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In recent years, cyberbullying, which can be considered as a new form of bullying, has emerged as a result of developments in the field of technology and communication. Cyberbullying has become a social problem which has affected individuals' lives negatively. The key to success in the elimination of cyberbullying and its negative effects lies in cyberbullying sensitivity. The present study aims to analyze teachers' cyberbullying and cyber victimization experiences and levels of cyberbullying sensitivity based on some variables which are supposed to develop awareness regarding cyberbullying. Using survey as a research model, the present study focused on 346 teachers working at schools affiliated with Ministry of National Education in Tasova District located in Amasya (Turkey). "Personal Information Form", "The Revised Cyberbullying Inventory for University Students" and "Cyberbullying Sensitivity Scale" were used as data collection tools. SPSS package program was used for data analysis and frequency and percentage values of demographic variables. Independent T test was used for gender and marital status variables, and One-Way ANOVA test was used for age and level of education variables. The findings of the present study revealed that most of the participants used social media websites actively and spent at least 2 or 3 hours on these websites on a daily basis. Teachers usually have a Facebook and/or Instagram account, and benefit from social media for research purposes and playing games. It can be stated that teachers have a significantly high level of cyberbullying sensitivity. However, it was also indicated that even though participants worked as a teacher, they still did cyberbully and suffered from cyber victimization in the past. While a significant difference was observed only in the dimension of cyber sensitivity in terms of marital status, age and level of education, a significant difference wasn't observed in the dimensions of cyberbullying, cyber victimization and cyber sensitivity in terms of gender.

The purpose of the article is presenting the application of the roller compacted concrete (RCC) as alternative solution to asphalt parking places and roads, showing the advantages and further possibilities for development of RCC in wide range of projects. RCC is produced similar to conventional concrete. However, RCC is zero slump concrete unlike conventional concrete. In this study the construction for parking area in RCC technology is presented for the real project. Presented cases concern heavy and light vehicles parking areas. The experimental results shows the very good quality of RCC placed on site, high compressive strength of the concrete, good workability of the concrete mixture that allows for proper placing of the concrete. RCC provides better mechanical-durable properties, more economical and less carbon footprint based on proper compaction and on lower water/cement ratio comparing to conventional concrete. The article draws attention to the role of the soil under the RCC as well, which should be designed and prepared on site with an appropriate stiffness and should be made according to the requirements resulting from the use of RCC. Such a comprehensive implementation of the soil-RCC subbase system guarantees the proper quality, load-bearing capacity and durability of the structure of the parking places as well as roads, for the assumed period of operation.

Human recombinant enzyme replacement therapy, given to compensate for genetic enzyme deficiency in lysosomal storage diseases, delays the progression of the disease and improves the quality of life. However, enzyme replacement therapy may cause hypersensitivity reactions. Within the scope of this research, we aimed to elucidate the frequency and clinical features of hypersensitivity reactions against enzyme replacement therapy in children with lysosomal storage diseases and clarify the management of these reactions. Medical records of pediatric patients with lysosomal storage disease and receiving enzyme replacement therapy were retrospectively reviewed, and patients who experienced allergic reactions were included in the study. The demographic characteristics of the patients, their diagnosis, the responsible enzyme, the time at which the reaction started and at what dose, the signs and symptoms associated with the reaction, diagnostic tests, the management of the reaction, and the protocol applied for the maintenance of enzyme replacement therapy after the reaction were recorded. Hypersensitivity reactions developed in 18 of 71 patients (25.3 %) who received enzyme replacement therapy. The most common cutaneous findings were observed. Anaphylaxis developed in 6 of 18 patients. Patients who experienced recurrent hypersensitivity reactions with premedication or a slower infusion rate, those with positive skin test results, and patients who developed anaphylaxis were given enzyme replacement therapy with desensitization. HSR may develop during enzyme replacement therapy, which are vital in lysosomal storage diseases, and discontinuation of enzyme replacement therapy is a significant loss for patients with metabolic disorders. These reactions can be treated with premedication and long-term infusions, but some patients may require desensitization protocols for continued treatment. [ABSTRACT FROM AUTHOR]

AbstractThe environmental consequences of Portland cement (PC) manufacturing have prompted the exploration of alternative binders, such as the alkali activation of blast furnace slag (BFS), which is generated as a byproduct during the extraction of iron. While alkali-activated blast furnace slag (AAS) binders have some benefits over regular PC binders, they also suffer from disadvantages such as significant drying shrinkage. The study investigated the impact of Na dosage and curing conditions on alkali-activated blast furnace slag mortar (AASM). The consistency of the specimens was tested for fresh, hardened properties, and was conducted. The optimum Na dosage and curing conditions were selected. In the second stage, 0.1% and 0.2% glass and nylon fibers were added to the selected optimum mortar. Consistency, fresh, mechanical, and durability properties tests were conducted on the fiber mortars. The results showed that increasing the Na content increased the compressive and flexural strengths of AASM specimens. Thermal curing provided high compressive and flexural strengths, whereas fiber addition reduced water absorption and drying shrinkage. The drying shrinkage value was reduced by 26.82 % for AASM specimens with 0.2 % nylon fibers by volume compared to AASM without fibers. [ABSTRACT FROM AUTHOR]

This article presents a case study of a 41-year-old man with metastatic renal cell carcinoma (RCC) who underwent cytoreductive surgery after receiving immunotherapy. The article discusses the history and indications for cytoreductive nephrectomy (CN) in patients with metastatic RCC and ongoing clinical trials examining its efficacy in the era of immunotherapy. It also discusses the management of metastatic RCC with venous tumor thrombus and the subsequent treatment options for relapsed or stage IV clear cell RCC. The article highlights the promising results of lenvatinib plus pembrolizumab combination therapy and the management of adverse events associated with it. It also discusses the importance of genetic testing in RCC and the ongoing clinical trials evaluating HIF-2α inhibitors. The article emphasizes the importance of multidisciplinary management and personalized treatment plans, and includes the patient's perspective and challenges faced throughout the treatment process. [Extracted from the article]

Byline: Musa. Temel, Ahmet. Yildirim Sir, Herpes zoster (HZ) is a viral disease that causes vesicular skin lesions and pain in dermatomal distributions. The varicella-zoster virus that causes the disease [...]

The purpose was to evaluate reliability of measurements during drop jump (DJ) and magnitude of differences in vertical jump height (VJH) when calculated using two variables: time-in-the-air and center-of-mass velocity. Thirty-seven handball players performed three single-leg and double-leg DJs on a portable force plate during two sessions. Sixteen outcome measures and four sets of reliability metrics, including intraclass correlation coefficients (ICCs), were estimated. All outcome measures, except vertical time-to-stabilization, yielded high (0.70–0.89) to very high (0.90–0.96) interday and intraday ICCs for the single-leg and double-leg DJ tests. These results indicated that the single-leg and double-leg DJ tests can be considered reliable for short-term and long-term monitoring of collegiate handball players of both sexes. In addition, the single-leg DJ VJH calculated using these two variables differed in magnitude (mean difference in test measurements: 0.64 cm, p <.001, effect size: 0.165). Therefore, we recommend using the same method to calculate single-leg VJH for long-term monitoring. [ABSTRACT FROM AUTHOR]

Background and objectives: We aimed to determine the effects of vanillic acid (VA) on fracture healing radiologically, histologically, immunohistochemically, and biomechanically using a rat femur open fracture injury model. Methods: 32 male Wistar-Albino rats were used and divided into two groups: the study group (VA) and the control group. From the time they were operated on until they were sacrificed, the rats in the study group were given 100 mg/kg/day VA by oral gavage. After sacrification, the femurs were analyzed. Results: It was observed that the Huo histological scoring was significantly higher in the VA group (p = 0.001), and the ratio of the amount of callus tissue compared to intact bone tissue was significantly higher. While no significant difference was observed in immunohistochemical H-scores in Coll antibody staining (p = 1.000), a borderline significant difference in favor of VA was observed in Colili antibody staining (p = 0.078). In biomechanical analysis, failure load (N), total energy (J), maximum stress (MPa), and stiffness (N/mm) measurements were significantly higher in the VA group (p = 0.040, p = 0.021, p = 0.015, and p = 0.035, respectively). Conclusion: It has been observed that VA, with its antioxidative properties, increases fracture healing in rats, in which an open fracture model was created. We are hopeful that such an antioxidant, which is common in nature, will increase fracture healing. Since this study is the first to examine the effect of VA on fracture healing, further studies are needed. [ABSTRACT FROM AUTHOR]

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