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4. Trends in glycemic control in patients with insulin therapy compared with non-insulin or no drugs in type 2 diabetes in Japan: a long-term view of real-world treatment between 2002 and 2018 (JDDM 66)

Author

Yokoyama, Hiroki, primary, Araki, Shin-ichi, additional, Yamazaki, Katsuya, additional, Kawai, Koichi, additional, Shirabe, Shin-Ichiro, additional, Oishi, Mariko, additional, Kanatsuka, Azuma, additional, Yagi, Noriharu, additional, Kabata, Daijiro, additional, Shintani, Ayumi, additional, and Maegawa, Hiroshi, additional

Published
2022
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5. Changes in prescription patterns and doses of oral antidiabetic drugs in Japanese patients with type 2 diabetes (JDDM70).

Author

Shirabe, Shinichiro, Yamazaki, Katsuya, Oishi, Mariko, Arai, Keiko, Yagi, Noriharu, Sato, Manaka, Takeuchi, Masakazu, Kai, Takahito, and Maegawa, Hiroshi

Subjects
TYPE 2 diabetes, JAPANESE people, ORAL medication, SODIUM-glucose cotransporter 2 inhibitors, CD26 antigen
Abstract

We assessed the prescription patterns of oral antidiabetic drugs in Japanese patients with type 2 diabetes between 2002 and 2020 using data from the Computerized Diabetes Care database. Among 172,960 patients treated with oral antidiabetic drugs, both the sulfonylurea prescription rate and dose decreased from 2002 to 2020. Prescriptions of biguanides, dipeptidyl peptidase‐4 inhibitors and sodium–glucose cotransporter 2 inhibitors increased; their dose and dose frequency remained relatively stable. Trends in oral antidiabetic drug prescriptions changed over time, reflecting guideline recommendations and existing evidence. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Cardiovascular Prognosis in Drug-Resistant Hypertension Stratified by 24-Hour Ambulatory Blood Pressure: The JAMP Study

Author

Kario, Kazuomi, primary, Hoshide, Satoshi, additional, Narita, Keisuke, additional, Okawara, Yukie, additional, Kanegae, Hiroshi, additional, Aoki, Kenji, additional, Kihara, Hajime, additional, Koga, Toshiro, additional, Nakata, Tomoaki, additional, Oku, Kenji, additional, Matsuoka, Yasufumi, additional, Omori, Hiroaki, additional, Nishizawa, Masafumi, additional, Tanno, Yasuo, additional, Fukase, Yoko, additional, Omi, Koki, additional, Takahashi, Jun, additional, Mizuno, Hiroyuki, additional, Saito, Michiya, additional, Yatabe, Junichi, additional, Eguchi, Kazuo, additional, Iwashita, Kiyoshi, additional, Kumada, Maki, additional, Oki, Gaku, additional, Kabutoya, Tomoyuki, additional, Hojo, Yukihiro, additional, Ichida, Masaru, additional, Ishikawa, Shizukiyo, additional, Komori, Takahiro, additional, Matsui, Yoshio, additional, Matsumoto, Masatoshi, additional, Nagasaka, Shoichiro, additional, Nakano, Masahiro, additional, Nishimura, Yoshioki, additional, Okada, Kenta, additional, Shimada, Kazuyuki, additional, Shimpo, Masahisa, additional, Takahashi, Nozomu, additional, Uno, Hideyuki, additional, Ishikawa, Joji, additional, Kuroda, Toshio, additional, Hirahara, Nobutsune, additional, Kemi, Yuta, additional, Yoshioka, Hisashi, additional, Hoshi, Sakuo, additional, Mizuno, Atsuhi, additional, Ohno, Kunihiko, additional, Okazaki, Osamu, additional, Saito, Tsunehiro, additional, Tanaka, Tetsu, additional, Yamashiro, Kazuo, additional, Yamauchi, Tatsuyuki, additional, Yo, Shisei, additional, Yomogita, Shigeru, additional, Hikita, Sayaka, additional, Kawase, Yasuhiro, additional, Nojiri, Yoshifumi, additional, Sato, Yukihiro, additional, Uchiba, Kiyoshi, additional, Ishiguro, Motoyuki, additional, Taguchi, Atsushi, additional, Iida, Kazumasa, additional, Takemoto, Tatsuya, additional, Tone, Katsuyuki, additional, Abe, Hideyasu, additional, Abe, Yasuhisa, additional, Hasegawa, Masami, additional, Katsuya, Tomohiro, additional, Okada, Yoshiharu, additional, Tanaka, Shinichiro, additional, Tanke, Genyo, additional, Takami, Takeshi, additional, Michiura, Jun, additional, Shiotani, Masahiko, additional, Aoki, Tomohiro, additional, Ogura, Koichi, additional, Kawamura, Yuzuru, additional, Nakanishi, Shigekiyo, additional, Sasaki, Nobuo, additional, Takahashi, Toshiyuki, additional, Fujii, Akihisa, additional, Tanaka, Eiichiro, additional, Katayama, Hiroyuki, additional, Fukutomi, Motoki, additional, Miyoshi, Kosuke, additional, Naito, Hiroaki, additional, Yokota, Sawa, additional, Nakamura, Kazumasa, additional, Yokota, Tetsu, additional, Takasugi, Shinsuke, additional, Fujita, Shuichiro, additional, Fujita, Yumiko, additional, Kaneko, Hitoshi, additional, Fujiwara, Takeshi, additional, Kitamura, Wataru, additional, Anan, Yuhei, additional, Deguchi, Tomohiro, additional, Imaizumi, Yuki, additional, Miyagi, Jun, additional, Tsuji, Takahiro, additional, Uchiwa, Yasuhiro, additional, Ueda, Shin, additional, Yamaguchi, Takeya, additional, Yoshida, Tetsuro, additional, Yoshinaga, Ryo, additional, Maeda, Kosuke, additional, Kunitomo, Kotaro, additional, Soda, Kyousei, additional, Baba, Hirotoshi, additional, Yonezu, Keisuke, additional, Hino, Akihiro, additional, Miura, Genta, additional, Nakamura, Tomoko, additional, Kuroki, Munetoshi, additional, Omori, Fumihiko, additional, Hidaka, Toshiaki, additional, Hidaka, Takanori, additional, Yano, Yuichiro, additional, Kanemaru, Yoshimasa, additional, Kitani, Michitaka, additional, Koga, Masahiro, additional, Kubo, Hirohide, additional, Kuwabara, Masachika, additional, Miyata, Junichi, additional, Nagata, Masahiko, additional, Sasaki, Koji, additional, Tamaki, Noboru, additional, Tasaka, Hiroyasu, additional, Yokota, Naoto, additional, Miyata, Takahiro, additional, Katsuren, Eiyu, additional, Kudeken, Norifumi, additional, and Yagi, Noriharu, additional

Published
2021
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8. Current status of oral antidiabetic drug prescribing patterns based on the body mass index for Japanese type 2 diabetes mellitus patients and yearly changes in diabetologists' prescribing patterns from 2002 to 2019 (JDDM61).

Author

Yagi, Noriharu, Komiya, Ichiro, Arai, Keiko, Oishi, Mariko, Fukumoto, Yoshihide, Shirabe, Shinichirou, Yokoyama, Hiroki, Yamazaki, Katsuya, Sugimoto, Hidekatsu, and Maegawa, Hiroshi

Subjects
*TYPE 2 diabetes, *BODY mass index, *PEOPLE with diabetes, *SODIUM-glucose cotransporter 2 inhibitors, *DRUG prescribing
Abstract

Aims/Introduction: Type 2 diabetes mellitus is caused by a relative imbalance between insulin secretion and sensitivity related to the body mass index (BMI). Seven categories of oral antidiabetic drugs (OADs) are available in Japan. It is important to assess the OAD utilization patterns based on patients' BMI levels. Materials and methods: OAD prescribing patterns from 2002 to 2019 were analyzed using the data collected in the computerized diabetes care database provided by the Japan Diabetes Clinical Data Management Study Group; OAD utilization patterns in 25,751 OAD‐treated type 2 diabetes mellitus patients registered in 2019 were analyzed after classifying them into five categories of BMI. Results: Comparing OAD usage between 2002 and 2019, sulfonylureas decreased from 44.5 to 23.2%, and biguanides (BGs) increased from 19.3 to 50.3%. Dipeptidyl peptidase‐4 inhibitors (DPP4is) increased to 56.9% in 2019. Sodium–glucose cotransporter 2 inhibitors (SGLT2is) increased to 23.6% in 2019. About 90% of type 2 diabetes mellitus patients had BMI < 30 kg/m2. DPP4is were the most used OADs in 2019. When BMI exceeded 30 kg/m2, use of BGs and sodium–glucose cotransporter 2 inhibitors increased, and use of sulfonylureas and DPP4is decreased. Although DPP4is were the most used OADs for patients with BMI <30 kg/m2, they were the third most prescribed OADs for patients with BMI >35 kg/m2 after BGs and sodium–glucose cotransporter 2 inhibitors. Conclusions: DPP4i usage was as high as that of BG in the analysis of Japanese type 2 diabetes mellitus patients with relatively low BMI. This was considered to be a treatment option appropriate for the pathophysiology in Japanese patients. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Self-reported rate of eating is significantly associated with body mass index in Japanese patients with type 2 diabetes. Japan Diabetes Clinical Data Management Study Group (JDDM26)

Author

Saito, Aki, Kawai, Koichi, Yanagisawa, Morifumi, Yokoyama, Hiroki, Kuribayashi, Nobuichi, Sugimoto, Hidekatsu, Oishi, Mariko, Wada, Takako, Iwasaki, Koichi, Kanatsuka, Azuma, Yagi, Noriharu, Okuguchi, Fuminobu, Miyazawa, Kazuhiro, Arai, Keiko, Saito, Kazumi, and Sone, Hirohito

Published
2012
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10. Liraglutide versus Sitagliptin in a 24-week, Multicenter, Open-label, Randomized, Parallel-group Study in Japanese Type 2 Diabetes Mellitus Patients Responding Inadequately to a Sulfonylurea and/or One or Two Other Oral Antidiabetic Drugs (JDDM 33)

Author

Yokoyama, Hiroki, primary, Hirao, Koichi, additional, Yamaguchi, Kohei, additional, Oishi, Mariko, additional, Lee, Gendai, additional, Yagi, Noriharu, additional, Takamura, Hiroshi, additional, and Kashiwagi, Atsunori, additional

Published
2014
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11. An abnormal sodium metabolism in Japanese patients with essential hypertension, judged by serum sodium distribution, renal function and the renin-aldosterone system

Author

Komiya, Ichiro, primary, Yamada, Takashi, additional, Takasu, Nobuyuki, additional, Asawa, Takayuki, additional, Akamine, Hiromitsu, additional, Yagi, Noriharu, additional, Nagasawa, Yoshitaka, additional, Ohtsuka, Hiromi, additional, Miyahara, Yasuhiro, additional, Sakai, Hideki, additional, Sato, Akira, additional, and Aizawa, Toru, additional

Published
1997
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12. An abnormal sodium metabolism in Japanese patients with essential hypertension judged by serum sodium distribution renal function and the reninaldosterone system

Author

Komiya, Ichiro, Yamada, Takashi, Takasu, Nobuyuki, Asawa, Takayuki, Akamine, Hiromitsu, Yagi, Noriharu, Nagasawa, Yoshitaka, Ohtsuka, Hiromi, Miyahara, Yasuhiro, Sakai, Hideki, Sato, Akira, and Aizawa, Toru

Abstract

The role of the renin–aldosterone system and the ability of renal sodium reabsorption to facilitate pressure natriuresis were analyzed by using a sufficient number of Japanese patients with essential hypertension.

Published
1997

13. Relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetic patients (JDDM38).

Author

Kanatsuka A, Sato Y, Kawai K, Hirao K, Kobayashi M, Kashiwagi A, Abe N, Arai K, Fujiya H, Fukumoto Y, Dake F, Iizumi T, Ito M, Iwasaki K, Kanamori A, Kato S, Kato M, Kawara A, Kimura K, Chikamori K, Iemitsu K, Kou S, Kudo M, Kurihara Y, Lee G, Tsuruoka A, Manda N, Matoba K, Hayashi H, Minami M, Kuribayashi N, Miyazawa K, Chiba Y, Osonoi T, Nakamura S, Sasaki H, Komori K, Oishi M, Okada A, Okuguchi F, Yanagisawa M, Sugimoto H, Sugiyama H, Takai M, Takaki M, Takamura H, Takeda H, Takeda H, Tanaka K, Miwa T, Tomonaga O, Taguchi M, Yamazaki K, Wada T, Yagi N, Yamaoka K, and Yuhara A

Subjects
Administration, Oral, Aged, Body Mass Index, Cohort Studies, Diabetes Mellitus, Type 2 metabolism, Dipeptidyl-Peptidase IV Inhibitors administration & dosage, Female, Glycated Hemoglobin metabolism, Humans, Hypoglycemic Agents administration & dosage, Male, Metformin administration & dosage, Middle Aged, Propensity Score, Sulfonylurea Compounds administration & dosage, Treatment Outcome, Diabetes Mellitus, Type 2 drug therapy, Dipeptidyl-Peptidase IV Inhibitors therapeutic use, Hypoglycemic Agents therapeutic use, Metformin therapeutic use, Sulfonylurea Compounds therapeutic use
Abstract

Aims/introduction: We carried out an observational cohort study to examine the relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetics., Materials and Methods: We analyzed the CoDiC(®) database of the Japan Diabetes Data Management Study Group across 67 institutions in Japan. In a total of 3,698 drug-naïve patients who were initiated with metformin, dipeptidyl peptidase-4 inhibitor (DPP-4i) or sulfonylurea (SU) from 2007 to 2012, we evaluated body mass index (BMI) and hemoglobin A1c (HbA1c). The patients were stratified according to their clinical features, and matched using a propensity score to adjust for baseline factors., Results: HbA1c was reduced with all drugs, with the largest effect elicited by DPP-4i and the smallest by SU (P = 0.00). HbA1c increased with SU after 6 months in the patients stratified by an age-of-onset of <50 years (P = 0.00). BMI increased with SU in the patients stratified by a BMI of <25 (P = 0.00), and decreased with metformin in the patients with a BMI >25 (P = 0.00). The reduction in HbA1c was larger in patients with HbA1c of ≥8%, compared with that in patients with HbA1c of <8% (P = 0.00). HbA1c during the study period was higher in patients who were added to or swapped with other drug(s), than in patients continued on the original drug (P = 0.00)., Conclusions: The effect on bodyweight and glycemic control differed among metformin, DPP-4i and SU, and the difference was associated with clinical features.

Published
2016
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