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1,068 results on '"Yamada, Nobuhiro"'

4. Effect of a mobile health app on initiating antihypertensive medications in patients with untreated hypertension (Preprint)

Author

Matsumura, Koichiro, primary, Nakagomi, Atsushi, additional, Yagi, Eijiro, additional, Yamada, Nobuhiro, additional, Funauchi, Yohei, additional, Kakehi, Kazuyoshi, additional, Yoshida, Ayano, additional, Kawamura, Takayuki, additional, Ueno, Masafumi, additional, Nakazawa, Gaku, additional, and Tabuchi, Takahiro, additional

Published
2023
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6. Prognostic impact of early aortic volume changes at hospital discharge in patients with acute type B aortic dissection

Author

Kakehi, Kazuyoshi, primary, Ueno, Masafumi, additional, Kawamura, Takayuki, additional, Yamada, Nobuhiro, additional, Takahashi, Kuniaki, additional, Fujita, Kosuke, additional, Yasuda, Masakazu, additional, Matsumura, Koichiro, additional, Miyoshi, Tatsuya, additional, Mizutani, Kazuki, additional, Takase, Toru, additional, Sakaguchi, Genichi, additional, and Nakazawa, Gaku, additional

Published
2023
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10. Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression

Author

Kikuchi, Takuya, Orihara, Kana, Oikawa, Fusaka, Han, Song-iee, Kuba, Motoko, Okuda, Kanako, Satoh, Aoi, Osaki, Yoshinori, Takeuchi, Yoshinori, Aita, Yuichi, Matsuzaka, Takashi, Iwasaki, Hitoshi, Yatoh, Shigeru, Sekiya, Motohiro, Yahagi, Naoya, Suzuki, Hiroaki, Sone, Hirohito, Nakagawa, Yoshimi, Yamada, Nobuhiro, and Shimano, Hitoshi

Published
2016
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12. Hiatal Hernia with Prolapse of the Pancreas Causing Bile Duct Stricture and Liver Function Disorders: A Case Report and Literature Review

Author

Miyagishima, Daisuke, primary, Yoshida, Masakatsu, additional, Yamada, Nobuhiro, additional, Kinjo, Kaori, additional, Fujita, Naoto, additional, Suzuki, Hiromasa, additional, Sugimura, Kaoru, additional, Kubota, Michio, additional, Nakagawa, Akihiko, additional, Kikuchi, Yasuharu, additional, and Shinozaki, Masami, additional

Published
2023
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16. A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

Author

Nishi‐Tatsumi, Makiko, Yahagi, Naoya, Takeuchi, Yoshinori, Toya, Naoki, Takarada, Ayako, Murayama, Yuki, Aita, Yuichi, Sawada, Yoshikazu, Piao, Xiaoying, Oya, Yukari, Shikama, Akito, Masuda, Yukari, Kubota, Midori, Izumida, Yoshihiko, Matsuzaka, Takashi, Nakagawa, Yoshimi, Sekiya, Motohiro, Iizuka, Yoko, Kawakami, Yasushi, Kadowaki, Takashi, Yamada, Nobuhiro, and Shimano, Hitoshi

Published
2017
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27. Polyunsaturated Fatty Acids Selectively Suppress Sterol Regulatory Element-binding Protein-1 through Proteolytic Processing and Autoloop Regulatory Circuit

Author

Takeuchi, Yoshinori, Yahagi, Naoya, Izumida, Yoshihiko, Nishi, Makiko, Kubota, Midori, Teraoka, Yuji, Yamamoto, Takashi, Matsuzaka, Takashi, Nakagawa, Yoshimi, Sekiya, Motohiro, Iizuka, Yoko, Ohashi, Ken, Osuga, Jun-ichi, Gotoda, Takanari, Ishibashi, Shun, Itaka, Keiji, Kataoka, Kazunori, Nagai, Ryozo, Yamada, Nobuhiro, Kadowaki, Takashi, and Shimano, Hitoshi

Published
2010
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33. Hepatic CREB3L3 Controls Whole-Body Energy Homeostasis and Improves Obesity and Diabetes

Author

Nakagawa, Yoshimi, Satoh, Aoi, Yabe, Sachiko, Furusawa, Mika, Tokushige, Naoko, Tezuka, Hitomi, Mikami, Motoki, Iwata, Wakiko, Shingyouchi, Akiko, Matsuzaka, Takashi, Kiwata, Shiori, Fujimoto, Yuri, Shimizu, Hidehisa, Danno, Hirosuke, Yamamoto, Takashi, Ishii, Kiyoaki, Karasawa, Tadayoshi, Takeuchi, Yoshinori, Iwasaki, Hitoshi, Shimada, Masako, Kawakami, Yasushi, Urayama, Osamu, Sone, Hirohito, Takekoshi, Kazuhiro, Kobayashi, Kazuto, Yatoh, Shigeru, Takahashi, Akimitsu, Yahagi, Naoya, Suzuki, Hiroaki, Yamada, Nobuhiro, and Shimano, Hitoshi

Published
2014

37. Intakes of dietary fiber, vegetables, and fruits and incidence of cardiovascular disease in Japanese patients with type 2 diabetes

Author

Tanaka, Shiro, Yoshimura, Yukio, Kamada, Chiemi, Tanaka, Sachiko, Horikawa, Chika, Okumura, Ryota, Ito, Hideki, Ohashi, Yasuo, Akanuma, Yasuo, Yamada, Nobuhiro, and Sone, Hirohito

Subjects
Fiber in human nutrition -- Health aspects -- Research, Cardiovascular diseases -- Risk factors -- Research, Diabetics -- Health aspects -- Food and nutrition -- Research, Health
Abstract

OBJECTIVE--Foods rich in fiber, such as vegetables and fruits, prevent cardiovascular disease (CVD) among healthy adults, but such data in patients with diabetes are sparse. We investigated this association in [...]

Published
2013
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38. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis

Author

Kodama, Satoru, Saito, Kazumi, Tanaka, Shiro, Maki, Miho, Yachi, Yoko, Asumi, Mihoko, Sugawara, Ayumi, Totsuka, Kumiko, Shimano, Hitoshi, Ohashi, Yasuo, Sone, Hirohito, and Yamada, Nobuhiro

Subjects
Cardiovascular diseases -- Risk factors, Cardiovascular diseases -- Influence, Coronary heart disease -- Risk factors, Physical fitness -- Health aspects
Abstract

A study was conducted to evaluate the quantitative relationship between cardiorespiratory fitness (CRF) and all-cause mortality associated with cardiovascular events among healthy men and women. Results indicated that better CRF led to a lesser mortality risk due to coronary heart disease (CHD) as well as cardiovascular disease (CVD).

Published
2009

40. Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes

Author

Matsumoto, Takayuki, Noguchi, Eri, Ishida, Keiko, Kobayashi, Tsuneo, Yamada, Nobuhiro, and Kamata, Katsuo

Subjects
Metformin -- Health aspects, Endothelium -- Properties, Vasoconstrictors -- Properties, Mesentery -- Properties, Type 2 diabetes -- Development and progression, Biological sciences
Abstract

We previously reported that in mesenteric arteries from aged Otsuka Long-Evans Tokushima fatty (OLETF) rats (a type 2 diabetes model) endothelium-derived hyperpolarizing factor (EDHF)-type relaxation is impaired while endothelium-derived contracting factor (EDCF)-mediated contraction is enhanced (Matsumoto T, Kakami M, Noguchi E, Kobayashi T, Kamata K. Am J Physiol Heart Circ Physiol 293: H1480-H1490, 2007). Here we investigated whether acute and/or chronic treatment with metformin might improve this imbalance between the effects of the above endothelium-derived factors in mesenteric arteries isolated from OLETF rats. In acute studies on OLETF mesenteric arteries, ACh-induced relaxation was impaired and the relaxation became weaker at high ACh concentrations. Both metformin and 5-aminoimidazole-4-carboxamide-1-[beta]-D-ribofuranoside [AICAR, an AMP-activated protein kinase (AMPK) activator that is also activated by metformin] 1) diminished the tendency for the relaxation to reverse at high ACh concentrations and 2) suppressed both ACh-induced EDCF-mediated contraction and ACh-stimulated production of prostanoids (thromboxane [A.sub.2] and [PGE.sub.2]). In studies on OLETF arteries from chronically treated animals, metformin treatment (300 mg x [kg.sup.-1] x [day.sup.-1] for 4 wk) 1) improved ACh-induced nitric oxide- or EDHF-mediated relaxation and cyclooxygenase (COX)-mediated contraction, 2) reduced EDCF-mediated contraction, 3) suppressed production of prostanoids, and 4) reduced superoxide generation. Metformin did not alter the protein expressions of endothelial nitric oxide synthase (eNOS), phospho-eNOS (Ser1177), or COX-1, but it increased COX-2 protein. These results suggest that metformin improves endothelial functions in OLETF mesenteric arteries by suppressing vasoconstrictor prostanoids and by reducing oxidative stress. Our data suggest that within the timescale studied here, metformin improves endothelial function through this direct mechanism, rather than by improving metabolic abnormalities. cyclooxygenase; endothelium-derived contracting factor; endothelium-derived hypopolarizing factor

Published
2008

41. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Author

Matsuzaka, Takashi, Shimano, Hitoshi, Yahagi, Naoya, Kato, Toyonori, Atsumi, Ayaka, Yamamoto, Takashi, Inoue, Noriyuki, Ishikawa, Mayumi, Okada, Sumiyo, Ishigaki, Naomi, Iwasaki, Hitoshi, Iwasaki, Yuko, Karasawa, Tadayoshi, Kumadaki, Shin, Matsui, Toshiyuki, Sekiya, Motohiro, Ohashi, Ken, Hasty, Alyssa H, Nakagawa, Yoshimi, Takahashi, Akimitsu, Suzuki, Hiroaki, Yatoh, Sigeru, Sone, Hirohito, Toyoshima, Hideo, Osuga, Jun-ichi, and Yamada, Nobuhiro

Abstract

Insulin resistance is often associated with obesity and can precipitate type 2 diabetes. To date, most known approaches that improve insulin resistance must be preceded by the amelioration of obesity and hepatosteatosis. Here, we show that this provision is not mandatory; insulin resistance and hyperglycemia are improved by the modification of hepatic fatty acid composition, even in the presence of persistent obesity and hepatosteatosis. Mice deficient for Elovl6, the gene encoding the elongase that catalyzes the conversion of palmitate to stearate, were generated and shown to become obese and develop hepatosteatosis when fed a high-fat diet or mated to leptin-deficient ob/ob mice. However, they showed marked protection from hyperinsulinemia, hyperglycemia and hyperleptinemia. Amelioration of insulin resistance was associated with restoration of hepatic insulin receptor substrate-2 and suppression of hepatic protein kinase C [epsilon] activity resulting in restoration of Akt phosphorylation. Collectively, these data show that hepatic fatty acid composition is a new determinant for insulin sensitivity that acts independently of cellular energy balance and stress. Inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity., Author(s): Takashi Matsuzaka [1, 2]; Hitoshi Shimano (corresponding author) [1, 2]; Naoya Yahagi [2, 3]; Toyonori Kato [1]; Ayaka Atsumi [1]; Takashi Yamamoto [1]; Noriyuki Inoue [1]; Mayumi Ishikawa [1]; [...]

Published
2007
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45. TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

Author

Nakagawa, Yoshimi, Shimano, Hitoshi, Yoshikawa, Tomohiro, Ide, Tomohiro, Tamura, Mariko, Furusawa, Mika, Yamamoto, Takashi, Inoue, Noriyuki, Matsuzaka, Takashi, Takahashi, Akimitsu, Hasty, Alyssa H, Suzuki, Hiroaki, Sone, Hirohito, Toyoshima, Hideo, Yahagi, Naoya, and Yamada, Nobuhiro

Abstract

Using an expression cloning strategy, we have identified TFE3, a basic helix-loop-helix protein, as a transactivator of metabolic genes that are regulated through an E-box in their promoters. Adenovirus-mediated expression of TFE3 in hepatocytes in culture and in vivo strongly activated expression of IRS-2 and Akt and enhanced phosphorylation of insulin-signaling kinases such as Akt, glycogen synthase kinase 3[beta] and p70S6 kinase. TFE3 also induced hexokinase II (HK2) and insulin-induced gene 1 (INSIG1). These changes led to metabolic consequences, such as activation of glycogen and protein synthesis, but not lipogenesis, in liver. Collectively, plasma glucose levels were markedly reduced both in normal mice and in different mouse models of diabetes, including streptozotocin-treated, db/db and KK mice. Promoter analyses showed that IRS2, HK2 and INSIG1 are direct targets of TFE3. Activation of insulin signals in both insulin depletion and resistance suggests that TFE3 could be a therapeutic target for diabetes., Author(s): Yoshimi Nakagawa [1, 2]; Hitoshi Shimano (corresponding author) [1, 2]; Tomohiro Yoshikawa [1]; Tomohiro Ide [1]; Mariko Tamura [1]; Mika Furusawa [1]; Takashi Yamamoto [1]; Noriyuki Inoue [1]; Takashi [...]

Published
2006
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