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This article discusses the creation of an effective mechanism to attract investment in the regional economy with the participation of public-private partnerships, with a view to the successful implementation of large infrastructure projects of national importance. In the modern conditions of the development of the Russian economy, a public-private partnership is the most universal and effective interaction mechanism, creating the necessary effect for the development of various sectors of the economy. The need for modernization of the regional economy necessitates the need for further studies of the problem of attracting sufficient investment in the innovative development of the region, including the participation of publicprivate partnership, in the development of specific measures to improve the mechanism of investment support of the economy at the regional level, the development of strategies for investment support of the economy of the region with the participation of public-private partnership. Based on the study, the authors proposed a methodology for implementing the mechanism of investment support for the economy at the regional level. Also we formulated the conditions for improving the effectiveness of the mechanism of public-private partnership. The authors identified the tools that make it possible to increase the efficiency of interaction between government and business structures in the form of public private partnership and proposed the measures to increase the efficiency of management decisions of investing regional projects. In conclusion, the given article proposes specific measures to improve the mechanism of investment support of the economy at the regional level. [ABSTRACT FROM AUTHOR]