energy loss spectroscopy, near-total-reflection hard X-ray photoemission spectroscopy, and ab-initio theory to address this issue. We achieve a direct, quantitative, atomic-scale characterization of the polarization-induced charge density changes at the interface between the ferroelectric BiFeO3 and the doped Mott insulator Ca1-xCexMnO3, thus providing insight on how interface-engineering can enhance these switching effects., Comment: Work supported by ERC Consolidator grant MINT (Contract No. 615759)

Published
2017
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31. Efficacy of plasma exchange in anti-Ro52 and anti-MDA5 antibody-positive dermatomyositis with progressive interstitial lung disease: a case report.

Author

Kojima, M, Sawasaki, N, Senzaki, K, Aoki, K, Matsushita, H, Ito, H, Uchida, M, Noda, S, Oishi, M, Kawahara, Y, and Yamada, H

Subjects
MACROPHAGE colony-stimulating factor, TYPE I interferons, VITAL capacity (Respiration), PULMONARY function tests, THERAPEUTICS, DERMATOMYOSITIS
Abstract

A case report published in the Scandinavian Journal of Rheumatology discusses the efficacy of plasma exchange in a 53-year-old female with anti-Ro52 and anti-MDA5 antibody-positive dermatomyositis and progressive interstitial lung disease. The patient presented with skin manifestations and ILD, leading to emergency admission. Treatment with triple therapy and plasma exchange resulted in remission, highlighting the potential benefits of this combination therapy in refractory cases. Further research is needed to validate these findings and explore the role of plasma exchange in similar cases. [Extracted from the article]

Published
2024
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32. Neutron capture reaction cross-section of 79Se through the 79Se(d,p) reaction in inverse kinematics

Author

Imai, N., primary, Dozono, M., additional, Michimasa, S., additional, Sumikama, T., additional, Ota, S., additional, Hayakawa, S., additional, Hwang, J.W., additional, Iribe, K., additional, Iwamoto, C., additional, Kawase, S., additional, Kawata, K., additional, Kitamura, N., additional, Masuoka, S., additional, Nakano, K., additional, Schrock, P., additional, Suzuki, D., additional, Tsunoda, R., additional, Wimmer, K., additional, Ahn, D.S., additional, Beliuskina, O., additional, Chiga, N., additional, Fukuda, N., additional, Ideguchi, E., additional, Kusaka, K., additional, Miki, H., additional, Miyatake, H., additional, Nagae, D., additional, Ohmika, S., additional, Ohtake, M., additional, Ong, H.J., additional, Otsu, H., additional, Sakurai, H., additional, Shimizu, H., additional, Shimizu, Y., additional, Sun, X., additional, Suzuki, H., additional, Takaki, M., additional, Takeda, H., additional, Takeuchi, S., additional, Teranishi, T., additional, Watanabe, Y., additional, Watanabe, Y.X., additional, Yako, K., additional, Yamada, H., additional, Yamaguchi, H., additional, Yang, L., additional, Yanagihara, R., additional, Yanagisawa, Y., additional, Yoshida, K., additional, and Shimoura, S., additional

Published
2024
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33. Study of Multi-neutron Systems with SAMURAI Spectrometer

Author

Yang, Z. H., Marqués, F. M., Achouri, N. L., Ahn, D. S., Aumann, T., Baba, H., Beaumel, D., Böhmer, M., Boretzky, K., Caamaño, M., Chen, S., Chiga, N., Cortés, M. L., Cortina, D., Doornenbal, P., Douma, C. A., Dufter, F., Feng, J., Fernández-Domínguez, B., Elekes, Z., Forsberg, U., Fujino, T., Fukuda, N., Gašparić, I., Ge, Z., Gernhäuser, R., Gheller, J. M., Gibelin, J., Gillibert, A., Godoy, B. M., Halász, Z., Harada, T., Harakeh, M. N., Hirayama, A., Huang, S. W., Inabe, N., Isobe, T., Kahlbow, J., Kalantar-Nayestanaki, N., Kim, D., Kim, S., Knösel, M. A., Kobayashi, T., Kondo, Y., Koseoglou, P., Kubota, Y., Kuti, I., Lehr, C., Li, P. J., Liu, Y., Maeda, Y., Masuoka, S., Matsumoto, M., Mayer, J., Miki, H., Miwa, M., Murray, I., Nakamura, T., Obertelli, A., Orr, N. A., Otsu, H., Panin, V., Park, S., Parlog, M., Paschalis, S., Potlog, M., Reichert, S., Revel, A., Rossi, D., Saito, A., Sasano, M., Sato, H., Scheit, H., Schindler, F., Shimada, T., Shimizu, Y., Shimoura, S., Stefan, I., Storck, S., Stuhl, L., Suzuki, H., Symochko, D., Takeda, H., Takeuchi, S., Tanaka, J., Togano, Y., Tomai, T., Törnqvsit, H. T., Tscheuschner, J., Uesaka, T., Wagner, V., Wimmer, K., Yamada, H., Yang, B., Yang, L., Yasuda, Y., Yoneda, K., Zanetti, L., Zenihiro, J., Orr, N. A., editor, Ploszajczak, M., editor, Marqués, F. M., editor, and Carbonell, J., editor

Published
2020
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34. Electrochemical kinetics and dimensional considerations at the nanoscale

Author

Yamada, H. and Bandaru, P. R.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science, Physics - Chemical Physics
Abstract

It is shown that the consideration of the density of states variation in nanoscale electrochemical systems yields modulations in the rate constant and concomitant electrical currents. The proposed models extend the utility of Marcus-Hush-Chidsey (MHC) kinetics to a larger class of materials and could be used as a test of dimensional character. The implications of the study are of much significance to an understanding and modulation of charge transfer nanostructured electrodes., Comment: 15 pages, 6 figures

Published
2016

36. Experimental study of ⁴n with ⁸He(p,2p) reaction

Author

Huang, S. W., Yang, H., Marqués, F. M., Achouri, N. L., Ahn, D. S., Aumann, T., Baba, H., Beaumel, D., Böhmer, M., Boretzky, K., Caamaño, M., Chen, S., Chiga, N., Cortés, M. L., Cortina, D., Doornenbal, P., Douma, C. A., Dufter, F., Feng, J., Fernández-Domínguez, B., Elekes, Z., Forsberg, U., Fujino, T., Fukuda, N., Gašparić, I., Ge, Z., Gernhäuser, R., Gheller, J. M., Gibelin, J., Gillibert, A., Godoy, B. M., Halász, Z., Harada, T., Harakeh, M. N., Hirayama, A., Inabe, N., Isobe, T., Kahlbow, J., Kalantar-Nayestanaki, N., Kim, D., Kim, S., Knösel, M. A., Kobayashi, T., Kondo, Y., Koseoglou, P., Kubota, Y., Kuti, I., Lehr, C., Li, P. J., Liu, Y., Maeda, Y., Masuoka, S., Matsumoto, M., Mayer, J., Miki, H., Miwa, M., Murray, I., Nakamura, T., Obertelli, A., Orr, N., Otsu, H., Panin, V., Park, S., Parlog, M., Paschalis, S., Potlog, M., Reichert, S., Revel, A., Rossi, D., Saito, A., Sasano, M., Sato, H., Scheit, H., Schindler, F., Shimada, T., Shimizu, Y., Shimoura, S., Stefan, I., Storck, S., Stuhl, L., Suzuki, H., Symochko, D., Takeda, H., Takeuchi, S., Tanaka, J., Togano, Y., Tomai, T., Törnqvsit, H. T., Tscheuschner, J., Uesaka, T., Wagner, V., Wimmer, K., Yamada, H., Yang, B., Yang, L., Yasuda, Y., Yoneda, K., Zanetti, L., Zenihiro, J., Elidiano, T., Lenain, C., Huang, S. W., Yang, H., Marqués, F. M., Achouri, N. L., Ahn, D. S., Aumann, T., Baba, H., Beaumel, D., Böhmer, M., Boretzky, K., Caamaño, M., Chen, S., Chiga, N., Cortés, M. L., Cortina, D., Doornenbal, P., Douma, C. A., Dufter, F., Feng, J., Fernández-Domínguez, B., Elekes, Z., Forsberg, U., Fujino, T., Fukuda, N., Gašparić, I., Ge, Z., Gernhäuser, R., Gheller, J. M., Gibelin, J., Gillibert, A., Godoy, B. M., Halász, Z., Harada, T., Harakeh, M. N., Hirayama, A., Inabe, N., Isobe, T., Kahlbow, J., Kalantar-Nayestanaki, N., Kim, D., Kim, S., Knösel, M. A., Kobayashi, T., Kondo, Y., Koseoglou, P., Kubota, Y., Kuti, I., Lehr, C., Li, P. J., Liu, Y., Maeda, Y., Masuoka, S., Matsumoto, M., Mayer, J., Miki, H., Miwa, M., Murray, I., Nakamura, T., Obertelli, A., Orr, N., Otsu, H., Panin, V., Park, S., Parlog, M., Paschalis, S., Potlog, M., Reichert, S., Revel, A., Rossi, D., Saito, A., Sasano, M., Sato, H., Scheit, H., Schindler, F., Shimada, T., Shimizu, Y., Shimoura, S., Stefan, I., Storck, S., Stuhl, L., Suzuki, H., Symochko, D., Takeda, H., Takeuchi, S., Tanaka, J., Togano, Y., Tomai, T., Törnqvsit, H. T., Tscheuschner, J., Uesaka, T., Wagner, V., Wimmer, K., Yamada, H., Yang, B., Yang, L., Yasuda, Y., Yoneda, K., Zanetti, L., Zenihiro, J., Elidiano, T., and Lenain, C.

Abstract

The tetraneutron has attracted the attention of nuclear physicists during the past decades, but there is still no unambiguous confirmation of its existence or non-existence. A new experiment based on ⁸He(p,2p)⁷H{t+⁴ n} reaction, with direct detection of the four neutrons, has been carried out at RIBF, which can hopefully help to draw a definite conclusion on the tetraneutron system.

Published
2024

37. Lifetime measurement of the ²⁶O g.s. at SAMURAI

Author

Storck, S., Caesar, C., Kahlbow, J., Panin, V., Ahn, D. S., Atar, L., Aumann, T., Baba, H., Boretzky’, K., Chae, H., Chiga, N., Choi, S., Cortés, M. L., Cortina-Gil, D., Deshayes, Q., Doornenbal, P., Elekes, Z., Fukuda, N., Gašparić, I., Hahn, K. I., Halász, Z., Hirayama, A., Hwang, J., Inabe, N., Isobe, T., Kim, S., Kobayashi, T., Körper, D., Marques, M., Matsumoto, M., Murakami, T., Murray, I., Nakamura, T., Nilsson, T., Otsu, H., Paschalis, S., Parlog, M., Petri, M., Rossi, D., Saito, A., Sasano, M., Scheit, H., Schrock, P., Shimizu, Y., Simon, H., Sohler, D., Sorlin, O., Stuhl, L., Suzuki, H., Syndikus, I., Takeda, H., Törnqvist, H., Togano, Y., Tomai, T., Uesaka, T., Yamada, H., Yang, Z., Yasuda, M., Yoneda, K. I., Storck, S., Caesar, C., Kahlbow, J., Panin, V., Ahn, D. S., Atar, L., Aumann, T., Baba, H., Boretzky’, K., Chae, H., Chiga, N., Choi, S., Cortés, M. L., Cortina-Gil, D., Deshayes, Q., Doornenbal, P., Elekes, Z., Fukuda, N., Gašparić, I., Hahn, K. I., Halász, Z., Hirayama, A., Hwang, J., Inabe, N., Isobe, T., Kim, S., Kobayashi, T., Körper, D., Marques, M., Matsumoto, M., Murakami, T., Murray, I., Nakamura, T., Nilsson, T., Otsu, H., Paschalis, S., Parlog, M., Petri, M., Rossi, D., Saito, A., Sasano, M., Scheit, H., Schrock, P., Shimizu, Y., Simon, H., Sohler, D., Sorlin, O., Stuhl, L., Suzuki, H., Syndikus, I., Takeda, H., Törnqvist, H., Togano, Y., Tomai, T., Uesaka, T., Yamada, H., Yang, Z., Yasuda, M., and Yoneda, K. I.

Abstract

The ground state of the neutron unbound nucleus ²⁶O is speculated to have a lifetime in the pico-second regime. In order to determine the decay lifetime of the ²⁶O ground state with high sensitivity and precision, a new method has been applied. The experiment was performed in December 2016 at the Superconducting Analyzer for MUlti-particle from Radio Isotope Beams (SAMURAI) at the Radioactive Isotope Beam Factory (RIBF) at RIKEN. A ²⁷F beam was produced in the fragment separator BigRIPS and impinged on a W/Pt target ²⁶O ²⁶O outside the target. Thus, the velocity difference between the decay neutrons and the fragment 1 O delivers a characteristic spectrum from which the lifetime can be extracted.

Published
2024

38. Turbulence Transition in Magnetically Confined Hydrogen and Deuterium Plasmas

Author

Kinoshita, T., Tanaka, K., Ishizawa, A., Sakai, H., Nunami, M., Ohtani, Y., Yamada, H., Sato, M., Nakata, M., Tokuzawa, T., Yasuhara, R., Takemura, Y., Yamada, I., Funaba, H., Ida, K., Yoshinuma, M., Tsujimura, T., Seki, R., Ichiguchi, K., Michael, C. A., Kinoshita, T., Tanaka, K., Ishizawa, A., Sakai, H., Nunami, M., Ohtani, Y., Yamada, H., Sato, M., Nakata, M., Tokuzawa, T., Yasuhara, R., Takemura, Y., Yamada, I., Funaba, H., Ida, K., Yoshinuma, M., Tsujimura, T., Seki, R., Ichiguchi, K., and Michael, C. A.

Abstract

In this study, we discovered a turbulence transition in a large helical device. The turbulence level and turbulence-driven energy transport decrease to a specific transition density and increase above it. The ruling turbulences below and above the transition density were ion-temperature gradient (ITG) and resistive-interchange (RI) turbulences, consistent with the predictions of gyrokinetic theory and two-fluid MHD model, respectively. Isotope experiments on hydrogen (H) and deuterium (D) clarified the role of transitions. In the ITG regime, turbulence levels and energy transport were comparable in the H and D plasmas. In contrast, in the RI regime, they were clearly suppressed in the D plasma. The results provide crucial knowledge for understanding isotope effects and future optimization of stellarator and heliotron devices.

Published
2024

42. Study of spin-isospin responses of radioactive nuclei with the background-reduced neutron spectrometer, PANDORA

Author

Stuhl, L., Sasano, M., Gao, J., Hirai, Y., Yako, K., Wakasa, T., Ahn, D.S., Baba, H., Chilug, A.I., Franchoo, S., Fujino, Y., Fukuda, N., Gibelin, J., Hahn, I.S., Halász, Z., Harada, T., Harakeh, M.N., Inomoto, D., Isobe, T., Kasahara, H., Kim, D., Kiss, G.G., Kobayashi, T., Kondo, Y., Korkulu, Z., Koyama, S., Kubota, Y., Kurihara, A., Liu, H.N., Matsumoto, M., Michimasa, S., Miki, H., Miwa, M., Motobayashi, T., Nakamura, T., Nishimura, M., Otsu, H., Panin, V., Park, S., Saito, A.T., Sakai, H., Sato, H., Shimada, T., Shimizu, Y., Shimoura, S., Spiridon, A., Stefanescu, I.C., Sun, X., Sun, Y.L., Suzuki, H., Takada, E., Togano, Y., Tomai, T., Trache, L., Tudor, D., Uesaka, T., Yamada, H., Yang, Z., Yasuda, M., Yoneda, K., Yoshida, K., Zenihiro, J., and Zhang, N.

Published
2020
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45. High-performance ferroelectric memory based on fully patterned tunnel junctions

Author

Boyn, S., Girod, S., Garcia, V., Fusil, S., Xavier, S., Deranlot, C., Yamada, H., Carrétéro, C., Jacquet, E., Bibes, M., Barthélémy, A., and Grollier, J.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

In tunnel junctions with ferroelectric barriers, switching the polarization direction modifies the electrostatic potential profile and the associated average tunnel barrier height. This results in strong changes of the tunnel transmission and associated resistance. The information readout in ferroelectric tunnel junctions (FTJs) is thus resistive and non-destructive, which is an advantage compared to the case of conventional ferroelectric memories (FeRAMs). Initially, endurance limitation (i.e. fatigue) was the main factor hampering the industrialization of FeRAMs. Systematic investigations of switching dynamics for various ferroelectric and electrode materials have resolved this issue, with endurance now reaching $10^{14}$ cycles. Here we investigate data retention and endurance in fully patterned submicron Co/BiFeO$_3$/Ca$_{0.96}$Ce$_{0.04}$MnO$_3$ FTJs. We report good reproducibility with high resistance contrasts and extend the maximum reported endurance of FTJs by three orders of magnitude ($4\times10^6$ cycles). Our results indicate that here fatigue is not limited by a decrease of the polarization or an increase of the leakage but rather by domain wall pinning. We propose directions to access extreme and intermediate resistance states more reliably and further strengthen the potential of FTJs for non-volatile memory applications.

Published
2014
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46. Experimental Study of 4n by Directly Detecting the Decay Neutrons

Author

Huang, S. W., Yang, Z. H., Marqués, F. M., Achouri, N. L., Ahn, D. S., Aumann, T., Baba, H., Beaumel, D., Böhmer, M., Boretzky, K., Caamaño, M., Chen, S., Chiga, N., Cortés, M. L., Cortina, D., Doornenbal, P., Douma, C. A., Dufter, F., Feng, J., Fernández-Domínguez, B., Elekes, Z., Forsberg, U., Fujino, T., Fukuda, N., Gašparić, I., Ge, Z., Gernhäuser, R., Gheller, J. M., Gibelin, J., Gillibert, A., Halász, Z., Harada, T., Harakeh, M. N., Hirayama, A., Inabe, N., Isobe, T., Kahlbow, J., Kalantar-Nayestanaki, N., Kim, D., Kim, S., Kiyotake, S., Kobayashi, T., Kondo, Y., Koseoglou, P., Kubota, Y., Kuti, I., Lehr, C., Lenain, C., Li, P. J., Liu, Y., Maeda, Y., Masuoka, S., Matsumoto, M., Matta, A., Mayer, J., Miki, H., Miwa, M., Monteagudo, B., Murray, I., Nakamura, T., Obertelli, A., Orr, N. A., Otsu, H., Panin, V., Park, S., Parlog, M., Paschalis, S., Potlog, M., Reichert, S., Revel, A., Rossi, D., Saito, A., Sasano, M., Sato, H., Scheit, H., Schindler, F., Shimada, T., Shimizu, Y., Shimoura, S., Simon, H., Stefan, I., Storck, S., Stuhl, L., Suzuki, H., Symochko, D., Takeda, H., Takeuchi, S., Tanaka, J., Togano, Y., Tomai, T., Törnqvist, H. T., Tronchin, E., Tscheuschner, J., Uesaka, T., Wagner, V., Wimmer, K., Yamada, H., Yang, B., Yang, L., Yasuda, Y., Yoneda, K., Zanetti, L., and Zenihiro, J.

Published
2021
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47. Prevalence of Facet Effusion and Its Relationship with Lumbar Spondylolisthesis and Low Back Pain: The Wakayama Spine Study

Author

Shinto K, Minamide A, Hashizume H, Oka H, Matsudaira K, Iwahashi H, Ishimoto Y, Teraguchi M, Kagotani R, Asai Y, Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Yoshida M, Yoshimura N, and Yamada H

Subjects
lumbar spine, facet effusion, low back pain, spondylolisthesis, epidemiology, Medicine (General), R5-920
Abstract

Kazunori Shinto,1 Akihito Minamide,1 Hiroshi Hashizume,1 Hiroyuki Oka,2 Ko Matsudaira,2 Hiroki Iwahashi,1 Yuyu Ishimoto,1 Masatoshi Teraguchi,1 Ryohei Kagotani,1 Yoshiki Asai,1 Shigeyuki Muraki,3 Toru Akune,4 Sakae Tanaka,5 Hiroshi Kawaguchi,6 Kozo Nakamura,7 Munehito Yoshida,1,8 Noriko Yoshimura,3,* Hiroshi Yamada1,* 1Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama City, Wakayama, Japan; 2Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; 3Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; 4National Rehabilitation Center for Persons with Disabilities, Tokorozawa City, Saitama, Japan; 5Department of Orthopaedic Surgery, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; 6Tokyo Neurological Center, Minato-ku, Tokyo, Japan; 7Towa Hospital, Adachi-ku, Tokyo, Japan; 8Department of Orthopaedic Surgery, Sumiya Orthopaedic Hospital, Wakayama City, Wakayama, Japan*These authors contributed equally to this workCorrespondence: Hiroshi HashizumeDepartment of Orthopaedic Surgery, Wakayama Medical University, Wakayama City, 811-1 Kimiidera, Wakayama City, Wakayama 641-8510, JapanTel +81-73-441-0645Fax +81-73-448-3008Email hashizum@wakayama-med.ac.jpIntroduction: Facet effusion represents a magnetic resonance imaging finding suggesting accumulation of fluid in the facet joint, potentially predictive of lumbar spondylolisthesis and low back pain. However, its prevalence and epidemiological characteristics in the general population remain unclear, because previous studies only included patients or volunteers. The aim of the present study was to investigate the prevalence of facet effusion in the general population and to describe its potential relationship with spondylolisthesis and low back pain.Material and methods: Our study enrolled 808 participants from the Wakayama Spine Study who underwent magnetic resonance imaging investigations in supine position. Facet effusion was defined as a measurable, curvilinear, high-intensity signal within the facet joint, closely matching that of cerebrospinal fluid on the axial T2 images. We used standing lateral radiographs to diagnose L4 spondylolisthesis.Results: We found that the prevalence of facet effusion in the lumbar spine was 34.3%, which did not differ significantly between men and women (p=0.13) and did not tend to increase with age, either in men (p=0.81) or in women (p=0.65). Additionally, we found no significant association between facet effusion and low back pain (odds ratio, 1.04–1.49; 95% confidence interval, 0.57–2.64; p=0.17–0.85), or between facet effusion and L4 spondylolisthesis (odds ratio, 1.55; 95% confidence interval, 0.80–2.86; p=0.17). In a subset of participants with L4 spondylolisthesis, we also noted that facet effusion was not significantly associated with low back pain (odds ratio, 1.26; 95% confidence interval, 0.37–4.27; p=0.70).Discussion: This is the first study of facet effusion employing a population-based cohort, and the findings are thus expected to accurately describe the relationship between facet effusion and low back pain in the general population. We are planning a follow-up survey of the Wakayama Spine Study cohort to clarify the natural history of facet effusion and its relationship with clinical symptoms.Keywords: lumbar spine, facet effusion, low back pain, spondylolisthesis, epidemiology

Published
2019

50. Socioeconomic variations determine the clinical presentation, aetiology, and outcome of infective endocarditis: a prospective cohort study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) registry

Author

Sengupta, S, Prendergast, B, Laroche, C, Furnaz, S, Ronderos, R, Almaghraby, A, Asch, F, Blechova, K, Zaky, H, Strahilevitz, J, Dworakowski, R, Miyasaka, Y, Sebag, I, Izumi, C, Axler, O, Jamiel, A, Philip, M, Vieira, M, Lancellotti, P, Habib, G, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Iung, B, Popescu, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Sade, L, Sadeghpour, A, Sambola, A, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Granada, I, Mahia, M, Ressi, S, Na-Cinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streit-Enberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Melis-Sopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droog-Mans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Am-Sel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, Miglioranza, M, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gou-Vea, A, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Bellio de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Della Togna, D, Le Bihan, D, Miglioli, L, Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, El-Gebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J, Detoc, M, Mehalla, T, Boutoille, D, Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J, Aboyans, V, Bee-Harry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Go-Hier, S, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nick-Enig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Bar-Betseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Noohi Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Morad-Nejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Mar-Chionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, Orcese, C, Panzeri, F, Spano, F, Russo, C, Alferi, O, De Bonis, M, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasci-Uta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Di Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Actis Dato, G, De Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shi-Tan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, Park, S, Eun Kyoung, K, Ga Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, De la Vega, E, Jacobs-Orazi, L, Mallia Azzopardi, C, Xuereb, R, Pis-Copo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Gre-Jdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfle, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Waha-Dat, A, Gamela, T, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-Van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kamin-Ska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Ko-Tova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vi-Lacosta, I, Ferrera, C, Olmos, C, Abd El-Nasser, M, Calvo Iglesias, F, Bianco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tar-Radellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Navas Elorza, E, Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, Gutierrez-Diez, J, Arminanzas, C, Arnaiz de las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-De-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Ham-Mami, R, Kammoun, S, Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Zemedkun, M, Alyavi, B, Uzokov, J, Sengupta S. P., Prendergast B., Laroche C., Furnaz S., Ronderos R., Almaghraby A., Asch F. M., Blechova K., Zaky H., Strahilevitz J., Dworakowski R., Miyasaka Y., Sebag I., Izumi C., Axler O., Jamiel A., Philip M., Vieira M. L. C., Lancellotti P., Habib G., Gale C. P., Beleslin B., Budaj A., Chioncel O., Dagres N., Danchin N., Emberson J., Erlinge D., Glikson M., Gray A., Kayikcioglu M., Maggioni A. P., Nagy V. K., Nedoshivin A., Petronio A. -S., Roos-Hesselink J., Wallentin L., Zeymer U., Cosyns B., Donal E., Erba P., Iung B., Popescu B. A., Tornos P., Andarala M., Berle C., Brunel-Lebecq A., Fiorucci E., Missiamenou V., Taylor C., Ali Tatar-Chentir N. N., Al-Mallah M., Astrom Aneq M., Athanassopoulos G., Badano L. P., Benyoussef S., Calderon Aranda E., Cardim N. M., Chan K. -L., Cruz I., Edvardsen T., Goliasch G., Hagendorff A., Hristova K., Kamp O., Kang D. -H., Kong W., Matskeplishvili S., Meshaal M., Mirocevic M., Neskovic A. N., Pazdernik M., Plonska-Gosciniak E., Raissouni M., Sade L. E., Sadeghpour A., Sambola A., Separovic-Hanzevacki J., Takeuchi M., Tucay E., Tude Rodrigues A. C., Varga A., Vaskelyte J., Yamagata K., Yiangou K., Granada I., Mahia M., Ressi S., Na-Cinovich F., Iribarren A., Fernandez Oses P., Avegliano G., Filipini E., Obregon R., Bangher M., Dho J., Cartasegna L., Plastino M. L., Novas V., Shigel C., Reyes G., De Santos M., Gastaldello N., Granillo Fernandez M., Potito M., Streit-Enberger G., Velazco P., Casabe J. H., Cortes C., Guevara E., Salmo F., Seijo M., Weidinger F., Heger M., Brooks R., Stollberger C., Ho C. -Y., Perschy L., Puskas L., Binder C., Rosenhek R., Schneider M., Winter M. -P., Hoffer E., Melis-Sopoulou M., Lecoq E., Legrand D., Jacquet S., Massoz M., Pierard L., Marchetta S., Dulgheru R., D'Emal C., Oury C., Droog-Mans S., Kerkhove D., Plein D., Soens L., Weytjens C., Motoc A., Roosens B., Lemoine I., Rodrigus I., Paelinck B., Am-Sel B., Unger P., Konopnicki D., Beauloye C., Pasquet A., Vanoverschelde J. L., Pierard S., Vancraeynest D., Sinnaeve F., Andrade J. L., Staszko K., Dos Santos Monteiro R., Miglioranza M. H., Shuha D. L., Alcantara M., Cravo V., Fazzio L., Felix A., Iso M., Musa C., Siciliano A. P., Villaca Filho F., Rodrigues A., Vilela F., Braga J., Silva R., Rodrigues D., Silva L., Morhy S., Fischer C., Afonso T., Abreu J., Falcao S. N., Moises V. A., Gou-Vea A., Mancuso F. J., Souza A. C., Silva C. Y., Joao G., Abboud C. S., Bellio de Mattos Barretto R., Ramos A., Arnoni R., Assef J. E., Della Togna D. J., Le Bihan D., Miglioli L., Romero Oliveira A. P., Tadeu Magro Kroll R., Cortez D., Gelape C. L., Peirira Nunes M. D. C., De Abreu Ferrari T. C., Hay K., Le V., Page M., Poulin F., Sauve C., Serri K., Mercure C., Beaudoin J., Pibarot P., Rudski L. G., Ricafort G., Barsic B., Krajinovic V., Vargovic M., Lovric D., Reskovic-Luksic V., Vincelj J., Jaksic Jurinjak S., Yiannikourides V., Ioannides M., Pofaides C., Masoura V., Pudich J., Linhart A., Siranec M., Marek J., Kamenik M., Pelouch R., Coufal Z., Mikulica M., Griva M., Jancova E., Mikulcova M., Taborsky M., Precek J., Jecmenova M., Latal J., Widimsky J., Butta T., Machacek S., Vancata R., Spinar J., Holicka M., Pow Chon Long F., Anzules N., Bajana Carpio A., Largacha G., Penaherrera E., Moreira D., Mahfouz E., Elsafty E., Soliman A., Zayed Y., Aboulenein J., Abdel-Hay M., Abdelnaby M., Ahmed M., Hammad B., Saleh Y., Zahran H., El-Gebaly O., Saad A., Ali M., Zeid A., El Sharkawy R., Al Kholy A., Doss R., Osama D., Rizk H., Elmogy A., Mishriky M., Assayag P., El Hatimi S., Hubert S., Casalta J. -P., Gouriet F., Arregle F., Cammilleri S., Tessonnier L., Riberi A., Botelho-Nevers E., Gagneux-Brunon A., Pierrard R., Tulane C., Campisi S., Fuzellier J. -F., Detoc M., Mehalla T., Boutoille D., Lecompte A. S., Lefebvre M., Pattier S., Al Habash O., Asseray-Madani N., Biron C., Brochard J., Caillon J., Cueff C., Le Tourneau T., Lecomte R., Magali Michel M. M., Orain J., Delarue S., Le Bras M., Faucher J. -F., Aboyans V., Bee-Harry A., Durox H., Lacoste M., Magne J., Mohty D., David A., Pradel V., Sierra V., Neykova A., Bettayeb B., Elkentaoui S., Tzvetkov B., Landry G., Strady C., Ainine K., Baumard S., Brasselet C., Tassigny C., Valente-Pires V., Lefranc M., Hoen B., Lefevre B., Curlier E., Callier C., Fourcade N., Jobic Y., Ansard S., Le Berre R., Le Ven F., Pouliquen M. -C., Prat G., Le Roux P., Bouchart F., Savoure A., Alarcon C., Chapuzet C., Gueit I., Tribouilloy C., Bohbot Y., Peugnet F., Gun M., Duval X., Lescure X., Ilic-Habensus E., Sadoul N., Selton-Suty C., Alla F., Goehringer F., Huttin O., Chevalier E., Garcia R., Le Marcis V., Tattevin P., Flecher E., Revest M., Chirouze C., Bouiller K., Hustache-Mathieu L., Klopfenstein T., Moreau J., Fournier D., Brunel A. -S., Lim P., Oliver L., Ternacle J., Moussafeur A., Chavanet P., Piroth L., Salmon-Rousseau A., Buisson M., Mahy S., Martins C., Go-Hier S., Baumann F., Lebras S., Piper C., Guckel D., Borgermann J., Horstkotte D., Winkelmann E., Brockmeier B., Grey D., Nick-Enig G., Schueler R., Ozturk C., Stohr E., Hamm C., Walther T., Brandt R., Fruhauf A. -C., Hartung C. T., Hellner C., Wild C., Becker M., Hamada S., Kaestner W., Stangl K., Knebel F., Baldenhofer G., Brecht A., Dreger H., Isner C., Pfafflin F., Stegemann M., Zahn R., Fraiture B., Kilkowski C., Karcher A. -K., Klinger S., Tolksdorf H., Tousoulis D., Aggeli C., Sideris S., Venieri E., Sarri G., Tsiapras D., Armenis I., Koutsiari A., Floros G., Grassos C., Dragasis S., Rallidis L., Varlamos C., Michalis L., Naka K., Bechlioulis A., Kotsia A., Lakkas L., Pappas K., Papadopoulos C., Kiokas S., Lioni A., Misailidou S., Bar-Betseas J., Bonou M., Kapelios C., Tomprou I., Zerva K., Manolis A., Hamodraka E., Athanasiou D., Haralambidis G., Samaras H., Poulimenos L., Nagy A., Bartykowszki A., Gara E., Mungulmare K., Kasliwal R., Bansal M., Ranjan S., Bhan A., Kyavar M., Maleki M., Noohi Bezanjani F., Alizadehasl A., Boudagh S., Ghavidel A., Morad-Nejad P., Pasha H. R., Ghadrdoost B., Gilon D., Wanounou M., Israel S., d'Agostino C., Colonna P., De Michele L., Fumarola F., Stante M., Mar-Chionni N., Scheggi V., Alterini B., Del Pace S., Stefano P., Sparano C., Ruozi N., Tenaglia R., Muraru D., Limbruno U., Cresti A., Baratta P., Solari M., Giannattasio C., Moreo A., De Chiara B., Lopez Montero B., Musca F., Orcese C. A., Panzeri F., Spano F., Russo C. F., Alferi O., De Bonis M., Chiappetta S., Del Forno B., Ripa M., Scarpellini P., Tassan Din C., Castiglioni B., Pasci-Uta R., Carletti S., Ferrara D., Guffanti M., Iaci G., Lapenna E., Nisi T., Oltolini C., Busnardo E., Pajoro U., Agricola E., Meneghin R., Schiavi D., Piscione F., Citro R., Benvenga R. M., Greco L., Soriente L., Radano I., Prota C., Bellino M., Di Vece D., Santini F., Salsano A., Olivieri G. M., Turrini F., Messora R., Tondi S., Olaru A., Agnoletto V., Grassi L., Leonardi C., Sansoni S., Del Ponte S., Actis Dato G. M., De Martino A., Ohte N., Kikuchi S., Wakami K., Aonuma K., Seo Y., Ishizu T., Machino-Ohtsuka T., Yamamoto M., Iida N., Nakajima H., Nakagawa Y., Amano M., Miyake M., Takahashi K., Shiojima I., Maeba H., Suwa Y., Taniguchi N., Tsujimoto S., Kitai T., Ota M., Yuda S., Sasaki S., Hagiwara N., Yamazaki K., Ashihara K., Arai K., Saitou C., Saitou S., Suzuki G., Shibata Y., Watanabe N., Nishino S., Ashikaga K., Kuriyama N., Mahara K., Okubo T., Fujimaki H., Shi-Tan H., Yamamoto H., Abe K., Terada M., Takanashi S., Sata M., Yamada H., Kusunose K., Saijo Y., Seno H., Yuichiro O., Onishi T., Sera F., Nakatani S., Mizuno H., Sengoku K., Park S. W., Eun Kyoung K., Ga Yeon L., Hwang J. -W., Jin-Oh C., Park S. -J., Sang-Chol L., Sung-A C., Jang S. Y., Heo R., Lee S., Song J. -M., Jung E., Plisiene J., Dambrauskaite A., Gruodyte G., Jonkaitiene R., Mizariene V., Atkocaityte J., Zvirblyte R., Sow R., Codreanu A., Staub T., Michaux C., De la Vega E. C. L., Jacobs-Orazi L., Mallia Azzopardi C., Xuereb R. G., Pis-Copo T., Farrugia J., Fenech M., Pllaha E., Vella C., Borg D., Casha R., Grib L., Raevschi E., Gre-Jdieru A., Kravcenco D., Prisacari E., Samohvalov E., Samohvalov S., Sceglova N., Panfle E., Cardaniuc L., Corcea V., Feodorovici A., Gaina V., Girbu L., Jimbei P., Balan G., Cardaniuc I., Benesco I., Marian V., Sumarga N., Bozovic B., Bulatovic N., Lakovic P., Music L., Budde R., Waha-Dat A., Gamela T., Meijers T., Van Melle J. P., Deursen V. M., Crijns H. J., Bekkers S. C., Cheriex E. C., Gilbers M., Kietselaer B. L., Knackstedt C., Lorusso R., Schalla S., Streukens S. A., Chamuleau S., Cramer M. -J., Teske A., Van der Spoel T., Wind A., Lokhorst J., Liesbek O., Van Heusden H., Tanis W., Van der Bilt I., Vriend J., De Lange-Van Bruggen H., Karijodikoro E., Riezebos R., van Dongen E., Schoep J., Stolk V., Offstad J. T., Beitnes J. O., Helle-Valle T., Skulstad H., Skardal R., Qamar N., Ahmed B., Butt M. H., Khanzada M. F., Saghir T., Wahid A., Hryniewiecki T., Szymanski P., Marzec K., Misztal-Ogonowska M., Kosmala W., Przewlocka-Kosmala M., Rojek A., Woznicka K., Zachwyc J., Lisowska A., Kamin-Ska M., Kasprzak J. D., Kowalczyk E., Strzecka D. F., Wejner-Mik P., Trabulo M., Freitas P., Ranchordas S., Rodrigues G., Pinto P., Queiros C., Azevedo J., Marques L., Seabra D., Branco L., Cruz M., Galrinho A., Moreira R., Rio P., Timoteo A. T., Selas M., Carmelo V., Duque Neves B., Pereira H., Guerra A., Marques A., Pintassilgo I., Tomescu M. C., Trofenciuc N. -M., Andor M., Bordejevic A., Branea H. S., Caruntu F., Velcean L. A., Mavrea A., Onel M. F., Parvanescu T., Pop D., Pop-Moldovan A. L., Puticiu M. I., Cirin L., Citu I. M., Cotoraci C. A., Darabantiu D., Farcas R., Marincu I., Ionac A., Cozma D., Mornos C., Goanta F., Popescu I., Beyer R., Mada R., Rancea R., Tomoaia R., Rosianu H., Stanescu C., Kobalava Z., Karaulova J., Ko-Tova E., Milto A., Pisaryuk A., Povalyaev N., Sorokina M., Alrahimi J., Elshiekh A., Ahmed A., Attia N., Putnikovic B., Dimic A., Ivanovic B., Matic S., Trifunovic D., Petrovic J., Kosevic D., Stojanovic I., Petrovic I., Dabic P., Milojevic P., Srdanovic I., Susak S., Velicki L., Vulin A., Kovacevic M., Redzek A., Stefanovic M., Yeo T. C., Kong W. K. F., Poh K. K., Vi-Lacosta I., Ferrera C., Olmos C., Abd El-Nasser M., Calvo Iglesias F., Bianco-Gonzalez E., Bravo Amaro M., Lopez-Rodriguez E., Lugo Adan J., Germinas A. N., Pazos-Lopez P., Pereira Loureiro M., Perez M. T., Raposeiras-Roubin S., Rasheed Yas S., Suarez-Varela M. -M., Vasallo Vidal F., Garcia-Dorado D., Fernandez-Hidalgo N., Gonzalez-Alujas T., Lozano J., Maisterra O., Pizzi N., Rios R., Bayes-Genis A., Pedro Botet L., Vallejo N., Llibre C., Mateu L., Nunez R., Quesada D., Berastegui E., Bosch Portell D., Aboal Vinas J., Albert Bertran X., Brugada Tar-Radellas R., Loma-Osorio Ricon P., Tiron de Llano C., Arnau M. A., Bel A., Blanes M., Osa A., Anguita M., Carrasco F., Castillo J. C., Zamorano J. L., Moya Mur J. L., Alvaro M., Fernandez-Golfin C., Monteagudo J. M., Navas Elorza E., Farinas Alvarez M. C., Aguero Balbin J., Zarauza J., Gutierrez-Diez J. F., Arminanzas C., Arnaiz de las Revillas F., Arnaiz Garcia A., Cobo Belaustegui M., Fernandez Sampedro M., Gutierrez Cuadra M., Garcia Cuello L., Gonzalez Rico C., Rodriguez-Alvarez R., Goikoetxea J., Montejo M., Miro J. M., Almela M., Ambrosioni J., Moreno A., Quintana E., Sandoval E., Tellez A., Tolosana J. M., Vidal B., Falces C., Fuster D., Garcia-De-la-Maria C., Hernandez-Meneses M., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Ham-Mami R., Kammoun S., Mourali M. S., Mghaieth Zghal F., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Sinan U. Y., Canpolat U., Mutlu B., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Cannata S., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Zemedkun M., Alyavi B., Uzokov J., Sengupta, S, Prendergast, B, Laroche, C, Furnaz, S, Ronderos, R, Almaghraby, A, Asch, F, Blechova, K, Zaky, H, Strahilevitz, J, Dworakowski, R, Miyasaka, Y, Sebag, I, Izumi, C, Axler, O, Jamiel, A, Philip, M, Vieira, M, Lancellotti, P, Habib, G, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Iung, B, Popescu, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, 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Abstract

Aims Infective endocarditis (IE) is a life-threatening disease associated with high mortality and morbidity worldwide. We sought to determine how socioeconomic factors might influence its epidemiology, clinical presentation, investigation and management, and outcome, in a large international multicentre registry. Methods and results The EurObservational Programme (EORP) of the European Society of Cardiology EURO-ENDO (European Infective Endocarditis) registry comprises a prospective cohort of 3113 adult patients admitted for IE in 156 hospitals in 40 countries between January 2016 and March 2018. Patients were separated in three groups, according to World Bank economic stratification [group 1: high income (75.6%); group 2: upper-middle income (15.4%); group 3: lower-middle income (9.1%)]. Group 3 patients were younger [median age (interquartile range, IQR): group 1, 66 (53-75) years; group 2, 57 (41-68) years; group 3, 33 (26-43) years; P < 0.001] with a higher frequency of smokers, intravenous drug use, and human immunodeficiency virus infection (all P < 0.001) and presented later [median (IQR) days since symptom onset: group 1, 12 (3-35); group 2, 19 (6-54); group 3, 31 (12-62); P < 0.001] with a higher likelihood of developing congestive heart failure (13.6%, 11.1%, and 22.6%, respectively; P < 0.001) and persistent fever (9.8%, 14.2%, and 27.9%, respectively; P < 0.001). Among 2157 (69.3%) patients with theoretical indication for cardiac surgery, surgery was performed less frequently in group 3 patients (75.5%, 76.8%, and 51.3%, respectively; P < 0.001), who also demonstrated the highest mortality (15.0%, 23.0%, and 23.7%, respectively; P < 0.001). Conclusion Socioeconomic factors influence the clinical profile of patients presenting with IE across the world. Despite younger age, patients from the poorest countries presented with more frequent complications and higher mortality associated with delayed diagnosis and lower use of surgery.

Published
2023

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