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3. Comparative Study of Quarkonium Transport in Hot QCD Matter

Author

Andronic, A., Gossiaux, P. B., Petreczky, P., Rapp, R., Strickland, M., Blaizot, J. P., Brambilla, N., Braun-Munzinger, P., Chen, B., Delorme, S., Du, X., Escobedo, M. A., Ferreiro, E. G., Jaiswal, A., Rothkopf, A., Song, T., Stachel, J., Griend, P. Vander, Vogt, R., Wu, B., Zhao, J., and Yao, X.

Subjects
Nuclear Theory, High Energy Physics - Phenomenology
Abstract

This document summarizes the efforts of the EMMI Rapid Reaction Task Force on "Suppression and (re)generation of quarkonium in heavy-ion collisions at the LHC", centered around their 2019 and 2022 meetings. It provides a review of existing experimental results and theoretical approaches, including lattice QCD calculations and semiclassical and quantum approaches for the dynamical evolution of quarkonia in the quark-gluon plasma as probed in high-energy heavy-ion collisions. The key ingredients of the transport models are itemized to facilitate comparisons of calculated quantities such as reaction rates, binding energies, and nuclear modification factors. A diagnostic assessment of the various results is attempted and coupled with an outlook for the future., Comment: 54 pages, 19 figures

Published
2024

4. Single-frequency lasers' linewidth elegantly characterized with Sigmoid functions of observation time

Author

Ma, Xiaosong and Yao, X. Steve

Subjects
Physics - Optics
Abstract

Linewidth is the most important parameter for characterizing the coherence properties of a single-frequency laser, but unfortunately only the natural linewidth representing the contributions of the spontaneous emission or quantum noise can be described with an analytical expression known as the Schawlow-Townes-Henry formula. To the best of authors' knowledge, no analytical expression is formulized after 63 years since laser's invention for characterizing the effective linewidth of a single-frequency laser including the linewidth broadening caused by the flicker noises, which strongly depends on the measurement duration and is much larger than the natural linewidth. By carefully measuring the instantaneous frequency fluctuations of multiple commercial single-frequency lasers using a self-built optical frequency analyzer with ultra-high resolution and speed to obtain their linewidths with our time domain statistical analysis method, we discover and validate that the laser linewidths can be expressed as one or more Sigmoid functions of observation time. Not only the simple Sigmoid linewidth expression provides clear linewidth information of the laser, but also better understanding of the physical origins affecting the laser linewidths, which will benefit a large number of applications ranging from coherent distributed sensing to gravitational wave detection and therefore is worthy to be widely adopted to fully and elegantly characterize the linewidths of single-frequency lasers., Comment: 27 pages, 16 figures, 1 table, research article

Published
2023

5. Metabolic Syndrome and Socioeconomic Status in Association with Chronic Kidney Disease: A Cross-Sectional Study in Ningbo, China

Author

Huang S, Yao X, Chen X, Li Y, Kanwar Y, Chan FKS, Ye P, and Zhan M

Subjects
chronic kidney disease, metabolic syndrome, socioeconomic status, prevalence, risk factors, Specialties of internal medicine, RC581-951
Abstract

Shichun Huang,1,2 Xuejie Yao,2 Xueqin Chen,2 Xiuli Chen,3 Yanxia Li,3 Yashpal Kanwar,4 Faith Ka Shun Chan,5 Ping Ye,2 Ming Zhan2,6 1School of Medicine, Ningbo University, Ningbo, 315211, People’s Republic of China; 2Department of Medicine, The First Affiliated Hospital, Ningbo University, Ningbo, 315000, People’s Republic of China; 3Department of Medicine, Ningbo Baiyun Community Healthcare Center, Ningbo, 315000, People’s Republic of China; 4Department of Pathology and Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA; 5School of Geographical Sciences, University of Nottingham Ningbo China, Ningbo, 315100, People’s Republic of China; 6China Health Institute, University of Nottingham Ningbo China, Ningbo, 315100, People’s Republic of ChinaCorrespondence: Ming Zhan, Department of Medicine, The First Affiliated Hospital, Ningbo University, 59 Liuting Street, Ningbo, Zhejiang Province, 315000, People’s Republic of China, Email stephen0726@163.comBackground: Metabolic syndrome (MS) and low socioeconomic status (SES) may increase the risk for chronic kidney disease (CKD). This study aimed to investigate the prevalence of MS and CKD and the association between MS, SES, and CKD among adults in Ningbo, a city in Eastern China.Methods: A cross-sectional survey of 3212 adults was conducted between July 2019 and February 2021 in Ningbo. MS was defined as the presence of three or more risk factors: elevated blood pressure, reduced high-density lipoprotein (HDL) cholesterol, elevated triglycerides, elevated plasma glucose, and abdominal obesity. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 or the occurrence of albuminuria. SES was stratified according to personal education and income levels. Multivariate logistic regression was used to analyze the relationships among MS, sociodemographic factors, and CKD.Results: The age- and sex-adjusted prevalence of CKD was 9.1% (95% CI: 8.3– 10.0), the prevalence of eGFR less than 60 mL/min/per 1· 73 m² was 2.5% (95% CI 2.0– 3.0) and that of albuminuria was 7.9% (95% CI 7.0– 8.7), and the adjusted prevalence of MS was 23.1% (95% CI 21.7– 24.4). MS components, including elevated blood pressure, elevated fasting glucose, abdominal obesity, elevated serum triglyceride, or reduced serum HDL-C, were independent risk factors for CKD, and the adjusted prevalence of CKD proportionally increased with the number of MS-defined parameters. Participants with MS had 2.43-fold increased odds of developing CKD compared with those without MS. In addition, age, female sex, low SES including low educational level and low income were associated with increased odds of occurrence of albuminuria and CKD.Conclusion: The prevalence of metabolic syndrome and chronic kidney disease is high among adults in Ningbo. Metabolic syndrome and low socioeconomic status are associated with the high risk of developing chronic kidney disease.Keywords: chronic kidney disease, metabolic syndrome, socioeconomic status, prevalence, risk factors

Published
2024

6. Revolutionizing Intervertebral Disc Regeneration: Advances and Future Directions in Three-Dimensional Bioprinting of Hydrogel Scaffolds

Author

Zhang X, Gao X, Yao X, and Kang X

Subjects
intervertebral disc degeneration, 3d bioprinting, hydrogel, novel therapy, challenges, Medicine (General), R5-920
Abstract

Xiaobo Zhang,1,&ast; Xidan Gao,1,&ast; Xuefang Zhang,1 Xin Yao,1 Xin Kang2 1Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’An, Shaanxi, P.R. China; 2Department of Sports Medicine, Honghui Hospital, Xi’an Jiao Tong University, Xi’An, Shaanxi, P.R. China&ast;These authors contributed equally to this workCorrespondence: Xin Kang, Email honghuikangxin@163.comAbstract: Hydrogels are multifunctional platforms. Through reasonable structure and function design, they use material engineering to adjust their physical and chemical properties, such as pore size, microstructure, degradability, stimulus-response characteristics, etc. and have a variety of biomedical applications. Hydrogel three-dimensional (3D) printing has emerged as a promising technique for the precise deposition of cell-laden biomaterials, enabling the fabrication of intricate 3D structures such as artificial vertebrae and intervertebral discs (IVDs). Despite being in the early stages, 3D printing techniques have shown great potential in the field of regenerative medicine for the fabrication of various transplantable tissues within the human body. Currently, the utilization of engineered hydrogels as carriers or scaffolds for treating intervertebral disc degeneration (IVDD) presents numerous challenges. However, it remains an indispensable multifunctional manufacturing technology that is imperative in addressing the escalating issue of IVDD. Moreover, it holds the potential to serve as a micron-scale platform for a diverse range of applications. This review primarily concentrates on emerging treatment strategies for IVDD, providing an in-depth analysis of their merits and drawbacks, as well as the challenges that need to be addressed. Furthermore, it extensively explores the biological properties of hydrogels and various nanoscale biomaterial inks, compares different prevalent manufacturing processes utilized in 3D printing, and thoroughly examines the potential clinical applications and prospects of integrating 3D printing technology with hydrogels.Keywords: intervertebral disc degeneration, 3D bioprinting, hydrogel, novel therapy, challenges

Published
2024

7. Hot QCD White Paper

Author

Arslandok, M., Bass, S. A., Baty, A. A., Bautista, I., Beattie, C., Becattini, F., Bellwied, R., Berdnikov, Y., Berdnikov, A., Bielcik, J., Blair, J. T., Bock, F., Boimska, B., Bossi, H., Caines, H., Chen, Y., Chien, Y. -T., Chiu, M., Connors, M. E., Csanád, M., da Silva, C. L., Dash, A. P., David, G., Dehmelt, K., Dexheimer, V., Dong, X., Drees, A., Du, L., Durham, J. M., Ehlers, R. J., Elfner, H., Evdokimov, O., Finger, M., Finger Jr., M., Frantz, J., Frawley, A. D., Gale, C., Geurts, F., Gonzalez, V., Grau, N., Greene, S. V., Grossberndt, S. K., Hachiya, T., He, X., Heinz, U., Hong, B., Humanic, T. J., Ivanishchev, D., Jacak, B. V., Jahan, J., Jeon, S., Jheng, H. R., Jia, J., Judd, E. G., Kapusta, J. I., Karpenko, I., Khachatryan, V., Kharzeev, D. E., Kim, M., Kimelman, B., Klay, J. L., Klein, S. R., Knospe, A. G., Koch, V., Kotov, D, Krintiras, G. K., Elayavalli, R. Kunnawalkam, Kuo, C. M., Lajoie, J. G., Lee, Y. -J., Li, W., Liao, J., Likmeta, I., Lim, S. H., Liu, M. X., Loizides, C., Longo, R., Luo, X., Luzum, M., Ma, R., Majumder, A., Mak, S., Markert, C., Mehtar-Tani, Y., Mignerey, A. C., Minafra, N., Morrison, D. P., Mueller, B., Nagle, J. L., Narde, A., Nattrass, C. E., Niida, T., Noronha, J., Noronha-Hostler, J., Nouicer, R., Novitzky, N., O'Brien, E., Odyniec, G., Okorokov, V. A., Osborn, J. D., Paquet, J. -F., Park, S., Parotto, P., Perepelitsa, D. V., Petreczky, P., Pinkenburg, C., Praszalowicz, M., Pruneau, C., Putschke, J., Ramasubramanian, N. V., Rapp, R., Ratti, C., Read, K. F., Teles, P. Rebello, Reed, R., Rinn, T., Roland, G., Rosati, M., Royon, C., Ruan, L., Sakaguchi, T., Salur, S., Sarsour, M., Menon, A. S., Schenke, B., Schmidt, N. V., Schmier, A., Schäfer, T., Seger, J., Seto, R., Sheibani, Oveis, Shen, C., Shi, Z., Shulga, E., Sickles, A. M., Singh, M., Singh, B. K., Smirnov, N., Smith, K. L., Song, H., Soudi, I., Leiton, A. G. Stahl, Steinberg, P., Stephanov, M., Strickland, M., Sumbera, M., Cerci, D. Sunar, Tachibana, Y., Tang, A. H., Takaki, D. Tapia, Teaney, D., Thomas, D., Timmins, A. R., Tribedy, P., Tu, Z., Tuo, S., Rueda, O. V., Velkovska, J., Venugopalan, R., Videbæk, F., Voloshin, S. A., Vovchenko, V., Vujanovic, G., Wang, X., Wang, F., Wang, X. -N., Weyhmiller, S., Xie, W., Xu, N., Yang, Y., Yao, X., Ye, Z., Yee, H. -U., and Zajc, W. A.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

Hot QCD physics studies the nuclear strong force under extreme temperature and densities. Experimentally these conditions are achieved via high-energy collisions of heavy ions at the Relativistic Heavy Ion Collider (RHIC) and the Large Hadron Collider (LHC). In the past decade, a unique and substantial suite of data was collected at RHIC and the LHC, probing hydrodynamics at the nucleon scale, the temperature dependence of the transport properties of quark-gluon plasma, the phase diagram of nuclear matter, the interaction of quarks and gluons at different scales and much more. This document, as part of the 2023 nuclear science long range planning process, was written to review the progress in hot QCD since the 2015 Long Range Plan for Nuclear Science, as well as highlight the realization of previous recommendations, and present opportunities for the next decade, building on the accomplishments and investments made in theoretical developments and the construction of new detectors. Furthermore, this document provides additional context to support the recommendations voted on at the Joint Hot and Cold QCD Town Hall Meeting, which are reported in a separate document., Comment: 190 pages, 69 figures

Published
2023

8. The Present and Future of QCD

Author

Achenbach, P., Adhikari, D., Afanasev, A., Afzal, F., Aidala, C. A., Al-bataineh, A., Almaalol, D. K., Amaryan, M., Androić, D., Armstrong, W. R., Arratia, M., Arrington, J., Asaturyan, A., Aschenauer, E. C., Atac, H., Avakian, H., Averett, T., Gayoso, C. Ayerbe, Bai, X., Barish, K. N., Barnea, N., Basar, G., Battaglieri, M., Baty, A. A., Bautista, I., Bazilevsky, A., Beattie, C., Behera, S. C., Bellini, V., Bellwied, R., Benesch, J. F., Benmokhtar, F., Bernardes, C. A., Bernauer, J. C., Bhatt, H., Bhatta, S., Boer, M., Boettcher, T. J., Bogacz, S. A., Bossi, H. J., Brandenburg, J. D., Brash, E. J., Briceño, R. A., Briscoe, W. J., Brodsky, S. J., Brown, D. A., Burkert, V. D., Caines, H., Cali, I. A., Camsonne, A., Carman, D. S., Caylor, J., Cerci, S., Llatas, M. Chamizo, Chatterjee, S., Chen, J. P., Chen, Y., Chen, Y. -C., Chien, Y. -T., Chou, P. -C., Chu, X., Chudakov, E., Cline, E., Cloët, I. C., Cole, P. L., Connors, M. E., Constantinou, M., Cosyn, W., Dusa, S. Covrig, Cruz-Torres, R., D'Alesio, U., da Silva, C., Davoudi, Z., Dean, C. T., Dean, D. J., Demarteau, M., Deshpande, A., Detmold, W., Deur, A., Devkota, B. R., Dhital, S., Diefenthaler, M., Dobbs, S., Döring, M., Dong, X., Dotel, R., Dow, K. A., Downie, E. J., Drachenberg, J. L., Dumitru, A., Dunlop, J. C., Dupre, R., Durham, J. M., Dutta, D., Edwards, R. G., Ehlers, R. J., Fassi, L. El, Elaasar, M., Elouadrhiri, L., Engelhardt, M., Ent, R., Esumi, S., Evdokimov, O., Eyser, O., Fanelli, C., Fatemi, R., Fernando, I. P., Flor, F. A., Fomin, N., Frawley, A. D., Frederico, T., Fries, R. J., Gal, C., Gamage, B. R., Gamberg, L., Gao, H., Gaskell, D., Geurts, F., Ghandilyan, Y., Ghimire, N., Gilman, R., Gleason, C., Gnanvo, K., Gothe, R. W., Greene, S. V., Grießhammer, H. W., Grossberndt, S. K., Grube, B., Hackett, D. C., Hague, T. J., Hakobyan, H., Hansen, J. -O., Hatta, Y., Hattawy, M., Havener, L. B., Hen, O., Henry, W., Higinbotham, D. W., Hobbs, T. J., Hodges, A. M., Holmstrom, T., Hong, B., Horn, T., Howell, C. R., Huang, H. Z., Huang, M., Huang, S., Huber, G. M., Hyde, C. E., Isupov, E. L., Jacobs, P. M., Jalilian-Marian, J., Jentsch, A., Jheng, H., Ji, C. -R., Ji, X., Jia, J., Jones, D. C., Jones, M. K., Kalantarians, N., Kalicy, G., Kang, Z. B., Karthein, J. M., Keller, D., Keppel, C., Khachatryan, V., Kharzeev, D. E., Kim, H., Kim, M., Kim, Y., King, P. M., Kinney, E., Klein, S. R., Ko, H. S., Koch, V., Kohl, M., Kovchegov, Y. V., Krintiras, G. K., Kubarovsky, V., Kuhn, S. E., Kumar, K. S., Kutz, T., Lajoie, J. G., Lauret, J., Lavrukhin, I., Lawrence, D., Lee, J. H., Lee, K., Lee, S., Lee, Y. -J., Li, S., Li, W., Li, Xiaqing, Li, Xuan, Liao, J., Lin, H. -W., Lisa, M. A., Liu, K. -F., Liu, M. X., Liu, T., Liuti, S., Liyanage, N., Llope, W. J., Loizides, C., Longo, R., Lorenzon, W., Lunkenheimer, S., Luo, X., Ma, R., McKinnon, B., Meekins, D. G., Mehtar-Tani, Y., Melnitchouk, W., Metz, A., Meyer, C. A., Meziani, Z. -E., Michaels, R., Michel, J. K. L., Milner, R. G., Mkrtchyan, H., Mohanmurthy, P., Mohanty, B., Mokeev, V. I., Moon, D. H., Mooney, I. A., Morningstar, C., Morrison, D. P., Müller, B., Mukherjee, S., Mulligan, J., Camacho, C. Munoz, Quijada, J. A. Murillo, Murray, M. J., Nadeeshani, S. A., Nadel-Turonski, P., Nam, J. D., Nattrass, C. E., Nijs, G., Noronha, J., Noronha-Hostler, J., Novitzky, N., Nycz, M., Olness, F. I., Osborn, J. D., Pak, R., Pandey, B., Paolone, M., Papandreou, Z., Paquet, J. -F., Park, S., Paschke, K. D., Pasquini, B., Pasyuk, E., Patel, T., Patton, A., Paudel, C., Peng, C., Peng, J. C., Da Costa, H. Pereira, Perepelitsa, D. V., Peters, M. J., Petreczky, P., Pisarski, R. D., Pitonyak, D., Ploskon, M. A., Posik, M., Poudel, J., Pradhan, R., Prokudin, A., Pruneau, C. A., Puckett, A. J. R., Pujahari, P., Putschke, J., Pybus, J. R., Qiu, J. -W., Rajagopal, K., Ratti, C., Read, K. F., Reed, R., Richards, D. G., Riedl, C., Ringer, F., Rinn, T., West, J. Rittenhouse, Roche, J., Rodas, A., Roland, G., Romero-López, F., Rossi, P., Rostomyan, T., Ruan, L., Ruimi, O. M., Saha, N. R., Sahoo, N. R., Sakaguchi, T., Salazar, F., Salgado, C. W., Salmè, G., Salur, S., Santiesteban, S. N., Sargsian, M. M., Sarsour, M., Sato, N., Satogata, T., Sawada, S., Schäfer, T., Scheihing-Hitschfeld, B., Schenke, B., Schindler, S. T., Schmidt, A., Seidl, R., Shabestari, M. H., Shanahan, P. E., Shen, C., Sheng, T. -A., Shepherd, M. R., Sickles, A. M., Sievert, M. D., Smith, K. L., Song, Y., Sorensen, A., Souder, P. A., Sparveris, N., Srednyak, S., Leiton, A. G. Stahl, Stasto, A. M., Steinberg, P., Stepanyan, S., Stephanov, M., Stevens, J. R., Stewart, D. J., Stewart, I. W., Stojanovic, M., Strakovsky, I., Strauch, S., Strickland, M., Cerci, D. Sunar, Suresh, M., Surrow, B., Syritsyn, S., Szczepaniak, A. P., Tadepalli, A. S., Tang, A. H., Takaki, J. D. Tapia, Tarnowsky, T. J., Tawfik, A. N., Taylor, M. I., Tennant, C., Thiel, A., Thomas, D., Tian, Y., Timmins, A. R., Tribedy, P., Tu, Z., Tuo, S., Ullrich, T., Umaka, E., Upton, D. W., Vary, J. P., Velkovska, J., Venugopalan, R., Vijayakumar, A., Vitev, I., Vogelsang, W., Vogt, R., Vossen, A., Voutier, E., Vovchenko, V., Walker-Loud, A., Wang, F., Wang, J., Wang, X., Wang, X. -N., Weinstein, L. B., Wenaus, T. J., Weyhmiller, S., Wissink, S. W., Wojtsekhowski, B., Wong, C. P., Wood, M. H., Wunderlich, Y., Wyslouch, B., Xiao, B. W., Xie, W., Xiong, W., Xu, N., Xu, Q. H., Xu, Z., Yaari, D., Yao, X., Ye, Z., Ye, Z. H., Yero, C., Yuan, F., Zajc, W. A., Zhang, C., Zhang, J., Zhao, F., Zhao, Y., Zhao, Z. W., Zheng, X., Zhou, J., and Zurek, M.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, Nuclear Experiment, Nuclear Theory
Abstract

This White Paper presents the community inputs and scientific conclusions from the Hot and Cold QCD Town Meeting that took place September 23-25, 2022 at MIT, as part of the Nuclear Science Advisory Committee (NSAC) 2023 Long Range Planning process. A total of 424 physicists registered for the meeting. The meeting highlighted progress in Quantum Chromodynamics (QCD) nuclear physics since the 2015 LRP (LRP15) and identified key questions and plausible paths to obtaining answers to those questions, defining priorities for our research over the coming decade. In defining the priority of outstanding physics opportunities for the future, both prospects for the short (~ 5 years) and longer term (5-10 years and beyond) are identified together with the facilities, personnel and other resources needed to maximize the discovery potential and maintain United States leadership in QCD physics worldwide. This White Paper is organized as follows: In the Executive Summary, we detail the Recommendations and Initiatives that were presented and discussed at the Town Meeting, and their supporting rationales. Section 2 highlights major progress and accomplishments of the past seven years. It is followed, in Section 3, by an overview of the physics opportunities for the immediate future, and in relation with the next QCD frontier: the EIC. Section 4 provides an overview of the physics motivations and goals associated with the EIC. Section 5 is devoted to the workforce development and support of diversity, equity and inclusion. This is followed by a dedicated section on computing in Section 6. Section 7 describes the national need for nuclear data science and the relevance to QCD research., Comment: QCD Town Meeting White Paper, as submitted to 2023 NSAC LRP committee on Feb. 28, 2023

Published
2023
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9. Degree of Blood Glucose Control and Risk of Hypertension in Chinese Adults with T2DM: A Cross-Sectional Study

Author

Zhang J, Yao X, Chen Y, Feng Q, Zhang Y, Jiang T, Tang S, Zhang N, Dai F, Hu H, and Zhang Q

Subjects
fpg, hba1c, t2dm, hypertension., Specialties of internal medicine, RC581-951
Abstract

Jie Zhang, Xuelin Yao, Yijing Chen, Qing Feng, Yi Zhang, Tian Jiang, Songtao Tang, Nan Zhang, Fang Dai, Honglin Hu, Qiu Zhang Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of ChinaCorrespondence: Qiu Zhang; Honglin Hu, Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Shushan District, 230032, People’s Republic of China, Email zhangqiu@ahmu.edu.cn; huhonglin@ahmu.edu.cnBackground: Diabetes mellitus and hypertension often coexist and share common risk factors. This study investigated the correlation between glycemic management and the prevalence of hypertension among Chinese adults diagnosed with type 2 diabetes mellitus (T2DM).Methods: This study included 1715 patients with T2DM from four cities in Anhui Province, China. Sociodemographic characteristics of the sample participants were collected via questionnaires. A univariate analysis of variance (ANOVA) was utilized for continuous variables, and chi-square testing was used for categorical variables. Binary logistic regression was utilized to examine the relationship between blood pressure and variables including fasting plasma glucose (FPG), glycosylated haemoglobin (HbA1c), body mass index (BMI), waist circumference (WC), physical activity, dyslipidemia, and family history of hypertension.Results: FPG levels did not increase the risk of hypertension, while HbA1c was significantly and negatively associated with hypertension risk. HbA1c levels ranged from 7.2 to 8.6%, with odds ratios (OR) of 0.68 and 95% confidence intervals (CI) of 0.48 to 0.97 and a significant p value of less than 0.05. For the HbA1c levels above 8.6%, the OR was 0.58 with a 95% CI of 0.39 to 0.87 and a significant p value of less than 0.01. Furthermore, advanced age, higher BMI, greater waist circumference, presence of dyslipidemia, and positive family history of hypertension were all found to be significantly and independently linked to a heightened risk of developing hypertension. These associations remain significant after further adjustment.Conclusion: There was a negative association between HbA1c and the risk of hypertension, and the association remained significant after adjustment for antihypertensive drug use.Keywords: FPG, HbA1c, T2DM, hypertension

Published
2024

10. Recent Advances in Whiskers: Properties and Clinical Applications in Dentistry

Author

Han W, Zhang R, Liu S, Zhang T, Yao X, Cao Y, Li J, Liu X, and Li B

Subjects
whiskers, dentistry, growth mechanism, biomaterials, Medicine (General), R5-920
Abstract

Wenze Han,1,2 Ran Zhang,1,2 Shuzhi Liu,1,2 Tong Zhang,1,2 Xuemin Yao,1,2 Yuxin Cao,1,2 Jiadi Li,1,2 Xiaoming Liu,1,2 Bing Li1,2 1Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi, 030001, People’s Republic of China; 2Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, Shanxi, People’s Republic of ChinaCorrespondence: Xiaoming Liu; Bing Li, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi, 030001, People’s Republic of China, Email lxming0912@163.com; libing1975vip@163.comAbstract: Whiskers are nanoscale, high-strength fibrous crystals with a wide range of potential applications in dentistry owing to their unique mechanical, thermal, electrical, and biological properties. They possess high strength, a high modulus of elasticity and good biocompatibility. Hence, adding these crystals to dental composites as reinforcement can considerably improve the mechanical properties and durability of restorations. Additionally, whiskers are involved in inducing the value-added differentiation of osteoblasts, odontogenic osteocytes, and pulp stem cells, and promoting the regeneration of alveolar bone, periodontal tissue, and pulp tissue. They can also enhance the mucosal barrier function, inhibit the proliferation of tumor cells, control inflammation, and aid in cancer prevention. This review comprehensively summarizes the classification, properties, growth mechanisms and preparation methods of whiskers and focuses on their application in dentistry. Due to their unique physicochemical properties, excellent biological properties, and nanoscale characteristics, whiskers show great potential for application in bone, periodontal, and pulp tissue regeneration. Additionally, they can be used to prevent and treat oral cancer and improve medical devices, thus making them a promising new material in dentistry.Keywords: whiskers, dentistry, growth mechanism, biomaterials

Published
2024

11. Designing Mesoporous Prussian Blue@zinc Phosphate Nanoparticles with Hierarchical Pores for Varisized Guest Delivery and Photothermally-Augmented Chemo-Starvation Therapy

Author

Yuan Y, Hou M, Song X, Yao X, Wang X, Chen X, and Li S

Subjects
prussian blue, glucose oxidase, co-delivery system, photothermal therapy, chemotherapy, Medicine (General), R5-920
Abstract

Yuan Yuan,1,&ast; Mingyi Hou,2,&ast; Xiaoning Song,1 Xintao Yao,1 Xuerui Wang,1 Xiangjun Chen,2 Shengnan Li1 1School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300401, People’s Republic of China; 2School of Pharmacy, Shandong New Drug Loading & Release Technology and Preparation Engineering Laboratory, Binzhou Medical University, Yantai, 264003, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Shengnan Li; Xiaoning Song, School of Chemical Engineering and Technology, Hebei University of Technology, Xiping Road, Tianjin, 300401, People’s Republic of China, Email lisn027@hebut.edu.cn; songxn123@hebut.edu.cnBackground: With the rapid development of nanotechnology, constructing a multifunctional nanoplatform that can deliver various therapeutic agents in different departments and respond to endogenous/exogenous stimuli for multimodal synergistic cancer therapy remains a major challenge to address the inherent limitations of chemotherapy.Methods: Herein, we synthesized hollow mesoporous Prussian Blue@zinc phosphate nanoparticles to load glucose oxidase (GOx) and DOX (designed as HMPB-GOx@ZnP-DOX NPs) in the non-identical pore structures of their HMPB core and ZnP shell, respectively, for photothermally augmented chemo-starvation therapy.Results: The ZnP shell coated on the HMPB core, in addition to providing space to load DOX for chemotherapy, could also serve as a gatekeeper to protect GOx from premature leakage and inactivation before reaching the tumor site because of its degradation characteristics under mild acidic conditions. Moreover, the loaded GOx can initiate starvation therapy by catalyzing glucose oxidation while causing an upgradation of acidity and H2O2 levels, which can also be used as forceful endogenous stimuli to trigger smart delivery systems for therapeutic applications. The decrease in pH can improve the pH-sensitivity of drug release, and O2 can be supplied by decomposing H2O2 through the catalase-like activity of HMPBs, which is beneficial for relieving the adverse conditions of anti-tumor activity. In addition, the inner HMPB also acts as a photothermal agent for photothermal therapy and the generated hyperthermia upon laser irradiation can serve as an external stimulus to further promote drug release and enzymatic activities of GOx, thereby enabling a synergetic photothermally enhanced chemo-starvation therapy effect. Importantly, these results indicate that HMPB-GOx@ZnP-DOX NPs can effectively inhibit tumor growth by 80.31% and exhibit no obvious systemic toxicity in mice.Conclusion: HMPB-GOx@ZnP-DOX NPs can be employed as potential theranostic agents that incorporate multiple therapeutic modes to efficiently inhibit tumors. Keywords: Prussian Blue, glucose oxidase, co-delivery system, photothermal therapy, chemotherapy

Published
2024

12. Molecular Landscape and Prognostic Value in the Post-Translational Ubiquitination, SUMOylation and Neddylation in Osteosarcoma: A Transcriptome Study

Author

Jia C, Yao X, Dong Z, Wang L, Zhao F, Gao J, and Cai T

Subjects
post-translational modifications, osteosarcoma, immune microenvironment, immune therapy, rad21, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Chenguang Jia,1,&ast; Xiaowei Yao,1,&ast; Zhaoliang Dong,1 Lianbo Wang,1 Fangchao Zhao,2,&ast; Jianguo Gao,1,&ast; Tao Cai3,&ast; 1Department of Orthopedics, Hebei Chest Hospital, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 3Hebei Chest Hospital, Shijiazhuang, Hebei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Tao Cai, Hebei Chest Hospital, No. 372, Shengli North Street, Shijiazhuang, Hebei, People’s Republic of China, Tel/Fax +86-311-86911080, Email caitaoxiongke@163.comBackground: Post-translational modifications (PTM) significantly influence the pathogenesis and progression of diverse neoplastic conditions. Nevertheless, there has been limited research focusing on the potential of PTM-related genes (PTMRGs) as tumor biomarkers for predicting the survival of specific patients.Methods: The datasets utilized in this research were obtained from the TARGET and GEO repositories, respectively. The gene signature was constructed through the utilization of LASSO Cox regression method. GSEA and GO was used to identify hub pathways associated with risk genes. The functionality of risk genes in osteosarcoma (OS) cell lines was verified through the implementation of the CCK-8 assay, cell cycle analysis, and immunofluorescence assay.Results: Two distinct PTM patterns and gene clusters were finally determined. Significant differences in the prognosis of patients were found among two different PTM patterns and gene clusters, so were in the function enrichment and the landscape of TME immune cell infiltration. Moreover, we examined two external immunotherapy cohorts and determining that patients in the low-risk group was more likely to profit from immunotherapy. In addition, we mapped the expression of the genes in the signature in distinct cells using single-cell analysis. Finally, CCK-8 assay, cell cycle analysis, and immunofluorescence assay were utilized to confirm that RAD21 was expressed and functioned in OS.Conclusion: In conclusion, this study elucidated the potential link between PTM and immune infiltration landscape of OS for the first time and provided a new assessment protocol for the precise selection of treatment strategies for patients with advanced OS.Keywords: post-translational modifications, osteosarcoma, immune microenvironment, immune therapy, RAD21

Published
2024

13. J-Shaped Relationship Between Weight-Adjusted-Waist Index and Cardiovascular Disease Risk in Hypertensive Patients with Obstructive Sleep Apnea: A Cohort Study

Author

Zhao J, Cai X, Hu J, Song S, Zhu Q, Shen D, Yang W, Luo Q, Yao X, Zhang D, Hong J, and Li N

Subjects
hypertensive, obstructive sleep apnea, weight-adjusted-waist index, cardiovascular disease, visceral obesity, Specialties of internal medicine, RC581-951
Abstract

Jianwen Zhao,1– 5,&ast; Xintian Cai,1– 5,&ast; Junli Hu,1– 5 Shuaiwei Song,1– 5 Qing Zhu,1– 5 Di Shen,1– 5 Wenbo Yang,1– 5 Qin Luo,1– 5 Xiaoguang Yao,1– 5 Delian Zhang,1– 5 Jing Hong,1– 5 Nanfang Li1– 5 1Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, 830001, People’s Republic of China; 2Xinjiang Hypertension Institute, Urumqi, Xinjiang, 830001, People’s Republic of China; 3NHC Key Laboratory of Hypertension Clinical Research, Urumqi, Xinjiang 830001 People’s Republic of China; 4Key Laboratory of Xinjiang Uygur Autonomous Region ”Hypertension Research Laboratory”, Urumqi, Xinjiang, 830001, People’s Republic of China; 5Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, Xinjiang, 830001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Nanfang Li, Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumuqi, Xinjiang, 830001, People’s Republic of China, Tel +86 8564818, Email lnanfang2016@sina.comBackground: A newly introduced obesity-related index, the weight-adjusted-waist index (WWI), emerges as a promising predictor of cardiovascular disease (CVD). Given the known synergistic effects of hypertension and obstructive sleep apnea (OSA) on cardiovascular risk, we aimed to explore the relationship between the WWI and CVD risk specifically within this high-risk cohort.Methods: A total of 2265 participants with hypertension and OSA were included in the study. Multivariate Cox regression analysis was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD events. The restricted cubic spline (RCS) was used to further evaluate the nonlinear dose-response relationship.Results: During a median follow-up period of 6.8 years, 324 participants experienced a CVD event. Multivariate Cox regression analysis revealed that compared to the reference group, the HRs for the second, third, and fourth groups were 1.12 (95% CI, 0.79– 1.59), 1.35 (95% CI, 0.96– 1.89), and 1.58 (95% CI, 1.13– 2.22), respectively. Moreover, RCS analysis illustrated a clear J-shaped relationship between the WWI and CVD risk, particularly notable when WWI exceeded 11.5 cm/, signifying a significant increase in CVD risk.Conclusion: There was a J-shaped relationship between WWI and CVD in hypertensive patients with OSA, especially when the WWI was greater than 11.5 cm/, the risk of CVD was significantly increased.Keywords: hypertensive, obstructive sleep apnea, weight-adjusted-waist index, cardiovascular disease, visceral obesity

Published
2024

14. Albumin-to-Globulin Ratio Combined with Neutrophil-to-Lymphocyte Ratio as a Prognostic Predictor in Multiple Myeloma with Renal Impairment

Author

Zhang Y, Yao X, Chen Z, Qin Z, Cai Y, Xia W, and Hu H

Subjects
multiple myeloma, renal impairment, neutrophil–lymphocyte ratio, albumin-to-globulin ratio, prognosis, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Yingzi Zhang,1 Xiajuan Yao,1 Yaoquan Zhang,1 Zhuyun Chen,1 Zhongke Qin,1 Ying Cai,2 Wenkai Xia,1 Hong Hu1 1Department of Nephrology, Jiangyin People’s Hospital Affiliated to Nantong University, Jiangyin, Jiangsu, 214400, People’s Republic of China; 2Department of Hematology, Jiangyin People’s Hospital Affiliated to Nantong University, Jiangyin, Jiangsu, 214400, People’s Republic of ChinaCorrespondence: Wenkai Xia; Hong Hu, Department of Nephrology, Jiangyin People’s Hospital Affiliated to Nantong University, 3 Yingrui Road, Jiangyin, Jiangsu, 214400, People’s Republic of China, Email xiawenkai.xia@gmail.com; huhong1523@163.comBackground: The albumin-to-globulin ratio (AGR) and neutrophil-to-lymphocyte ratio (NLR) have been recently regarded as promising prognostic factors in various malignancies. The present study investigated the prognostic value of combining the AGR and NLR (ANS) for risk assessments in multiple myeloma (MM) with renal impairment (RI).Methods: From 2011 to 2018, 79 patients with MM and RI were enrolled in this study. Receiver operating curves (ROCs) were constructed to determine optimal AGR and NLR thresholds for predicting overall survival (OS) and progression-free survival (PFS) during follow up. The prognostic values of AGR, NLR, and ANS were evaluated with Cox regression and Kaplan-Meier methods. We also created a predictive nomogram for prognostic evaluations of OS and PFS, and the predictive accuracy was assessed with a concordance index (c-index).Results: The ROC curves analyses showed that the optimal cut-off levels were 2.27 for NLR and 1.57 for AGR. A high NLR and a high ANS were significantly associated with worse OS and PFS. However, a high NLR combined with a low AGR was associated with worse OS. Multivariate analyses demonstrated that both the NLR and ANS were independent predictors for both OS and PFS and that a low AGR was an independent predictor of a reduced OS. The nomogram accurately predicted OS (c-index: 0.785) and PFS (c-index: 0.786) in patients with MM and RI.Conclusion: ANS may serve as a potential prognostic biomarker in patients with MM and RI. The proposed nomograms may facilitate prognostic predictions for patients with MM and RI.Keywords: multiple myeloma, renal impairment, neutrophil–lymphocyte ratio, albumin-to-globulin ratio, prognosis

Published
2024

15. Intestinal Targeted Nanogel with Broad-Spectrum Autonomous ROS Scavenging Performance for Enhancing the Bioactivity of trans-Resveratrol

Author

Xu J, Zhang Y, Yao X, Wang S, Lv K, Luo G, Wang J, and Li G

Subjects
resveratrol, seleno-polysaccharide, synergistic antioxidant, mucoadhesion, intestinal targeted delivery, Medicine (General), R5-920
Abstract

Jingwen Xu,1,2 Yue Zhang,1,2 Xiaolin Yao,1 Sijuan Wang,1,2 Kaiqiang Lv,1,2 Guangwen Luo,1,2 Jiaqi Wang,1,2 Guoliang Li1 1School of Food Science and Engineering, School of Biological and Pharmaceutical Sciences, Shaanxi University of Science & Technology, Xi’an, 710021, People’s Republic of China; 2Xi’an Key Laboratory of Antiviral and Antimicrobial-Resistant Bacteria Therapeutics Research, Xi’an, 710021, People’s Republic of ChinaCorrespondence: Guoliang Li, Email 61254368@163.comIntroduction: To improve the bioavailability of trans-resveratrol (trans-Res), it is commonly co-delivered with antioxidant bioactives using a complex synthetic intestinal targeted carrier, however, which makes practical application challenging.Methods: A nanogel (Ngel), as broad-spectrum autonomous ROS scavenger, was prepared using selenized thiolated sodium alginate (TSA-Se) and crosslinked with calcium lactate (CL) for loading trans-Res to obtain Ngel@Res, which maintained spherical morphology in the upper digestive tract but broke down in the lower digestive tract, resulting in trans-Res release.Results: Under protection of Ngel, trans-Res showed enhanced stability and broad-spectrum ROS scavenging activity. The synergistic mucoadhesion of Ngel prolonged the retention time of trans-Res in the intestine. Ngel and Ngel@Res increased the lifespan of Caenorhabditis elegans to 26.00 ± 2.17 and 26.00 ± 4.27 days by enhancing the activity of antioxidases, upregulating the expression of daf-16, sod-5 and skn-1, while downregulating the expression of daf-2 and age-1.Conclusion: This readily available, intestinal targeted selenized alginate-based nanogel effectively improves the bioactivity of trans-Res. Keywords: trans-resveratrol, seleno-alginate, synergistic antioxidant, mucoadhesion, intestinal targeted delivery

Published
2024

16. The Clinical and Pathological Characteristics of POLE-Mutated Endometrial Cancer: A Comprehensive Review

Author

Yao X, Feng M, and Wang W

Subjects
endometrial cancer, molecular subtyping, pole, pole-mutated endometrial cancer, immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Xiaohong Yao,1 Min Feng,1,2 Wei Wang1,2 1Department of Pathology, West China Second University Hospital, Sichuan University, Sichuan, Chengdu, People’s Republic of China; 2Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Wei Wang, Email bearwin2000@126.comAbstract: Endometrial cancer shows high histological and molecular heterogeneity. The POLE mutation is a significant molecular alteration in endometrial cancer, leading to the identification of a specific subtype known as POLE-mutated endometrial cancer. This subtype exhibits a high tumor mutation burden, abundant lymphocyte infiltration, and a favorable prognosis, making it a promising candidate for immune checkpoint inhibitor therapy. This paper presents a comprehensive review of the clinical and pathological characteristics, outcomes, treatment advancements, pathogenic POLE gene detection, and alternative testing methods for POLE-mutated endometrial cancer.Keywords: endometrial cancer, molecular subtyping, POLE, POLE-mutated endometrial cancer, immunotherapy

Published
2024

17. Two long-period transiting exoplanets on eccentric orbits: NGTS-20 b (TOI-5152 b) and TOI-5153 b

Author

Ulmer-Moll, S., Lendl, M., Gill, S., Villanueva, S., Hobson, M. J., Bouchy, F., Brahm, R., Dragomir, D., Grieves, N., Mordasini, C., Anderson, D. R., Acton, J. S., Bayliss, D., Bieryla, A., Burleigh, M. R., Casewell, S. L., Chaverot, G., Eigmüller, P., Feliz, D., Gaudi, S., Gillen, E., Goad, M. R., Gupta, A. F., Günther, M. N., Henderson, B. A., Henning, T., Jenkins, J. S., Jones, M., Jordán, A., Kendall, A., Latham, D. W., Mireles, I., Moyano, M., Nadol, J., Osborn, H. P., Pepper, J., Pinto, M. T., Psaridi, A., Queloz, D., Quinn, S., Rojas, F., Sarkis, P., Schlecker, M., Tilbrook, R. H., Torres, P., Trifonov, T., Udry, S., Vines, J. I., West, R., Wheatley, P., Yao, X., Zhao, Y., and Zhou, G.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Long-period transiting planets provide the opportunity to better understand the formation and evolution of planetary systems. Their atmospheric properties remain largely unaltered by tidal or radiative effects of the host star, and their orbital arrangement reflects a different, and less extreme, migrational history compared to close-in objects. The sample of long-period exoplanets with well determined masses and radii is still limited, but a growing number of long-period objects reveal themselves in the TESS data. Our goal is to vet and confirm single transit planet candidates detected in the TESS space-based photometric data through spectroscopic and photometric follow up observations with ground-based instruments. We use the Next Generation Transit Survey (NGTS) to photometrically monitor the candidates in order to observe additional transits. We report the discovery of two massive, warm Jupiter-size planets, one orbiting the F8-type star TOI-5153 and the other orbiting the G1-type star NGTS-20 (=TOI-5152). From our spectroscopic analysis, both stars are metal-rich with a metallicity of 0.12 and 0.15, respectively. Follow-up radial velocity observations were carried out with CORALIE, CHIRON, FEROS, and HARPS. TOI-5153 hosts a 20.33 day period planet with a planetary mass of 3.26 (+-0.18) Mj, a radius of 1.06 (+-0.04) Rj , and an orbital eccentricity of 0.091 (+-0.026). NGTS-20 b is a 2.98 (+-0.16) Mj planet with a radius of 1.07 (+-0.04) Rj on an eccentric (0.432 +- 0.023) orbit with an orbital period of 54.19 days. Both planets are metal-enriched and their heavy element content is in line with the previously reported mass-metallicity relation for gas giants. Both warm Jupiters orbit moderately bright host stars making these objects valuable targets for follow-up studies of the planetary atmosphere and measurement of the spin-orbit angle of the system., Comment: 17 pages, 13 figures, accepted to A&A

Published
2022
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21. Serum Albumin Level Can Predict Immunotherapy Response of Neuromyelitis Optica Spectrum Disorders in the Acute Phase

Author

Xiang W, Wu Y, Li H, Zhu D, Yao X, Ding J, Wang Z, and Guan Y

Subjects
immune diseases, nmosd, immunotherapy, albumin, multivariate analysis, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Weiwei Xiang,1,&ast; Yifan Wu,2,&ast; Hongyan Li,1,&ast; Desheng Zhu,1 Xiaoying Yao,1 Jie Ding,1 Ze Wang,1 Yangtai Guan1 1Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yangtai Guan, Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, No. 160, Pujian Road, Shanghai, People’s Republic of China, Email yangtaiguan@sina.comBackground: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disease of the central nervous system. However, few biomarkers have been found to predict the outcome of immunotherapy. We investigated the relationship between the serum albumin (S-Alb) and response to immunotherapy in acute NMOSD patients.Methods: A total of 107 consecutive Chinese patients with acute NMOSD diagnosed between January 2013 and January 2022 were included in our prospective observational study. S-Alb was measured by the use of bromocresol green and immunoturbidimetric methods on admission. The immunotherapy response was assessed by the percentage change in the expanded disability status scale (EDSS) score from admission to discharge after treatment. We evaluated the association between S-Alb and immunotherapy response through multivariate logistic regression analysis.Results: S-Alb levels were significantly lower in patients who were resistant to immunotherapy than in those who were responsive to treatment (p< 0.001). S-Alb levels were positively related to a favorable response to immunotherapy (r=0.386, p< 0.001). The odds ratio (95% CI) for the association between S-Alb level and response to immunotherapy was 1.27 (95% CI=1.08, 1.50; p=0.004) after adjusting for potential factors. ROC analysis showed that patients with S-Alb levels lower than 40.85 g/L were likely to be resistant to immunotherapy.Conclusion: Our study indicated that a higher S-Alb was an independent indicator of response to immunotherapy in acute NMOSD patients.Keywords: immune diseases, NMOSD, immunotherapy, albumin, multivariate analysis

Published
2024

22. Identification of Key Genes for Pyroptosis-Induced Salivary Gland Inflammation in Sjogren’s Syndrome Based on Microarray Data and Immunohistochemistry Analysis

Author

Zhang K, Luo Z, Zhu X, Yao X, Lu D, Chen L, Hong T, Ren Y, and Wang X

Subjects
sjogren's syndrome, pyroptosis, bioinformatics analysis, salivary gland, immunology, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Kaiyuan Zhang,1,&ast; Ziyue Luo,1,&ast; Xinchao Zhu,1 Xinyi Yao,1 Dingqi Lu,2 Liying Chen,1 Tao Hong,1 Yating Ren,1 Xinchang Wang3 1Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People’s Republic of China; 2First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People’s Republic of China; 3Department of Rheumatology, The Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xinchang Wang, The Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People’s Republic of China, Tel +86 13065714635, Email ossani@126.comPurpose: Sjogren’s Syndrome (SS) is a systemic autoimmune disease primarily characterized by dysfunction of the exocrine glands. Research into the etiology and pathogenesis of salivary glands (SG) inflammation of SS is very limited. The aim of this study was to identify potential pyroptosis-related genes in SG inflammation through bioinformatics analysis and validation of the SG in SS.Methods: GSE157159 dataset and GSE159574 dataset were downloaded from Gene Expression Omnibus (GEO). Differentially Expressed Genes (DEGs) analysis was used to screen DEGs from SS and non-SS SG samples. Pyroptosis-related genes were obtained from GeneCards. After intersecting DEGs with pyroptosis-related genes, the pyroptosis-related DEGs in SS were obtained. Subsequently, ClueGO enrichment analysis, Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analysis, Protein-protein Interaction (PPI), and identification and co-expression analysis of hub genes were performed. Subsequently, we collected SG samples from 17 SS patients and 17 non-SS patients and validated the expression of two hub genes (GZMA, GBP1) and characteristic genes (GSDMD) of pyroptosis through immunohistochemistry. The accuracy of hub genes as biomarkers for predicting SS was evaluated by receiver operating characteristic (ROC) curve.Results: 834 DEGs were selected from the GSE157159 dataset, and a total of 39 pyroptosis-related DEGs were obtained. Functional analysis showed that these DEGs were significantly enriched in some inflammatory signaling pathways. Through the intersection of seven algorithms proposed by CytoHubba and validation using the GSE159574 dataset, 11 hub genes were identified, including IL18, AIM2, CCL5, CD274, GBP1, GBP5, GZMA, GZMB, TLR8, TNFS13B, and ICAM1. Finally, the results of immunohistochemistry showed that GSDMD, GZMA and GBP1 were all significantly highly expressed in SG from SS. And ROC analysis showed a high combined diagnostic value of the 3 genes (AUC=0.8858).Conclusion: Our study revealed enhanced levels of pyroptosis in the SS. GZMA and GBP1 were identified as candidate genes for pyroptosis-induced inflammation of the SG in SS, which may be used as biomarkers or potential therapeutic targets for SS.Keywords: Sjogren’s syndrome, pyroptosis, bioinformatics analysis, salivary gland, immunology

Published
2023

23. High Performance Polarization Management Devices Based on Thin-Film Lithium Niobate

Author

Lin, Zhongjin, Lin, Yanmei, Li, Hao, Xu, Mengyue, He, Mingbo, Ke, Wei, Li, Zhaohui, Wang, Dawei, Yao, X. Steve, Yu, Siyuan, and Cai, Xinlun

Subjects
Physics - Optics
Abstract

High-speed polarization management is highly desirable for many applications, such as remote sensing, telecommunication, and medical diagnosis. However, most of the approaches for polarization management rely on bulky optical components that are slow to respond, cumbersome to use, and sometimes with high drive voltages. Here, we overcome these limitations by harnessing photonic integrated circuits based on thin-film lithium niobate platform. We successfully realize a portfolio of thin-film lithium niobate devices for essential polarization management functionalities, including arbitrary polarization generation, fast polarization measurement, polarization scrambling, and automatic polarization control. The present devices feature ultra-fast control speed, low drive voltages, low optical losses and compact footprints. Using these devices, we achieve high fidelity polarization generation with a polarization extinction ratio up to 41.9 dB, fast polarization scrambling with a scrambling rate up to 65 Mrad/s, and endless polarization control with a tracking speed up to 10 Krad/s, all of which are best results in integrated optics. The demonstrated devices unlock a drastically new level of performance and scales in polarization management devices, leading to a paradigm shift in polarization management., Comment: 26 pages, 20 figures

Published
2021

24. The present and future of QCD

Author

Achenbach, P., Adhikari, D., Afanasev, A., Afzal, F., Aidala, C.A., Al-bataineh, A., Almaalol, D.K., Amaryan, M., Androić, D., Armstrong, W.R., Arratia, M., Arrington, J., Asaturyan, A., Aschenauer, E.C., Atac, H., Avakian, H., Averett, T., Ayerbe Gayoso, C., Bai, X., Barish, K.N., Barnea, N., Basar, G., Battaglieri, M., Baty, A.A., Bautista, I., Bazilevsky, A., Beattie, C., Behera, S.C., Bellini, V., Bellwied, R., Benesch, J.F., Benmokhtar, F., Bernardes, C.A., Bernauer, J.C., Bhatt, H., Bhatta, S., Boer, M., Boettcher, T.J., Bogacz, S.A., Bossi, H.J., Brandenburg, J.D., Brash, E.J., Briceño, R.A., Briscoe, W.J., Brodsky, S.J., Brown, D.A., Burkert, V.D., Caines, H., Cali, I.A., Camsonne, A., Carman, D.S., Caylor, J., Cerci, D.S., Cerci, S., Chamizo Llatas, M., Chatterjee, S., Chen, J.P., Chen, Y., Chen, Y.-C., Chien, Y.-T., Chou, P.-C., Chu, X., Chudakov, E., Cline, E., Cloët, I.C., Cole, P.L., Connors, M.E., Constantinou, M., Cosyn, W., Covrig Dusa, S., Cruz-Torres, R., D'Alesio, U., da Silva, C., Davoudi, Z., Dean, C.T., Dean, D.J., Demarteau, M., Deshpande, A., Detmold, W., Deur, A., Devkota, B.R., Dhital, S., Diefenthaler, M., Dobbs, S., Döring, M., Dong, X., Dotel, R., Dow, K.A., Downie, E.J., Drachenberg, J.L., Dumitru, A., Dunlop, J.C., Dupre, R., Durham, J.M., Dutta, D., Edwards, R.G., Ehlers, R.J., El Fassi, L., Elaasar, M., Elouadrhiri, L., Engelhardt, M., Ent, R., Esumi, S., Evdokimov, O., Eyser, O., Fanelli, C., Fatemi, R., Fernando, I.P., Flor, F.A., Fomin, N., Frawley, A.D., Frederico, T., Fries, R.J., Gal, C., Gamage, B.R., Gamberg, L., Gao, H., Gaskell, D., Geurts, F., Ghandilyan, Y., Ghimire, N., Gilman, R., Gleason, C., Gnanvo, K., Gothe, R.W., Greene, S.V., Grießhammer, H.W., Grossberndt, S.K., Grube, B., Hackett, D.C., Hague, T.J., Hakobyan, H., Hansen, J.-O., Hatta, Y., Hattawy, M., Havener, L.B., Hen, O., Henry, W., Higinbotham, D.W., Hobbs, T.J., Hodges, A.M., Holmstrom, T., Hong, B., Horn, T., Howell, C.R., Huang, H.Z., Huang, M., Huang, S., Huber, G.M., Hyde, C.E., Isupov, E.L., Jacobs, P.M., Jalilian-Marian, J., Jentsch, A., Jheng, H., Ji, C.-R., Ji, X., Jia, J., Jones, D.C., Jones, M.K., Joosten, S., Kalantarians, N., Kalicy, G., Kang, Z.B., Karthein, J.M., Keller, D., Keppel, C., Khachatryan, V., Kharzeev, D.E., Kim, H., Kim, M., Kim, Y., King, P.M., Kinney, E., Klein, S.R., Ko, H.S., Koch, V., Kohl, M., Kovchegov, Y.V., Krintiras, G.K., Kubarovsky, V., Kuhn, S.E., Kumar, K.S., Kutz, T., Lajoie, J.G., Lauret, J., Lavrukhin, I., Lawrence, D., Lee, J.H., Lee, K., Lee, S., Lee, Y.-J., Li, S., Li, W., Li, Xiaqing, Li, Xuan, Liao, J., Lin, H.-W., Lisa, M.A., Liu, K.-F., Liu, M.X., Liu, T., Liuti, S., Liyanage, N., Llope, W.J., Loizides, C., Longo, R., Lorenzon, W., Lunkenheimer, S., Luo, X., Ma, R., McKinnon, B., Meekins, D.G., Mehtar-Tani, Y., Melnitchouk, W., Metz, A., Meyer, C.A., Meziani, Z.-E., Michaels, R., Michel, J.K.L., Milner, R.G., Mkrtchyan, H., Mohanmurthy, P., Mohanty, B., Mokeev, V.I., Moon, D.H., Mooney, I.A., Morningstar, C., Morrison, D.P., Müller, B., Mukherjee, S., Mulligan, J., Munoz Camacho, C., Murillo Quijada, J.A., Murray, M.J., Nadeeshani, S.A., Nadel-Turonski, P., Nam, J.D., Nattrass, C.E., Nijs, G., Noronha, J., Noronha-Hostler, J., Novitzky, N., Nycz, M., Olness, F.I., Osborn, J.D., Pak, R., Pandey, B., Paolone, M., Papandreou, Z., Paquet, J.-F., Park, S., Paschke, K.D., Pasquini, B., Pasyuk, E., Patel, T., Patton, A., Paudel, C., Peng, C., Peng, J.C., Pereira Da Costa, H., Perepelitsa, D.V., Peters, M.J., Petreczky, P., Pisarski, R.D., Pitonyak, D., Ploskon, M.A., Posik, M., Poudel, J., Pradhan, R., Prokudin, A., Pruneau, C.A., Puckett, A.J.R., Pujahari, P., Putschke, J., Pybus, J.R., Qiu, J.-W., Rajagopal, K., Ratti, C., Read, K.F., Reed, R., Richards, D.G., Riedl, C., Ringer, F., Rinn, T., Rittenhouse West, J., Roche, J., Rodas, A., Roland, G., Romero-López, F., Rossi, P., Rostomyan, T., Ruan, L., Ruimi, O.M., Saha, N.R., Sahoo, N.R., Sakaguchi, T., Salazar, F., Salgado, C.W., Salmè, G., Salur, S., Santiesteban, S.N., Sargsian, M.M., Sarsour, M., Sato, N., Satogata, T., Sawada, S., Schäfer, T., Scheihing-Hitschfeld, B., Schenke, B., Schindler, S.T., Schmidt, A., Seidl, R., Shabestari, M.H., Shanahan, P.E., Shen, C., Sheng, T.-A., Shepherd, M.R., Sickles, A.M., Sievert, M.D., Smith, K.L., Song, Y., Sorensen, A., Souder, P.A., Sparveris, N., Srednyak, S., Stahl Leiton, A.G., Stasto, A.M., Steinberg, P., Stepanyan, S., Stephanov, M., Stevens, J.R., Stewart, D.J., Stewart, I.W., Stojanovic, M., Strakovsky, I., Strauch, S., Strickland, M., Sunar Cerci, D., Suresh, M., Surrow, B., Syritsyn, S., Szczepaniak, A.P., Tadepalli, A.S., Tang, A.H., Tapia Takaki, J.D., Tarnowsky, T.J., Tawfik, A.N., Taylor, M.I., Tennant, C., Thiel, A., Thomas, D., Tian, Y., Timmins, A.R., Tribedy, P., Tu, Z., Tuo, S., Ullrich, T., Umaka, E., Upton, D.W., Vary, J.P., Velkovska, J., Venugopalan, R., Vijayakumar, A., Vitev, I., Vogelsang, W., Vogt, R., Vossen, A., Voutier, E., Vovchenko, V., Walker-Loud, A., Wang, F., Wang, J., Wang, X., Wang, X.-N., Weinstein, L.B., Wenaus, T.J., Weyhmiller, S., Wissink, S.W., Wojtsekhowski, B., Wong, C.P., Wood, M.H., Wunderlich, Y., Wyslouch, B., Xiao, B.W., Xie, W., Xiong, W., Xu, N., Xu, Q.H., Xu, Z., Yaari, D., Yao, X., Ye, Z., Ye, Z.H., Yero, C., Yuan, F., Zajc, W.A., Zhang, C., Zhang, J., Zhao, F., Zhao, Y., Zhao, Z.W., Zheng, X., Zhou, J., and Zurek, M.

Published
2024
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25. The orbital effect on the anomalous magnetism and evolution in La$_x$Y$_{1-x}$VO$_3$($0\le x \le 0.2$) single crystals

Author

Wan, Y., Jiao, J., Lin, G., Sun, Q., Wang, G., Zhu, J., Zhao, B., Ren, Q., Zhang, M., Chen, M., Zhang, R., Tong, W., Weissenrieder, J., Yao, X., and Ma, J.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

The orbital effect on the anomalous magnetism and evolution of low La-doping single crystals, La$_x$Y$_{1-x}$VO$_{3}$ (x = 0, 0.1, and 0.2), has been investigated by applying the X-ray diffraction, specific heat, magnetization and Raman scattering techniques. The larger nearest-neighbor (NN) exchange interaction along c-axis stabilizes the fluctuant G-type orbital ordering (G-OO) which favors the exotic C-type antiferromagnetic order (C-AF). It is found that the NN exchange interaction in ab plane is anisotropy relating to the in plane magnetic anisotropy, which becomes smaller in high La-doped sample. Most interestingly, with increasing the La$^{3+}$ content the orbital fluctuation and hybridization are decreased which stabilizes the C-OO phase and destabilizes the G-OO phase. Meanwhile, the diamagnetism in the exotic C-AF phase becomes weak and the possible mechanism relates to the change of the competition between the single-ion magnetic anisotropy and the Dzyaloshinsky-Moriya (DM) interaction with increasing x. Finally, the strong spin-orbital coupling has been observed at temperature just above T$_N$ in La$_{0.2}$Y$_{0.8}$VO$_{3}$ and a short range spin-orbital correlation is suggested.

Published
2021

26. Wavelength-switchable ultra-narrow linewidth fiber laser enabled by a figure-8 compound-ring-cavity filter and a polarization-managed four-channel filter

Author

Feng, Ting, Wei, Da, Bi, Wenwen, Sun, Weiwei, Wu, Shengbao, Jiang, Meili, Yan, Fengping, Suo, Yuping, and Yao, X. Steve

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

We propose and demonstrate a high performance four-wavelength erbium-doped fiber laser (EDFL), enabled by a figure-8 compound-ring-cavity (F8-CRC) filter for single-longitudinal-mode (SLM) selection and a polarization-managed four-channel filter (PM-FCF) for defining four lasing wavelengths. We introduce a novel methodology utilizing signal-flow graph combined with Mason's rule to analyze a CRC filter in general and apply it to obtain the important design parameters for the F8-CRC filter used in this paper. By combining the functions of the F8-CRC filter and the PM-FCF filter assisted by the enhanced polarization hole-burning and polarization dependent loss, we achieve the EDFL with fifteen lasing states, including four single-, six dual-, four tri- and one quad-wavelength lasing operations. In particular, all the four single-wavelength operations are in stable SLM oscillation, typically with a linewidth of <600 Hz, a RIN of <=-154.58 dB/Hz@>=3 MHz and an output power fluctuation of <=+/-3.45%. In addition, all the six dual-wavelength operations have very similar performances, with the performance parameters close to those of the single-wavelength lasing operations. Finally, we achieve the wavelength spacing tuning of the dual-wavelength operations for the photonic generation of tunable microwave signals, and successfully obtain a signal at 23.10 GHz as a demonstration., Comment: 21 pages, 14 figures

Published
2021
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28. Quantum simulation of open quantum systems in heavy-ion collisions

Author

De Jong, WA, Metcalf, M, Mulligan, J, Płoskoń, M, Ringer, F, and Yao, X

Abstract

We present a framework to simulate the dynamics of hard probes such as heavy quarks or jets in a hot, strongly coupled quark-gluon plasma (QGP) on a quantum computer. Hard probes in the QGP can be treated as open quantum systems governed in the Markovian limit by the Lindblad equation. However, due to large computational costs, most current phenomenological calculations of hard probes evolving in the QGP use semiclassical approximations of the quantum evolution. Quantum computation can mitigate these costs and offers the potential for a fully quantum treatment with exponential speed-up over classical techniques. We report a simplified demonstration of our framework on IBM Q quantum devices and apply the random identity insertion method to account for cnot depolarization noise, in addition to measurement error mitigation. Our work demonstrates the feasibility of simulating open quantum systems on current and near-term quantum devices, which is of broad relevance to applications in nuclear physics, quantum information, and other fields.

Published
2021

32. Photo-induced nonequilibrium response in underdoped YBa$_2$Cu$_3$O$_{6+x}$ probed by time-resolved terahertz spectroscopy

Author

Zhang, S. J., Wang, Z. X., Xiang, H., Yao, X., Liu, Q. M., Shi, L. Y., Lin, T., Dong, T., Wu, D., and Wang, N. L.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

Intense laser pulses have recently emerged as a tool to tune between different orders in complex quantum materials. Among different light-induced phenomena, transient superconductivity far above the equilibrium transition temperature in cuprates is particularly attractive. Key to those experiments was the resonant pumping of specific phonon modes, which was believed to induce superconducting phase coherence by suppressing the competing orders or modifying the structure slightly. Here, we present a comprehensive study of photo-induced nonequilibrium response in underdoped YBa$_2$Cu$_3$O$_{6+x}$. We find that upon photo-excitations, Josephson plasma edge in superconducting state is initially removed accompanied by quasiparticle excitations, and subsequently reappears at frequency lower than the static plasma edge within short time. In normal state, an enhancement or weaker edge-like shape is indeed induced by pump pulses in the reflectance spectrum accompanied by simultaneous rises in both real and imaginary parts of conductivity. We compare the pump-induced effects between near- and mid-infrared excitations and exclude phonon pumping as a scenario for the photo-induced effects above. We further elaborate the transient responses in normal state are unlikely to be explained by photo-induced superconductivity., Comment: 8 pages, 4 figures and supplementary

Published
2019
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35. A Robust Deep Learning Approach for Automatic Classification of Seizures Against Non-seizures

Author

Yao, X., Li, X., Ye, Q., Huang, Y., Cheng, Q., and Zhang, G. -Q.

Subjects
Computer Science - Machine Learning, Quantitative Biology - Neurons and Cognition, Statistics - Machine Learning
Abstract

Identifying epileptic seizures through analysis of the electroencephalography (EEG) signal becomes a standard method for the diagnosis of epilepsy. Manual seizure identification on EEG by trained neurologists is time-consuming, labor-intensive and error-prone, and a reliable automatic seizure/non-seizure classification method is needed. One of the challenges in automatic seizure/non-seizure classification is that seizure morphologies exhibit considerable variabilities. In order to capture essential seizure patterns, this paper leverages an attention mechanism and a bidirectional long short-term memory (BiLSTM) to exploit both spatial and temporal discriminating features and overcome seizure variabilities. The attention mechanism is to capture spatial features according to the contributions of different brain regions to seizures. The BiLSTM is to extract discriminating temporal features in the forward and the backward directions. Cross-validation experiments and cross-patient experiments over the noisy data of CHB-MIT are performed to evaluate our proposed approach. The obtained average sensitivity of 87.00%, specificity of 88.60% and precision of 88.63% in cross-validation experiments are higher than using the current state-of-the-art methods, and the standard deviations of our approach are lower. The evaluation results of cross-patient experiments indicate that, our approach has better performance compared with the current state-of-the-art methods and is more robust across patients., Comment: 13 pages, 10 figures, submitted to Biomedical Signal Processing and Control

Published
2018

40. Development and Validation of a Coronary Heart Disease Risk Prediction Model in Snorers with Hypertension: A Retrospective Observed Study

Author

Wang M, Zhu Q, Yao X, Heizhati M, Cai X, Ma Y, Wang R, Hong J, Yao L, Sun L, Yue N, Ren Y, and Li N

Subjects
snorer, hypertension, coronary heart disease, prediction model, Public aspects of medicine, RA1-1270
Abstract

Mengru Wang,1,&ast; Menghui Wang,1,&ast; Qing Zhu,1,2 Xiaoguang Yao,1 Mulalibieke Heizhati,1 Xintian Cai,1,2 Yue Ma,1 Run Wang,1 Jing Hong,1 Ling Yao,1 Le Sun,1 Na Yue,1 Yingli Ren,1 Nanfang Li1 1Hypertension Center, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Medical Research Center for Hypertension Diseases, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China; 2Graduate School, Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Nanfang Li, Hypertension Center, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Medical Research Center for Hypertension Diseases, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China, Email lnanfang2016@sina.comPurpose: To develop and validate a risk prediction model for coronary heart disease (CHD) in snorers with hypertension, including traditional and new risk factors.Patients and Methods: Twenty factors were evaluated in the records of 2810 snorers with hypertension. Training (70%) and validation (30%) sets were created by random allocation of data, and a new nomogram model was developed. The model’s discrimination and calibration were measured by calculating the area under the receiver operating curve (AUC) and creating calibration charts. The performance of the nomogram model was compared with that of the Prediction for ASCVD Risk in China (China-PAR) and Framingham models by decision curve analysis. An optimal cutoff point for the risk score in the training set was computed to stratify patients.Results: In the nomogram model, the AUCs for predicting CHD at 5, 7 and 9 years in the training set were 0.706 (95% confidence interval [CI] 0.649– 0.763), 0.703 (95% CI 0.655– 0.751) and 0.669 (95% CI 0.593– 0.744), respectively. The respective AUCs were 0.682 (95% CI 0.607– 0.758), 0.689 (95% CI 0.618– 0.760) and 0.664 (95% CI 0.539– 0.789) in the validation set. The calibration chart showed that the predicted events from the nomogram score were close to the observed events. Decision curve analysis indicated that the nomogram score was slightly better than the Prediction for ASCVD Risk in China (China-PAR) and Framingham models for predicting the risk of CHD in snorers with hypertension. A cutoff point was identified for being CHD-free (a nomogram score of ≤ 121), which could be helpful for the early identification of individuals at high-risk of CHD.Conclusion: The nomogram score predicts the risk probability of CHD in snorers with hypertension at 5, 7 and 9 years, and shows good capability in terms of discrimination and calibration. It may be a useful tool for identifying individuals at high risk of CHD.Keywords: snorer, hypertension, coronary heart disease, prediction model

Published
2022

41. The Osteogenic Role of Barium Titanate/Polylactic Acid Piezoelectric Composite Membranes as Guiding Membranes for Bone Tissue Regeneration

Author

Dai X, Yao X, Zhang W, Cui H, Ren Y, Deng J, and Zhang X

Subjects
barium titanate, polylactic acid, bio-piezoelectric materials, polarization, osteogenic differentiation, bone regeneration, Medicine (General), R5-920
Abstract

Xianglin Dai,1 Xijun Yao,1 Wenfeng Zhang,1 Hongyuan Cui,2 Yifan Ren,1 Jiupeng Deng,1 Xia Zhang3 1College of Stomatology, North China University of Science and Technology, Tangshan, 063200, People’s Republic of China; 2College of Electrical Engineering, North China University of Science and Technology, Tangshan, 063200, People’s Republic of China; 3Library, North China University of Science and Technology, Tangshan, 063200, People’s Republic of ChinaCorrespondence: Jiupeng Deng, College of Stomatology, North China University of Technology, Tangshan, 063200, People’s Republic of China, Email jinpeng00261@sina.comPurpose: Biopiezoelectric materials have good biocompatibility and excellent piezoelectric properties, and they can generate local currents in vivo to restore the physiological electrical microenvironment of the defect and promote bone regeneration. Previous studies of guided bone regeneration membranes have rarely addressed the point of restoring it, so this study prepared a Barium titanate/Polylactic acid (BT/PLA) piezoelectric composite membrane and investigated its bone-formation, with a view to providing an experimental basis for clinical studies of guided bone tissue regeneration membranes.Methods: BT/PLA composite membranes with different BT ratio were prepared by solution casting method, and piezoelectric properties were performed after corona polarization treatment. The optimal BT ratio was selected and then subjected to in vitro cytological experiments and in vivo osteogenic studies in rats. The effects on adhesion, proliferation and osteogenic differentiation of the pre-osteoblastic cell line (MC3T3-E1) were investigated. The effect of composite membranes on bone repair of cranial defects in rats was investigated after 4 and 12 weeks.Results: The highest piezoelectric coefficient d33 were obtained when the BT content was 20%, reaching (7.03 ± 0.26) pC/N. The value could still be maintained at (4.47± 0.17) pC/N after 12 weeks, meeting the piezoelectric constant range of bone. In vitro, the MC3T3-E1 cells showed better adhesion and proliferative activity in the group of polarized 20%BT. The highest alkaline phosphatase (ALP) content was observed in cells of this group. In vivo, it promoted rapid bone regeneration. At 4 weeks postoperatively, new bone formation was evident at the edges of the defect, with extensive marrow cavity formation; after 12 weeks, the defect was essentially completely closed, with density approximating normal bone tissue and significant mineralization.Conclusion: The BT/PLA piezoelectric composite membrane has good osteogenic properties and provides a new idea for guiding the research of membrane materials for bone tissue regeneration.Keywords: barium titanate, polylactic acid, bio-piezoelectric materials, polarization, osteogenic differentiation, bone regeneration

Published
2022

47. Using digital cameras on an unmanned aerial vehicle to derive optimum color vegetation indices for leaf nitrogen concentration monitoring in winter wheat

Author

Jiang, J, Cai, W, Zheng, H, Cheng, T, Tian, Y, Zhu, Y, Ehsani, R, Hu, Y, Niu, Q, Gui, L, and Yao, X

Subjects
leaf nitrogen concentration, leaf nitrogen accumulation, unmanned aerial vehicle, digital camera, vegetation indices, Classical Physics, Physical Geography and Environmental Geoscience, Geomatic Engineering
Abstract

Commercially available digital cameras can be mounted on an unmanned aerial vehicle (UAV) for crop growth monitoring in open-air fields as a low-cost, highly effective observation system. However, few studies have investigated their potential for nitrogen (N) status monitoring, and the performance of camera-derived vegetation indices (VIs) under different conditions remains poorly understood. In this study, five commonly used VIs derived from normal color (RGB) images and two typical VIs derived from color near-infrared (CIR) images were used to estimate leaf N concentration (LNC). To explore the potential of digital cameras for monitoring LNC at all crop growth stages, two new VIs were proposed, namely, the true color vegetation index (TCVI) from RGB images and the false color vegetation index (FCVI) from CIR images. The relationships between LNC and the different VIs varied at different stages. The commonly used VIs performed well at some stages, but the newly proposed TCVI and FCVI had the best performance at all stages. The performances of the VIs with red (or near-infrared) and green bands as the numerator were limited by saturation at intermediate to high LNCs (LNC > 3.0%), but the TCVI and FCVI had the ability to mitigate the saturation. The results of model validations further supported the superiority of the TCVI and FCVI for LNC estimation. Compared to the other VIs derived using RGB cameras, the relative root mean square errors (RRMSEs) of the TCVI were improved by 8.6% on average. For the CIR images, the best-performing VI for LNC was the FCVI (R2 = 0.756, RRMSE = 14.18%). The LNC-TCVI and LNC-FCVI were stable under different cultivars, N application rates, and planting densities. The results confirmed the applicability of UAVbased RGB and CIR cameras for crop N status monitoring under different conditions, which should assist the precision management of N fertilizers in agronomic practices.

Published
2019

49. Association Between Triglyceride Glucose Index-Waist Circumference and Risk of First Myocardial Infarction in Chinese Hypertensive Patients with Obstructive Sleep Apnoea: An Observational Cohort Study

Author

Hu J, Cai X, Li N, Zhu Q, Wen W, Hong J, Zhang D, Yao X, Luo Q, and Sun L

Subjects
triglyceride glucose index-waist circumference, myocardial infarction, hypertension, obstructive sleep apnoea, cohort study, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Junli Hu,1– 5,&ast; Xintian Cai,1– 5,&ast; Nanfang Li,1– 5 Qing Zhu,1– 5 Wen Wen,1– 5 Jing Hong,1– 5 Delian Zhang,1– 5 Xiaoguang Yao,1– 5 Qin Luo,1 Le Sun1– 5 1Hypertension Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China; 2Xinjiang Hypertension Institute, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China; 3National Health Committee Key Laboratory of Hypertension Clinical Research, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China; 4Key Laboratory of Xinjiang Uygur Autonomous Region, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China; 5Xinjiang Clinical Medical Research Center for Hypertension Diseases, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Nanfang Li, Hypertension Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China, Tel/Fax +86 991-8564818, Email lnanfang2016@sina.comPurpose: This study aimed to investigate the association between triglyceride glucose index-waist circumference (TyG-WC) and the risk of first myocardial infarction (MI) in Chinese hypertensive patients with obstructive sleep apnoea (OSA).Methods: This study was an observational cohort study. A total of 2224 Chinese hypertensive patients with OSA without a history of MI were included in this study. Hazard ratio (HR) and 95% confidence interval (CI) were estimated using multivariable Cox proportion hazard models. A generalized additive model was used to identify nonlinear relationships. Additionally, we performed hierarchical analysis and test for interaction.Results: During a median follow-up of 7.15 years, 85 incidents of MI developed. Overall, there was a positive association between TyG-WC and the risk of first MI. In the multivariable-adjusted model, the risk of MI increased with quartiles of the TyG-WC, the HR in quartile 4 versus quartile 1 was 4.29. A generalized additive model and a smooth curve fitting showed that there existed a similar J-shaped association between TyG-WC and the risk of first MI, with an inflection point at about 785.Conclusion: Elevated levels of the baseline TyG-WC are associated with an increased risk of first MI. This finding indicates that the TyG-WC might be useful to identify the high risk of first MI in Chinese hypertensive patients with OSA.Keywords: triglyceride glucose index-waist circumference, myocardial infarction, hypertension, obstructive sleep apnoea, cohort study

Published
2022

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