Search

Copyright of Revista Colombiana de Ciencias Químico-Farmacéuticas is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In the present study, in vitro and in vivo antioxidant studies were performed on the leaves of Ficus benjamina L. ethanolic extracts of the drug were evaluated for in vitro antioxidant activity using nitric oxide and DPPH free radicals. The plant extracts and isolated compound exhibited dose dependent scavenging effects against the both free radicals tested. The ethanolic extract (Ficus benjamina Linn.) was subjected to in vivo antioxidant activity studies using CCl4 induced hepatotoxicity model in Wistar albino rats. The extract and isolated compounds was exhibited significant increase in the levels of glutathione and enzymes viz. SOD, catalase and peroxidase at different dose levels. The extent of lipid peroxidation was significantly reduced in the extract treated groups and isolated compounds. Results were comparable with that of standard antioxidant silymarin. [ABSTRACT FROM AUTHOR]

Carica papaya L has been traditionally claimed for curing inflammation hence the present work exemplifies the anti-arthritic potential of crude leaves extract and its fractions in arthritic models. Screening on this plant has established presence of kaempferol which might possess antiarthritic properties. Kaempferol was quantitatively estimated by high performance thin layer chromatographic method in chloroform fraction and was found to be 0.08% w/w. Arthritis was induced by intraplantar administration considering formaldehyde (2%v/v), turpentine oil emulsion (10%v/v) and complete Freund's adjuvant (1%v/v) in left hind paw of rats. Paw oedema, body weight, haematological parameters, level of serum enzyme markers, biochemical parameters, interleukin-6 and histopathological analysis were observed in all groups. Present experimental work justifies that in chronic arthritis, iinvolvement of interleukin-6 is associated with non-articular manifestations considering joint inflammation including anaemia. The plant extract and chloroform fraction possess dose dependent antiarthritic effect in acute and complete Freund's adjuvant induced arthritic model by ameliorating the level of serum enzyme biomarkers, haematological and biochemical parameters, body weight abnormalities, interleukin-6. The experimental explanation established that extract and its fraction of Carica papaya L. revealed anti-arthritic potential. [ABSTRACT FROM AUTHOR]