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21 results on '"Yaggi, Klar"'

16. Reducing Cardiovascular Risk through Treatment of Obstructive Sleep Apnea: Two Methodological Approaches

Author

Yaggi, Klar, Mittleman, Murray A, Bravata, Dawn M., Concato, John, Ware, James, Stoney, Catherine M., and Redline, Susan

Subjects
Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Cardiovascular Diseases, Risk Factors, Incidence, Humans, Patient Compliance, Global Health, Article, Randomized Controlled Trials as Topic
Abstract

Obstructive sleep apnea (OSA) significantly impacts cardiovascular health, demonstrated by observational investigations showing an independently increased risk of ischemic heart disease, diabetes, hypertension, congestive heart failure, acute coronary syndrome, stroke, cardiovascular mortality, and all-cause mortality. Positive airway pressure (PAP), a medical therapy for sleep apnea, reverses airway obstruction and may help reduce cardiovascular risk. Prior to planning large Phase III randomized controlled trials to test the impact of PAP on cardiovascular outcomes, several gaps in knowledge need to be addressed. This paper describes two independent studies that worked collaboratively to fill these gaps. The populations, design features, and relative benefits/challenges of the two studies (SleepTight and BestAIR) are described. Both studies were encouraged to have multidisciplinary teams with expertise in behavioral interventions to improve PAP compliance. Both studies provide key information that will be useful to the research community in future large-scale, event-driven, randomized trials to evaluate the efficacy and/or effectiveness of strategies to identify and treat significant obstructive sleep apnea for decreasing risk of major adverse cardiovascular events in high-risk patients.

Published
2015

19. “It’s all connected:” A mixed methods study of insomnia, stigma, and discrimination among individuals on medication for opioid use disorder

Author

Nwanaji-Enwerem, Uzoji, Sadler, Lois S., O’Connell, Meghan, Barry, Declan, Knobf, Tish M., Jeon, Sangchoon, Scheinost, Dustin, Yaggi, Klar, and Redeker, Nancy S.

Abstract

Insomnia is one of the most common sleep disorders among those with opioid use disorder (OUD), including those on medication for OUD. There is a dearth of literature exploring the role of social stressors on sleep outcomes among this group. The purpose of this study was to explore the association between OUD-related stigma and intersectional discrimination with insomnia among individuals on medication for OUD.

Published
2023
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21. Abstract W P129.

Author

Stahl, Stephanie M, Taylor, Stanley, Ofner, Susan, Qin, Li, Yaggi, Klar, Ivan, C. Simona, and Bravata, Dawn M

Published
2014

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