Search

Lennox-Gastaut syndrome (LGS) is a severe, epileptic encephalopathy.In recent years, a variety of drugs have been approved for the treatment of LGS. The U.S. Food and Drug Administration approved clobazam and cannabidiol as adjunctive therapy for LGS in October 2011 and June 2018, respectively. This article provides an overview of clobazam and cannabidiol, including their chemical structures, pharmacological actions, curative effects, safety profile, drug interactions, to introduce the current state of research and the achievements of both drugs.

Infantile epileptic spasm syndrome (IESS) is a new concept proposed recently. IESS is a unique and age-specific refractory epilepsy syndrome. The recent advances in molecular biology, neuroimmunology and the in-depth study of anti-epileptic mechanism in antiepileptic drugs have led to the achievements in the definition and treatment of infantile epileptic spasm. At present, the use of traditional antiepileptic drugs is decreasing, while the use of new antiepileptic drugs is increasing. In this paper, based on the relevant literature in recent years, the authors discuss the pathogenesis, epidemiology, etiology, diagnosis, treatment, therapeutic drugs, clinical progress, efficacy, and safety of infantile epileptic spasm, hoping to introduce the latest status in research and achievements of IESS.

To explore the best duration of moxibustion on lumbar disk herniation (LDH).

With the advancement of source-load interaction in the new power systems, data-driven approaches have provided a foundational support for aggregating and interacting between sources and loads. However, with the widespread integration of distributed energy resources, fine-grained perception of intelligent sensing devices, and the inherent stochasticity of source-load dynamics, a massive amount of raw data is being recorded and accumulated in the data center. Valuable information is often dispersed across different paragraphs of the raw data, making it challenging to extract effectively. Distribution substation inspection plays a crucial role in ensuring the safe operation of the power system. Traditional methods for inspection report text classification typically rely on manual judgment and accumulated experience, resulting in low efficiency and a significant misjudgment rate. Therefore, this paper proposes a text classification method for inspection reports based on the pre-trained BERT-TextRCNN model. By utilizing the dense connection between the BERT embedding layer and the neural network, the proposed method improves the accuracy of matching long texts. This article collected 2,831 maintenance data for the first quarter of 2023 from the distribution room, including approximately 58 environmental testing data, 738 environmental box testing data, approximately 672 distribution room testing data, and approximately 1,363 box type substation testing data. A text corpus was constructed for experiments. Experimental results demonstrate that the proposed model automatically classifies a large volume of manually recorded inspection report data based on time, location, and faults, achieving a classification accuracy of 94.7%, precision of 92%, recall of 92%, and F1 score of 90.3%.

The thermal expansion curves of 20CrMnTiH test steel with three compositions at different cooling rates were measured by DIL805 type quench deformation expansion instrument ， and the microstructures at room temperature were observed， the continuous cooling transition （CCT） curves were drawn. The test results show that the composition fluctuation mainly affects the cooling range of bainite and martensite phase transformation during the cooling transformation of 20CrMnTiH， and has little effect on the critical phase transformation temperature. The kinetic parameters of martensitic transformation of the three test steels were fitted by using K-M equation. Combined with the optimized Li empirical model and the regression equation of critical transition temperature， a prediction model of phase transformation prediction model of ferrite，pearlite and bainite during continuous cooling of 20CrMnTiH was established ，the influence of composition fluctuation on CCT curve of the test steels were predicted successfully. Furthermore， the end-quenching simulation model of 20CrMnTiH steel was established by finite element analysis method， which can better predict the influence of composition fluctuation on the hardenability of the test steel. This method can provide reference for the composition optimization design and material selection of gear steel.

Objective To explore the research hotspots and trends in the field of quality of life of oral cancer patients, so as to provide a guiding basis for quality of life studies on oral cancer patients in China. Methods Using the literature related to the quality of life of oral cancer patients published in Web of Science from 2000 to 2022 as the data source. The CiteSpace software was used for visual analysis. Results A total of 860 relevant articles were included after removing the duplicates by Citespace, and the number of annual publications basically showed an upward trend. The main body of the researches was concentrated in universities and research institutes in the United States and the United Kingdom, and the institutions and countries have formed a certain scale of cooperative groups. Research hotspots are the factors influencing the quality of life of oral cancer patients, assessment tools for quality of life, interventions and management of influencing factors. Conclusion It is recommended that researchers learn from the advanced theories and models of foreign countries to further develop a quality of life assessment scale more suitable for oral cancer patients in China. In the future, the main focus should be on personalized treatment plans, rehabilitation training methods and management, supportive care needs, and body imagery changes so as to better improve the quality of life of oral cancer patients. (目的 使用文献计量法探讨国际口腔癌患者生活质量研究的热点及趋势, 为我国口腔癌患者生活质量研究提供指导依据。方法 以2000年—2022年Web of Science收录的口腔癌患者生活质量相关文献为数据来源, 运用CiteSpace软件进行可视化分析。结果 经CiteSpace去重后共纳入860篇相关文献, 年度发文量基本呈上升趋势; 研究主体集中在美国和英国的高校及研究所, 各机构和国家形成了一定规模的合作团体; 研究热点为口腔癌患者生活质量的影响因素、生活质量的评估工具、影响因素的干预和管理。结论 建议研究者学习借鉴国外先进理论及模式, 进一步研制更适合我国口腔癌患者的生活质量评估量表。未来应重点关注个性化治疗方案、康复训练方法及管理、支持性照护需求、身体意象改变, 以更好地提高口腔癌患者生活质量。)

Power system planning, load forecasting, and energy utilization analysis are significantly impacted by power load anomalies, necessitating prompt detection and identification. Firstly, the abnormal classification, causes, and characteristics of power load data are analyzed. Secondly, it enhances the traditional Transformer encoder structure by replacing the mask multi-header attention layer with the multi-header attention layer and eliminating the feedforward network. These improvements aim to enhance the model's global attention to the load sequence. To capture trend characteristics more effectively and expedite convergence, an improved generative adversarial networks (GAN)-Transformer model is proposed based on the generator and discriminator game structure of traditional GAN. Additionally, a multi-stage mapping and training approach along with an integrated focus score scoring mechanism are introduced. These techniques facilitate phased load sequence reconstruction, enabling the model to better extract anomalous features of the load data. Finally, through an analysis of an arithmetic example, the results demonstrate that the GAN-Transformer model outperforms in terms of load data anomaly detection accuracy, recall, F1 value, and training time. These results validate the effectiveness and superiority of the proposed method. The findings of this research provide valuable insights for advancements in power load data anomaly classification and data repair based on deep learning.

In view of the high viscosity, poor fluidity and high transportation cost of heavy oil, water-annular transportation is an effective solution to realize the flow drag reduction during heavy oil transportation, but the large density difference between oil and water leads to the instability of water annular. For this reason, a superhydrophilic surface is introduced to improve the stability of the water annular in the pipeline and reduce the transportation resistance of heavy oil. Besides, the enhancement of heavy oil transportation by superhydrophilic surface was verified through numerical simulation and experiments in combination. Meanwhile, the effect of various factors on oil-water flow, oil-water distribution and pressure drop in pipelines during water-annular transportation were analyzed. The research results show that the superhydrophilic surface could improve the stability of water annular in the water-annular transportation system of heavy oil, with the obvious effect of flow drag reduction. Compared with the water-annular white oil transportation by ordinary pipeline, the flow drag reduction of over 17.49% can be realized, the maximum flow drag reduction is up to 50.15%, and the enhancement is within 9.06%-39.09% after the superhydrophilic surface is introduced. Compared with the white oil transportation without water annular, the flow drag reduction can reach 72.02%-78.21%. Generally, the superhydrophilic surface could significantly enhance water-annular heavy oil transportation with promising application prospects, capable of effectively improving the applicability of water-annular heavy oil transportation technology.

The precise detection of military targets under complex conditions is a key factor to enhance the ability of war situation generation and prediction. The current technology can not overcome the problems of smoke and occlusion interference, target height change, and different scales in aerial video. In this paper, a multi feature cross fusion and cross layer cascade aerial military target detection algorithm (YOLOv5-MFLC) is proposed. Firstly, aiming at the high confidentiality of the military targets and the shortage of battlefield aerial image resources, a real scene based aerial military target dataset is constructed, and the methods of random splicing and random extraction embedding are used for data enhancement in order to improve the diversity and generalization of targets. Secondly, aiming at the problem of complex background interference, a multi feature cross fusion attention mechanism is constructed to enhance the available information of target features. Finally, for the multi-scale problem of targets in aerial images, a cross layer cascaded multi-scale feature fusion pyramid is designed to improve the detection accuracy of cross scale targets. The experimental results show that, comparing with the existing advanced detection models, the detection accuracy of the algorithm in this paper has been greatly improved. The average accuracy of the algorithm can reach 81.0%, which is 5.2% higher than the original network. In particular, it has reached 55.9% in the smaller target category "person", which is 9.4% higher. And the experimental results further show the usefulness of the improved algorithm for small target detection. At the same time, the detection rate of this algorithm can reach 56 frame/s, which can effectively achieve accurate and fast detection of battlefield targets, and has certain experience value for guiding complex modern wars.

ObjectiveTo understand the current situation of tobacco use among rural adolescents in Sichuan Province and its influencing factors， to explore the relationship between smoking behavior and psychosocial influencing factors of rural adolescents in Sichuan Province， and to provide a scientific basis for the prevention and control of smoking among rural adolescents.MethodsAn "Adolescent Health Questionnaire" was used as the survey tool to investigate 2 671 students in the 8th and 11th grades of two township middle schools in Zizhong County， Sichuan Province. The structural equation model in Mplus 7.0 was used to analyze the relationship between adolescent tobacco use behavior， mental health， and life satisfaction.ResultsAmong the surveyed adolescents， 28.3% （756/2 671） had tried tobacco products， and 9.5% （255/2 671） had used tobacco products in the past 30 days. The prevalence of tobacco use was higher among boys （16.6%） than girls （3.5%）， and among 11th grade students （21.9%） compared to 8th grade students （7.3%）， with statistically significant differences （χ2=131.99 and 4.24， both P

Objective To explore the changes in the expression of long non-coding RNA (LncRNA) LINC00294 in breast cancer tissues and cells, and investigate its effects and the possible mechanisms on the biological properties of breast cancer cells. Methods The differentially expressed genes (DEGs) were analyzed using transcriptome sequencing data from 41 breast cancer tissues and 11 para-cancerous tissues from the Gene Expression Omnibus (GEO) database (GSE45827). Then qRT-PCR assay was used to measure the expression of LINC00294 in 20 pairs of breast cancer and para-cancerous tissues from the breast cancer patients diagnosed in our department, as well as in the normal human breast epithelial MCF-10A cells and the human breast cancer cell lines MCF-7, K-BR-3 and MDA-MB-231. After MCF-7 cells were transfected with lentiviral vector of si-LINC to interfere LINC00294 expression, CCK-8 assay was used to detect cell proliferation, flow cytometry and Western blotting were employed to measure cell apoptosis and expression of related proteins, cell scratch assay and Transwell assay were applied to observe cell migration and invasion. Then, the effect of interference with LINC00294 on tumor growth in nude mice model of in situ subcutaneous tumorigenesis was observed. The expression of AKT/mTOR pathway-related proteins p-mTOR, mTOR, p-AKT, AKT, and its downstream target molecule HIF-1α was detected by Western blotting. Results LncRNA LINC00294 was screened out as a DEG in breast cancer tissues from the GEO database. It was also highly expressed in breast cancer tissues and MCF-7, SK-BR-3 and MDA-MB-231 cells (P < 0.05). Interference of LINC00294 resulted in reduced proliferation, enhanced expression of apoptosis-related proteins, and decreased invasion and migration abilities in MCF-7 cells (P < 0.05). The expression of LINC00294 was inhibited by HIF-1α interference (P < 0.05), and LINC00294 interference decreased the expression of p-AKT, p-mTOR, mTOR and its downstream target molecule HIF-1α in the AKT/mTOR signaling pathway (P < 0.05). Conclusion High expression of LINC00294 in breast cancer may affect the proliferation, invasion, and migration of breast cancer through the AKT/mTOR/HIF-1α signaling pathway, and LINC00294 may be closely associated with the pathogenesis of breast cancer.

Objective To evaluate the Orem support-education system theory in nursing of patients with autogenous arteriovenous fistula (AVF) for hemodialysis. Methods By the convenience sampling method, 60 cases of registered hemodialysis patients were recruited and divided into two groups by dialysis date: 30 cases in the control group (receiving dialysis on Tuesday, Thursday and Saturday) were given routine health education, and 30 cases in the intervention group(receiving dialysis on Monday, Wednesday and Friday) were given 3 months Orem support-education system intervention on the basis of conventional education. The self-care behavior level and dysfunction of arteriovenous fistula were measured and compared between two groups. Results After the intervention, the score of assessment of self-care behaviors with arteriovenous fistula in hemodialysis (ASBHD-AVF) increased in both two groups and ASBHD-AVF score was significantly higher in the intervention group than that in the control group (P＜0. 05). The incidence of internal fistula stenosis, infection and thrombosis in the intervention group was significantly lower than that in the control group (P＜0. 05). Conclusion Orem support-education system not only improves the level of self-care behavior of patients autogenous arteriovenous fistula for hemodialysis, but also plays an important role in reducing the incidence of arteriovenous fistula complications. (目的 探讨Orem自护理论中的支持-教育系统在血液透析患者自体动静脉内瘘护理中的应用效果。方法 采用便利抽样法, 抽取医院血液透析中心登记血液透析患者60例作为研究对象。按透析时间进行分组, 透析时间为周一、三、五的30例患者为干预组, 在常规教育基础上给予3个月支持-教育系统干预, 透析时间为周二、四、六的30例患者为对照组, 给予常规健康教育。干预3个月后对两组患者的AVF自我护理行为水平和瘘管失功情况进行比较。结果 干预后, 两组血液透析患者动静脉内瘘自我护理行为量表(ASBHD – AVF)得分均较干预前提高, 且干预组ASBHD–AVF量表得分高于对照组, 差异有统计学意义(P＜0. 05)。干预组内瘘狭窄、感染和血栓形成发生率较对照组低, 差异有统计学意义(P＜0. 05)。结论 Orem支持-教育系统不仅提高血液透析患者自体动静脉内瘘自我护理行为水平, 而且对降低动静脉内瘘并发症的发生率具有重要意义。)

In view of the risks and challenges facing China’s energy and mining security, this article analyzes the changes and development pattern of China’s energy demand under the target of carbon peak and carbon neutrality. The coupling development of new and fossil energy resources is an inevitable path for ensuring a stable supply of diversified energies in China in the future. In this article, we study the characteristics of fifth-generation communication, big data, blockchain, and artificial intelligence technologies and their application prospects in the energy and mining fields, and propose a technological path for reforming China’s energy and mining governance system based on the new-generation information technologies. Specifically, we explore the integration of the newgeneration information technologies with the energy and mining development technologies and their application to energy production, transportation, consumption, market, and government regulation. Moreover, we propose a strategic approach of building a new governance model of energy and mining industries based on the new-generation information technologies. To this end, it is necessary to strengthen basic research and equipment development, support new infrastructure construction in energy and mining fields, provide policy and fund guarantee, and establish a national intelligent platform for energy and mining safety production and trade.

Objective: This study focused on improving comprehensive utilization rate of ziziphi spinosae semen resources. Methods: With the ultrasonic power, ultrasonic time, solid-liquid ratio, ethanol volume fraction and ultrasonic temperature as the influencing factors, and the extraction rate of isovitexin-glucopyranoside in ziziphi spinosae semen as the index, the extraction process parameters of isovitexin-glucopyranoside were optimized by response surface methodology. Results: The optimal extraction conditions of isovitexin-glucopyranoside were ultrasonic power 405 W, ultrasonic time 60 min, solid-liquid ratio 1∶16 （g/mL） and ethanol volume fraction 75%. Under the control of these conditions, the extraction rate of isovitexin-glucopyranoside was 0.705%, which was close to the predicted value （0.719%）, indicating that the predicted value of the extraction rate of isovitexin-glucopyranoside fit well with the actual situation. Conclusion: The ultrasonic assisted extraction of isovitexin-glucopyranoside is stable and reliable with high extraction rate.

The influence of Artificial Intelligence (AI) tool usage on students' learning ability has received much attention from the society. The present study reviews prior studies examining the effect of AI on learning motivation in English as a Foreign Language (EFL) classrooms. Previous studies examinethe effects of AI on EFL students' motivation using a mixed-methods approach. The findings reveal a significant correlation between AI usage and student motivation. Other studies focuses on AI-assisted language learning's impact on English learning outcomes, self-regulated learning as well as L2 motivation, among EFL learners. AI-mediated instruction is proved to positively influences English learning motivation, self-regulated learning and learning outcomes. Additionally, findings from interview suggest learners' positive perceptions of AI platforms. Moreover, evidence from meta-analysis and studies on VR learning program demonstrate the beneficial role of AI on learning. The present study underscore AI's potential to enhance learning motivation in EFL contexts. Furthermore, more researches on AI's application to EFL instruction can be done in the future.

Forest competition is a key factor driving forest dynamics and stand structure, and is one of the core issues in ecological research. Competition is a complex ecological process with temporal changes, which is interrelated and affected with forest growth, stand structure dynamics and environmental changes. Although there have been many researches on competition, tree growth, stand structure and climate, the interactions among trees have been studied by static competition index measurement, which usually lacks temporal variation related to natural forest development and environmental conditions, and the response mechanism and related theory of competition to stand development and environmental fluctuation have been studied insufficiently.(2) Single tree competition index model;(3) Interaction between tree competition and tree growth, stand structure and environment;(4) Tree competition based on complex network. Finally, according to the complex interaction of tree competition, the research strategy of tree competition network structure with “single tree” as node and “single tree competition relationship” as edge is discussed, in order to provide reference for the study of tree interaction and forest ecosystem dynamics.

The establishment of nature reserves is an important measure to protect rare wild animals and plants and their habitats. This plays a positive role in alleviating the ill effects of change in land use and protecting ecological diversity. Since the establishment of the first nature reserve in China, there has been notable development in the construction and infrastructure industry. Owing to this development, understanding whether nature reserves can effectively achieve the purpose of protection has gradually become a hot topic. An in-depth understanding of the evolution of land use types in nature reserves and their adjacent areas can evaluate the effectiveness of the construction of nature reserves, provide decision support for land resource planning, and help maintaining the balance of the ecosystem and sustainable development. Understanding the spatio-temporal evolution pattern of land use is important to create and preserve ecological security in protected areas. In this research, we studied the land use dynamics in Guangxi Golden Camellia national nature reserve and its adjacent two-kilometer buffer zone. Land use information was extracted from seven Landsat TM/OLI images from 1986, 1994, 1999, 2004, 2009, 2014, and 2019. The spatio-temporal dynamics of land use over the past 35 years were studied using decision tree analysis and a transition matrix. The results showed that the land use in the reserve is mainly dominated by forestland, and the adjacent areas of the reserve is mainly dominated by forestland and arable land. Although the proportion of construction land is small, it has increased annually over the past 35 years. It was observed from the studies that the dynamic degree of construction land was always relatively high in the non-core region of the reserve and the adjacent areas, whereas the dynamic degrees of other land types fluctuated more gently, and the integrated land use dynamic degree of the adjacent areas was less. The core area changed more drastically, the change in the trend of the comprehensive land use dynamic degree in the adjacent areas and the non-core area was similar. After the establishment of the reserve, human disturbance was reduced in this region, and the land-use pattern became more stable. Furthermore, the conversion of land use types in the adjacent areas was frequent, of which the transfer and exchange between cultivated land and forest land was the most drastic, the conversion of land use in the non-core region was less. This shows that the establishment and management of the reserve effectively protects the local ecological environment. Additionally, the studies showed that the migration of the land use center of gravity had a certain direction. The center of gravity of all land use types in the non-core area of the reserve generally migrated to the northeast, and the center of gravity of construction land and cultivated land in the adjacent area of the reserve generally migrated to the west, indicating that the expansion of the original construction land had a strong influence on land use dynamics. The management of the reserve has achieved relatively remarkable effects and the ecological environment inside the reserve has been improved, but the slow increase of land for internal construction and resources exploitation still have a negative impact on the habitat quality of the reserve. This study provides data to support the dynamic monitoring of land use and further improvement of protection and restoration measures in subtropical natural reserves.

The regulation UN R127 is the must for the import country since 2018, In order to successfully pass the regulatory certification, so the pedestrian protection performance of the vehicle should be evaluated. In this paper, the pedestrian protection analysis was done by finite method, and the results show that the legform satisfy the regulation, but some area of the head don′t satisfy the requirements of the regulation. So some optimization analysis was made that aimed at the fail area to pass the UN R127 pedestrian protection certification test successfully. Comparing the optimized data of risk points with the experiment, the deviation is 1.9%, which shows the reliability of building the finite element model, and provide reference for the design and development of pedestrian protection for subsequent models.

This paper summarized the nursing experience a patient with duodenal fistula and deep venous thrombosis (DVT) after resection of giant retroperitoneal tumor. Nursing interventions included preoperative evaluation, DVT-associated nursing, skin care, enteral nutrition, etc. Diversified interventions before and after surgery are required to prevent the postoperative complicanions and improve the recovery. (本文总结1例全麻下行腹膜后巨大肿瘤切除术后合并十二指肠瘘及深静脉血栓的护理经验, 包括术前评估、深静脉血栓护理、皮肤管理、肠内营养护理等, 通过多元化的术前、术后护理, 积极预防并发症, 提高患者舒适度, 促进患者早日康复。)

Abstract Emerging studies suggest the application of self-regulation learning (SRL) to improve generalization abilities in poststroke patients. SRL has been proposed to have an added effect on computer-aided cognitive training (CACT). This study aimed to examine the efficacy of an intervention combining computer-aided SRL (CA-SRL) training and CACT for generalization abilities and cognitive function in patients with poststroke cognitive impairment (PSCI). A total of 75 patients recruited from a rehabilitation centre were randomly assigned to a CA-SRL group, demonstration learning (DL) group and traditional learning (TL) group. Finally, 72 patients were included in the analysis. Over 3 weeks, the patients in these three groups underwent CA-SRL or DL training combined with cognitive training. After the intervention, all outcomes significantly improved (P

Ordered core(PEO)-shell(PHB) microfibers were prepared by coaxial electrostatic spinning technology and high-speed rotating receiving roller with polyoxyethylene (PEO)/chloroform solvent as core spinning solution and poly(β-hydroxybutyrate) (PHB)/chloroform solvent as shell spinning solution. The surface morphology, core-shell structure, thermal properties, crystallization properties and mechanical properties of core(PEO)-shell(PHB) microfiber film were characterized and analyzed by SEM, TEM, DSC, TGA, XRD and DMA. The results show that PEO/PHB microfiber has remarkable core-shell structure; fiber arranges in the same direction and the average diameter are 0.57-1.27 μm; the crystal structure of core(PEO)-shell(PHB) microfiber includes α-type crystal of PHB and monoclinic crystal of PEO; when the spinning voltage is increased, the diameter of the fiber decreases, and the crystallinity increases first and then decreases; the fiber diameter increases with the increase of injection speed, and the crystallinity first increases and then decreases; with the increase of the collection distance, the fiber diameter first decreases and then increases, and the crystallinity first increases and then decreases. By changing the single spinning condition, the corresponding fiber films with the spinning voltage of 18 kV, the push velocity of 0.07 mm/min and the collection distance of 8 cm all have high mechanical properties. Compared with pure PHB fiber and PEO fiber, the thermal stability of each component in ordered core(PEO)-shell(PHB) microfiber is improved.

Objective To compare the research status and hotspots of immunotherapy for liver cancer at home and abroad. Methods Papers about immunotherapy for liver cancer published from the establishment to 2019 were searched in PubMed database and Chinese database. Information were extracted and sorted by BICOMB-2 software, and then we created the word matrix and co-occurrence matrix of high-frequency subject headings. The cluster analysis of subject headings was conducted by gCLUTO 1.0. NetDraw 2.089 was used to draw social network diagrams, UCINET 6.212 was used to conduct the centrality analysis. Results There were 2 081 foreign literatures and 901 Chinese literatures, involving 655 foreign periodicals and 275 Chinese periodicals. Four themes of immunotherapy for liver cancer were determined: the correlation between the immune inoculation of hepatitis B patients and the occurrence of liver cancer, the study between dendritic cells and immunotherapy for liver cancer, the study of the combination of radiotherapy and immunotherapy on liver cancer, and related research of natural killer cells and liver cancer immunotherapy. Conclusion The number of researches on immunotherapy for liver cancer have shown an increasing trend year by year. We can learn from the international research status and hotspots to create a new way for liver cancer treatment.

This paper summarized the nursing experience of non-invasive ventilation in prone position for a patient with acute respiratory distress syndrome combined with COVID-19. Key issues in nursing management included nursing assessment in the whole procedure of non-invasive ventilation in prone position, infection prevention, management of body position and tube, skin care, health education and so on. In the early stage of COVID-19 complicated with ARDS, non-invasive ventilation in prone position can not only effectively reduce the tube intubation and improve hypoxemia, but also reduce the labor cost and level of difficulty in nursing, reduce the workload and exposure time of medical staff, and reduce the risk of infection among medical staff. (本文总结1例新型冠状病毒肺炎合并急性呼吸窘迫综合征(ARDS)患者俯卧位无创通气治疗康复的护理经验。护理措施包括俯卧位无创通气全程护理评估、感染预防、体位及管道的管理、皮肤护理、健康宣教等。新型冠状病毒肺炎合并ARDS早期患者在清醒状态下进行无创呼吸机俯卧位通气, 不仅有效减少插管, 改善低氧血症, 同时也可以减轻人力成本和护理难度, 减少医务人员的工作量及暴露时间, 减少医务人员的感染风险。)

Cystic pheochromocytoma is an uncommon neuroendocrine tumor, which mostly has no obvious clinical symptoms, and difficult to make correct diagnosis before surgical operation. When a cystic mass in the adrenal gland is found by imaging examination, the possibility of cystic pheochromocytoma should be screened. At present, the most curative treatment is surgical resection. Laparoscopic adrenalectomy is the first choice. Adequate preoperative preparation and strict postoperative monitoring are important pre-requisites for ensuring the safety of patients during the peri-operative period.

Objective To explore the expression of CD4+ effector memory T cells (CD4+ TEM) in peripheral blood of acute ischemic stroke patients with pulmonary infection, and to analyze the value of CD4+ TEM combined with interleukin⁃6 (IL⁃6) and hypersensitive C⁃reactive protein (hs⁃CRP) in the diagnosis of pulmonary infection in patients with acute ischemic stroke. Methods Totally 54 confirmed acute ischemic stroke patients with pulmonary infection who were treated in the Department of Neurology at The Affiliated Hospital of Xuzhou Medical University from June 2018 to December 2019 were chosen as the infection group, meanwhile, 55 acute ischemic stroke patients without pulmonary infection were assigned as the control group. The clinical characters and the expression levels of CD4+ TEM cells were compared in the 2 groups. Univariate and multivariate Logistic regression analysis were used to screen the risk factors of pulmonary infection in patients with acute ischemic stroke, and receiver operating characteristic (ROC) curve was further conducted to evaluate the diagnostic value of the percentage of CD4+ TEM, IL⁃6, hs⁃CRP and combined detection in pulmonary infection patients with acute ischemic stroke. Results Multivariate Logistic regression analysis showed that the increased percentage of CD4+ TEM cells (OR=1.153, 95%CI:1.069-1.244; P=0.000), IL⁃6 (OR=1.351, 95%CI:1.046-1.747; P=0.021) and hs⁃CRP (OR=1.087, 95%CI:1.008-1.172; P=0.021) were important risk factors for pulmonary infection with acute ischemic stroke. When the percentage of CD4+ TEM cells, IL⁃6 and hs⁃CRP were used as predictors of pulmonary infection with acute ischemic stroke alone, the area under the ROC curve were 0.906 (95%CI:0.850⁃0.961), 0.799 (95%CI:0.714-0.885) and 0.831 (95%CI:0.754-0.908) respectively. When the percentage of CD4+ TEM cells were combined with IL⁃6 and hs⁃CRP, the area under the curve increased to 0.943 (95%CI:0.904-0.982). Conclusions The percentage of CD4+ TEM cells combined with IL⁃6 and hs⁃CRP has better diagnostic value for pulmonary infection with acute ischemic stroke, and can be used as biomarkers for early prediction of pulmonary infection with acute ischemic stroke. doi:10.3969/j.issn.1672⁃6731.2021.04.013

The purpose of this study was to prepare a kind of Zearalenone fast quantitative test strip based on time-resolved fluorescence immunochromatographic assay.Europium nanoparticles were used as fluorescent probes to label anti-zearalenone monoclonal antibodies,and a quantitative immunochromatography method was established based on competitive inhibition principle.The results showed that the sensitivity of Zearalenone fluorescent detection strip was 0.1 ng/mL,the linear range was 0.1～5.0 ng/mL,the standard recovery rate of negative samples of corn and wheat was between 93.45% and 112.2%,and the coefficient of variation of 5 repeats for the same sample was less than 15%.The results show that the Zearalenone fluorescent test strip has the technical characteristics of high sensitivity,short reaction time and accurate quantification,which is suitable for the rapid quantitative detection of Zearalenone in grain and its products.

Cyclophilin A (CypA) is the first foldable enzyme in human cells that has peptidyl proliferase-trans isomerase activity and has a strong proinflammatory effect. CD147 can act as the signal receptor of CypA. The interaction of the two through cell-surface heparin binding activates extracellular regulated protein kinases (ERK1/2) and nuclear factor kappa-B (NF-κB) signaling pathways in macrophages and increases the expression of MMPs and other inflammatory factors. The CypA/CD147 interaction regulates inflammation, promotes the inflammatory response and bone resorption and is involved in the pathological processes of a variety of systemic diseases. CypA and CD147 may take part in the chemotaxis of inflammatory cells, increase white blood cell infiltration in tissues, and increase CypA and CD147 expression in periodontitis gum tissue and gingival groove liquid with inflammation, prompting their interaction to promote the progression of periodontitis. However, the specific function of the signaling pathways in the periodontitis mechanism still requires further elucidation.

Using HZSM-5 zeolite, potassium permanganate and methanol as raw materials, MnOx/HZSM-5 catalyst was prepared to oxidize formaldehyde at room temperature. X-ray diffraction (XRD), Raman spectroscopy (Raman), scanning electron microscopy (SEM), transmission electron microscopy (TEM), photoelectron spectroscopy (XPS) and other characterization methods were used to analyze the morphology, structure and chemical composition of the catalyst. The catalytic activity and regeneration performance of MnOx/HZSM-5 on formaldehyde were studied, and the mechanism of formaldehyde catalytic oxidation was discussed. The results show that the formaldehyde removal rate of MnOx/HZSM-5 remains at 90% after 1020 minutes of dynamic testing. After five regeneration tests, the removal rate of formaldehyde by MnOx/HZSM-5 remains at 91%. In the static test, the formaldehyde removal rate reaches 97% and the conversion rate of formaldehyde reaches 92%. After analyzing the mechanism of oxidizing formaldehyde with MnOx/HZSM-5, it is found that formaldehyde is first adsorbed by the catalyst to the active site of MnOx. Then it is preliminarily oxidized to intermediate products such as formates or carbonates. Finally, it is deeply oxidized with carbon dioxide and water.

The design of MMC-STATCOM controller based on auto disturbance rejection technology is studied. Based on the ADRC, the active disturbance rejection controller is designed for the active and reactive current decoupling tracking. By scheduling the transition process, setting the expansion observer and the nonlinear state error feedback link, etc. The simulation model is built in MATLAB/Simulink to verify the effectiveness of the proposed control strategy. The results show that the MMC-STATCOM controller based on ADRC technology effectively overcomes the contradiction between PI control response speed and overshoot, achieves effective dynamic compensation of disturbance, solves the problem that the current tracking effect of the inner loop current tracker based on PI regulation is poor when the input of MMC-STATCOM is disturbed, and leads to a long transition process or even instability of the system.

Introdução: A pandemia pela Covid-19 trouxe desafios aos serviços de saúde, com necessidade de adaptações da estrutura, insumos e profissionais para atender a fluxos súbitos de pacientes, o que pode ter acarretado em quebras de medidas de prevenção de infecções relacionadas à assistência à saúde (IRAS). Características do paciente Covid-19 crítico, com admissões na terapia intensiva, múltiplos acessos centrais, ventilação mecânica prolongada, posição prona e uso de corticoides, os tornam vulneráveis às IRAS. Dados da literatura mundial apontam para maiores taxas de IRAS em pacientes Covid-19, mas pouco se sabe sobre a epidemiologia de IRAS nesse cenário em nosso meio. Objetivos: Avaliar a epidemiologia e desfecho em 30 dias de pacientes Covid-19 e outras condições que desenvolveram IRAS. Métodos: Estudo observacional, de coorte retrospectivo de casos consecutivos de IRAS em pacientes adultos Covid e não Covid, admitidos em um centro único, terciário e de ensino, entre março/2020 a agosto/2021. Resultados: No período estudado, ocorreram 144 casos de IRAS. Nos pacientes Covid-19, a prevalência de IRAS foi 3,5% (76/2150 admissões) e nos pacientes admitidos por outras causas foi 0,4% (68/17.074 admissões), p < 0,001. Com relação às topografias, nos pacientes Covid-19 as infecções primárias da corrente sanguínea (IPCS) n = 36/76 (47%) foram mais frequentes, seguidas de pneumonia associada à ventilação mecânica (PAV) n = 28/76 (37%). Nos pacientes admitidos por outras condições, as principais topografias foram IPCS n = 34/68 (50%) e gastrointestinais (Clostridioides difficile) n = 19/68 (28%). Em pacientes Covid-19, Pseudomonas aeruginosa foi o principal agente isolado em n = 18/83 amostras de culturas isoladas dos 76 casos (22%) e Staphylococcus epidermidis n=14/83 (17%). Nos pacientes não Covid-19, os agentes mais comuns foram Clostridioides difficile n=19/73 amostras de culturas isoladas dos 68 episódios (40%) e Klebsiella pneumoniae n = 15/73 (32%). A taxa de mortalidade em 30 dias de pacientes que desenvolveram IRAS, foi 53% em pacientes Covid-19 versus 28% em pacientes não Covid-19, p = 0,002. Conclusões: Em nossa coorte de pacientes, as IRAS foram mais frequentes nos pacientes Covid-19 com relação aos admitidos por outras condições. A etiologia diferiu nos 2 grupos, com predomínio de P. aeruginosa em pacientes Covid-19. A mortalidade em 30 dias de pacientes com Covid-19 que desenvolveram IRAS foi elevada, demonstrando o impacto negativo das IRAS nesse contexto.

Endometrial cancer (EC) is one of the most common gynaecological tumours in the worldwide. Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) promotes cell proliferation, migration and invasion in EC cells. However, the molecular mechanisms of NEAT1 in EC have not been fully clarified. We conducted this study to reveal the function of NEAT1 in EC tissues and cell lines.

Objective To study the detection rate of Streptococcus mutans in oral cavities of 3⁃5⁃year⁃old Han, Uygur and Mongolian children in Bortala Mongolian Autonomous Prefecture, and the correlation between genotype and dental caries of preschool children. Methods Ninety children were randomly selected from the sample bank of chil⁃ dren′s oral epidemiological survey data in the Bozhou area of Xinjiang. Forty⁃five children were included in the high caries group (more than 5 missing teeth), and 45 children were included in the noncaries group (0 missing teeth); each group comprised 15 children of each of the Han, Uygur and Mongolian nationalities. Plaque samples were collected and cultured with light saliva⁃bacillin agar medium and brain⁃heart infusion medium. Streptococcus mutans were cultured, and clinical isolates were further isolated and identified by Gram staining, biochemical identification and polymerase chain reaction. Genotype distribution was detected by random primer polymerase chain reaction. Results The detec⁃ tion rate of Streptococcus mutans in the 90 included children was 75.5%. The detection rate of Streptococcus mutans in the high caries group was 86.7%, which was significantly higher than that in the caries⁃free group (64.4%) (P＝0.014). There was no significant difference in the distribution of Streptococcus mutans among Han, Uygur and Mongolian nation⁃ alities (P＝0.457). A total of 549 clinical strains of Streptococcus mutans were obtained, and 113 different genotypes were found. In the high caries group, 61.5% carried more than one genotype of Streptococcus mutans, and 37.9% of the caries ⁃ free group had more than one genotype. The genetic polymorphism of Streptococcus mutans in the high caries group was significantly higher than that in the caries⁃free group (P＝0.035). Spearman correlation analysis showed that there was a positive correlation between oral Streptococcus mutans gene polymorphism and caries sensitivity (r＝0.258, P＝0.034). Conclusion The distribution of Streptococcus mutans in children′s oral cavity in the Bozhou area was dif⁃ ferent between the high caries group and the caries⁃free group, but there was no difference among nationalities. Strepto⁃ coccus mutans in the high caries group had more genotypes than those in the caries⁃free group. The genetic polymor⁃ phism of Streptococcus mutans might be related to the caries⁃causing ability of Streptococcus mutans.

Abstract Background The costs for treating coronary artery disease (CAD) are high worldwide. We performed a prespecified analyses of cost-effectiveness of three therapeutic strategies for multivessel CAD. Methods From May 1995 to May 2000, a total of 611 patients were randomly assigned to coronary artery bypass graft (CABG), n = 203; percutaneous coronary intervention (PCI), n = 205; or medical treatment (MT), n = 203. This cost analysis study was based on the perspective of the Public Health Care System. Initial procedural and follow-up costs for medications, cardiology examinations, and hospitalizations for complications were calculated after randomization. Life-years and quality-adjusted life years (QALYs) were used as effectiveness measures. Incremental cost-effectiveness ratios (ICER) were obtained by using nonparametric bootstrapping methods with 5000 resamples. Results Initial procedural costs were lower for MT. However, the subsequent 5-year cumulative costs were lower for CABG. Compared with baseline, the three treatment options produced significant improvements in QALYs. After 5 years, PCI and CABG had better QALYs results compared with MT. The ICER results favored CABG and PCI, and favored PCI over CABG in 61% of the drawings. On the other hand, sensitivity analysis showed MT as the preferred therapy compared with CABG and PCI, in the analysis considering higher costs. Conclusions At 5-year follow-up, the three treatment options yielded improvements in quality of life, with comparable and acceptable costs. However, despite higher initial costs, the comparison of cost-effectiveness after 5 years of follow-up among the three treatments showed both interventions (CABG and PCI) to be cost-effective strategies compared with MT. Trial registration ISRCTN, ISRCTN66068876, Registered 06/10/1994, http://www.controlled-trials.com/ISRCTN66068876

With social media booming, newspapers are facing an enormous challenge, and some have even had to exit the market. Likewise, their role as a main force of public opinion guidance in China has also been challenged. They have lost their vantage ground. The present study conducted a case study on one well-known Chinese online public opinion event. Through analyzing the newspapers' role played in different public opinion development stages, this study displayed how Chinese newspapers worked together and successfully guided online public opinion in that case. The newspapers' advantages in guiding public opinion and suggestions as to how newspapers can survive and guide public opinion in the new media era are put forward in the final section.