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Diabetic hyperglycemia in males is a significant contributing factor to the development of spermatogenesis disorder. The hypothalamic-pituitary-gonadal (HPG) axis serves as a crucial center for autonomic sexual function and the neuroendocrine network within the human body. It dominates physiological prominence in human reproduction, growth, and development, while also being susceptible to hyperglycemia, which is one of the key mechanisms in the development of spermatogenic disorder in type 2 diabetes mellitus (T2DM). This mechanism involves kidney deficiency, which is a common etiology and pathogenesis of both spermatogenesis disorder and T2DM. The kidney storing essence, which encompasses the functions of "dominating reproduction, manufacturing marrow to fill up the brain" bears similarities to the HPG axis. Kidney tonifying therapy can regulate and improve the function of HPG axis, thereby establishing a theoretical basis for the use of kidney tonification therapy in the treatment of spermatogenesis disorder in T2DM. The traditional formula of tonifying the kidney can serve as a complementary treatment for both DM and spermatogenesis disorder. This approach offers a conceptual framework and methodology for the prevention and treatment of T2DM-induced infertility through kidney tonification.

In fermented foods, acetic acid bacteria (AAB), kinds of bacteria with a long history of utilization, contribute to safety, nutritional, and sensory properties primarily through acetic acid fermentation. AAB are commonly found in various fermented foods such as vinegar, sour beer, fermented cocoa and coffee beans, kefir beverages, kombucha, and sourdough. They interact and cooperate with a variety of microorganisms, resulting in the formation of diverse metabolites and the production of fermented foods with distinct flavors. Understanding the interactions between AAB and other microbes is crucial for effectively controlling and utilizing AAB in fermentation processes. However, these microbial interactions are influenced by factors such as strain type, nutritional conditions, ecological niches, and fermentation duration. In this review, we examine the relationships and research methodologies of microbial interactions and interaction studies between AAB and yeasts, lactic acid bacteria (LAB), and bacilli in different food fermentation processes involving these microorganisms. The objective of this review is to identify key interaction models involving AAB and other microorganisms. The insights gained will provide scientific guidance for the effective utilization of AAB as functional microorganisms in food fermentation processes. [ABSTRACT FROM AUTHOR]

Climate change and urbanization have led to the increasing prominence of urban heat islands (UHIs) today, posing a huge challenge to cities. Urban resilience (UR) refers to the ability of a city or region to adapt to changes and risks. However, the influence between the heat island effect and regional urban resilience is not well understood. In this study, we proposed a methodological framework for unveiling the coupling coordination and interaction mechanism between UHIs and UR. This study first explored UHIs in the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) and described the creation of a multidimensional index system that evaluates urban resilience across social, economic, ecological, and engineering dimensions. Furthermore, this study unveiled the coupling coordination effect of UHIs and UR through the coupling coordination degree model, and the influence mechanism between the drivers of UHIs and the change in UR was detected using a geographic probe. The results showed that the UHI region forms a ring-shaped belt around the entrance to the Pearl River Delta. The UHIs of the GBA show a significant trend of expansion and escalation over time. The UR of the GBA shows a spatial distribution pattern of high resilience among regional central cities and low resilience among peripheral cities, with significantly uneven development in sub-resilience dimensions. The UHIs and UR of the GBA showed a certain coupling and coordination effect, improving from barely synergistic to a primary coordination state. Among the drivers of UHIs, population density, precipitation, average nighttime light brightness, and ground-average CO2 emissions have strong explanatory power for the spatial variation in UR. The interaction between two factors has a stronger influence on UR than individual factors. The purpose of this paper is to initially reveal the influence mechanism between UHIs and UR and to provide a theoretical basis for further exploring the path of sustainable urban development. [ABSTRACT FROM AUTHOR]

Lucent Technologies' plans to enhance the reverse link (RL) data throughput of the forthcoming release of the code division multiple access (CDMA200) standard are described and discussed.

In this study, a precise and high-efficient clinching assembly strategy was proposed to improve the automobile wheel hub bearing's reliability of service quality consistency. The structure of the wheel hub bearing was first improved to enable the requirement of axial working clearance. During assembly, the accuracy of each bearing was monitored online via micro-laser sensor to achieve precise and consistent axial working clearance. The effect of processing parameters were analyzed via simulation analysis. According to simulation results, it only cost 2.35 s to complete assembly process and the optimal clamping force of 38.8 kN was generated. The prototype bearings were manufactured and exhibited a reliable service life of more than 250,000 km, which verified the reasonability of the proposed clinching assembly strategy. Additionally, the assembly mechanism was further analyzed. The ferrite in the clinched hub shaft end was gradually lengthened and the cementite aggregation was improved. [ABSTRACT FROM AUTHOR]

Background: Triple-negative breast cancer (TNBC) is a highly heterogeneous disease. The CBCSG010 trial is a prospective and multicenter phase III clinical trial confirming that adding adjuvant capecitabine significantly improved the 5-year disease-free survival (DFS) rate in patients with TNBC by 5.9%. In this study, we attempted to identify the specific population that benefited from adjuvant therapy., Methods: In this retrospective exploratory analysis, we performed RNA sequencing of tumor tissues from patients with TNBC in the CBCSG010 clinical trial. A single-sample gene set enrichment analysis algorithm and survival analysis were performed to characterize the intrinsic molecular features of the TNBC microenvironment and assess the associations between immune-related gene expression levels or immune cell counts with capecitabine treatment efficacy. Additionally, we performed immunohistochemical staining of 2 markers, PD-L1 and CD8, and hematoxylin-eosin staining of stromal tumor-infiltrating lymphocytes (sTILs) on formalin-fixed, paraffin-embedded specimens to validate findings from bioinformatics analyses., Results: We found that patients with TNBC with high immune-infiltration treated with capecitabine were more likely to have a better prognosis. We used a cutoff of ≥25 combined positive score (CPS) of PD-L1, ≥10% positive sTILs, and ≥10% positive cells of CD8 to define the "immune-hot" patients. Among immune-hot patients, Kaplan-Meier curves showed that 5-year DFS rates were 96.9% and 79.4% in the capecitabine and control groups, respectively (hazard ratio, 0.13; 95% CI, 0.03-0.52; P=.049 in favor of capecitabine). In the capecitabine group, the 5-year DFS rate was higher for immune-hot patients than for immune-cold patients (96.9% vs 76.4%; hazard ratio, 0.11; 95% CI, 0.04-0.29; P=.028)., Conclusions: Our study suggested that immune-hot patients with TNBC are more likely to benefit from adjuvant capecitabine, and that combining immunotherapy with chemotherapy may be expected to be more effective in immune-hot patients.