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961 results on '"Yamada, Yoshiya"'

1. Brachytherapy

Author

Kutuk, Tugce, Taggar, Amandeep Singh, Damato, Antonio L., Cohen, Gil’ad N., Voros, Laszlo, Yamada, Yoshiya, Chang, Eric L., editor, Brown, Paul D., editor, Lo, Simon S., editor, Sahgal, Arjun, editor, and Suh, John H., editor

Published
2024
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5. Phase 3 Multi-Center, Prospective, Randomized Trial Comparing Single-Dose 24 Gy Radiation Therapy to a 3-Fraction SBRT Regimen in the Treatment of Oligometastatic Cancer

Author

Zelefsky, Michael J, Yamada, Yoshiya, Greco, Carlo, Lis, Eric, Schöder, Heiko, Lobaugh, Stephanie, Zhang, Zhigang, Braunstein, Steve, Bilsky, Mark H, Powell, Simon N, Kolesnick, Richard, and Fuks, Zvi

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Clinical Research, Clinical Trials and Supportive Activities, Biomedical Imaging, Adult, Aged, Humans, Male, Middle Aged, Neoplasm Metastasis, Neoplasms, Radiation Dosage, Radiosurgery, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Other Physical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis, Theoretical and computational chemistry, Medical and biological physics
Abstract

PurposeThis prospective phase 3 randomized trial was designed to test whether ultra high single-dose radiation therapy (24 Gy SDRT) improves local control of oligometastatic lesions compared to a standard hypofractionated stereotactic body radiation therapy regimen (3 × 9 Gy SBRT). The secondary endpoint was to assess the associated toxicity and the impact of ablation on clinical patterns of metastatic progression.Methods and materialsBetween November 2010 and September 2015, 117 patients with 154 oligometastatic lesions (≤5/patient) were randomized in a 1:1 ratio to receive 24 Gy SDRT or 3 × 9 Gy SBRT. Local control within the irradiated field and the state of metastatic spread were assessed by periodic whole-body positron emission tomography/computed tomography and/or magnetic resonance imaging. Median follow-up was 52 months.ResultsA total of 59 patients with 77 lesions were randomized to 24 Gy SDRT and 58 patients with 77 lesions to 3 × 9 Gy SBRT. The cumulative incidence of local recurrence for SDRT-treated lesions was 2.7% (95% confidence interval [CI], 0%-6.5%) and 5.8% (95% CI, 0.2%-11.5%) at years 2 and 3, respectively, compared with 9.1% (95% CI, 2.6%-15.6%) and 22% (95% CI, 11.9%-32.1%) for SBRT-treated lesions (P = .0048). The 2- and 3-year cumulative incidences of distant metastatic progression in the SDRT patients were 5.3% (95% CI, 0%-11.1%), compared with 10.7% (95% CI, 2.5%-18.8%) and 22.5% (95% CI, 11.1%-33.9%), respectively, for the SBRT patients (P = .010). No differences in toxicity were observed.ConclusionsThe study confirms SDRT as a superior ablative treatment, indicating that effective ablation of oligometastatic lesions is associated with significant mitigation of distant metastatic progression.

Published
2021

10. Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury

Author

Bodo, Sahra, Campagne, Cécile, Thin, Tin Htwe, Higginson, Daniel S, Vargas, H Alberto, Hua, Guoqiang, Fuller, John D, Ackerstaff, Ellen, Russell, James, Zhang, Zhigang, Klingler, Stefan, Cho, HyungJoon, Kaag, Matthew G, Mazaheri, Yousef, Rimner, Andreas, Manova-Todorova, Katia, Epel, Boris, Zatcky, Joan, Cleary, Cristian R, Rao, Shyam S, Yamada, Yoshiya, Zelefsky, Michael J, Halpern, Howard J, Koutcher, Jason A, Cordon-Cardo, Carlos, Greco, Carlo, Haimovitz-Friedman, Adriana, Sala, Evis, Powell, Simon N, Kolesnick, Richard, and Fuks, Zvi

Subjects
Genetics, Cancer, Animals, Cell Line, Tumor, Chromatin, Homologous Recombination, Humans, Mice, Neoplasm Proteins, Neoplasms, Reperfusion Injury, Signal Transduction, Small Ubiquitin-Related Modifier Proteins, Ubiquitins, DNA repair, Oncology, Vascular Biology, Medical and Health Sciences, Immunology
Abstract

Tumor cure with conventional fractionated radiotherapy is 65%, dependent on tumor cell-autonomous gradual buildup of DNA double-strand break (DSB) misrepair. Here we report that single-dose radiotherapy (SDRT), a disruptive technique that ablates more than 90% of human cancers, operates a distinct dual-target mechanism, linking acid sphingomyelinase-mediated (ASMase-mediated) microvascular perfusion defects to DNA unrepair in tumor cells to confer tumor cell lethality. ASMase-mediated microcirculatory vasoconstriction after SDRT conferred an ischemic stress response within parenchymal tumor cells, with ROS triggering the evolutionarily conserved SUMO stress response, specifically depleting chromatin-associated free SUMO3. Whereas SUMO3, but not SUMO2, was indispensable for homology-directed repair (HDR) of DSBs, HDR loss of function after SDRT yielded DSB unrepair, chromosomal aberrations, and tumor clonogen demise. Vasoconstriction blockade with the endothelin-1 inhibitor BQ-123, or ROS scavenging after SDRT using peroxiredoxin-6 overexpression or the SOD mimetic tempol, prevented chromatin SUMO3 depletion, HDR loss of function, and SDRT tumor ablation. We also provide evidence of mouse-to-human translation of this biology in a randomized clinical trial, showing that 24 Gy SDRT, but not 3×9 Gy fractionation, coupled early tumor ischemia/reperfusion to human cancer ablation. The SDRT biology provides opportunities for mechanism-based selective tumor radiosensitization via accessing of SDRT/ASMase signaling, as current studies indicate that this pathway is tractable to pharmacologic intervention.

Published
2019

12. Multidisciplinary Treatment of Non-Spine Bone Metastases: Results of a Modified Delphi Consensus Process

Author

Gillespie, Erin F., Mathis, Noah J., Vaynrub, Max, Santos Martin, Ernesto, Kotecha, Rupesh, Panoff, Joseph, Salner, Andrew L., McIntosh, Alyson F., Gupta, Ranju, Gulati, Amitabh, Yerramilli, Divya, Xu, Amy J., Bartelstein, Meredith, Guttmann, David M., Yamada, Yoshiya J., Lin, Diana, Lapen, Kaitlyn, Korenstein, Deborah, Pfister, David G., Lipitz-Snyderman, Allison, and Yang, Jonathan T.

Published
2022
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17. Introduction

Author

Chang, Eric, Fiveash, John B., Knisely, Jonathan, Yamada, Yoshiya, Yamada, Yoshiya, editor, Chang, Eric, editor, Fiveash, John B., editor, and Knisely, Jonathan, editor

Published
2020
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19. Genomic biomarkers of CNS-specific outcomes in patients with breast cancer brain metastases.

Author

Khatri, Ishaani S., primary, Eichholz, Jordan, additional, Boe, Lillian A, additional, Safonov, Anton, additional, Smith, Deborah Ruth, additional, Ferraro, Emanuela, additional, Shen, Junchao, additional, Imber, Brandon S., additional, Yu, Yao, additional, Yamada, Yoshiya, additional, Miao, Emily, additional, Moss, Nelson S., additional, Wilcox, Jessica, additional, Walch, Henry S., additional, Chatila, Walid Khaled, additional, Schultz, Nikolaus, additional, Razavi, Pedram, additional, and Pike, Luke R. G., additional

Published
2024
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29. Prospective evaluation of patient-reported outcomes of invisible ink tattoos for the delivery of external beam radiation therapy: the PREFER trial

Author

Hardy-Abeloos, Camille, primary, Gorovets, Daniel, additional, Lewis, Aurora, additional, Ji, Wenyan, additional, Lozano, Alicia, additional, Tung, Chih Chun, additional, Yu, Francis, additional, Hanlon, Alexandra, additional, Lin, Haibo, additional, Kha, Anh, additional, Yamada, Yoshiya, additional, Kabarriti, Rafi, additional, Lazarev, Stanislav, additional, Hasan, Shaakir, additional, Chhabra, Arpit M., additional, Simone, Charles B., additional, and Choi, J. Isabelle, additional

Published
2024
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30. High-dose hypofractionated radiotherapy is effective and safe for tumors in the head-and-neck

Author

Teckie, Sewit, Lok, Benjamin H, Rao, Shyam, Gutiontov, Stanley I, Yamada, Yoshiya, Berry, Sean L, Zelefsky, Michael J, and Lee, Nancy Y

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Clinical Research, Cancer, Dental/Oral and Craniofacial Disease, Evaluation of treatments and therapeutic interventions, 6.5 Radiotherapy and other non-invasive therapies, Adolescent, Adult, Aged, Aged, 80 and over, Dose Fractionation, Radiation, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Retrospective Studies, Survival Analysis, Young Adult, Head-and-neck cancer, High-dose radiation therapy, Stereotactic body radiation therapy, Recurrent head and neck cancer, Palliation, Dentistry, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

ObjectivesHigh-dose, hypofractionated radiotherapy (HFRT) is sometimes used to treat malignancy in the head-and-neck (HN), both in the curative and palliative setting. Its safety and efficacy have been reported in small studies and are still controversial.Materials and methodsWe retrospectively evaluated the outcomes and toxicities of HFRT, including ultra-high-dose fractionation schemes (⩾8Gray per fraction), for HN malignancies.ResultsA total of 62 sites of measurable gross disease in 48 patients were analyzed. The median follow-up was 54.3months among five survivors and 6.0months in the remaining patients. Median RT dose was 30Gray in 5 fractions; 20/62 lesions (32%) received dose-per-fraction of ⩾8Gray. Overall response rate at first follow-up was 79%. One-year local-progression free rate was 50%. On multivariate analysis for locoregional control, dose-per-fraction ⩾6Gray was associated with control (p=0.04) and previous radiation was associated with inferior control (p=0.04). Patients who achieved complete response to RT had longer survival than those who did not (p=0.01). Increased toxicity rates were not observed among patients treated with dose-per-fraction ⩾8Gray; only re-irradiation increased toxicity rates.ConclusionDespite the poor prognostic features noted in this cohort of patients with HN malignancies, HFRT was associated with high response rates, good local control, and acceptable toxicity. Sites that were treated with 6Gray per fraction or higher and had not been previously irradiated had the best disease control. A prospective trial is warranted to further refine the use and indications of HFRT in this setting.

Published
2016

32. Feasibility Study of Real-Time Planning for Stereotactic Radiosurgery

Author

Zhang, Qinghui, Song, Yulin, Chan, Maria, Burman, Chandra, and Yamada, Yoshiya

Subjects
Physics - Medical Physics
Abstract

Purpose: 3D rotational setup errors in radiotherapy are often ignored by most clinics due to inability to correct or simulate them accurately and efficiently. There are two types of rotation-related problems in a clinical setting. One is to assess the affected dose distribution in real-time if correction is not applied and the other one is to correct the rotational setup errors prior to the initiation of the treatment. Here, we present our analytical solutions to both problems., Comment: 10 figures, 34 pages

Published
2013
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34. EPCO-01. THE GENOMIC LANDSCAPE OF BRAIN METASTASIS

Author

Skakodub, Anna, primary, Walch, Henry, additional, Kumar, Rahul, additional, Eichholz, Jordan, additional, Cooper, Claire, additional, Khatri, Ishaani, additional, Del Balzo, Luke, additional, Miao, Emily, additional, Gui, Chengcheng, additional, Ma, Jennifer, additional, Tringale, Kathryn, additional, Gaeta, Benjamin, additional, Kelly, Daniel, additional, Moss, Nelson, additional, Yu, Kenny Kwok Hei, additional, Wilcox, Jessica, additional, Bale, Tejus, additional, Yu, Yao, additional, Yamada, Yoshiya, additional, Imber, Brandon, additional, Gomez, Daniel, additional, Schultz, Nikolaus, additional, and Pike, Luke, additional

Published
2023
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35. BIOM-01. PROGNOSTIC IMPLICATIONS OF SMALL CELL LUNG CANCER (SCLC) TRANSCRIPTIONAL SUBTYPING FOR CENTRAL NERVOUS SYSTEM (CNS) METASTASES

Author

Skakodub, Anna, primary, Tringale, Kathryn, additional, Egger, Jacklynn, additional, Eichholz, Jordan, additional, Yu, Yao, additional, Gomez, Daniel, additional, Rimner, Andreas, additional, Li, Bob, additional, Yamada, Yoshiya, additional, Wilcox, Jessica, additional, Moss, Nelson, additional, Imber, Brandon, additional, Rekhtman, Natasha, additional, Baine, Marina, additional, Rudin, Charles, additional, and Pike, Luke, additional

Published
2023
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36. Primary Spine Tumors

Author

Thiagarajan, Anuradha, Yamada, Yoshiya, Lee, Nancy Y., Series editor, Lu, Jiade J., Series editor, Leeman, Jonathan E., editor, Cahlon, Oren, editor, Sine, Kevin, editor, Jiang, Guoliang, editor, and Both, Stefan, editor

Published
2018
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37. Adult Intracranial Tumors

Author

Lockney, Natalie A., Han, Zhiqiang, Sine, Kevin, Maes, Dominic, Yamada, Yoshiya, Lee, Nancy Y., Series editor, Lu, Jiade J., Series editor, Leeman, Jonathan E., editor, Cahlon, Oren, editor, Sine, Kevin, editor, Jiang, Guoliang, editor, and Both, Stefan, editor

Published
2018
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38. Brachytherapy

Author

Taggar, Amandeep Singh, Damato, Antonio L., Cohen, Gil’ad N., Voros, Laszlo, Yamada, Yoshiya, Chang, Eric L., editor, Brown, Paul D., editor, Lo, Simon S., editor, Sahgal, Arjun, editor, and Suh, John H., editor

Published
2018
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46. Radiation therapy for colorectal liver metastasis: the effect of RT dose and chemotherapy on local control and survival

Author

Chen, Ishita, primary, Jeong, Jeho, additional, Romesser, Paul B., additional, Hilal, Lara, additional, Cuaron, John, additional, Zinovoy, Melissa, additional, Hajj, Carla, additional, Yang, T. Jonathan, additional, Tsai, Jillian, additional, Yamada, Yoshiya, additional, Wu, Abraham J., additional, White, Charlie, additional, Fiasconaro, Megan, additional, Segal, Neil H, additional, Kemeny, Nancy E., additional, Zhang, Zhigang, additional, Crane, Christopher H., additional, and Reyngold, Marsha, additional

Published
2023
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